Roger Kornberg

Roger David Kornberg (born April 24,1947) is an American biochemist and professor of structural biology at Stanford University School of Medicine. Kornberg was awarded the Nobel Prize in Chemistry in 2006 for his studies of the process by which genetic information from DNA is copied to RNA, "the molecular basis of eukaryotic transcription."

Kornberg was born in St. Louis, Missouri, the eldest son of biochemist Arthur Kornberg, who won the Nobel Prize, and Sylvy Ruth (Levy) who was also a biochemist. He earned his bachelor's degree in chemistry from Harvard University in 1967 and his Ph.D. in chemical physics from Stanford in 1972 supervised by Harden M. McConnell.

Kornberg became a postdoctoral research fellow at the Laboratory of Molecular Biology in Cambridge, England and then an Assistant Professor of Biological Chemistry at Harvard Medical School in 1976, before moving to his present position as Professor of Structural Biology at Stanford Medical School in 1978.

Awards And Honors:

1981: Eli Lilly Award in Biological Chemistry

1982: Passano Award from the Passano Foundation

1990: Ciba-Drew Award

1997: Harvey Prize from the Technion – Israel Institute of Technology

2000: Gairdner Foundation International Award

2001: Hoppe-Seyler Award, Society for Biochemistry and Molecular Biology, Germany

2001: Welch Award in Chemistry

2002: ASBMB-Merck Award

2002: Pasarow Award in Cancer Research

2002: Grand Prix Charles-Leopold Mayer

2003: Elected to EMBO Membership

2003: Massry Prize from the Keck School of Medicine, University of Southern California

2005: General Motors Cancer Research Foundation’s Alfred P. Sloan, Jr. Prize

2006: Dickson Prize from University of Pittsburgh

2006: Nobel Prize in Chemistry

2006: Louisa Gross Horwitz Prize from Columbia University

2009: Elected a Foreign Member of the Royal Society

Current Research and Scholarly Interests:

Our goal is to elucidate the fundamental basis of gene regulation. We study the control of transcription, the first step in the pathway of gene expression. Current work focuses on discovery of the molecular machines involved in transcription, reconstitution of the process with purified components, structure determination of the transcription machinery, and structure-function relationships in chromatin, the natural DNA template for transcription.

Highlights of work from the past three years include:

1. Discovery of a human homolog of the 20-protein yeast Mediator complex. Mediator is the central processing unit of gene regulation, receiving both positive and negative inputs and transducing the information to the transcription machinery.

2. Structure determination of 10-subunit, half million Dalton RNA polymerase II, in the act of transcription, with template DNA and protduct RNA, by X-ray crystallography at atomic resolution.

3. Structure determination of the entire transcription initiation complex by two-dimensional protein crystallography.

4. Discovery of a stably altered nucleosome produced by a purified chromatin-remodeling complex.

Current work is directed towards the structure of the entire transcription apparatus at atomic resolution and the mechanism of transcription control in living cells.

Publications

• Real-time observation of the initiation of RNA polymerase II transcription. NatureFazal, F. M., Meng, C. A., Murakami, K., Kornberg, R. D., Block, S. M.2015; 525 (7568): 274-277
• Uncoupling Promoter Opening from Start-Site Scanning. Molecular cellMurakami, K., Mattei, P., Davis, R. E., Jin, H., Kaplan, C. D., Kornberg, R. D.2015; 59 (1): 133-138
• Role of DNA sequence in chromatin remodeling and the formation of nucleosome-free regions GENES & DEVELOPMENTLorch, Y., Maier-Davis, B., Kornberg, R. D.2014; 28 (22): 2492-2497
• Nanoparticle imaging. Electron microscopy of gold nanoparticles at atomic resolution. ScienceAzubel, M., Koivisto, J., Malola, S., Bushnell, D., Hura, G. L., Koh, A. L., Tsunoyama, H., Tsukuda, T., Pettersson, M., Häkkinen, H., Kornberg, R. D.2014; 345 (6199): 909-912
• Electron microscopy of gold nanoparticles at atomic resolution SCIENCEAzubel, M., Koivisto, J., Malola, S., Bushnell, D., Hura, G. L., Koh, A. L., Tsunoyama, H., Tsukuda, T., Pettersson, M., Hakkinen, H., Kornberg, R. D.2014; 345 (6199): 909-912
• Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICASchweikhard, V., Meng, C., Murakami, K., Kaplan, C. D., Kornberg, R. D., Block, S. M.2014; 111 (18): 6642-6647
• Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex SCIENCEMurakami, K., Elmlund, H., Kalisman, N., Bushnell, D. A., Adams, C. M., Azubel, M., Elmlund, D., Levi-Kalisman, Y., Liu, X., Gibbons, B. J., Levitt, M., Kornberg, R. D.2013; 342 (6159): 709-?
• Architecture of an RNA polymerase II transcription pre-initiation complex. ScienceMurakami, K., Elmlund, H., Kalisman, N., Bushnell, D. A., Adams, C. M., Azubel, M., Elmlund, D., Levi-Kalisman, Y., Liu, X., Gibbons, B. J., Levitt, M., Kornberg, R. D.2013; 342 (6159): 1238724-?
• Formation and Fate of a Complete 31-Protein RNA Polymerase II Transcription Preinitiation Complex JOURNAL OF BIOLOGICAL CHEMISTRYMurakami, K., Calero, G., Brown, C. R., Liu, X., Davis, R. E., Boeger, H., Kornberg, R. D.2013; 288 (9): 6325-6332
• RNA polymerase II transcription: Structure and mechanism BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMSLiu, X., Bushnell, D. A., Kornberg, R. D.2013; 1829 (1): 2-8
• Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICARobinson, P. J., Bushnell, D. A., Trnka, M. J., Burlingame, A. L., Kornberg, R. D.2012; 109 (44): 17931-17935
• Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALarson, M. H., Zhou, J., Kaplan, C. D., Palangat, M., Kornberg, R. D., Landick, R., Block, S. M.2012; 109 (17): 6555-6560
• Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAMurakami, K., Gibbons, B. J., Davis, R. E., Nagai, S., Liu, X., Robinson, P. J., Wu, T., Kaplan, C. D., Kornberg, R. D.2012; 109 (13): 4816-4821
• Subunit architecture of general transcription factor TFIIH PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAGibbons, B. J., Brignole, E. J., Azubel, M., Murakami, K., Voss, N. R., Bushnell, D. A., Asturias, F. J., Kornberg, R. D.2012; 109 (6): 1949-1954
• Lock and Key to Transcription: sigma-DNA Interaction CELLLiu, X., Bushnell, D. A., Kornberg, R. D.2011; 147 (6): 1218-1219
• Selective removal of promoter nucleosomes by the RSC chromatin-remodeling complex NATURE STRUCTURAL & MOLECULAR BIOLOGYLorch, Y., Griesenbeck, J., Boeger, H., Maier-Davis, B., Kornberg, R. D.2011; 18 (8): 881-U34
• Initiation Complex Structure and Promoter Proofreading SCIENCELiu, X., Bushnell, D. A., Silva, D., Huang, X., Kornberg, R. D.2011; 333 (6042): 633-637
• Architecture of the Mediator head module NATUREImasaki, T., Calero, G., Cai, G., Tsai, K., Yamada, K., Cardelli, F., Erdjument-Bromage, H., Tempst, P., Berger, I., Kornberg, G. L., Asturias, F. J., Kornberg, R. D., Takagi, Y.2011; 475 (7355): 240-U45
• Isolation of an activator-dependent, promoter-specific chromatin remodeling factor PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAEhrensberger, A. H., Kornberg, R. D.2011; 108 (25): 10115-10120
• Electronic and Vibrational Signatures of the Au-102(p-MBA)(44) Cluster JOURNAL OF THE AMERICAN CHEMICAL SOCIETYHulkko, E., Lopez-Acevedo, O., Koivisto, J., Levi-Kalisman, Y., Kornberg, R. D., Pettersson, M., Hakkinen, H.2011; 133 (11): 3752-3755
• Synthesis and Characterization of Au-102(p-MBA)(44) Nanoparticles JOURNAL OF THE AMERICAN CHEMICAL SOCIETYLevi-Kalisman, Y., Jadzinsky, P. D., Kalisman, N., Tsunoyama, H., Tsukuda, T., Bushnell, D. A., Kornberg, R. D.2011; 133 (9): 2976-2982
• RNA polymerase II trigger loop residues stabilize and position the incoming nucleotide triphosphate in transcription PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAHuang, X., Wang, D., Weiss, D. R., Bushnell, D. A., Kornberg, R. D., Levitt, M.2010; 107 (36): 15745-15750
• Mechanism of chromatin remodeling PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALorch, Y., Maier-Davis, B., Kornberg, R. D.2010; 107 (8): 3458-3462
• Synthesis and Bioconjugation of 2 and 3 nm-Diameter Gold Nanoparticles BIOCONJUGATE CHEMISTRYAckerson, C. J., Jadzinsky, P. D., Sexton, J. Z., Bushnell, D. A., Kornberg, R. D.2010; 21 (2): 214-218
• Structure of an RNA Polymerase II-TFIIB Complex and the Transcription Initiation Mechanism SCIENCELiu, X., Bushnell, D. A., Wang, D., Calero, G., Kornberg, R. D.2010; 327 (5962): 206-209
• An Rtt109-Independent Role for Vps75 in Transcription-Associated Nucleosome Dynamics MOLECULAR AND CELLULAR BIOLOGYSelth, L. A., Lorch, Y., Ocampo-Hafalla, M. T., Mitter, R., Shales, M., Krogan, N. J., Kornberg, R. D., Svejstrup, J. Q.2009; 29 (15): 4220-4234
• Schizosacharomyces pombe RNA polymerase II at 3.6-angstrom resolution PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICASpahr, H., Calero, G., Bushnell, D. A., Kornberg, R. D.2009; 106 (23): 9185-9190
• Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution SCIENCEWang, D., Bushnell, D. A., Huang, X., Westover, K. D., Levitt, M., Kornberg, R. D.2009; 324 (5931): 1203-1206
• Structure of a RSC-nucleosome complex and insights into chromatin remodeling NATURE STRUCTURAL & MOLECULAR BIOLOGYChaban, Y., Ezeokonkwo, C., Chung, W., Zhang, F., Kornberg, R. D., Maier-Davis, B., Lorch, Y., Asturias, F. J.2008; 15 (12): 1272-1277
• The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin MOLECULAR CELLKaplan, C. D., Larsson, K., Kornberg, R. D.2008; 30 (5): 547-556
• Nucleosome retention and the stochastic nature of promoter chromatin remodeling for transcription CELLBoeger, H., Griesenbeck, J., Kornberg, R. D.2008; 133 (4): 716-726
• Structural Basis of RNA Polymerase II Pausing and ArrestWang, D., Bushnell, D., Westover, K., Kornberg, R.FEDERATION AMER SOC EXP BIOL. 2008
• A bridge to transcription by RNA polymerase. Journal of biologyKaplan, C. D., Kornberg, R. D.2008; 7 (10): 39-?
• Chromatin rules NATURE STRUCTURAL & MOLECULAR BIOLOGYKornberg, R. D., Lorch, Y.2007; 14 (11): 986-988
• Structure of a thiol monolayer-protected gold nanoparticle at 1.1 angstrom resolution SCIENCEJadzinsky, P. D., Calero, G., Ackerson, C. J., Bushnell, D. A., Kornberg, R. D.2007; 318 (5849): 430-433
• The molecular basis of eukaryotic transcription PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAKornberg, R. D.2007; 104 (32): 12955-12961
• INOR 1285-Structural basis of Mg2+inhibition in RNA polymerase II transcriptionWang, D., Bushnell, D. A., Kornberg, R. D.AMER CHEMICAL SOC. 2007: 283–283
• The molecular basis of eukaryotic transcription (Nobel Lecture). Angewandte Chemie (International ed. in English)Kornberg, R.2007; 46 (37): 6956-6965
• The molecular basis of eukaryotic transcription (Nobel lecture) ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONKornberg, R.2007; 46 (37): 6957-6965
• Structural basis of transcription: Role of the trigger loop in substrate specificity and catalysis CELLWang, D., Bushnell, D. A., Westover, K. D., Kaplan, C. D., Kornberg, R. D.2006; 127 (5): 941-954
• Head module control of mediator interactions MOLECULAR CELLTakagi, Y., Calero, G., Komori, H., Brown, J. A., Ehrensberger, A. H., Hudmon, A., Asturias, F., Kornberg, R. D.2006; 23 (3): 355-364
• Rigid, specific, and discrete gold nanoparticle/antibody conjugates JOURNAL OF THE AMERICAN CHEMICAL SOCIETYAckerson, C. J., Jadzinsky, P. D., Jensen, G. J., Kornberg, R. D.2006; 128 (8): 2635-2640
• Chromatin remodeling by nucleosome disassembly in vitro PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALorch, Y., Maier-Davis, B., Kornberg, R. D.2006; 103 (9): 3090-3093
• Mediator as a general transcription factor JOURNAL OF BIOLOGICAL CHEMISTRYTakagi, Y., Kornberg, R. D.2006; 281 (1): 80-89
• Defined DNA/nanoparticle conjugates PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAAckerson, C. J., Sykes, M. T., Kornberg, R. D.2005; 102 (38): 13383-13385
• Thiolate ligands for synthesis of water-soluble gold clusters JOURNAL OF THE AMERICAN CHEMICAL SOCIETYAckerson, C. J., Jadzinsky, P. D., Kornberg, R. D.2005; 127 (18): 6550-6551
• Mediator and the mechanism of transcriptional activation TRENDS IN BIOCHEMICAL SCIENCESKornberg, R. D.2005; 30 (5): 235-239
• Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage MOLECULAR CELLTakagi, Y., Masuda, C. A., Chang, W. H., Komori, H., Wang, D., Hunter, T., Joazeiro, C. A., Kornberg, R. D.2005; 18 (2): 237-243
• Structural basis of eukaryotic gene transcription 130th Nobel Symposium on Molecular Mechanisms in Biological ProcessesBoeger, H., Bushnell, D. A., Davis, R., Griesenbeck, J., Lorch, Y., Strattan, J. S., Westover, K. D., Kornberg, R. D.ELSEVIER SCIENCE BV. 2005: 899–903
• Chromatin remodeling by DNA bending, not twisting PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALorch, Y., Davis, B., Kornberg, R. D.2005; 102 (5): 1329-1332
• Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICABatada, N. N., Westover, K. D., Bushnell, D. A., Levitt, M., Kornberg, R. D.2004; 101 (50): 17361-17364
• Structural basis of transcription: Nucleotide selection by rotation in the RNA polymerase II active center CELLWestover, K. D., Bushnell, D. A., Kornberg, R. D.2004; 119 (4): 481-489
• Removal of promoter nucleosomes by disassembly rather than sliding in vivo MOLECULAR CELLBoeger, H., Griesenbeck, J., Strattan, J. S., Kornberg, R. D.2004; 14 (5): 667-673
• Structural basis of transcription: Separation of RNA from DNA by RNA polymerase II SCIENCEWestover, K. D., Bushnell, D. A., Kornberg, R. D.2004; 303 (5660): 1014-1016
• Structural basis of transcription: An RNA polymerase II-TFIIB cocrystal at 4.5 angstroms SCIENCEBushnell, D. A., Westover, K. D., Davis, R. E., Kornberg, R. D.2004; 303 (5660): 983-988
• Electron microscopic analysis of the RSC chromatin remodeling complex CHROMATIN AND CHROMATIN REMODELING ENZYMES, PT BAsturias, F. J., Ezeokonkwo, C., Kornberg, R. D., Lorch, Y.2004; 376: 48-62
• Purification of defined chromosomal domains CHROMATIN AND CHROMATIN REMODELING ENZYMES, PT AGriesenbeck, J., Boeger, H., Strattan, J. S., Kornberg, R. D.2004; 375: 170-178
• Isolation and assay of the RSC chromatin-remodeling complex from Saccharomyces cerevisiae CHROMATIN AND CHROMATIN REMODELING ENZYMES, PT CLorch, Y., Kornberg, R. D.2004; 377: 316-322
• Affinity purification of specific chromatin segments from chromosomal loci in yeast MOLECULAR AND CELLULAR BIOLOGYGriesenbeck, J., Boeger, H., Strattan, J. S., Kornberg, R. D.2003; 23 (24): 9275-9282
• Association of the mediator complex with enhancers of active genes PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAKuras, L., Borggrefe, T., Kornberg, R. D.2003; 100 (24): 13887-13891
• Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH JOURNAL OF BIOLOGICAL CHEMISTRYTakagi, Y., Komori, H., Chang, W. H., Hudmon, A., Erdjument-Bromage, H., Tempst, P., Kornberg, R. D.2003; 278 (45): 43897-43900
• RNA polymerase II/TFIIF structure and conserved organization of the initiation complex MOLECULAR CELLChung, W. H., Craighead, J. L., Chang, W. H., Ezeokonkwo, C., Bareket-Samish, A., Kornberg, R. D., Asturias, F. J.2003; 12 (4): 1003-1013
• Complete, 12-subunit RNA polymerase II at 4.1-angstrom resolution: Implications for the initiation of transcription PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICABushnell, D. A., Kornberg, R. D.2003; 100 (12): 6969-6973
• Nucleosomes unfold completely at a transcriptionally active promoter MOLECULAR CELLBoeger, H., Griesenbeck, J., Strattan, J. S., Kornberg, R. D.2003; 11 (6): 1587-1598
• A complex of the Srb8,-9,-10, and-11 transcriptional regulatory proteins from yeast JOURNAL OF BIOLOGICAL CHEMISTRYBorggrefe, T., Davis, R., Erdjument-Bromage, H., Tempst, P., Kornberg, R. D.2002; 277 (46): 44202-44207
• Structural analysis of the RSC chromatin-remodeling complex PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAAsturias, F. J., Chung, W. H., Kornberg, R. D., Lorch, Y.2002; 99 (21): 13477-13480
• Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction MOLECULAR CELLDavis, J. A., Takagi, Y., Kornberg, R. D., Asturias, F. J.2002; 10 (2): 409-415
• Chromatin and transcription: where do we go from here. Current opinion in genetics & developmentKornberg, R. D., Lorch, Y.2002; 12 (2): 249-251
• Structural basis of transcription: alpha-Amanitin-RNA polymerase II cocrystal at 2.8 A resolution PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICABushnell, D. A., Cramer, P., Kornberg, R. D.2002; 99 (3): 1218-1222
• A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICANagy, P. L., Griesenbeck, J., Kornberg, R. D., Cleary, M. L.2002; 99 (1): 90-94
• Quantitation of the RNA polymerase II transcription machinery in yeast JOURNAL OF BIOLOGICAL CHEMISTRYBorggrefe, T., Davis, R., Bareket-Samish, A., Kornberg, R. D.2001; 276 (50): 47150-47153
• A multiprotein complex that interacts with RNA polymerase II elongator JOURNAL OF BIOLOGICAL CHEMISTRYLi, Y., Takagi, Y., Jiang, Y. W., Tokunaga, M., Erdjument-Bromage, H., Tempst, P., Kornberg, R. D.2001; 276 (32): 29628-29631
• The eukaryotic gene transcription machinery BIOLOGICAL CHEMISTRYKornberg, R. D.2001; 382 (8): 1103-1107
• Structural basis of transcription: RNA polymerase II at 2.8 angstrom ngstrom resolution SCIENCECramer, P., Bushnell, D. A., Kornberg, R. D.2001; 292 (5523): 1863-1876
• Structural basis of transcription: An RNA polymerase II elongation complex at 3.3 angstrom resolution SCIENCEGnatt, A. L., Cramer, P., Fu, J. H., Bushnell, D. A., Kornberg, R. D.2001; 292 (5523): 1876-1882
• Selenomethionine incorporation in Saccharomyces cerevisiae RNA polymerase II STRUCTUREBushnell, D. A., Cramer, P., Kornberg, R. D.2001; 9 (1): R11-R14
• RSC unravels the nucleosome MOLECULAR CELLLorch, Y., Zhang, M. C., Kornberg, R. D.2001; 7 (1): 89-95
• Structural organization of yeast and mammalian mediator complexes PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICADotson, M. R., Yuan, C. X., Roeder, R. G., Myers, L. C., Gustafsson, C. M., Jiang, Y. W., Li, Y., Kornberg, R. D., Asturias, F. J.2000; 97 (26): 14307-14310
• Electron crystal structure of the transcription factor and DNA repair complex, core TFIIH CELLChang, W. H., Kornberg, R. D.2000; 102 (5): 609-613
• Defocus-gradient corrected back-projection ULTRAMICROSCOPYJensen, G. J., Kornberg, R. D.2000; 84 (1-2): 57-64
• Mediator-nucleosome interaction MOLECULAR CELLLorch, Y., Beve, J., Gustafsson, C. M., Myers, L. C., Kornberg, R. D.2000; 6 (1): 197-201
• Architecture of RNA polymerase II and implications for the transcription mechanism SCIENCECramer, P., Bushnell, D. A., Fu, J. H., Gnatt, A. L., Maier-Davis, B., THOMPSON, N. E., Burgess, R. R., Edwards, A. M., David, P. R., Kornberg, R. D.2000; 288 (5466): 640-649
• Subunit interactions in yeast transcription/repair factor TFIIH - Requirement for Tfb3 subunit in nucleotide excision repair JOURNAL OF BIOLOGICAL CHEMISTRYFeaver, W. J., Huang, W. Y., Gileadi, O., Myers, L., Gustafsson, C. M., Kornberg, R. D., Friedberg, E. C.2000; 275 (8): 5941-5946
• Mediator of transcriptional regulation ANNUAL REVIEW OF BIOCHEMISTRYMyers, L. C., Kornberg, R. D.2000; 69: 729-749
• Eukaryotic transcriptional control (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999) TRENDS IN CELL BIOLOGYKornberg, R. D.1999; 9 (12): M46-M49
• Eukaryotic transcriptional control TRENDS IN BIOCHEMICAL SCIENCESKornberg, R. D.1999; 24 (12): M46-M49
• Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains MOLECULAR CELLCairns, B. R., Schlichter, A., Erdjument-Bromage, H., Tempst, P., Kornberg, R. D., Winston, F.1999; 4 (5): 715-723
• Electron crystal structure of an RNA polymerase II transcription elongation complex CELLPoglitsch, C. L., Meredith, G. D., Gnatt, A. L., Jensen, G. J., Chang, W. H., Fu, J. H., Kornberg, R. D.1999; 98 (6): 791-798
• Yeast RNA polymerase II at 5 angstrom resolution CELLFu, J. H., Gnatt, A. L., Bushnell, D. A., Jensen, G. J., THOMPSON, N. E., Burgess, R. R., David, P. R., Kornberg, R. D.1999; 98 (6): 799-810
• Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome CELLKornberg, R. D., Lorch, Y. L.1999; 98 (3): 285-294
• Chromatin-modifying and -remodeling complexes CURRENT OPINION IN GENETICS & DEVELOPMENTKornberg, R. D., Lorch, Y.1999; 9 (2): 148-151
• Protein crystallization on lipid layers and structure determination of the RNA polymerase II transcription initiation complex JOURNAL OF BIOLOGICAL CHEMISTRYAsturias, F. J., Kornberg, R. D.1999; 274 (11): 6813-6816
• Structure of DNA-dependent protein kinase: implications for its regulation by DNA EMBO JOURNALLeuther, K. K., Hammarsten, O., Kornberg, R. D., Chu, G.1999; 18 (5): 1114-1123
• Conserved structures of mediator and RNA polymerase II holoenzyme SCIENCEAsturias, F. J., Jiang, Y. W., Myers, L. C., Gustafsson, C. M., Kornberg, R. D.1999; 283 (5404): 985-987
• Histone octamer transfer by a chromatin-remodeling complex CELLLorch, Y., Zhang, M., Kornberg, R. D.1999; 96 (3): 389-392
• Mediator protein mutations that selectively abolish activated transcription PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAMyers, L. C., Gustafsson, C. M., Hayashibara, K. C., Brown, P. O., Kornberg, R. D.1999; 96 (1): 67-72
• Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae JOURNAL OF BIOLOGICAL CHEMISTRYGustafsson, C. M., Myers, L. C., Beve, J., Spahr, H., Lui, M., Erdjument-Bromage, H., Tempst, P., Kornberg, R. D.1998; 273 (47): 30851-30854
• Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF MOLECULAR CELLCairns, B. R., Erdjument-Bromage, H., Tempst, P., Winston, F., Kornberg, R. D.1998; 2 (5): 639-651
• Single-particle selection and alignment with heavy atom cluster-antibody conjugates PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAJensen, G. J., Kornberg, R. D.1998; 95 (16): 9262-9267
• Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAJiang, Y. W., Veschambre, P., Erdjument-Bromage, H., Tempst, P., Conaway, J. W., Conaway, R. C., Kornberg, R. D.1998; 95 (15): 8538-8543

• Repeated tertiary fold of RNA polymerase II and implications for DNA binding JOURNAL OF MOLECULAR BIOLOGYFu, J. H., Gerstein, M., David, P. R., Gnatt, A. L., Bushnell, D. A., Edwards, A. M., Kornberg, R. D.1998; 280 (3): 317-322
• Activated RSC-nucleosome complex and persistently altered form of the nucleosome CELLLorch, Y., Cairns, B. R., Zhang, M. C., Kornberg, R. D.1998; 94 (1): 29-34
• Structure of wild-type yeast RNA polymerase II and location of Rpb4 and Rpb7 EMBO JOURNALJensen, G. J., Meredith, G., Bushnell, D. A., Kornberg, R. D.1998; 17 (8): 2353-2358
• The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain GENES & DEVELOPMENTMyers, L. C., Gustafsson, C. M., Bushnell, D. A., Lui, M., Erdjument-Bromage, H., Tempst, P., Kornberg, R. D.1998; 12 (1): 45-54
• Mechanism and regulation of yeast RNA polymerase II transcription Cold Spring Harbor Symposium on Quantitative Biology - Mechanisms of TranscriptionKornberg, R. D.COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT. 1998: 229–232
• Electron crystallography of yeast RNA polymerase II preserved in vitreous ice ULTRAMICROSCOPYAsturias, F. J., Chang, W. H., Li, Y., Kornberg, R. D.1998; 70 (3): 133-143
• Formation and crystallization of yeast RNA polymerase II elongation complexes JOURNAL OF BIOLOGICAL CHEMISTRYGnatt, A., Fu, J. H., Kornberg, R. D.1997; 272 (49): 30799-30805
• Two conformations of RNA polymerase II revealed by electron crystallography JOURNAL OF MOLECULAR BIOLOGYAsturias, F. J., Meredith, G. D., Poglitsch, C. L., Kornberg, R. D.1997; 272 (4): 536-540
• Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH - Homology to human cyclin-dependent kinase activating kinase and IIH subunits JOURNAL OF BIOLOGICAL CHEMISTRYFeaver, W. J., Henry, N. L., Wang, Z. G., Wu, X. H., Svejstrup, J. Q., Bushnell, D. A., Friedberg, E. C., Kornberg, R. D.1997; 272 (31): 19319-19327
• Yeast RNA polymerase II transcription reconstituted with purified proteins METHODS-A COMPANION TO METHODS IN ENZYMOLOGYMyers, L. C., Leuther, K., Bushnell, D. A., Gustafsson, C. M., Kornberg, R. D.1997; 12 (3): 212-216
• Evidence for a mediator cycle at the initiation of transcription PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICASvejstrup, J. Q., Li, Y., Fellows, J., Gnatt, A., Bjorklund, S., Kornberg, R. D.1997; 94 (12): 6075-6078
• Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression MOLECULAR AND CELLULAR BIOLOGYCao, Y. X., Cairns, B. R., Kornberg, R. D., Laurent, B. C.1997; 17 (6): 3323-3334
• Morphologies of two-dimensional crystals of streptavidin.Wang, S. W., Yatcilla, M., Kornberg, R., Robertson, C., Gast, A. P.AMER CHEMICAL SOC. 1997: 37-BIOT
• The RAD7, RAD16, and RAD23 genes of Saccharomyces cerevisiae: Requirement for transcription-independent nucleotide excision repair in vitro and interactions between the gene products MOLECULAR AND CELLULAR BIOLOGYWang, Z. G., Wei, S. G., Reed, S. H., Wu, X. H., Svejstrup, J. Q., Feaver, W. J., Kornberg, R. D., Friedberg, E. C.1997; 17 (2): 635-643
• Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme JOURNAL OF BIOLOGICAL CHEMISTRYGustafsson, C. M., Myers, L. C., Li, Y., Redd, M. J., Lui, M., ERDJUMENTBROMAGE, H., Tempst, P., Kornberg, R. D.1997; 272 (1): 48-50
• Two-dimensional protein crystals in aid of three-dimensional protein crystal growth MACROMOLECULAR CRYSTALLOGRAPHY, PT AEdwards, A. M., Darst, S. A., Hemming, S. A., Asturias, F. J., David, P. R., Kornberg, R. D.1997; 276: 166-171
• RSC, an essential, abundant chromatin-remodeling complex CELLCairns, B. R., Lorch, Y., Li, Y., Zhang, M. C., Lacomis, L., ERDJUMENTBROMAGE, H., Tempst, P., Du, J., Laurent, B., Kornberg, R. D.1996; 87 (7): 1249-1260
• A yeast transcriptional stimulatory protein similar to human PC4 JOURNAL OF BIOLOGICAL CHEMISTRYHenry, N. L., Bushnell, D. A., Kornberg, R. D.1996; 271 (36): 21842-21847
• The yeast GAL11 protein binds to the transcription factor IIE through GAL11 regions essential for its in vivo function PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICASakurai, H., Kim, Y. J., Ohishi, T., Kornberg, R. D., Fukasawa, T.1996; 93 (18): 9488-9492
• Essential role of Swp73p in the function of yeast Swi/Snf complex GENES & DEVELOPMENTCairns, B. R., Levinson, R. S., Yamamoto, K. R., Kornberg, R. D.1996; 10 (17): 2131-2144
• A minimal set of RNA polymerase II transcription protein interactions JOURNAL OF BIOLOGICAL CHEMISTRYBushnell, D. A., Bamdad, C., Kornberg, R. D.1996; 271 (33): 20170-20174
• TFG3/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9 MOLECULAR AND CELLULAR BIOLOGYCairns, B. R., Henry, N. L., Kornberg, R. D.1996; 16 (7): 3308-3316
• Two-dimensional crystallography of TFIIB- and IIE-RNA polymerase II complexes: Implications for start site selection and initiation complex formation CELLLeuther, K. K., Bushnell, D. A., Kornberg, R. D.1996; 85 (5): 773-779
• The C-terminal domain revealed in the structure of RNA polymerase II JOURNAL OF MOLECULAR BIOLOGYMeredith, G. D., Chang, W. H., Li, Y., Bushnell, D. A., Darst, S. A., Kornberg, R. D.1996; 258 (3): 413-419
• Subunits of yeast RNA polymerase II transcription factor TFIIH encoded by the CCL1 gene JOURNAL OF BIOLOGICAL CHEMISTRYSvejstrup, J. Q., Feaver, W. J., Kornberg, R. D.1996; 271 (2): 643-645
• Yeast RNA polymerase II holoenzyme RNA POLYMERASE AND ASSOCIATED FACTORS, PT ALi, Y., Bjorklund, S., Kim, Y. J., Kornberg, R. D.1996; 273: 172-176
• YEAST GLOBAL TRANSCRIPTIONAL REGULATORS SIN4 AND RGR1 ARE COMPONENTS OF MEDIATOR COMPLEX RNA-POLYMERASE-II HOLOENZYME PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALi, Y., Bjorklund, S., Jiang, Y. W., Kim, Y. J., Lane, W. S., Stillman, D. J., Kornberg, R. D.1995; 92 (24): 10864-10868
• DOSAGE SUPPRESSORS OF THE DOMINANT G1 CYCLIN MUTANT CLN3-2 - IDENTIFICATION OF A YEAST GENE ENCODING A PUTATIVE RNA/SSDNA BINDING-PROTEIN MOLECULAR AND GENERAL GENETICSSugimoto, K., Matsumoto, K., Kornberg, R. D., Reed, S. I., Wittenberg, C.1995; 248 (6): 712-718
• IDENTIFICATION AND CHARACTERIZATION OF A TFIID-LIKE MULTIPROTEIN COMPLEX FROM SACCHAROMYCES-CEREVISIAE PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAPoon, D., Bai, Y., Campbell, A. M., Bjorklund, S., Kim, Y. J., Zhou, S., Kornberg, R. D., Weil, P. A.1995; 92 (18): 8224-8228
• INTERPLAY BETWEEN CHROMATIN STRUCTURE AND TRANSCRIPTION CURRENT OPINION IN CELL BIOLOGYKornberg, R. D., Lorch, Y.1995; 7 (3): 371-375
• THE YEAST TFB1 AND SSL1 GENES, WHICH ENCODE SUBUNITS OF TRANSCRIPTION FACTOR IIH, ARE REQUIRED FOR NUCLEOTIDE EXCISION-REPAIR AND RNA-POLYMERASE-II TRANSCRIPTION MOLECULAR AND CELLULAR BIOLOGYWang, Z. G., Buratowski, S., Svejstrup, J. Q., Feaver, W. J., Wu, X. H., Kornberg, R. D., Donahue, T. F., Friedberg, E. C.1995; 15 (4): 2288-2293
• THE MECHANISM OF PROTEIN CRYSTAL-GROWTH FROM LIPID LAYERS JOURNAL OF MOLECULAR BIOLOGYHemming, S. A., Bochkarev, A., Darst, S. A., Kornberg, R. D., Ala, P., Yang, D. S., Edwards, A. M.1995; 246 (2): 308-316
• NUCLEOTIDE EXCISION-REPAIR IN THE YEAST SACCHAROMYCES-CEREVISIAE - ITS RELATIONSHIP TO SPECIALIZED MITOTIC RECOMBINATION AND RNA-POLYMERASE-II BASAL TRANSCRIPTION PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCESFriedberg, E. C., Bardwell, A. J., Bardwell, L., Feaver, W. J., Kornberg, R. D., Svejstrup, J. Q., Tomkinson, A. E., Wang, Z. G.1995; 347 (1319): 63-68
• DIFFERENT FORMS OF TFIIH FOR TRANSCRIPTION AND DNA-REPAIR - HOLO-TFIIH AND A NUCLEOTIDE EXCISION REPAIROSOME CELLSvejstrup, J. Q., Wang, Z. G., Feaver, W. J., Wu, X. H., Bushnell, D. A., Donahue, T. F., Friedberg, E. C., Kornberg, R. D.1995; 80 (1): 21-28
• A NOVEL METHOD FOR TRANSFER OF 2-DIMENSIONAL CRYSTALS FROM THE AIR-WATER-INTERFACE TO SPECIMEN GRIDS - EM-SAMPLE PREPARATION LIPID-LAYER CRYSTALLIZATION JOURNAL OF STRUCTURAL BIOLOGYAsturias, F. J., Kornberg, R. D.1995; 114 (1): 60-66
• RELATIONSHIP OF CDK-ACTIVATING KINASE AND RNA-POLYMERASE-II CTD KINASE TFIIH/TFIIK CELLFeaver, W. J., Svejstrup, J. Q., Henry, N. L., Kornberg, R. D.1994; 79 (6): 1103-1109
• TFIIF-TAF-RNA POLYMERASE-II CONNECTION GENES & DEVELOPMENTHenry, N. L., Campbell, A. M., Feaver, W. J., Poon, D., Weil, P. A., Kornberg, R. D.1994; 8 (23): 2868-2878
• RNA-POLYMERASE TRANSCRIPTION FACTOR IIH HOLOENZYME FROM YEAST JOURNAL OF BIOLOGICAL CHEMISTRYSvejstrup, J. Q., Feaver, W. J., Lapointe, J., Kornberg, R. D.1994; 269 (45): 28044-28048
• ISOLATION OF THE YEAST HISTONE OCTAMER PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALorch, Y., Kornberg, R. D.1994; 91 (23): 11032-11034
• YEAST TFIIE - CLONING, EXPRESSION, AND HOMOLOGY TO VERTEBRATE PROTEINS JOURNAL OF BIOLOGICAL CHEMISTRYFeaver, W. J., Henry, N. L., Bushnell, D. A., Sayre, M. H., Brickner, J. H., Gileadi, O., Kornberg, R. D.1994; 269 (44): 27549-27553
• YEAST NUCLEOTIDE EXCISION-REPAIR PROTEINS RAD2 AND RAD4 INTERACT WITH RNA-POLYMERASE-II BASAL TRANSCRIPTION FACTOR-B (TFIIW) MOLECULAR AND CELLULAR BIOLOGYBardwell, A. J., Bardwell, L., Iyer, N., Svejstrup, J. Q., Feaver, W. J., Kornberg, R. D., Friedberg, E. C.1994; 14 (6): 3569-3576
• A MULTIPROTEIN MEDIATOR OF TRANSCRIPTIONAL ACTIVATION AND ITS INTERACTION WITH THE C-TERMINAL REPEAT DOMAIN OF RNA-POLYMERASE-II CELLKim, Y. J., Bjorklund, S., Li, Y., Sayre, M. H., Kornberg, R. D.1994; 77 (4): 599-608
• EFFECTS OF ACTIVATION-DEFECTIVE TBP MUTATIONS ON TRANSCRIPTION INITIATION IN YEAST NATUREKim, T. K., Hashimoto, S., Kelleher, R. J., Flanagan, P. M., Kornberg, R. D., Horikoshi, M., Roeder, R. G.1994; 369 (6477): 252-255
• YEAST RADS PROTEIN BINDS DIRECTLY TO BOTH SSL2 AND SSL1 PROTEINS - IMPLICATIONS FOR THE STRUCTURE AND FUNCTION OF TRANSCRIPTION/REPAIR FACTOR-B PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICABardwell, L., Bardwell, A. J., Feaver, W. J., Svejstrup, J. Q., Kornberg, R. D., Friedberg, E. C.1994; 91 (9): 3926-3930
• INTERPLAY OF POSITIVE AND NEGATIVE EFFECTORS IN FUNCTION OF THE C-TERMINAL REPEAT DOMAIN OF RNA-POLYMERASE-II PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALi, Y., Kornberg, R. D.1994; 91 (6): 2362-2366
• TRANSCRIPTION FACTOR-B (TFIIH) IS REQUIRED DURING NUCLEOTIDE-EXCISION REPAIR IN YEAST NATUREWang, Z. G., Svejstrup, J. Q., Feaver, W. J., Wu, X. H., Kornberg, R. D., Friedberg, E. C.1994; 368 (6466): 74-76
• A MULTISUBUNIT COMPLEX CONTAINING THE SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, AND SNF6 GENE-PRODUCTS ISOLATED FROM YEAST PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICACairns, B. R., Kim, Y. J., Sayre, M. H., Laurent, B. C., Kornberg, R. D.1994; 91 (5): 1950-1954
• EPITAXIAL-GROWTH OF PROTEIN CRYSTALS ON LIPID LAYERS NATURE STRUCTURAL BIOLOGYEdwards, A. M., Darst, S. A., Hemming, S. A., Li, Y., Kornberg, R. D.1994; 1 (3): 195-197
• RNA POLYMERASE-II INITIATION-FACTOR INTERACTIONS AND TRANSCRIPTION START SITE SELECTION SCIENCELi, Y., Flanagan, P. M., Tschochner, H., Kornberg, R. D.1994; 263 (5148): 805-807
• RECENT INSIGHTS ON DNA-REPAIR - THE MECHANISM OF DAMAGED NUCLEOTIDE EXCISION IN EUKARYOTES AND ITS RELATIONSHIP TO OTHER CELLULAR PROCESSES Conference on DNA Damage: Effects on DNA Structure and Protein RecognitionBardwell, A. J., Bardwell, L., Wang, Z. G., Siede, W., Reagan, M. S., Tomkinson, A. E., Friedberg, A. S., Pittenger, C., Feaver, W. J., Svejstrup, J., Kornberg, R. D., Friedberg, E. C.NEW YORK ACAD SCIENCES. 1994: 281–291
• DUAL ROLES OF A MULTIPROTEIN COMPLEX FROM SACCHAROMYCES-CEREVISIAE IN TRANSCRIPTION AND DNA-REPAIR CELLFeaver, W. J., Svejstrup, J. Q., Bardwell, L., Bardwell, A. J., Buratowski, S., Gulyas, K. D., Donahue, T. F., Friedberg, E. C., Kornberg, R. D.1993; 75 (7): 1379-1387
• CRYSTAL-STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAChasman, D. I., Flaherty, K. M., Sharp, P. A., Kornberg, R. D.1993; 90 (17): 8174-8178
• A POSSIBLE ROLE FOR THE YEAST TATA-ELEMENT-BINDING PROTEIN IN DNA-REPLICATION PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALue, N. F., Kornberg, R. D.1993; 90 (17): 8018-8022
• DENDRITIC GROWTH OF 2-DIMENSIONAL PROTEIN CRYSTALSKu, A. C., Darst, S. A., Kornberg, R. D., Robertson, C. R., Gast, A. P.AMER CHEMICAL SOC. 1993: 27-COLL
• MOLECULAR ANALYSIS OF 2-DIMENSIONAL PROTEIN CRYSTALLIZATION JOURNAL OF PHYSICAL CHEMISTRYKu, A. C., Darst, S. A., Robertson, C. R., Gast, A. P., Kornberg, R. D.1993; 97 (12): 3013-3016
• NEAR-ZERO LINKING DIFFERENCE UPON TRANSCRIPTION FACTOR-IID BINDING TO PROMOTER DNA MOLECULAR AND CELLULAR BIOLOGYLorch, Y., Kornberg, R. D.1993; 13 (3): 1872-1875
• YEAST RNA POLYMERASE-II TRANSCRIPTION - STRUCTURE, MECHANISM AND REGULATIONKornberg, R. D., Chasman, D. I., Darst, S. A., David, P., Edwards, A. M., Feaver, W. J., Flanagan, P. M., Gileadi, O., Henry, N. L., Kelleher, R. J., Li, Y., Lorch, Y., Meredith, G., POGLITSCH, C., Sayre, M. H., Tschochner, H.WILEY-BLACKWELL. 1993: 55–55
• EPITAXIAL-GROWTH OF RNA POLYMERASE-II CRYSTALS - A POTENTIALLY GENERAL-APPROACH TO STRUCTURAL PROBLEMSEdwards, A. M., Darst, S. A., Hussey, D., Li, Y., Kornberg, R. D.WILEY-BLACKWELL. 1993: 217–217
• MECHANISM AND REGULATION OF YEAST RNA POLYMERASE-II TRANSCRIPTION 2nd Austin Spring Meeting - The Transcription Machine: Assembly and FunctionSayre, M. H., Kornberg, R. D.PERGAMON-ELSEVIER SCIENCE LTD. 1993: 349–54
• INITIATION ON CHROMATIN TEMPLATES IN A YEAST RNA POLYMERASE-II TRANSCRIPTION SYSTEM GENES & DEVELOPMENTLorch, Y., Lapointe, J. W., Kornberg, R. D.1992; 6 (12A): 2282-2287
• YEAST RNA POLYMERASE-II INITIATION FACTOR-E - ISOLATION AND IDENTIFICATION AS THE FUNCTIONAL COUNTERPART OF HUMAN TRANSCRIPTION FACTOR-IIB PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICATschochner, H., Sayre, M. H., Flanagan, P. M., Feaver, W. J., Kornberg, R. D.1992; 89 (23): 11292-11296
• PURIFICATION AND PROPERTIES OF SACCHAROMYCES-CEREVISIAE RNA POLYMERASE-II GENERAL INITIATION FACTOR-A JOURNAL OF BIOLOGICAL CHEMISTRYSayre, M. H., Tschochner, H., Kornberg, R. D.1992; 267 (32): 23383-23387
• PURIFICATION AND CHARACTERIZATION OF YEAST RNA POLYMERASE-II GENERAL INITIATION FACTOR-G JOURNAL OF BIOLOGICAL CHEMISTRYHenry, N. L., Sayre, M. H., Kornberg, R. D.1992; 267 (32): 23388-23392
• RECONSTITUTION OF TRANSCRIPTION WITH 5 PURIFIED INITIATION-FACTORS AND RNA POLYMERASE-II FROM SACCHAROMYCES-CEREVISIAE JOURNAL OF BIOLOGICAL CHEMISTRYSayre, M. H., Tschochner, H., Kornberg, R. D.1992; 267 (32): 23376-23382
• CLONING OF A SUBUNIT OF YEAST RNA POLYMERASE-II TRANSCRIPTION FACTOR-B AND CTD KINASE SCIENCEGileadi, O., Feaver, W. J., Kornberg, R. D.1992; 257 (5075): 1389-1392
• SIMPLE DERIVATION OF TFIID-DEPENDENT RNA POLYMERASE-II TRANSCRIPTION SYSTEMS FROM SCHIZOSACCHAROMYCES POMBE AND OTHER ORGANISMS, AND FACTORS REQUIRED FOR TRANSCRIPTIONAL ACTIVATION PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAFlanagan, P. M., Kelleher, R. J., Tschochner, H., Sayre, M. H., Kornberg, R. D.1992; 89 (16): 7659-7663
• ORDER OF ACTION OF COMPONENTS IN THE YEAST PHEROMONE RESPONSE PATHWAY REVEALED WITH A DOMINANT ALLELE OF THE STE11-KINASE AND THE MULTIPLE PHOSPHORYLATION OF THE STE7-KINASE GENES & DEVELOPMENTCairns, B. R., Ramer, S. W., Kornberg, R. D.1992; 6 (7): 1305-1318
• YEAST AND HUMAN TFIIDS ARE INTERCHANGEABLE FOR THE RESPONSE TO ACIDIC TRANSCRIPTIONAL ACTIVATORS INVITRO GENES & DEVELOPMENTKelleher, R. J., Flanagan, P. M., Chasman, D. I., Ponticelli, A. S., Struhl, K., Kornberg, R. D.1992; 6 (2): 296-303
• CHROMATIN STRUCTURE AND TRANSCRIPTION ANNUAL REVIEW OF CELL BIOLOGYKornberg, R. D., Lorch, Y.1992; 8: 563-687
• YEAST RNA POLYMERASE-II TRANSCRIPTION - ENZYMATIC-ACTIVITIES OF GENERAL INITIATION-FACTORS, 3-D STRUCTURES OF INITIATION-FACTORS AND RNA-POLYMERASE, AND MECHANISM OF TRANSCRIPTIONAL ACTIVATIONKornberg, R., Chasman, D., Darst, S., Edwards, A., FEAVER, W., Flanagan, P., Gileadi, O., Hinds, D., Kelleher, R., Meredith, G., Li, Y., Lorch, Y., Park, B., Sayre, M., Tschochner, H.FEDERATION AMER SOC EXP BIOL. 1992: A274–A274
• CTD KINASE ASSOCIATED WITH YEAST RNA POLYMERASE-II INITIATION FACTOR-B CELLFeaver, W. J., Gileadi, O., Li, Y., Kornberg, R. D.1991; 67 (6): 1223-1230
• IRRESISTIBLE FORCE MEETS IMMOVABLE OBJECT - TRANSCRIPTION AND THE NUCLEOSOME CELLKornberg, R. D., Lorch, Y.1991; 67 (5): 833-836
• PURIFICATION AND CHARACTERIZATION OF YEAST RNA POLYMERASE-II TRANSCRIPTION FACTOR-B JOURNAL OF BIOLOGICAL CHEMISTRYFeaver, W. J., Gileadi, O., Kornberg, R. D.1991; 266 (28): 19000-19005
• 2-DIMENSIONAL AND EPITAXIAL CRYSTALLIZATION OF A MUTANT FORM OF YEAST RNA POLYMERASE-II JOURNAL OF MOLECULAR BIOLOGYDarst, S. A., KUBALEK, E. W., Edwards, A. M., Kornberg, R. D.1991; 221 (1): 347-357
• 3-DIMENSIONAL STRUCTURE OF YEAST RNA POLYMERASE-II AT 16-A RESOLUTION CELLDarst, S. A., Edwards, A. M., KUBALEK, E. W., Kornberg, R. D.1991; 66 (1): 121-128
• IMPROVED TRANSFER OF 2-DIMENSIONAL CRYSTALS FROM THE AIR-WATER-INTERFACE TO SPECIMEN SUPPORT GRIDS FOR HIGH-RESOLUTION ANALYSIS BY ELECTRON-MICROSCOPY ULTRAMICROSCOPYKUBALEK, E. W., Kornberg, R. D., Darst, S. A.1991; 35 (3-4): 295-304
• A MEDIATOR REQUIRED FOR ACTIVATION OF RNA POLYMERASE-II TRANSCRIPTION INVITRO NATUREFlanagan, P. M., Kelleher, R. J., Sayre, M. H., Tschochner, H., Kornberg, R. D.1991; 350 (6317): 436-438
• 2-DIMENSIONAL CRYSTALS OF STREPTAVIDIN ON BIOTINYLATED LIPID LAYERS AND THEIR INTERACTIONS WITH BIOTINYLATED MACROMOLECULES BIOPHYSICAL JOURNALDarst, S. A., Ahlers, M., MELLER, P. H., KUBALEK, E. W., Blankenburg, R., RIBI, H. O., Ringsdorf, H., Kornberg, R. D.1991; 59 (2): 387-396
• 2 DISSOCIABLE SUBUNITS OF YEAST RNA POLYMERASE-II STIMULATE THE INITIATION OF TRANSCRIPTION AT A PROMOTER INVITRO JOURNAL OF BIOLOGICAL CHEMISTRYEdwards, A. M., Kane, C. M., Young, R. A., Kornberg, R. D.1991; 266 (1): 71-75
• RNA POLYMERASE-II TRANSCRIPTION INVITRO METHODS IN ENZYMOLOGYLue, N. F., Flanagan, P. M., Kelleher, R. J., Edwards, A. M., Kornberg, R. D.1991; 194: 545-550
• STRUCTURAL STUDY OF THE YEAST RNA POLYMERASE-A - ELECTRON-MICROSCOPY OF LIPID-BOUND MOLECULES AND 2-DIMENSIONAL CRYSTALS JOURNAL OF MOLECULAR BIOLOGYSchultz, P., Celia, H., Riva, M., Darst, S. A., Colin, P., Kornberg, R. D., Sentenac, A., Oudet, P.1990; 216 (2): 353-362
• INTERCHANGEABLE RNA-POLYMERASE-I AND POLYMERASE-II ENHANCERS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALorch, Y., Lue, N. F., Kornberg, R. D.1990; 87 (21): 8202-8206
• ACCURATELY INITIATED, ENHANCER-DEPENDENT TRANSCRIPTION BY RNA POLYMERASE-I IN YEAST EXTRACTS JOURNAL OF BIOLOGICAL CHEMISTRYLue, N. F., Kornberg, R. D.1990; 265 (30): 18091-18094
• RESOLUTION OF FACTORS REQUIRED FOR THE INITIATION OF TRANSCRIPTION BY YEAST RNA POLYMERASE-II JOURNAL OF BIOLOGICAL CHEMISTRYFlanagan, P. M., Kelleher, R. J., Feaver, W. J., Lue, N. F., Lapointe, J. W., Kornberg, R. D.1990; 265 (19): 11105-11107
• A NOVEL MEDIATOR BETWEEN ACTIVATOR PROTEINS AND THE RNA POLYMERASE-II TRANSCRIPTION APPARATUS CELLKelleher, R. J., Flanagan, P. M., Kornberg, R. D.1990; 61 (7): 1209-1215
• GAL4 PROTEIN - PURIFICATION, ASSOCIATION WITH GAL80 PROTEIN, AND CONSERVED DOMAIN-STRUCTURE MOLECULAR AND CELLULAR BIOLOGYChasman, D. I., Kornberg, R. D.1990; 10 (6): 2916-2923
• A YEAST PROTEIN THAT INFLUENCES THE CHROMATIN STRUCTURE OF UASG AND FUNCTIONS AS A POWERFUL AUXILIARY GENE ACTIVATOR GENES & DEVELOPMENTChasman, D. I., Lue, N. F., Buchman, A. R., Lapointe, J. W., Lorch, Y., Kornberg, R. D.1990; 4 (4): 503-514
• PURIFICATION AND LIPID-LAYER CRYSTALLIZATION OF YEAST RNA POLYMERASE-II PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAEdwards, A. M., Darst, S. A., Feaver, W. J., THOMPSON, N. E., Burgess, R. R., Kornberg, R. D.1990; 87 (6): 2122-2126
• A YEAST ARS-BINDING PROTEIN ACTIVATES TRANSCRIPTION SYNERGISTICALLY IN COMBINATION WITH OTHER WEAK ACTIVATING FACTORS MOLECULAR AND CELLULAR BIOLOGYBuchman, A. R., Kornberg, R. D.1990; 10 (3): 887-897
• PURIFICATION AND CHARACTERIZATION OF POLYADENYLATE-BINDING PROTEIN METHODS IN ENZYMOLOGYSachs, A. B., Kornberg, R. D.1990; 181: 332-352
• GENE ACTIVATION AND TRANSCRIPTION WITH PURIFIED FACTORS FROM YEAST 1ST INTERNATIONAL CONF ON GENE REGULATION, ONCOGENESIS, AND AIDSKornberg, R. D., Buchman, A. R., Chasman, D. I., Darst, S. A., Edwards, A. M., Feaver, W. J., Flanagan, P. M., Kelleher, R. J., KUBALEK, E. W., Lapointe, J. W., Lorch, Y., Lue, N. F.GULF PUBL CO. 1990: 9–18
• INITIATION BY YEAST RNA POLYMERASE-II AT THE ADENOVIRAL MAJOR LATE PROMOTER INVITRO SCIENCELue, N. F., Flanagan, P. M., Sugimoto, K., Kornberg, R. D.1989; 246 (4930): 661-664
• ACTIVATION OF YEAST POLYMERASE-II TRANSCRIPTION BY HERPESVIRUS VP16 AND GAL4 DERIVATIVES INVITRO MOLECULAR AND CELLULAR BIOLOGYChasman, D. I., Leatherwood, J., Carey, M., Ptashne, M., Kornberg, R. D.1989; 9 (11): 4746-4749
• 3-DIMENSIONAL STRUCTURE OF ESCHERICHIA-COLI RNA-POLYMERASE HOLOENZYME DETERMINED BY ELECTRON CRYSTALLOGRAPHY NATUREDarst, S. A., KUBALEK, E. W., Kornberg, R. D.1989; 340 (6236): 730-732
• UPSTREAM ACTIVATION SEQUENCE-DEPENDENT ALTERATION OF CHROMATIN STRUCTURE AND TRANSCRIPTION ACTIVATION OF THE YEAST GAL1-GAL10 GENES MOLECULAR AND CELLULAR BIOLOGYFedor, M. J., Kornberg, R. D.1989; 9 (4): 1721-1732
• PREPARATION OF NUCLEOSOMES AND CHROMATIN METHODS IN ENZYMOLOGYKornberg, R. D., Lapointe, J. W., Lorch, Y.1989; 170: 3-14
• ACTIVATION OF YEAST RNA POLYMERASE-II TRANSCRIPTION BY A THYMIDINE-RICH UPSTREAM ELEMENT INVITRO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICALue, N. F., Buchman, A. R., Kornberg, R. D.1989; 86 (2): 486-490
• ON THE DISPLACEMENT OF HISTONES FROM DNA BY TRANSCRIPTION CELLLorch, Y., Lapointe, J. W., Kornberg, R. D.1988; 55 (5): 743-744
• CONNECTIONS BETWEEN TRANSCRIPTIONAL ACTIVATORS, SILENCERS, AND TELOMERES AS REVEALED BY FUNCTIONAL-ANALYSIS OF A YEAST DNA-BINDING PROTEIN MOLECULAR AND CELLULAR BIOLOGYBuchman, A. R., Lue, N. F., Kornberg, R. D.1988; 8 (12): 5086-5099
• STATISTICAL POSITIONING OF NUCLEOSOMES BY SPECIFIC PROTEIN-BINDING TO AN UPSTREAM ACTIVATING SEQUENCE IN YEAST JOURNAL OF MOLECULAR BIOLOGYFedor, M. J., Lue, N. F., Kornberg, R. D.1988; 204 (1): 109-127

• TWO-DIMENSIONAL CRYSTALS OF ESCHERICHIA-COLI RNA-POLYMERASE HOLOENZYME ON POSITIVELY CHARGED LIPID LAYERS JOURNAL OF MOLECULAR BIOLOGYDarst, S. A., RIBI, H. O., Pierce, D. W., Kornberg, R. D.1988; 203 (1): 269-273
• Statistical distributions of nucleosomes: nonrandom locations by a stochastic mechanism. Nucleic acids researchKornberg, R. D., Stryer, L.1988; 16 (14A): 6677-6690
• ROLES OF 2 DNA-BINDING FACTORS IN REPLICATION, SEGREGATION AND TRANSCRIPTIONAL REPRESSION MEDIATED BY A YEAST SILENCER EMBO JOURNALKIMMERLY, W., Buchman, A., Kornberg, R., Rine, J.1988; 7 (7): 2241-2253
• 3-DIMENSIONAL STRUCTURE OF CHOLERA-TOXIN PENETRATING A LIPID-MEMBRANE SCIENCERIBI, H. O., Ludwig, D. S., Mercer, K. L., SCHOOLNIK, G. K., Kornberg, R. D.1988; 239 (4845): 1272-1276
• 2 DNA-BINDING FACTORS RECOGNIZE S