DAVID KARASIK

USERN Advisory Board

Associate Professor, Faculty of Medicine, Bar Ilan University, Israel and Associate Scientist, Hebrew SeniorLife (Boston, MA)

Dr. Karasik holds a PhD degree in Anatomy and Anthropology (Tel Aviv University, Israel). Dr. Karasik’s research focuses on genetic mechanisms of aging-related diseases, such as osteoporosis, fractures, and muscle loss, studying both human populations and animal models. He was a founding member of the GEFOS and CHARGE consortia and is actively involved in the TopMED Initiative (USA). His recent efforts have focused on fine-mapping (by targeted sequencing) and functional follow-up of the GWAS-identified loci. The lab uses molecular biology techniques in vitro and the zebrafish (Danio rerio, ZF) as an in vivo model for functional follow-up of the human associations.

RESEARCH INTERESTS

The primary objective of our research is to understand the biology behind the function and pathology of complex physiological systems and metabolic processes. Our research focuses on identifying genes involved in the genetic variation of complex traits, including bone mass, muscle (lean) mass, and fatty liver.

PUBLICATIONS

Medina-Gomez, C., Mullin, B.H., Chesi, A., Prijatelj, V., Kemp, J.P., Shochat-Carvalho, C., Trajanoska, K., Wang, C., Joro, R., Evans, T.E., Schraut, K.E., Li-Gao, R., Ahluwalia, T.S., Zillikens, M.C., Zhu, K., Mook-Kanamori, D.O., Evans, D.S., Nethander, M., Knol, M.J., Thorleifsson, G., Prokic, I., Zemel, B., Broer, L., McGuigan, F.E., van Schoor, N.M., Reppe, S., Pawlak, M.A., Ralston, S.H., van der Velde, N., Lorentzon, M., Stefansson, K., Adams, H.H.H., Wilson, S.G., Ikram, M.A., Walsh, J.P., Lakka, T.A., Gautvik, K.M., Wilson, J.F., Orwoll, E.S., van Duijn, C.M., Bønnelykke, K., Uitterlinden, A.G., Styrkársdóttir, U., Akesson, K.E., Spector, T.D., Tobias, J.H., Ohlsson, C., Felix, J.F., Bisgaard, H., Grant, S.F.A., Richards, J.B., Evans, D.M., van der Eerden, B., van de Peppel, J., Ackert-Bicknell, C., Karasik, D., Kague, E., Rivadeneira, F. (2023) Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis. Communications biology. 6:691691

Grinberg, L., Dabbah Assadi, F., Baum, G., Zemel, R., Tur-Kaspa, R., Shochat, C., Karasik, D., Karpuj, M.V. (2023) Beneficial Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease (NAFLD) Progression in the Zebrafish Model. Nutrients. 15(6):

Khrystoforova, I., Shochat-Carvalho, C., Harari, R., Henke, K., Woronowicz, K., Harris, M.P., Karasik, D. (2022) Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation. Frontiers in endocrinology. 13:985304

Mesika, A., Nadav, G., Shochat, C., Kalfon, L., Jackson, K., Khalaileh, A., Karasik, D., Falik-Zaccai, T.C. (2022) NGLY1 Deficiency Zebrafish Model Manifests Abnormalities of the Nervous and Musculoskeletal Systems. Frontiers in cell and developmental biology. 10:902969

Banerjee, B., Khrystoforova, I., Polis, B., Zvi, I.B., Karasik, D. (2021) Acute hypoxia elevates arginase 2 and induces polyamine stress response in zebrafish via evolutionarily conserved mechanism. Cellular and molecular life sciences : CMLS. 79(1):41

Bek, J.W., Shochat, C., De Clercq, A., De Saffel, H., Boel, A., Metz, J., Rodenburg, F., Karasik, D., Willaert, A., Coucke, P.J. (2021) Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR-based functional screening of osteoporosis candidate genes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 36(9):1749-1764

Tobias, J.H., Duncan, E.L., Kague, E., Hammond, C.L., Gregson, C.L., Bassett, D., Williams, G.R., Min, J.L., Gaunt, T.R., Karasik, D., Ohlsson, C., Rivadeneira, F., Edwards, J.R., Hannan, F.M., Kemp, J.P., Gilbert, S.J., Alonso, N., Hassan, N., Compston, J.E., Ralston, S.H. (2021) Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020. Frontiers in endocrinology. 11:630875

Banerjee, B., Koner, D., Karasik, D., Saha, N. (2020) Genome-wide identification of novel long non-coding RNAs and their possible roles in hypoxic zebrafish brain. Genomics. 113(1 Pt 1):29-43

Shochat, C., Wang, Z., Mo, C., Nelson, S., Donaka, R., Huang, J., Karasik, D., Brotto, M. (2020) Deletion of SREBF1, a functional bone-muscle pleiotropic gene, alters bone density and lipid signaling in zebrafish. Endocrinology. 162(1):

Khajuria, D.K., Karasik, D. (2020) Novel model of restricted mobility induced osteopenia in zebrafish. Journal of Fish Biology. 98(4):1031-1038

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