Usern_member

Anthony Atala

USERN Advisory Board

Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine.  Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles, and has received over 250 national and international patents.  Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering.


Dr. Atala is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society; the World Technology Award in Health and Medicine, for achieving significant and lasting progress; the Edison Science/Medical Award for innovation, the R&D Innovator of the Year Award, and the Smithsonian Ingenuity Award for Bioprinting Tissue and Organs. Dr. Atala’s work was listed twice as Time Magazine’s Top 10 medical breakthroughs of the year, and once as one of 5 discoveries that will change the future of organ transplants. He was named by Scientific American as one of the world’s most influential people in biotechnology, by U.S. News & World Report as one of 14 Pioneers of Medical Progress in the 21st Century, by Life Sciences Intellectual Property Review as one of the top key influencers in the life sciences intellectual property arena, and by Nature Biotechnology as one of the top 10 translational researchers in the world. 


Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society. 


Education

BA, University of Miami, 1984

MD, University of Louisville School of Medicine, 1985

Internship
University of Louisville Affiliated Hospitals, 1986

Residency
University of Louisville Affiliated Hospitals, 1990

Fellowship
Harvard Medical School, 1991
Harvard Medical School, 1992


Board Certifications

American Board of Urology, Pediatric Urology
American Board of Urology, Urology


Memberships

American Urological Association
American College of Surgeons
Society of Genitourinary Reconstructive Surgeons
Institute of Medicine
American Association of Genito-Surgeons


Positions

Chair, Urology
Director, Wake Forest Institute for Regenerative Medicine
Professor, Urology
Professor, Wake Forest Institute for Regenerative Medicine
Professor, Physiology and Pharmacology


Departments and Affiliations

Urology
Wake Forest Institute for Regenerative Medicine
Physiology and Pharmacology
Comprehensive Cancer Center
Center on Diabetes, Obesity, and Metabolism


Awards

Elected to the Institute of Medicine of the National Academy of Sciences in 2011

Elected to the National Academy of Inventors as a Charter Fellow in 2013

Elected and to the American Institute for Medical and Biological Engineering in 2016.

The Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society.

The World Technology Award in Health and Medicine, presented to individuals achieving significant, lasting progress in 2011.

The Samuel D. Gross Prize, awarded every five years to a national leading surgical researcher by the Philadelphia Academy of Surgery.

The Barringer Medal from the American Association of Genitourinary Surgeons.

The Gold Cystoscope Award from the American Urological Association for advances in the field.

The American Ingenuity Award for Life Sciences, awarded by Smithsonian Magazine (2016).

The Innovation Award from the Society of Manufacturing Engineers for the creation of synthetic organs

The Rocovich Gold Medal, awarded to a distinguished scientist who has made a major impact on science

The 2013 Edison Awards

The 2016 Smithsonian Ingenuity Award

The 2016 R&D Magazine Innovator of the Year Award for his work with bioprinting

Named Nature Biotechnology as one of the top 10 translational researchers in the world

Life Sciences Intellectual Property Review as one of the top influencers in the life sciences intellectual property field

Named by U.S. News & World Report as one of 14 Pioneers of Medical Progress in the 21st Century

Named by Scientific American as one of the world's most influential people in biotechnology and as a

Medical Treatments Leader of the Year for his contributions to the fields of cell, tissue, and organ regeneration in 2015.

Dr. Atala's work has been listed twice as one of Time Magazine's top ten medical breakthroughs of the year and once as one of 5 discoveries that will change the future of organ transplantation

Discover Magazine's no. 1 top science story of the year in the field of medicine in 2007


Recent Publications




  1. Lu Z, Yao X, Lyu P, Yadav M, Yoo K, Atala A, Lu B. Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing. CRISPR J. 2021 Mar 16. PMID: 33733873.

    View in: PubMed Article has an altmetric score of 1



  2. Yao X, Lyu P, Yoo K, Yadav MK, Singh R, Atala A, Lu B. Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing. J Extracell Vesicles. 2021 Mar; 10(5):e12076. PMID: 33747370.

    View in: PubMed Article has an altmetric score of 2



  3. Vasyutin I, Butnaru D, Lyundup A, Timashev P, Vinarov A, Kuznetsov S, Atala A, Zhang Y. Frontiers in urethra regeneration: current state and future perspective. Biomed Mater. 2021 Mar 09; 16(4). PMID: 32503009.

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  4. Trevisan B, Morsi A, Aleman J, Rodriguez M, Shields J, Meares D, Farland AM, Doering CB, Spencer HT, Atala A, Skardal A, Porada CD, Almeida-Porada G. Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A. Front Bioeng Biotechnol. 2021; 9:639070. PMID: 33732691.

    View in: PubMed Article has an altmetric score of 1



  5. Jeon MJ, Choi YS, Yoo JJ, Atala A, Jackson JD. Optimized culture system to maximize ovarian cell growth and functionality in vitro. Cell Tissue Res. 2021 Feb 13. PMID: 33582866.

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  6. Weis VG, Deal AC, Mekkey G, Clouse C, Gaffley M, Whitaker E, Peeler CB, Weis JA, Schwartz MZ, Atala A. Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2021 04 01; 320(4):G658-G674. PMID: 33566727.

    View in: PubMed Article has an altmetric score of 44



  7. Lyu P, Lu Z, Cho SI, Yadav M, Yoo KW, Atala A, Kim JS, Lu B. Adenine Base Editor Ribonucleoproteins Delivered by Lentivirus-Like Particles Show High On-Target Base Editing and Undetectable RNA Off-Target Activities. CRISPR J. 2021 Feb; 4(1):69-81. PMID: 33616436.

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  8. Min S, Cleveland D, Ko IK, Kim JH, Yang HJ, Atala A, Yoo JJ. Accelerating neovascularization and kidney tissue formation with a 3D vascular scaffold capturing native vascular structure. Acta Biomater. 2021 04 01; 124:233-243. PMID: 33524561.

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  9. Jeon MJ, Choi YS, Kim ID, Criswell T, Atala A, Yoo JJ, Jackson JD. Engineering Functional Rat Ovarian Spheroids Using Granulosa and Theca Cells. Reprod Sci. 2021 Jan 28. PMID: 33511540.

    View in: PubMed Article has an altmetric score of 1



  10. Zhang X, Wang N, Huang Y, Li Y, Li G, Lin Y, Atala AJ, Hou J, Zhao W. Extracellular vesicles from three dimensional culture of human placental mesenchymal stem cells ameliorated renal ischemia/reperfusion injury. Int J Artif Organs. 2021 Jan 19; 391398820986809. PMID: 33467948.

    View in: PubMed Article has an altmetric score of 1



  11. Lu Z, Priya Rajan SA, Song Q, Zhao Y, Wan M, Aleman J, Skardal A, Bishop C, Atala A, Lu B. 3D scaffold-free microlivers with drug metabolic function generated by lineage-reprogrammed hepatocytes from human fibroblasts. Biomaterials. 2021 Feb; 269:120668. PMID: 33461059.

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  12. Abdelaal O, Deebel NA, Zarandi NP, Kogan S, Marini FC, Pranikoff T, Stogner-Underwood K, McLean TW, Atala A, Sadri-Ardekani H. Fertility preservation for pediatric male cancer patients: illustrating contemporary and future options; a case report. Transl Androl Urol. 2021 Jan; 10(1):520-526. PMID: 33532340.

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  13. Mekky G, Seeds M, Diab AEA, Shehata AM, Ahmed-Farid OA, Alzebdeh D, Bishop C, Atala A. The potential toxic effects of magnesium oxide nanoparticles and valproate on liver tissue. J Biochem Mol Toxicol. 2021 Mar; 35(3):e22676. PMID: 33315275.

    View in: PubMed Article has an altmetric score of 1



  14. Kim JH, Ko IK, Jeon MJ, Kim I, Vanschaayk MM, Atala A, Yoo JJ. Pelvic floor muscle function recovery using biofabricated tissue constructs with neuromuscular junctions. Acta Biomater. 2021 02; 121:237-249. PMID: 33321220.

    View in: PubMed Article has an altmetric score of 1



  15. Butler PD, Franz BD, Anderson SL, Atala A, Denneny J, Lindeman B, Mellinger JD, Spanknebel K, Shabahang MM. Enriching surgical residency training through the liberal arts. Am J Surg. 2020 Nov 30. PMID: 33292970.

    View in: PubMed Article has an altmetric score of 9



  16. Sequeira RC, Criswell T, Atala A, Yoo JJ. Microfluidic Systems for Assisted Reproductive Technologies: Advantages and Potential Applications. Tissue Eng Regen Med. 2020 12; 17(6):787-800. PMID: 33237567.

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  17. Visscher DO, Lee H, van Zuijlen PPM, Helder MN, Atala A, Yoo JJ, Lee SJ. A photo-crosslinkable cartilage-derived extracellular matrix bioink for auricular cartilage tissue engineering. Acta Biomater. 2021 02; 121:193-203. PMID: 33227486.

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  18. Pishavar E, Copus JS, Atala A, Lee SJ. Comparison Study of Stem Cell-Derived Extracellular Vesicles for Enhanced Osteogenic Differentiation. Tissue Eng Part A. 2020 Nov 19. PMID: 33045930.

    View in: PubMed Article has an altmetric score of 2



  19. Nzou G, Wicks RT, VanOstrand NR, Mekky GA, Seale SA, El-Taibany A, Wicks EE, Nechtman CM, Marrotte EJ, Makani VS, Murphy SV, Seeds MC, Jackson JD, Atala AJ. Author Correction: Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction. Sci Rep. 2020 Nov 18; 10(1):20384. PMID: 33204010.

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  20. Guo H, Deng N, Dou L, Ding H, Criswell T, Atala A, Furdui CM, Zhang Y. 3-D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening. ACS Biomater Sci Eng. 2020 12 14; 6(12):6701-6709. PMID: 33320634.

    View in: PubMed Article has an altmetric score of 1



  21. Sokolova V, Mekky G, van der Meer SB, Seeds MC, Atala AJ, Epple M. Transport of ultrasmall gold nanoparticles (2 nm) across the blood-brain barrier in a six-cell brain spheroid model. Sci Rep. 2020 10 22; 10(1):18033. PMID: 33093563.

    View in: PubMed Article has an altmetric score of 5



  22. Gillispie GJ, Han A, Uzun-Per M, Fisher J, Mikos AG, Niazi MKK, Yoo JJ, Lee SJ, Atala A. The Influence of Printing Parameters and Cell Density on Bioink Printing Outcomes. Tissue Eng Part A. 2020 Dec; 26(23-24):1349-1358. PMID: 32928068.

    View in: PubMed Article has an altmetric score of 1



  23. Lyu P, Yoo KW, Yadav MK, Atala A, Aartsma-Rus A, Putten MV, Duan D, Lu B. Sensitive and reliable evaluation of single-cut sgRNAs to restore dystrophin by a GFP-reporter assay. PLoS One. 2020; 15(9):e0239468. PMID: 32970732.

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  24. Ballard M, Shafiee A, Grage E, DeMarco M, Atala A, Ghadiri E. Inkjet Printing of Synthesized Melanin Nanoparticles as a Biocompatible Matrix for Pharmacologic Agents. Nanomaterials (Basel). 2020 Sep 15; 10(9). PMID: 32942599.

    View in: PubMed Article has an altmetric score of 3



  25. Carter T, Qi G, Wang W, Nguyen A, Cheng N, Ju YM, Lee SJ, Yoo JJ, Atala A, Sun XS. Self-Assembling Peptide Solution Accelerates Hemostasis. Adv Wound Care (New Rochelle). 2021 04; 10(4):191-203. PMID: 32716728.

    View in: PubMed Article has an altmetric score of 1



  26. Jorgensen AM, Yoo JJ, Atala A. Solid Organ Bioprinting: Strategies to Achieve Organ Function. Chem Rev. 2020 10 14; 120(19):11093-11127. PMID: 32885956.

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  27. Atala A, Henn A, Lundberg M, Ahsan T, Greenberg J, Krukin J, Lynum S, Lutz C, Cetrulo K, Albanna M, Pereira T, Eaker S, Hunsberger J. Regen med therapeutic opportunities for fighting COVID-19. Stem Cells Transl Med. 2021 01; 10(1):5-13. PMID: 32856432.

    View in: PubMed Article has an altmetric score of 56



  28. Kim SH, Park JH, Kwon JS, Cho JG, Park KG, Park CH, Yoo JJ, Atala A, Choi HS, Kim MS, Lee SJ. NIR fluorescence for monitoring in vivo scaffold degradation along with stem cell tracking in bone tissue engineering. Biomaterials. 2020 11; 258:120267. PMID: 32781325.

    View in: PubMed Article has an altmetric score of 4



  29. Butler PD, Nagler A, Atala A, Britt LD, Denneny J, Lindeman B, Mellinger J, Sachdeva AK, Spanknebel K, Shabahang M. Virtual surgery residency selection: Strategies for programs and candidates. Am J Surg. 2021 01; 221(1):59-61. PMID: 32888630.

    View in: PubMed Article has an altmetric score of 24



  30. Matz EL, Thakker PU, Gu X, Terlecki RP, Dou L, Walker SJ, Lue T, Lin G, Atala A, Yoo JJ, Zhang Y, Jackson JD. Administration of secretome from human placental stem cell-conditioned media improves recovery of erectile function in the pelvic neurovascular injury model. J Tissue Eng Regen Med. 2020 10; 14(10):1394-1402. PMID: 32652851.

    View in: PubMed Article has an altmetric score of 1



  31. Xu L, Varkey M, Jorgensen A, Ju J, Jin Q, Park JH, Fu Y, Zhang G, Ke D, Zhao W, Hou R, Atala A. Bioprinting small diameter blood vessel constructs with an endothelial and smooth muscle cell bilayer in a single step. Biofabrication. 2020 07 29; 12(4):045012. PMID: 32619999.

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  32. Jorgensen AM, Chou Z, Gillispie G, Lee SJ, Yoo JJ, Soker S, Atala A. Decellularized Skin Extracellular Matrix (dsECM) Improves the Physical and Biological Properties of Fibrinogen Hydrogel for Skin Bioprinting Applications. Nanomaterials (Basel). 2020 Jul 29; 10(8). PMID: 32751101.

    View in: PubMed Article has an altmetric score of 2



  33. Sun G, Ding B, Wan M, Chen L, Jackson J, Atala A. Formation and optimization of three-dimensional organoids generated from urine-derived stem cells for renal function in vitro. Stem Cell Res Ther. 2020 07 22; 11(1):309. PMID: 32698872.

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  34. Park JH, Gillispie GJ, Copus JS, Zhang W, Atala A, Yoo JJ, Yelick PC, Lee SJ. The effect of BMP-mimetic peptide tethering bioinks on the differentiation of dental pulp stem cells (DPSCs) in 3D bioprinted dental constructs. Biofabrication. 2020 07 01; 12(3):035029. PMID: 32428889.

    View in: PubMed Article has an altmetric score of 3



  35. Magalhaes RS, Williams JK, Yoo KW, Yoo JJ, Atala A. A tissue-engineered uterus supports live births in rabbits. Nat Biotechnol. 2020 11; 38(11):1280-1287. PMID: 32601434.

    View in: PubMed Article has an altmetric score of 1130



  36. West-Livingston LN, Park J, Lee SJ, Atala A, Yoo JJ. The Role of the Microenvironment in Controlling the Fate of Bioprinted Stem Cells. Chem Rev. 2020 10 14; 120(19):11056-11092. PMID: 32558555.

    View in: PubMed Article has an altmetric score of 8



  37. Trevisan BM, Porada CD, Atala A, Almeida-Porada G. Microfluidic devices for studying coagulation biology. Semin Cell Dev Biol. 2021 Apr; 112:1-7. PMID: 32563678.

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  38. Nzou G, Wicks RT, VanOstrand NR, Mekky GA, Seale SA, El-Taibany A, Wicks EE, Nechtman CM, Marrotte EJ, Makani VS, Murphy SV, Seeds MC, Jackson JD, Atala AJ. Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction. Sci Rep. 2020 06 17; 10(1):9766. PMID: 32555384.

    View in: PubMed Article has an altmetric score of 71



  39. Peak TC, Kogan SJ, Atala AJ, Fenu EM, Hodges SJ. A Case Report of an Obstructing Ureteral Nephrogenic Adenoma in a Child Managed With Open Ileal Ureter. Urology. 2020 Sep; 143:231-233. PMID: 32439556.

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  40. Sokolova V, Nzou G, van der Meer SB, Ruks T, Heggen M, Loza K, Hagemann N, Murke F, Giebel B, Hermann DM, Atala AJ, Epple M. Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model. Acta Biomater. 2020 07 15; 111:349-362. PMID: 32413579.

    View in: PubMed Article has an altmetric score of 1



  41. Smith WR, Atala AJ, Terlecki RP, Kelly EE, Matthews CA. Implementation Guide for Rapid Integration of an Outpatient Telemedicine Program During the COVID-19 Pandemic. J Am Coll Surg. 2020 Aug; 231(2):216-222.e2. PMID: 32360960.

    View in: PubMed Article has an altmetric score of 135



  42. Atala A. Bladder Tissue Engineering: The Past and the Future. Urology. 2020 Nov; 145:337-338. PMID: 32305542.

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  43. El-Akabawy N, Rodriguez M, Ramamurthy R, Rabah A, Trevisan B, Morsi A, George S, Shields J, Meares D, Farland A, Atala A, Doering CB, Spencer HT, Porada CD, Almeida-Porada G. Defining the Optimal FVIII Transgene for Placental Cell-Based Gene Therapy to Treat Hemophilia A. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:465-477. PMID: 32258210.

    View in: PubMed Article has an altmetric score of 41



  44. Grebenik EA, Gafarova ER, Istranov LP, Istranova EV, Ma X, Xu J, Guo W, Atala A, Timashev PS. Mammalian Pericardium-Based Bioprosthetic Materials in Xenotransplantation and Tissue Engineering. Biotechnol J. 2020 Aug; 15(8):e1900334. PMID: 32077589.

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  45. Skardal A, Aleman J, Forsythe S, Rajan S, Murphy S, Devarasetty M, Pourhabibi Zarandi N, Nzou G, Wicks R, Sadri-Ardekani H, Bishop C, Soker S, Hall A, Shupe T, Atala A. Drug compound screening in single and integrated multi-organoid body-on-a-chip systems. Biofabrication. 2020 02 26; 12(2):025017. PMID: 32101533.

    View in: PubMed Article has an altmetric score of 178



  46. Kim JH, Kim I, Seol YJ, Ko IK, Yoo JJ, Atala A, Lee SJ. Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function. Nat Commun. 2020 02 24; 11(1):1025. PMID: 32094341.

    View in: PubMed Article has an altmetric score of 95



  47. Gillispie G, Prim P, Copus J, Fisher J, Mikos AG, Yoo JJ, Atala A, Lee SJ. Assessment methodologies for extrusion-based bioink printability. Biofabrication. 2020 02 19; 12(2):022003. PMID: 31972558.

    View in: PubMed Article has an altmetric score of 2



  48. Rajan SAP, Aleman J, Wan M, Pourhabibi Zarandi N, Nzou G, Murphy S, Bishop CE, Sadri-Ardekani H, Shupe T, Atala A, Hall AR, Skardal A. Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform. Acta Biomater. 2020 04 01; 106:124-135. PMID: 32068138.

    View in: PubMed Article has an altmetric score of 2



  49. Liu G, Wu R, Yang B, Shi Y, Deng C, Atala A, Mou S, Criswell T, Zhang Y. A cocktail of growth factors released from a heparin hyaluronic-acid hydrogel promotes the myogenic potential of human urine-derived stem cells in vivo. Acta Biomater. 2020 04 15; 107:50-64. PMID: 32044457.

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  50. Javidi-Parsijani P, Lyu P, Makani V, Sarhan WM, Yoo KW, El-Korashi L, Atala A, Lu B. CRISPR/Cas9 increases mitotic gene conversion in human cells. Gene Ther. 2020 06; 27(6):281-296. PMID: 32020049.

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  51. Jorgensen AM, Varkey M, Gorkun A, Clouse C, Xu L, Chou Z, Murphy SV, Molnar J, Lee SJ, Yoo JJ, Soker S, Atala A. Bioprinted Skin Recapitulates Normal Collagen Remodeling in Full-Thickness Wounds. Tissue Eng Part A. 2020 05; 26(9-10):512-526. PMID: 31861970.

    View in: PubMed Article has an altmetric score of 1



  52. Gu X, Thakker PU, Matz EL, Terlecki RP, Marini FC, Allickson JG, Lue TF, Lin G, Atala A, Yoo JJ, Zhang Y, Jackson JD. Dynamic Changes in Erectile Function and Histological Architecture After Intracorporal Injection of Human Placental Stem Cells in a Pelvic Neurovascular Injury Rat Model. J Sex Med. 2020 03; 17(3):400-411. PMID: 32001204.

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  53. Almeida-Porada G, Atala AJ, Porada CD. Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery. Mol Ther Methods Clin Dev. 2020 Mar 13; 16:204-224. PMID: 32071924.

    View in: PubMed Article has an altmetric score of 3



  54. Shafiee A, Ghadiri E, Kassis J, Williams D, Atala A. Energy Band Gap Investigation of Biomaterials: A Comprehensive Material Approach for Biocompatibility of Medical Electronic Devices. Micromachines (Basel). 2020 Jan 18; 11(1). PMID: 31963748.

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  55. Zhang G, Varkey M, Wang Z, Xie B, Hou R, Atala A. ECM concentration and cell-mediated traction forces play a role in vascular network assembly in 3D bioprinted tissue. Biotechnol Bioeng. 2020 04; 117(4):1148-1158. PMID: 31840798.

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  56. Deebel NA, Galdon G, Zarandi NP, Stogner-Underwood K, Howards S, Lovato J, Kogan S, Atala A, Lue Y, Sadri-Ardekani H. Age-related presence of spermatogonia in patients with Klinefelter syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2020 01 01; 26(1):58-72. PMID: 31822886.

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  57. Zhang C, George SK, Wu R, Thakker PU, Abolbashari M, Kim TH, Ko IK, Zhang Y, Sun Y, Jackson J, Lee SJ, Yoo JJ, Atala A. Reno-protection of Urine-derived Stem Cells in A Chronic Kidney Disease Rat Model Induced by Renal Ischemia and Nephrotoxicity. Int J Biol Sci. 2020; 16(3):435-446. PMID: 32015680.

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  58. Atala A. Most-read articles 2019: A year of noteworthy research. Stem Cells Transl Med. 2020 01; 9(1):4-5. PMID: 31926060.

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  59. Willson K, Ke D, Kengla C, Atala A, Murphy SV. Extrusion-Based Bioprinting: Current Standards and Relevancy for Human-Sized Tissue Fabrication. Methods Mol Biol. 2020; 2140:65-92. PMID: 32207106.

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  60. Ding B, Sun G, Liu S, Peng E, Wan M, Chen L, Jackson J, Atala A. Three-Dimensional Renal Organoids from Whole Kidney Cells: Generation, Optimization, and Potential Application in Nephrotoxicology In Vitro. Cell Transplant. 2020 Jan-Dec; 29:963689719897066. PMID: 32166969.

    View in: PubMed Article has an altmetric score of 1



  61. Smith BT, Bittner SM, Watson E, Smoak MM, Diaz-Gomez L, Molina ER, Kim YS, Hudgins CD, Melchiorri AJ, Scott DW, Grande-Allen KJ, Yoo JJ, Atala A, Fisher JP, Mikos AG. Multimaterial Dual Gradient Three-Dimensional Printing for Osteogenic Differentiation and Spatial Segregation. Tissue Eng Part A. 2020 03; 26(5-6):239-252. PMID: 31696784.

    View in: PubMed Article has an altmetric score of 7



  62. Kim W, Lee H, Lee J, Atala A, Yoo JJ, Lee SJ, Kim GH. Efficient myotube formation in 3D bioprinted tissue construct by biochemical and topographical cues. Biomaterials. 2020 02; 230:119632. PMID: 31761486.

    View in: PubMed Article has an altmetric score of 2



  63. Murphy SV, De Coppi P, Atala A. Opportunities and challenges of translational 3D bioprinting. Nat Biomed Eng. 2020 04; 4(4):370-380. PMID: 31695178.

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  64. Yang H, Atala A, Yoo JJ. Kidney regeneration approaches for translation. World J Urol. 2020 Sep; 38(9):2075-2079. PMID: 31696256.

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  65. Khoury O, Atala A, Murphy SV. Stromal cells from perinatal and adult sources modulate the inflammatory immune response in vitro by decreasing Th1 cell proliferation and cytokine secretion. Stem Cells Transl Med. 2020 01; 9(1):61-73. PMID: 31638323.

    View in: PubMed Article has an altmetric score of 96



  66. Paulo Zambon J, Atala A, Yoo JJ. Methods to generate tissue-derived constructs for regenerative medicine applications. Methods. 2020 01 15; 171:3-10. PMID: 31606388.

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  67. Atala A. Re: ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. J Urol. 2019 11; 202(5):869-870. PMID: 31365309.

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  68. Atala A. Re: p27 Transcriptionally Coregulates cJun to Drive Programs of Tumor Progression. J Urol. 2019 11; 202(5):868. PMID: 31365310.

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  69. Atala A. Re: Recurrent Activating Mutations of PPAR? Associated with Luminal Bladder Tumors. J Urol. 2019 11; 202(5):869. PMID: 31365313.

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  70. Lyu P, Javidi-Parsijani P, Atala A, Lu B. Delivering Cas9/sgRNA ribonucleoprotein (RNP) by lentiviral capsid-based bionanoparticles for efficient 'hit-and-run' genome editing. Nucleic Acids Res. 2019 09 26; 47(17):e99. PMID: 31299082.

    View in: PubMed Article has an altmetric score of 37



  71. Atala A. Re: Mouse and Human Urothelial Cancer Organoids: A Tool for Bladder Cancer Research. J Urol. 2019 10; 202(4):664. PMID: 31287759.

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  72. Atala A. Re: The Induction of Core Pluripotency Master Regulators in Cancers Defines Poor Clinical Outcomes and Treatment Resistance. J Urol. 2019 10; 202(4):663. PMID: 31287760.

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  73. Atala A. Re: The Proteogenomic Landscape of Curable Prostate Cancer. J Urol. 2019 10; 202(4):664. PMID: 31287765.

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  74. Atala A. Re: Hydroxysteroid (17ß) Dehydrogenase 1 Expressed by Sertoli Cells Contributes to Steroid Synthesis and is Required for Male Fertility. J Urol. 2019 09; 202(3):461-462. PMID: 31180283.

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  75. Atala A. Re: Inhibition of De Novo Lipogenesis Targets Androgen Receptor Signaling in Castration-Resistant Prostate Cancer. J Urol. 2019 09; 202(3):460-461. PMID: 31180288.

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  76. Atala A. Re: Estrogen Receptor ß Promotes Renal Cell Carcinoma Progression via Regulating LncRNA HOTAIR-miR-138/200c/204/217 Associated CeRNA Network. J Urol. 2019 09; 202(3):461. PMID: 31180291.

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  77. Sittadjody S, Enck KM, Wells A, Yoo JJ, Atala A, Saul JM, Opara EC. Encapsulation of Mesenchymal Stem Cells in 3D Ovarian Cell Constructs Promotes Stable and Long-Term Hormone Secretion with Improved Physiological Outcomes in a Syngeneic Rat Model. Ann Biomed Eng. 2020 Mar; 48(3):1058-1070. PMID: 31367915.

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  78. Murphy SV, Skardal A, Nelson RA, Sunnon K, Reid T, Clouse C, Kock ND, Jackson J, Soker S, Atala A. Amnion membrane hydrogel and amnion membrane powder accelerate wound healing in a full thickness porcine skin wound model. Stem Cells Transl Med. 2020 01; 9(1):80-92. PMID: 31328435.

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  79. Atala A. Re: Inhibition of De Novo Lipogenesis Targets Androgen Receptor Signaling in Castration-Resistant Prostate Cancer. J Urol. 2019 08; 202(2):214. PMID: 31063054.

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  80. Atala A. Re: Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories. J Urol. 2019 08; 202(2):213-214. PMID: 31063059.

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  81. Atala A. Re: Host Restriction of Escherichia coli Recurrent Urinary Tract Infection Occurs in a Bacterial Strain-Specific Manner. J Urol. 2019 08; 202(2):215. PMID: 31063066.

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  82. Lee H, Ju YM, Kim I, Elsangeedy E, Lee JH, Yoo JJ, Atala A, Lee SJ. A novel decellularized skeletal muscle-derived ECM scaffolding system for in situ muscle regeneration. Methods. 2020 01 15; 171:77-85. PMID: 31278981.

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  83. George SK, Abolbashari M, Kim TH, Zhang C, Allickson J, Jackson JD, Lee SJ, Ko IK, Atala A, Yoo JJ. Effect of Human Amniotic Fluid Stem Cells on Kidney Function in a Model of Chronic Kidney Disease. Tissue Eng Part A. 2019 11; 25(21-22):1493-1503. PMID: 30829146.

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  84. Atala A. Re: Targeting FOXA1-Mediated Repression of TGF-ß Signaling Suppresses Castration-Resistant Prostate Cancer Progression. J Urol. 2019 07; 202(1):36. PMID: 30925087.

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  85. Atala A. Re: Alterations of Tumor Microenvironment by Nitric Oxide Impedes Castration-Resistant Prostate Cancer Growth. J Urol. 2019 07; 202(1):35-36. PMID: 30925098.

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  86. Atala A. Re: SIRT3 Inhibited the Formation of Calcium Oxalate-Induced Kidney Stones through Regulating NRF2/HO-1 Signaling Pathway. J Urol. 2019 07; 202(1):36-37. PMID: 30925129.

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  87. Shapiro L, Elsangeedy E, Lee H, Atala A, Yoo JJ, Lee SJ, Ju YM. In vitro evaluation of functionalized decellularized muscle scaffold for in situ skeletal muscle regeneration. Biomed Mater. 2019 06 05; 14(4):045015. PMID: 31100745.

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  88. Abdelaal O, Barber H, Atala A, Sadri-Ardekani H. Purging of malignant cell contamination prior to spermatogonia stem cell autotransplantation to preserve fertility: progress & prospects. Curr Opin Endocrinol Diabetes Obes. 2019 06; 26(3):166-174. PMID: 30998603.

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  89. Atala A. Re: Epigenetic Silencing of the Dual-Role Signal Mediator, ANGPTL4 in Tumor Tissues and Its Overexpression in the Urothelial Carcinoma Microenvironment. J Urol. 2019 06; 201(6):1057. PMID: 30864910.

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  90. Atala A. Re: Genetic Variation in the SIM1 Locus is Associated with Erectile Dysfunction. J Urol. 2019 06; 201(6):1056. PMID: 30864912.

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  91. Atala A. Re: Host Suppression of Quorum Sensing during Catheter-Associated Urinary Tract Infections. J Urol. 2019 06; 201(6):1057. PMID: 30864920.

    View in: PubMed Article has an altmetric score of 1



  92. Ko IK, Yoo ES, Park SM, Lee BK, Kim JH, Yoo JJ, Atala A. Use of uniformly sized muscle fiber fragments for restoration of muscle tissue function. J Tissue Eng Regen Med. 2019 07; 13(7):1230-1240. PMID: 31050866.

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  93. Chandra P, Atala A. Engineering blood vessels and vascularized tissues: technology trends and potential clinical applications. Clin Sci (Lond). 2019 05 15; 133(9):1115-1135. PMID: 31088895.

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  94. Lu B, Javidi-Parsijani P, Makani V, Mehraein-Ghomi F, Sarhan WM, Sun D, Yoo KW, Atala ZP, Lyu P, Atala A. Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing. Nucleic Acids Res. 2019 05 07; 47(8):e44. PMID: 30759231.

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  95. Atala A, Forgacs G. Three-Dimensional Bioprinting in Regenerative Medicine: Reality, Hype, and Future. Stem Cells Transl Med. 2019 08; 8(8):744-745. PMID: 31058436.

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  96. Atala A. Re: Immunogenomic Analyses Associate Immunological Alterations with Mismatch Repair Defects in Prostate Cancer. J Urol. 2019 05; 201(5):861-862. PMID: 30747894.

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  97. Atala A. Re: Classification of Prostate Cancer Using a Protease Activity Nanosensor Library. J Urol. 2019 05; 201(5):862-863. PMID: 30747895.

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  98. Atala A. Re: Conserved Collateral Antibiotic Susceptibility Networks in Diverse Clinical Strains of Escherichia coli. J Urol. 2019 05; 201(5):861. PMID: 30747896.

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  99. Huling J, Min SI, Kim DS, Ko IK, Atala A, Yoo JJ. Kidney regeneration with biomimetic vascular scaffolds based on vascular corrosion casts. Acta Biomater. 2019 09 01; 95:328-336. PMID: 30953799.

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  100. Atala A. Re: Metastatic Cells are Preferentially Vulnerable to Lysosomal Inhibition. J Urol. 2019 04; 201(4):668-669. PMID: 30652990.

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