Usern_member

Mohammad Reza Akbari

USERN Advisory Board

CURRICULUM VITAE





Identification:



Name: Mohammad R. Akbari


Address: 76 Grenville St, Room 6421


Toronto, ON, M5S 1B2


Canada


Tel: 416-351-3800 Ext. 5299


Email: [email protected]


Websites: http://www.dlsph.utoronto.ca/faculty-profile/akbari-mohammad-reza/


http://www.womensresearch.ca/researchers/core-faculty/mohammad-akbari,-md,-phd


https://ims.utoronto.ca/faculty/faculty-online-community/faculty-members/akbarimohammadreza/




Educations:



2010-2011: Postdoctoral fellowship in Genetic Epidemiology, Women’s College Research Institute, University of Toronto, Toronto, Canada


2006-2010: PhD in Molecular Human Genetics, Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada


2002-2004: Research fellowship in gastroenterology, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


2000-2001: Internship, Tehran University Hospitals (Dr. Shariati , Imam Khomeini, Sina, Bahrami, Amir-A-lam), Tehran, Iran


1994- 2000: MD Degree from Tehran University of Medical Sciences (TUMS), Tehran, Iran




Positions:



2015-Present: Adjunct Faculty, Institute of Medical Science, Faculty of Medicine, University of Toronto


2012-Present: Assistant Professor, Dalla Lana School of Public Health, University of Toronto


2012-Present: Scientist, Women’s College Research Institute, University of Toronto


2014-Present: Adjunct Faculty, Genetic Center, Social Welfare and Rehabilitation University, Tehran, Iran


2011-Present: Affiliated Scientist, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran


2010-2011: Postdoctoral fellow, Women’s College Research Institute, University of Toronto


2004-2005: Executive manager, Digestive Disease Research Institute, Tehran University of Medical Sciences


2002-2004: Postdoctoral fellow, Digestive Disease Research Institute, Tehran University of Medical Sciences


2001-2002: General Physician, Tehran Health Network, Tehran University of Medical Sciences




Honors and Awards:



2014: Capacity Development in Cancer Prevention Award, Canadian Cancer Society Research Institute, Ontario, Canada


2009: Ontario Graduate Scholarship (OGS) for studying Human Genetics in 2009-2010 academic year


2005: UICC International Cancer Technology Transfer Fellowship


1996: Third rank in comprehensive examination of basic sciences among


           medical students of the country (Iran) 


1993: Bronze medal winner of 25th International Chemistry Olympiad (I.Ch.O) in Italy


1992: Gold medal winner of the National Chemistry Olympiad in Iran




Invited Talks:


1-    Hereditary Gastrointestinal Cancers, International Congress of Gastroenterology and Hepatology-2016, November 2016, Tehran-Iran.


2-    Gene Discovery in Hereditary Cancer, Cancer Genetics 2016, September 2016, Szczecin-Poland.


3-    Next generation sequencing approach for molecular diagnosis of neuromuscular disorders, 1st International Neurogenetic Congress, March 2016, Tehran-Iran.


4-    Genetic Susceptibility to Breast Cancer, 11th International Breast Cancer Conference, February 2016, Tehran-Iran.


5-    RECQL: A new Breast Cancer Susceptibility Gene, 11th International Breast Cancer Conference, February 2016, Tehran-Iran.


6-    Power of Founder Population in Gene Discovery, 4th Next Generation Sequencing Sumposium, October 2015, Toronto-Canada.


7-    The Universal BRCAness Screening (UBS) Program, The Clinical Genomics Conference, June 2014, San Francisco-U.S.A.


8-    Hereditary Cancers, Cancer Genetics Symposium, Shariati Hospital, Tehran University of Medical Sciences, December 2013, Tehran-Iran.


9-    Mapping Disease-associated Genes. Genetic Centre. University of Social Welfare and Rehabilitation Sciences, December 2012, Tehran-Iran


10- Applications of Next Generation Sequencing in Medicine. Cancer Institute, Tehran University of Medical Sciences, December 2011, Tehran-Iran.


11- Exome Sequencing. Department of Biochemistry, Tehran university of Medical Sciences, November 2011, Tehran-Iran


12- Exome Sequencing: Approaches and Interpretation. Educational Session. 6th Annual Canadian Genetic Epidemiology & Statistical Genetics Meeting, May 2011, King City-Canada.



Creative Professional Activities:



Iranome Genome Browser: The genome browser of genetic variants exist in seven major ethnic groups who live in Iran and middle east region that are underrepresented in other human genome databases, www.iranome.com



Universal BRCA Screening (UBS): Developing the UBS test as a cancer genetic screening test for breast and ovarian cancer to be offered to all individuals at age 30 at a very low cost



Media Interviews:


April 2015: CTV National News,
RECQL: A New Breast Cancer Susceptibility Gene


April 2015: CTV Toronto News,
RECQL: A New Breast Cancer Susceptibility Gene


April 2015: Global Online News,
RECQL: A New Breast Cancer Susceptibility Gene


April 2015: Corus Radio (AM 1150), RECQL: A New Breast Cancer Susceptibility
Gene



Publications:




  1. 1.    Narod SA, Ahmed H, Akbari MR. Do acronyms belong in the medical literature?: A Countercurrents Series. Curr Oncol. 2016 Oct;23(5):295-296.



  1. Moran O, Nikitina D, Royer R, Poll A, Metcalfe K, Narod SA, Akbari MR, Kotsopoulos J. Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel. Breast Cancer Res Treat. 2016 Oct 31. [Epub ahead of print]



  1. Kotsopoulos J, Sopik V, Rosen B, Fan I, McLaughlin JR, Risch H, Sun P, Narod SA,
    Akbari MR.     Frequency of germline PALB2 mutations among women with epithelial ovarian cancer.
    Fam Cancer. 2016 Sep 8. [Epub ahead of print]



  1. Chehade R, Pettapiece-Phillips R, Salmena L, Kotlyar M, Jurisica I, Narod SA,
    Akbari MR, Kotsopoulos J. Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific. Breast Cancer Res. 2016 Aug 17;18(1):87.



  1. Donenberg T, Ahmed H, Royer R, Zhang S, Narod SA, George S, Akbari MR, Ali J, Hurley J. A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago. Breast Cancer Res Treat. 2016 Jul 28. [Epub ahead of print]



  1. Kim SJ, Zuchniak A, Sohn KJ, Lubinski J, Demsky R, Eisen A, Akbari MR, Kim YI, Narod SA, Kotsopoulos J. Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study. Am J Clin Nutr. 2016 Jul 27. pii: ajcn133470. [Epub ahead of print]



  1. Kwong A, Shin VY, Cheuk IW, Chen J, Au CH, Ho DN, Chan TL, Ma ES,
    Akbari MR    , Narod SA. Germline RECQL mutations in high risk Chinese breast cancer patients. Breast Cancer Res Treat. 2016 June;157(2):211-5.



  1. Fattahi Z, Kalhor Z, Fadaee M, Vazehan R, Parsimehr E, Abolhassani A, Beheshtian M, Zamani G, Nafissi S, Nilipour Y,
    Akbari MR, Kahrizi K, Kariminejad A, Najmabadi H.     Improved diagnostic yield of neuromuscular disorders applying clinical exome sequencing in patients arising from a consanguineous population. Clin Genet. 2016 May 28. [Epub ahead of print].



  1. 9.    Esmail Nia G, Fadaee M, Royer R, Najmabadi H,
    Akbari MR. Profiling Fanconi Anemia Gene Mutations among Iranian Patients. Arch Iran Med. 2016 Apr;19(4):236-40.


10. Fadaee M, Kariminejad A, Fattahi Z, Nafissi S, Godarzi HR, Beheshtian M, Vazehan R,
Akbari MR, Kahrizi K, Najmabadi H. Report of limb girdle muscular dystrophy type 2a in 6 Iranian patients, one with a novel deletion in CAPN3 gene. Neuromuscul Disord. 2016 Apr-May;26(4-5):277-82.



11. Faraji Zonooz M, Sabbagh-Kermani F, Fattahi Z, Fadaee M,
Akbari MR, Amiri R, Vahidnezhad H, Uitto J, Najmabadi H, Kariminejad A. Whole Genome Linkage Analysis Followed by Whole Exome Sequencing Identifies Nicastrin (NCSTN) as a Causative Gene in a Multiplex Family with γ-Secretase Spectrum of Autoinflammatory Skin Phenotypes. J Invest Dermatol. 2016 Jun;136(6):1283-6.



12. Babanejad M, Moein H, Akbari MR, Badiei A, Yaseri M, Soheilian M, Najmabadi H.
Investigating the CFH Gene Polymorphisms as a Risk Factor for Age-related Macular Degeneration in an Iranian Population.
Ophthalmic Genet. 2016 June;37(2):144-9.



13. Trottier M, Lunn J, Butler R, Curling D, Turnquest T, Francis W, Halliday D, Royer R, Zhang S, Li S, Thompson I, Donenberg T, Hurley J,
Akbari MR, Narod SA. Prevalence of Founder Mutations in the BRCA1 and BRCA2 genes among Unaffected Women from the Bahamas.
Clin Genet. 2016 mar;89(3):328-31.



14. Segev Y, Zhang S, Akbari MR, Sun P, Sellers TA, McLaughlin J, Risch HA, Rosen B, Shaw P, Schildkraut J, Narod SA, Pal T. Survival in women with ovarian cancer with and without microsatellite instability. Eur J Gynaecol Oncol. 2015;36(6):681-4.



15. Pal T, Bonner D, Cragun D, Monteiro AN, Phelan C, Servais L, Kim J, Narod SA,
Akbari MR, Vadaparampil ST. A high frequency of BRCA mutations in young black women with breast cancer residing in Florida. Cancer. 2015 Dec 1;121(23):4173-80.



16. Pettapiece-Phillips R, Kotlyar M, Chehade R, Salmena L, Narod SA,
Akbari MR, Jurisica I, Kotsopoulos J.Uninterrupted sedentary behavior downregulates BRCA1 gene expression. Cancer Prev Res (Phila). 2015 Nov 2. pii: canprevres.0291.



17. Beheshtian M, Saee Rad S, Babanejad M, Mohseni M, Hashemi H, Eshghabadi A, Hajizadeh F,
Akbari MR, Kahrizi K, Riazi Esfahani M, Najmabadi H. Impact of Whole Exome Sequencing among Iranian Patients with Autosomal Recessive Retinitis Pigmentosa. Arch Iran Med. 2015 Nov;18(11):776-85. 



18. Akbari MR, Cybulski C. RECQL: a DNA helicase in breast cancer. Oncotarget. 2015 Sep 29;6(29):26558-9.



19. Cybulski C, Carrot-Zhang J, Kluzniak W, Rivera B, Kashyap A, Wokolorczyk D, Giroux S, Nadaf J, Hamel N, Zhang S, Huzarski T, Gronwald J, Byrski T, Szwiec M, Jakubowska A, Rudnicka H, Lener M, Masojc B, Tonin PN, Rousseau F, Gorski B, Debniak T, Majewski J, Lubinski J, Foulkes WD, Narod SA,
Akbari MR. Germline RECQL mutations are associated with breast cancer susceptibility.
Nat Genet. 2015 Jun;47(6):643-6.



20. Giannakeas V, Sopik V, Shestopaloff K, Iqbal J, Rosen B,
Akbari MR, Narod SA. A model for estimating ovarian cancer risk: Application for preventive oophorectomy. Gynecol Oncol. 2015 Sep 2. pii: S0090-8258(15)30112-8.



21. Mehrjoo Z,
Akbari MR, Abedini SS, Vaziri S, Kahrizi K, Najmabadi H. Carrier Testing in Known Autosomal Recessive Intellectual Disability Genes in an Iranian Healthy Individual Using Exome Sequencing. Arch Iran Med. 2015 Oct;18(10):643-69.



22. Lerner-Ellis J, Wang M, White S, Lebo MS; Canadian Open Genetics Repository Group. Canadian Open Genetics Repository (COGR): a unified clinical genomics database as a community resource for standardising and sharing genetic interpretations. J Med Genet. 2015 Jul;52(7):438-45. 



23. Arcand SL,
Akbari MR, Mes-Masson AM, Provencher D, Foulkes WD, Narod SA, Tonin PN.
Germline TP53 mutational spectrum in French Canadians with breast cancer.
BMC Med Genet. 2015 Apr 12;16(1):24.



24. Akhtarkhavari T, Joghataei MT, Fattahi Z,
Akbari MR, Larti F, Najmabadi H, Kahrizi K. Genetic Investigation of an Iranian Supercentenarian by Whole Exome Sequencing. Arch Iran Med. 2015 Oct;18(10):688-97.



25. Cybulski C, Kluźniak W, Huzarski T, Wokołorczyk D, Kashyap A, Jakubowska A, Szwiec M, Byrski T, Dębniak T, Górski B, Sopik V,
Akbari MR, Sun P, Gronwald J, Narod SA, Lubiński J;
Polish Hereditary Breast Cancer Consortium. Clinical outcomes in women with breast cancer and a PALB2 mutation: a prospective cohort analysis.
Lancet Oncol. 2015 Jun;16(6):638-44.



26. Holter S, Borgida A, Dodd A, Grant R, Semotiuk K, Hedley D, Dhani N, Narod S,
Akbari MR, Moore M, Gallinger S.
Germline BRCA Mutations in a Large Clinic-Based Cohort of Patients With Pancreatic Adenocarcinoma.
J Clin Oncol. 2015 Oct 1;33(28):3124-9.



27. Cragun D, Bonner D, Kim J,
Akbari MR, Narod SA, Gomez-Fuego A, Garcia JD, Vadaparampil ST, Pal T.
Factors associated with genetic counseling and BRCA testing in a population-based sample of young Black women with breast cancer.
Breast Cancer Res Treat. 2015 May;151(1):169-76.



28. Snyder C, Metcalfe K, Sopik V, Royer R, Zhang S, Narod SA,
Akbari MR, Lynch HT.
Prevalence of PALB2 mutations in the Creighton University Breast Cancer Family Registry.
Breast Cancer Res Treat. 2015 Apr;150(3):637-41.



29. Villarreal-Garza C, Weitzel JN, Llacuachaqui M, Sifuentes E, Magallanes-Hoyos MC, Gallardo L, Alvarez-Gomez RM, Herzog J, Castillo D, Royer R,
Akbari MR, Lara-Medina F, Herrera LA, Mohar A, Narod SA.
The prevalence of BRCA1 and BRCA2 mutations among young Mexican women with triple-negative breast cancer.
Breast Cancer Res Treat. 2015 Apr;150(2):389-94.



30. Mohamadkhani A,
Akbari MR, Ghanbari R, Naderi E, Rezanejad-Asl P, Pourshams A.
Direct Sequencing of Cyclooxygenase-2 (COX-2) Revealed an Intronic Variant rs201231411 in Iranian Patients with Pancreatic Cancer.
Middle East J Dig Dis. 2015 Jan;7(1):14-8.



31. Fattahi Z, Kahrizi K, Nafissi S, Fadaee M, Abedini SS, Kariminejad A,
Akbari MR, Najmabadi H.
Report of a patient with limb-girdle muscular dystrophy, ptosis and ophthalmoparesis caused by plectinopathy.
Arch Iran Med. 2015 Jan;18(1):60-4.



32. Sopik V,
Akbari MR, Narod SA.
Genetic testing for RAD51C mutations: in the clinic and community.
Clin Genet. 2015 Oct;88(4):303-12.



33. Torres-Mejia G, Royer R, Llacuachaqui M,
Akbari MR, Giuliano AR, Martínez-Matsushita L, Angeles-Llerenas A, Ortega-Olvera C, Ziv E, Lazcano-Ponce E, Phelan CM, Narod SA.
Recurrent BRCA1 and BRCA2 mutations in Mexican women with breast cancer.
Cancer Epidemiol Biomarkers Prev. 2015 Mar;24(3):498-505.



34. Schütz E,
Akbari MR, Beck J, Urnovitz H, Zhang W, Mitchell WM, Nam RK, Narod SA.
Chromosomal instability in cell-free DNA is a serum biomarker for prostate cancer.
Clin Chem. 2015 Jan;61(1):239-48.



35. Cybulski C, Lubiński J, Wokołorczyk D, Kuźniak W, Kashyap A, Sopik V, Huzarski T, Gronwald J, Byrski T, Szwiec M, Jakubowska A, Górski B, Dębniak T, Narod SA,
Akbari MR. Mutations predisposing to breast cancer in 12 candidate genes in breast cancer patients from Poland.
Clin Genet. 2015 Oct;88(4):366-70.




  1. Akbari MR, Wallis CJD, Toi A,
    Trachtenberg J, Sun P, Narod SA, Nam RK    .
    The Impact of a BRCA2 Mutation on Mortality from Screen-Detected Prostate Cancer    .
    Br J Cancer. 2014 Sep 9;111(6):1238-40.



  1. Kotsopoulos J, Zhang S,
    Akbari MR    , Salmena L, Llacuachaqui M, Zeligs M, Sun P, Narod SA    .
    BRCA1 mRNA Levels Following a 4-6 Week Intervention with Oral 3,3'-Diindolylmethane.    Br J Cancer. 2014 Sep 23;111(7):1269-74.



  1. Trottier M, Lunn J, Butler R, Curling D, Turnquest T, Royer R,
    Akbari MR, Donenberg T, Hurley J, Narod SA.
    Strategies for Recruitment of Relatives of BRCA Mutation Carriers to a Genetic Testing Program in the Bahamas.
    2015 Aug;88(2):182-6.
  2. Kotsopoulos J, Metcalfe KA, Alston J, Nikitina D, Ginsburg OM, Eisen A, Demsky R,
    Akbari M, Zbuk K, Narod SA    .
    Prospective Study of High-Risk, BRCA1/2-Mutation Negative Women: the 'Negative Study'    .
    BMC Cancer. 2014 Mar 25;14:221.

40. Fattahi Z, Rostami P, Najmabadi A, Mohseni M, Kahrizi K,
Akbari MR, Kariminejad A, Najmabadi H.
Mutation profile of BBS genes in Iranian patients with Bardet-Biedl syndrome: genetic characterization and report of nine novel mutations in five BBS genes.
J Hum Genet 2014;59(7):368-75.



  1. Lee JH, Cragun D, Thompson Z, Coppola D, Nicosia SV,
    Akbari MR, Zhang S, McLaughlin J, Narod S, Schildkraut J, Sellers TA, Pal T.     Association between IHC and MSI testing to identify mismatch repair-deficient patients with ovarian cancer. Genet Test Mol Biomarkers. 2014 Apr;18(4):229-35.
  2. Malekzadeh MM, Radmard AR, Nouroozi A,
    Akbari MR    , Amini M, Navabakhsh B, Caleffi A, Pietrangelo A, Malekzadeh R    . Juvenile Hemochromatosis, Genetic Study and Long-term Follow up after Therapy. Middle East J Dig Dis. 2014 Apr;6(2):87-92.
  3. McMullin RP, Wittner BS, Yang C, Denton-Schneider BR, Hicks D, Singavarapu R, Moulis S, Lee J,
    Akbari MR, Narod SA, Aldape KD, Steeg PS, Ramaswamy S, Sgroi DC    .
    A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.
    Breast Cancer Res. 2014;16(2):R25.

44. Szwiec M, Jakubowska A, Górski B, Huzarski T, Tomiczek-Szwiec J, Gronwald J, Dębniak T, Byrski T, Kluźniak W, Wokołorczyk D, Birkenfeld B,
Akbari MR, Narod SA, Lubiński J, Cybulski C.
Recurrent mutations of BRCA1 and BRCA2 in Poland: an update.
Clin Genet. 2015 Mar;87(3):288-92.


45. Akbari MR, Lepage P, Rosen B, McLaughlin J, Risch H, Minden M, Narod SA.
PPM1D mutations in circulating white blood cells and the risk for ovarian cancer.
J Natl Cancer Inst. 2014 ;106(1):djt323.


46. Pal T, Bonner D, Cragun D, Johnson S,
Akbari M, Servais L, Narod S, Vadaparampil S.
BRCA sequencing and large rearrangement testing in young Black women with breast cancer.
J Community Genet. 2014;5(2):157-65.


47. Kashyap A, Kluźniak W, Wokołorczyk D, Gołąb A, Sikorski A, Słojewski M, Gliniewicz B, Świtała J, Borkowski T, Borkowski A, Antczak A, Wojnar L, Przybyła J, Sosnowski M, Małkiewicz B, Zdrojowy R, Sikorska-Radek P, Matych J, Wilkosz J, Różański W, Kiś J, Bar K, Bryniarski P, Paradysz A, Jersak K, Niemirowicz J, Słupski P, Jarzemski P, Skrzypczyk M, Dobruch J, Domagała P, Piotrowski K,  Jakubowska A, Gronwald J, Huzarski T1, Byrski T, Dębniak T, Górski B, Masojć B, Wetering T, Menkiszak  J, Akbari MR, Lubiński J, Narod SA, Cybulski C and the Polish Hereditary Prostate Cancer Consortium.
The Presence of Prostate Cancer at Biopsy is Predicted by a Number of Genetic Variants. Int J Can. 2014;134(5):1139-46.


48. Akbari MR, Donenberg T, Lunn J, Curling D, Turnquest T, Krill-Jackson E, Zhang S, Narod S, Hurley J. The spectrum of BRCA1 and BRCA2 mutations in breast cancer patients in the Bahamas. Clin Genet. 2014; 85(1):64-7.


49. Moghtadaei M, Hashemi Golpayegani MR, Almasganj F, Etemadi A,
Akbari MR, Malekzadeh R. Predicting the risk of squamous dysplasia and esophageal squamous cell carcinoma using minimum classification error method. Computers in Biology and Medicine 2014; 45:51-7.


50. Antczak A, Kluźniak W, Wokołorczyk D, Kashyap A, Jakubowska A, Gronwald J,Huzarski T, Byrski T, Dębniak T, Masojć B, Górski B, Gromowski T, Nagorna A,Gołąb A, Sikorski A, Słojewski M, Gliniewicz B, Borkowski T, Borkowski A,Przybyła J, Sosnowski M, Małkiewicz B, Zdrojowy R, Sikorska-Radek P, Matych J, Wilkosz J, Różański W, Kiś J, Bar K, Domagała P, Stawicka M, Milecki P,
Akbari MR, Narod SA, Lubiński J, Cybulski C; Polish Hereditary Prostate Cancer Consortium; Other members of the Polish Hereditary Prostate Cancer Consortium,Bryniarski P, Paradysz A, Jersak K, Niemirowicz J, Słupski P, Jarzemski P,Skrzypczyk M, Dobruch J, Domagała W, Chosia M, van de Wetering T,Serrano-Fernández P, Puszyński M, Soczawa M, Switała J, Archimowicz S, Kordowski M, Zyczkowski M, Borówka A, Bagińska J, Krajka K, Szwiec M, Haus O, Janiszewska H, Stembalska A, Sąsiadek MM. A common nonsense mutation of the BLM gene and prostate cancer risk and survival. Gene. 2013 Dec 15;532(2):173-6.


51. Akbari MR, Anderson LN, Buchanan DD, Clendenning M, Jenkins MA, Win AK, Hopper JL, Giles GG, Nam R, Narod S, Gallinger S, Cleary SP. Germline HOXB13 p.Gly84Glu mutation and risk of colorectal cancer. Cancer Epidemiol. 2013 Aug;37(4):424-7.


52. Gupta IR, Baldwin C, Auguste D, Ha KC, El Andalousi J, Fahiminiya S, Bitzan M, Bernard C,
Akbari MR, Narod SA, Rosenblatt DS, Majewski J, Takano T. ARHGDIA: a novel gene implicated in nephrotic syndrome. J Med Genet. 2013 May;50(5):330-8.


53. Akbari MR, Kluźniak W, Rodin R, Li S, Wokołorczyk D, Royer R, Kashyap A,Menkiszak J, Lubinski J, Narod SA, Cybulski C. The HOXB13 p.Gly84Glu mutation is not associated with the risk of breast cancer. Breast Cancer Res Treat 2012;136(3):907-9.


54. Kluźniak W, Wokołorczyk D, Kashyap A, Jakubowska A, Gronwald J, Huzarski T,Byrski T, Dębniak T, Gołąb A, Gliniewicz B, Sikorski A, Switała J, Borkowski T,Borkowski A, Antczak A, Wojnar L, Przybyła J, Sosnowski M, Małkiewicz B, Zdrojowy R, Sikorska-Radek P, Matych J, Wilkosz J, Różański W, Kiś J, Bar K, Bryniarski P, Paradysz A, Jersak K, Niemirowicz J, Słupski P, Jarzemski P, Skrzypczyk M, Dobruch J, Domagała P,
Akbari MR, Lubiński J, Narod SA, Cybulski C; the Polish Hereditary Prostate Cancer Consortium. The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland. Prostate 2013: 73(5):542-8.



  1. Akbari MR, Pal T, Sun P, Lee JH, Fulp J, Thompson Z, Coppola D, Nicosia S, Sellers TA, McLaughlin J, Schildkraut J, Narod SA. Frequency of Mutations in Mismatch Repair Genes in a Population-based Sample of Women with Ovarian Cancer. Br J Cancer 2012;107(10):1783-90.
  2. Akbari MR, Trachtenberg J, Lee J, Tam S, Bristow R, Loblaw A, Narod SA, Nam RK. Association between germline HOXB13 G84E mutation and risk of prostate cancer. JNCI 2012;104: 1260-2.
  3. Akbari MR, Zhang S, Fan I, Royer R, Li S, Risch H, McLaughlin J, Rosen B, Sun P, Narod SA. Clinical impact of unclassified variants of the BRCA1 and BRCA2 genes.
    J Med Genet. 2011 Nov;48(11):783-6.
  4. Lurie G, Gaudet MM, Spurdle AB, Carney ME, Wilkens LR, Yang HP, Weiss NS, Webb PM, Thompson PJ, Terada K, Setiawan VW, Rebbeck TR, Prescott J, Orlow I, O'Mara T, Olson SH, Narod SA, Matsuno RK, Lissowska J, Liang X, Levine DA, Le Marchand L, Kolonel LN, Henderson BE, Garcia-Closas M, Doherty JA, De Vivo I, Chen C, Brinton LA,
    Akbari MR    ; Australian National Endometrial Cancer Study Group; Epidemiology of Endometrial Cancer Consortium (E2C2), Goodman MT. The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. PLoS One. 2011 Feb 8;6(2):e16756.
  5. Akbari MR, Malekzadeh R, Lepage P, Roquis D, Sadjadi AR, Aghcheli K, Yazdanbod A, Shakeri R, Bashiri J, Sotoudeh M, Pourshams A, Ghadirian P, Narod SA. Mutations in Fanconi Anemia Genes and the Risk of Esophageal Cancer. Hum Genet
    2010 may;129(5):573-82.
  6. Akbari MR, Tonin P, Foulkes WD, Ghadirian P, Tischkowitz M, Narod SA. RAD51C germline mutations in breast and ovarian cancer patients. Breast Cancer Res. 2010 Aug 19;12(4):404.
  7. Ghadirian P, Robidoux A, Zhang P, Royer R, Akbari MR, Zhang S, Fafard E, Costa M, Martin G, Potvin C, Patocskai E, Larouche N, Younan R, Nassif E, Giroux S, Narod SA, Rousseau F, Foulkes WD. The contribution of founder mutations to early-onset breast cancer in French-Canadian women. Clin Genet 2009 Nov; 76 (5):421-6.
  8. Akbari MR, Malekzadeh R, Shakeri R, Nasrollahzadeh D, Foumani M, Sun Y, Pourshams A, Sadjadi A, Jafari E, Sotoudeh M, Kamangar F, Boffetta P, Dawsey SM, Ghadirian P, Narod SA. Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. Cancer Res. 2009 Oct 15; 69 (20):7994-8000.
  9. Bentov Y, Brown TJ, Akbari MR, Royer R, Risch H, Rosen B, McLaughlin J, Sun P, Zhang S, Narod SA, Casper RF. Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer.. PLoS One. 2009 Jun 15; 4 (6):e5918.
  10. Ginsburg OM, Akbari MR, Aziz Z, Young R, Lynch H, Ghadirian P, Robidoux A, Londono J, Vasquez G, Gomes M, Costa MM, Dimitrakakis C, Gutierrez G, Pilarski R, Royer R, Narod SA. The prevalence of germ-line TP53 mutations in women diagnosed with breast cancer before age 30. Fam Cancer. 2009; 8 (4):563-7.
  11. Setiawan VW, Doherty JA, Shu XO, Akbari MR, Chen C, De Vivo I, Demichele A, Garcia-Closas M, Goodman MT, Haiman CA, Hankinson SE, Henderson BE, Horn-Ross PL, Lacey JV Jr, Le Marchand L, Levine DA, Liang X, Lissowska J, Lurie G, McGrath M, Narod SA, Rebbeck TR, Ursin G, Weiss NS, Xiang YB, Yang HP, Zheng W, Olson SH. Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18 (1):242-7.
  12. Akbari MR, Ghadirian P, Robidoux A, Foumani M, Sun Y, Royer R, Zandvakili I, Lynch H, Narod SA. Germline RAP80 mutations and susceptibility to breast cancer. Breast Cancer Res Treat. 2009 Jan; 113 (2):377-81.
  13. Akbari MR, Malekzadeh R, Nasrollahzadeh D, Amanian D, Islami F, Li S, Zandvakili I, Shakeri R, Sotoudeh M, Aghcheli K, Salahi R, Pourshams A, Semnani S, Boffetta P, Dawsey SM, Ghadirian P, Narod SA. Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma. Oncogene. 2008 Feb 21; 27 (9):1290-6.
  14. Rodriguez RC, Esperon AA, Ropero R, Rubio MC, Rodriguez R, Ortiz RM, Anta JJ, de los Rios M, Carnesolta D, del Olivera MC, Vansam SS, Royer R,
    Akbari MR, Donenberg T, Narod SA. Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba. Fam Cancer. 2008; 7 (3) :275-9.
  15. Foulkes WD, Ghadirian P, Akbari MR, Hamel N, Giroux S, Sabbaghian N, Darnel A, Royer R, Poll A, Fafard E, Robidoux A, Martin G, Bismar TA, Tischkowitz M, Rousseau F, Narod SA. Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women. Breast Cancer Res. 2007; 9 (6):R83.
  16. Malekzadeh R, Akbari MR. Prevalence of gluten-sensitive enteropathy and coeliac disease in Iran. Eur J Gastroenterol Hepatol. 2007 Sep;19(9):825-6
  17. Zogopoulous G, Rothenmund H, Eppel A, Ash C, Akbari MR, Hedley D, Narod SA, Gallinger S. The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer. Hum Genet. 2007 Jun;121(5):635-7.
  18. Akbari MR,
    Malekzadeh R, Nasrollahzadeh D, Amanian D, Sun P, Islami F, Sotoudeh M, Semnani S, Boffeta P, Dawsey SM, Ghadirian P, Narod SA.
    Familial risks of esophageal cancer among the Turkmen population of the Caspian littoral of Iran. International Journal of Cancer. Int J Cancer. 2006 Sep 1;119(5):1047-51.
  19. Akbari MR, Mohammadkhani A, Fakheri H, Zahedi MJ, Shahbazkhani B, Nouraei M, Sotoudeh M, Shakeri R, Malekzadeh R. Adult population screening for celiac disease: Comparison of tissue-transglutaminase antibody and antiendomysial antibody tests. Eur J Gastroenterol Hepatol. 2006 Nov;18(11):1181-6.
  20. Safaralizadeh R, Siavoshi F, Malekzadeh R, Akbari MR, Derakhshan MH, Sohrabi MR, Massarat S. Furazolidone Antimicrobial Effectiveness against Metronidazole Resistant Strains of H.Pylori. East Mediterr Health J. 2006 May-Jul;12(3-4):286-93.

75. Imanzadeh F, Sayyari AA, Yaghoobi M,
Akbari MR, Shafagh H, Farsar AR. Coeliac   disease in children with diarrhea is more frequent than previously suspected: A case-control study.
Journal of Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr 2005 March; 40(3):309 -11


76. Pourshams A, Malekzadeh R, Monavvari A,
Akbari MR, Mohammadkhani A, Merat S, Seddighi N, Mohammadnejad M, Sotoudeh M, Madjlessi A. The prevalence and etiology of persistently elevated alanine aminotransferase levels in healthy Iranian blood donors. Journal of Gastroenterology and Hepatology. J Gastroenterol Hepatol 2005 Feb;20(2):229 -33    



  1. Yaghoobi M, Rakhshani N, Sadr F, Bijarchi R, Joshaghani Y, Mohammadkhani A, Attari A,
    Akbari MR, Hormazdi M, Malekzadeh R. Hereditary risk factors for the development of gastric cancer in younger patients. BMC Gastroenterol. 2004 Oct 27;4(1):28.

78. Rostami K, Malekzadeh R, Shahbazkhani B,
Akbari MR, Catassi C. Coeliac Disease in Middle Eastern countries: a challenge for the evolutionary history of  this complex disorder? Dig Liver Dis. 2004 oct; 36(10):694-7.


79. Nouraie M, Pourshams A, Kamangar F, Sotoudeh M, Derakhshan MH,
Akbari MR,  Fakheri H, Zahedi MJ, Abnet CC, Taylor PR, Malekzadeh R, Dawsey SM. Ecologic Study   of Serum Selenium and Upper Gastrointestinal Cancers in Iran. World J Gastroenterol 2004; 10(17): 2547-9


80. Shahbazkhani B, Mohammadnejad M, Malekzadeh R,
Akbari MR,  Esfahani MM, Nasserimoghadam S, Sotoudeh M, Elahyfar A. Coeliac Disease is the Most Common Cause of Chronic Diarrhoea in Iran. Eur J Gastroenterol Hepatol. 2004 Jul;16(7):665-8.


81. Shahbazkhani B, Faezi T, Akbari MR, Mohamadnejad M, Sotoudeh M, Rajab A,       Tahaghoghi S, Malekzadeh R. Coeliac Disease in Iranian type I Diabetic Patients.       Digestive and Liver Disease. 2004 Mar;36(3):191-4


82. Shahbazkhani B, Forootan M, Merat S,
Akbari MR, Nasserimoghadam S, Vahedi H,      Malekzadeh R. Coeliac disease presenting with symptoms of irritable bowel syndrome. Aliment Pharmacol Ther. 2003 Jul;18(2):231-5


83. Nahavandi A, Mani AR, Homayounfar H,
Akbari MR, Dehpour AR. The role of the      interaction between endogenous opioids and nitric oxide in the pathophysiology of      ethanol-induced gastric damage in cholestatic rats. Fundam Clin Pharmacol 2001       Jun;15(3):181-7


84. Mahmoudi S, Pourshams A, Akbari MR,
Malekzadeh R. [The Prevalence of Irritable      Bowel Syndrome and Gastroesophageal Reflux Disease among new entrance of Tehran     University in 2001]. Gowaresh 2003; 8(4): 159- 62


85. Pourshams A, Akbari MR. [The relative frequency of hepatitis B surface antigen among new entrants of tehran university in 2001]. Gowaresh 2003; 8(4): 126-131.


86. Mohammadnejad M, Pourshams A, Sohrabpour A, Malekzadeh R,
Akbari MR,   Mohammadkhani A, Rajabiani A, Zamani F, Faghihi A, Aliasgari A. [Healthy ranges of         Serum alanine aminotransferase levels in Iranian blood donors]. Gowaresh 2003; 8(4): 79 – 83



Grant Support:





  1. 1.    Investigators: Kotsopoulos J (Principal Investigator),
    Akbari MR (Co-applicant), Narod SA (Co-Applicant), Metcalfe K (Co-Applicant)

Agency: Canadian Institute for  Health Research (CIHR)


Funding type: Research Project


Title of grant: Evaluating the utility of circulating cell-free or tumour DNA as a tool for the early diagnosis of BRCA1-associated breast cancer Evaluating the utility of circulating cell-free or tumour DNA as a tool for the early diagnosis of BRCA1-associated breast cancer


Financial support held: $408,000


Years of tenure: 2016-20




  1. Investigators: Cybulski C (Principal Investigator), Akbari MR (Co-Applicant), Lubinski JA (Co-Applicant), Narod SA (Co-Applicant)

Agency: Polish Science Center


Funding type: Research


Title of grant: Identification of new mutations predisposing to prostate cancer in the Polish population by means of next generation sequencing


Financial support held: $550,000 


Years of tenure: 2016-19




  1. Investigators: Cybulski C (Principal Investigator), Akbari MR (Co-Applicant), Lubinski JA (Co-Applicant), Narod SA (Co-Applicant)

Agency: Polish Science Center


Funding type: Research


Title of grant: Identification of new breast cancer susceptibility genes by whole-exome sequencing in the genetically homogeneous Polish population


 Financial support held: $650,000 


Years of tenure: 2016-19




  1. Investigators: Akbari MR (Principal Applicant), Narod SA (Co-Applicant)

Agency: Canadian Breast Cancer Foundation (CBCF)


Funding type: Operating Grant


Title of grant: Identifying new genes for hereditary breast cancer


Financial support held: $440,000


Years of tenure: 2015-18




  1. Investigators: Narod SA (Principal Applicant),
    Akbari MR         (Co-Applicant), Kotsopoulos J (Co-Applicant), Metcalfe K (Co-Applicant)

Agency: Canadian Foundation for Innovation (CFI)


Funding type: Infrastructure Building


Title of grant: Measuring low frequency genetic markers in cancer management 


Financial support held: $2,400,000


Years of tenure: 2015-17




  1. Co-Applicant), Narod S (Co-Applicant) [Was declined]

Agency: Caribbean Public Health Agency (CARPHA)


Funding type: Operating Grant


Title of grant: Identifying new genes for hereditary breast cancer
in Bahamas


Financial support held: $50,000


Years of tenure: 2015-17




  1. Investigators: Akbari MR (Principal Applicant)

Agency: Canadian Cancer Society Research Institute (CCSRI)


Funding type: Capacity Development in Cancer Prevention


Title of grant: Genetic Susceptibility to Cancer


Financial support held: $225,000


Years of tenure: 2014-17



  1. Investigators: Narod SA (Principal Applicant), Quan ML (Co-Principal Applicant), Metcalfe K (Sub-Project PI), Friedenreich C (Sub-Project PI), Warner E (Sub-Project PI), Baxter N (Sub-Project PI), Stephen J (Sub-Project PI), Simunovic M (Sub-Project Co-Principal Applicant), Tyldesley S (Sub-Project Co-Principal Applicant),
    Akbari MR     (Co-applicant), Olivotto I (Co-applicant), Porter G (Co-applicant), Dabbs K (Collaborator), Baliski C (Collaborator), Brackstone M (Collaborator), Boileau JF (Collaborator), Cil T (Collaborator), Engel J (Collaborator), Hebbard P (Collaborator), Megueditchian A (Collaborator), Provencher L (Collaborator), Tait H (Collaborator), Kapala M (Collaborator), Wright F (Collaborator), McCready D (Collaborator), Meiers P (Collaborator), Hanrahan R (Collaborator), Gomes A (Collaborator), Cox C (Collaborator), Chang M (Collaborator), Mak T (Collaborator), Robidoux A (Collaborator), Arnaout A (Collaborator), George R (Collaborator), McFadden A (Collaborator), Hodgson N (Collaborator), Helyer L (Collaborator), Down N (Collaborator), Bilberdorf D (Collaborator), Brenner D (Collaborator), Damaraju S (Collaborator), Poole A (Collaborator), Caron N (Collaborator), Warburton R (Collaborator), Brockton N (Sub-Project Co-Applicant), Cotterchio M (Sub-Project Co-Applicant), Boucher B (Sub-Project Co-Applicant), Knight J (Sub-Project Co-Applicant), Giese-Davis J (Sub-Project Co-Applicant), Kennedy E (Sub-Project Co-Applicant), Sutradhar R (Sub-Project Co-Applicant), Cao J (Sub-Project Co-Applicant), Lemieux J (Sub-Project Co-Applicant), Winget M (Sub-Project Co-Applicant), Fergus K (Sub-Project Co-Applicant), Kotsopoulos J (Sub-Project Co-Applicant), Courneya K (Sub-Project Co-Applicant), Fong S (Sub-Project Co-Applicant), Glass K (Sub-Project Co-Applicant), Latosinksy S (Sub-Project Co-Applicant), Russell C (Sub-Project Collaborator), Sylvestre C (Sub-Project Collaborator), Motan T (Sub-Project Collaborator), Holzer H (Sub-Project Collaborator), Taylor E (Sub-Project Collaborator)

Funding type: Operating Grant


Agency: Canadian Breast Cancer Foundation & Canadian Institutes of Health Research joint initiative


Title of grant: Towards better outcomes for young women with breast cancer: A Pan-Canadian Collaborative


Financial support held: $5,695,303


Years of tenure: 2014 – 2019



  1. 9.    Investigators: Kotsopoulos J (Principal Investigator),
    Akbari MR (Co-applicant), El-Sohemy A (Co-Applicant)

Agency: Cancer Care Ontario (CCO)


Funding type: Pilot Studies


Title of grant: Lifestyle Determinants of BRCA1 Expression


Financial support held: $50,000


Years of tenure: 2014-15


10. Investigators: Gallinger S (Principal Investigator),
Akbari MR (Co-applicant), Serra S (Co-Applicant), Zogopoulos G (Co-applicant), Hedley D (Co-applicant), Bristow R (Co-applicant)


Agency: Canadian Cancer Society Research Institute (CCSRI)


Funding type: Impact Grant


Title of grant: Hallmarks and Therapeutic Implications of "BRCAness" in Pancreatic Cancer


Financial support held: $1,229,000


Years of tenure: 2014-19



11. Investigators: Narod SA (Principal Investigator),
Akbari MR (Co-applicant), Metcalfe K (Co-Applicant)


Agency: Canadian Foundation for Innovation (CFI)


Funding type: Infrastructure Building


Title of grant: Prevention and Personalized Treatment in Hereditary Cancer


Financial support held: $400,000


Years of tenure: 2014-15



12. Investigators: Metcalfe K (Principal Investigator), Eisen A (Co-PI), Narod SA (Co-PI),
Akbari MR (Co-Applicant), Boileau JF (Co-Applicant), Chun K (Co-Applicant), Cil T (Co-Applicant), Escallon J (Co-Applicant)


Agency: Canadian Institutes of Health Research (CIHR)


Funding type: Grant


Title of grant: Rapid Genetic Testing for BRCA1 and BRCA2 in Selected Newly Diagnosed Breast Cancer Patients


Financial support held: $1,607,000


Years of tenure: 2013-17



13. Investigators: Cybulski C (Principal Investigator),
Akbari MR (Co-Applicant), Lubinski JA (Co-Applicant), Gorski BA (Co-Applicant), Narod SA (Co-Applicant), Wokolorcyzk D (Co-Applicant)


Agency: Polish Science Center


Funding type: Grant


Title of grant: Finding new genes for hereditary breast cancer in Polish population


Financial support held: $350,000 


Years of tenure: 2012-14



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