G-Quadruplexes as INnovative ThERApeutiC Targets (G4_INTERACT)
Objective
The group interest is to connect expert young people in the G4-field to share information on the groundbreaking research and results on DNA and RNA G-Quadruplex. The scope of this group includes, but is not limited to: - Selectivity development in targeting G4s - New strategic approaches in G4 imaging and binding - G4-related biological processes and pathways: connection to human diseases - G4 structural aspect; biophysics and biomolecular data - Other unusual non-canonical nucleic acids structures Keep in touch! https://twitter.com/g4interact
Definition
G-Quadruplexes (G4) are non-canonical higher-order supramolecular structures that form on repeats of short guanine(G)-tracts. G4s have gained increasing attention in medicinal chemistry because they are not randomly distributed across the cell genome but are mainly clustered in “hot” genomic regions. Including telomeres, gene promoters, open reading frames and untranslated regions. Thus, they are involved in the control of key biological processes as well as regulation of gene expression, genomic instability and viral transcription.
Group members
Founder
Managing Director
Member
Virtual Event
- Special Issue "Principles and Molecular Mechanisms of DNA and RNA G-Quadruplexes in Gene Regulation"
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This Special Issue on Biomolecules (MDPI) intends to bring together specialists to cover different aspects of the biology of DNA and RNA G4s. Special Issue Editors: Assist. Prof. Pavel Ivanov, Dr. Prakash Kharel, Dr. Anna Varizhuk and Dr. Valentina Pirota
- Twitter account
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- Special Issue ""G-quadruplex Folding Modulation: Structural Insights, Selective Interaction, and Functional Activity"
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School
- INTERACTION WINS 2021
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Innovative ThERApeutiC Targets In nOn-canonical Nucleic acids structures Winter InterNationalSchool INTERACTION WINS 2021 aims to provide an overview of non-canonical secondary structures of nucleic acids (NA).Our goal is to familiarize the young scientists with a general methodology for investigating NA structures, support international collaborations, and provide a platform for free discussions on the limitations and prospects of NA-targeting therapeutics.
- INTERACTION WINS 2023
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Innovative ThERApeutiC Targets In nOn-canonical Nucleic acids structures Winter InterNationalSchool INTERACTION WINS 2021 aims to provide an overview of non-canonical secondary structures of nucleic acids (NA).Our goal is to familiarize the young scientists with a general methodology for investigating NA structures, support international collaborations, and provide a platform for free discussions on the limitations and prospects of NA-targeting therapeutics.
Paper
- Selective Binding and Redox-Activity on Parallel G-Quadruplexes by Pegylated Naphthalene Diimide-Copper Complexes
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V. Pirota*, E. Lunghi, A. Benassi, E. Crespan, M. Freccero, F. Doria*
- Probing GFP Chromophore Analogs as Anti-HIV Agents Targeting LTR-III G-Quadruplex
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Dmitriy Y. Ryazantsev, Mikhail Yu. Myshkin, Vera A. Alferova, Vladimir B. Tsvetkov, Elena Y. Shustova, Polina N. Kamzeeva, Polina V. Kovalets, Elvira R. Zaitseva, Nadezhda S. Baleeva, Timofei S. Zatsepin, Zakhar O. Shenkarev, Mikhail S. Baranov, Liubov I. Kozlovskaya and Andrey V. Aralov
- Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core
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Julia Svetlova, Makar Sardushkin, Natalia Kolganova and Edward Timofeev
- Multimeric G-quadruplexes: A review on their biological roles and targeting
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I. Frasson,V. Pirota, Richter Sara N., F. Doria
- Anticancer activity of G4-targeting phenoxazine derivatives in vitro
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S.Lizunova, V.Tsvetkov, D.Skvortsov, P.Kamzeeva, O.Ivanova, L.Vasilyeva, A.Chistov, E.Belyaev, A.Khrulev, T.Vedekhina, A.Bogomazova, M.Lagarkova, A.Varizhuk, A.Aralov
- Modeling G4s in chromatin context confirms partial nucleosome exclusion and reveals nucleosome-disrupting effects of the least selective G4 ligands
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Iu.Pavlova, N.Barinov, R.Novikov, V.Severov, M.Iudin, T.Vedekhina, A.Larin, V.Babenko, A.Aralov, E.Gnuchikh, M.Sardushkin, D.Klinov, V.Tsvetkov, A.Varizhuk
- Ratiometric i-Motif-Based Sensor for Precise Long-Term Monitoring of pH Micro Alterations in the Nucleoplasm and Interchromatin Granules
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N.Petrunina, A.Shtork, M.Lukina, V.Tsvetkov, Yu.Khodarovich, A.Feofanov, A.Moysenovich, E.Maksimov, V.Shipunova, T.Zatsepin, A.Bogomazova, V.Shender, A.Aralov, M.Lagarkova, A.Varizhuk