Kenneth Kosik

Harriman Professor of Neuroscience Research in Molecular, Cellular and Developmental Biology at UCSB Co-Director, Neuroscience Research Institute

Biography

Kenneth S. Kosik completed a B.A. and M.A. in English literature from Case Western Reserve University in 1972 and an M.D. from the Medical College of Pennsylvania in 1976. He served as a resident in neurology at Tufts New England Medical Center and was Chief Resident there in 1980. Beginning in 1980 he held a series of academic appointments at the Harvard Medical School and achieved the rank of full professor there in 1996. He also held appointments at McLean Hospital, Brigham and Women's Hospital, the Massachusetts General Hospital and the Dana-Farber Cancer Institute. In 2004, Kosik became the Harriman Professor of Neuroscience Research and Co-Director of the Neuroscience Research Institute at the University of California, Santa Barbara. He founded and serves as Medical Director of the non-profit center, Cottage Center for Brain Fitness (CCBF).

Research Topics

The Kosik lab intends to create an intellectual setting conducive to the exploration of fundamental biological processes, particularly those related to the brain and its evolution. Although the approach is largely reductionist with an emphasis on genes, molecules and cells, studies in the lab also encompass systems level informatic approaches that include large genomic and transcriptional and imaging data sets. One theme in the lab is how cells acquire and lose their identities. A specialized case of altered cellular identity is synaptic plasticity. The lab is interested in the underlying molecular basis of plasticity, particularly how protein translation at the synapse affects learning and how impairments of plasticity lead to neurodegenerative diseases. Behind all the lab projects stands the overarching principle succinctly stated by Theodosius Dobzhansky, "Nothing in Biology Makes Sense Except in the Light of Evolution."

 

Areas of Study

• Biomedical Sciences
• Cell Biology
• Developmental & Stem Cell Biology
• Genetics & Genomics
• Neuroscience
• Systems & Quantitative Biology

 Honors & Awards

• Whitaker Health Sciences Award, Massachusetts Institute of Technology
• Metropolitan Life Foundation Medical Award
• Derek Denny-Brown Neurological Scholar Award, the American Neurological Association (1990)
• Zenith Award from the Alzheimer's Association
• Ranwell Caputo Medal, the Argentine Society of Neurochemistry
• NASA Group Achievement Award to the Neurolab Science Team

 

Publications

LRP1 is a master regulator of tau uptake and spread.

Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS.Nature. 2020 Apr;580(7803):381-385. doi: 10.1038/s41586-020-2156-5. Epub 2020 Apr 1.PMID: 32296178 

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease.

Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, Miller BL, Berretta S, Hedreen JC, Grinberg LT, Seeley WW, Hyman BT, Steen H, Steen JA.Cell. 2020 Dec 10;183(6):1699-1713.e13. doi: 10.1016/j.cell.2020.10.029. Epub 2020 Nov 13.PMID: 33188775

Microglial microRNAs mediate sex-specific responses to tau pathology.

Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC, Clelland CD, Cheng Z, Yu G, Li Q, Kosik KS, Gan L.Nat Neurosci. 2020 Feb;23(2):167-171. doi: 10.1038/s41593-019-0560-7. Epub 2019 Dec 23.PMID: 31873194 

Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.

Arboleda-Velasquez JF, Lopera F, O'Hare M, Delgado-Tirado S, Marino C, Chmielewska N, Saez-Torres KL, Amarnani D, Schultz AP, Sperling RA, Leyton-Cifuentes D, Chen K, Baena A, Aguillon D, Rios-Romenets S, Giraldo M, Guzmán-Vélez E, Norton DJ, Pardilla-Delgado E, Artola A, Sanchez JS, Acosta-Uribe J, Lalli M, Kosik KS, Huentelman MJ, Zetterberg H, Blennow K, Reiman RA, Luo J, Chen Y, Thiyyagura P, Su Y, Jun GR, Naymik M, Gai X, Bootwalla M, Ji J, Shen L, Miller JB, Kim LA, Tariot PN, Johnson KA, Reiman EM, Quiroz YT.Nat Med. 2019 Nov;25(11):1680-1683. doi: 10.1038/s41591-019-0611-3. Epub 2019 Nov 4.PMID: 31686034 

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.

Sohn PD, Huang CT, Yan R, Fan L, Tracy TE, Camargo CM, Montgomery KM, Arhar T, Mok SA, Freilich R, Baik J, He M, Gong S, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, Gan L.Neuron. 2019 Nov 6;104(3):458-470.e5. doi: 10.1016/j.neuron.2019.08.008. Epub 2019 Sep 18.PMID: 31542321 

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.

Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S; Tau Consortium Stem Cell Group.Stem Cell Reports. 2019 Nov 12;13(5):939-955. doi: 10.1016/j.stemcr.2019.09.006. Epub 2019 Oct 17.PMID: 31631020 

Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.

Nowakowski TJ, Rani N, Golkaram M, Zhou HR, Alvarado B, Huch K, West JA, Leyrat A, Pollen AA, Kriegstein AR, Petzold LR, Kosik KS.Nat Neurosci. 2018 Dec;21(12):1784-1792. doi: 10.1038/s41593-018-0265-3. Epub 2018 Nov 19.PMID: 30455455 

COVID-19 in older people with cognitive impairment in Latin America.

Ibanez A, Kosik KS; Latin America and the Caribbean Consortium on Dementia (LAC-CD).Lancet Neurol. 2020 Sep;19(9):719-721. doi: 10.1016/S1474-4422(20)30270-2.PMID: 32822627  No abstract available.

Synaptic dysregulation in a human iPS cell model of mental disorders.

Wen Z, Nguyen HN, Guo Z, Lalli MA, Wang X, Su Y, Kim NS, Yoon KJ, Shin J, Zhang C, Makri G, Nauen D, Yu H, Guzman E, Chiang CH, Yoritomo N, Kaibuchi K, Zou J, Christian KM, Cheng L, Ross CA, Margolis RL, Chen G, Kosik KS, Song H, Ming GL.Nature. 2014 Nov 20;515(7527):414-8. doi: 10.1038/nature13716. Epub 2014 Aug 17.PMID: 25132547 

The proline-rich domain promotes Tau liquid-liquid phase separation in cells.

Zhang X, Vigers M, McCarty J, Rauch JN, Fredrickson GH, Wilson MZ, Shea JE, Han S, Kosik KS.J Cell Biol. 2020 Nov 2;219(11):e202006054. doi: 10.1083/jcb.202006054.PMID: 32997736

Tau Condensates.

Kosik KS, Han S.Adv Exp Med Biol. 2019;1184:327-339. doi: 10.1007/978-981-32-9358-8_24.PMID: 32096047 Review.

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS.Sci Rep. 2018 Apr 23;8(1):6382. doi: 10.1038/s41598-018-24904-z.PMID: 29686391 

A molecular signature for anastasis, recovery from the brink of apoptotic cell death.

Sun G, Guzman E, Balasanyan V, Conner CM, Wong K, Zhou HR, Kosik KS, Montell DJ.J Cell Biol. 2017 Oct 2;216(10):3355-3368. doi: 10.1083/jcb.201706134. Epub 2017 Aug 2.PMID: 28768686 

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.

Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS.Sci Transl Med. 2019 Mar 27;11(485):eaat3005. doi: 10.1126/scitranslmed.aat3005.PMID: 30918111 

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease.

Mair W, Muntel J, Tepper K, Tang S, Biernat J, Seeley WW, Kosik KS, Mandelkow E, Steen H, Steen JA.Anal Chem. 2016 Apr 5;88(7):3704-14. doi: 10.1021/acs.analchem.5b04509. Epub 2016 Mar 7.PMID: 26877193 

MOV10 and FMRP regulate AGO2 association with microRNA recognition elements.

Kenny PJ, Zhou H, Kim M, Skariah G, Khetani RS, Drnevich J, Arcila ML, Kosik KS, Ceman S.Cell Rep. 2014 Dec 11;9(5):1729-1741. doi: 10.1016/j.celrep.2014.10.054. Epub 2014 Nov 20.PMID: 25464849 

Evolution of New miRNAs and Cerebro-Cortical Development.

Kosik KS, Nowakowski T.Annu Rev Neurosci. 2018 Jul 8;41:119-137. doi: 10.1146/annurev-neuro-080317-061822. Epub 2018 Apr 4.PMID: 29618285 Review.

Cell biology in support of neurological research: 2018 highlights.

Kosik KS.Lancet Neurol. 2019 Jan;18(1):19-20. doi: 10.1016/S1474-4422(18)30462-9.PMID: 30563677 No abstract available.

Non-contact monitoring of extra-cellular field potentials with a multi-electrode array.

Sharf T, Hansma PK, Hari MA, Kosik KS.Lab Chip. 2019 Apr 9;19(8):1448-1457. doi: 10.1039/c8lc00984h.PMID: 30887972

In vitro validation of in silico identified inhibitory
interactions.

Liu H, Bridges D, Randall C, Solla SA, Wu B, Hansma P, Yan X, Kosik KS, Bouchard K.J Neurosci Methods. 2019 Jun 1;321:39-48. doi: 10.1016/j.jneumeth.2019.04.002. Epub 2019 Apr 6.PMID: 30965073

The message and the messenger: delivering RNA in neurons.

Kosik KS, Krichevsky AM.Sci STKE. 2002 Apr 2;2002(126):pe16. doi: 10.1126/stke.2002.126.pe16.PMID: 11930084 Review.

MicroRNAs: regulators of oncogenesis and stemness.

Papagiannakopoulos T, Kosik KS.BMC Med. 2008 Jun 24;6:15. doi: 10.1186/1741-7015-6-15.PMID: 18577221  Review.

 

Beyond phrenology, at last.

Kosik KS.Nat Rev Neurosci. 2003 Mar;4(3):234-9. doi: 10.1038/nrn1053.PMID: 12612636 Review.

Tau-er of Power.

Kosik KS.Cerebrum. 2015 May 1;2015:6. eCollection 2015 May-Jun.PMID: 26380035 

 

MicroRNAs potentiate neural development.

Fineberg SK, Kosik KS, Davidson BL.Neuron. 2009 Nov 12;64(3):303-9. doi: 10.1016/j.neuron.2009.10.020.PMID: 19914179  Review.

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions.

Lin Y, McCarty J, Rauch JN, Delaney KT, Kosik KS, Fredrickson GH, Shea JE, Han S.Elife. 2019 Apr 5;8:e42571. doi: 10.7554/eLife.42571.PMID: 30950394 

The neuronal microRNA system.

Kosik KS.Nat Rev Neurosci. 2006 Dec;7(12):911-20. doi: 10.1038/nrn2037.PMID: 17115073 Review.

 

Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred.

Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hanseeuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT.J Prev Alzheimers Dis. 2019;6(2):112-120. doi: 10.14283/jpad.2019.6.PMID: 30756118  Review.

Control over single-cell distribution of G1 lengths by WNT governs pluripotency.

Jang J, Han D, Golkaram M, Audouard M, Liu G, Bridges D, Hellander S, Chialastri A, Dey SS, Petzold LR, Kosik KS.PLoS Biol. 2019 Sep 26;17(9):e3000453. doi: 10.1371/journal.pbio.3000453. eCollection 2019 Sep.PMID: 31557150 

Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau.

Lin Y, Fichou Y, Longhini AP, Llanes LC, Yin P, Bazan GC, Kosik KS, Han S.J Mol Biol. 2021 Jan 22;433(2):166731. doi: 10.1016/j.jmb.2020.166731. Epub 2020 Dec 3.PMID: 33279579

A path toward understanding neurodegeneration.

Kosik KS, Sejnowski TJ, Raichle ME, Ciechanover A, Baltimore D.Science. 2016 Aug 26;353(6302):872-3. doi: 10.1126/science.aai7622.PMID: 27563087 

Genetic origin of a large family with a novel PSEN1 mutation
(Ile416Thr).

Ramirez Aguilar L, Acosta-Uribe J, Giraldo MM, Moreno S, Baena A, Alzate D, Cuastumal R, Aguillón D, Madrigal L, Saldarriaga A, Navarro A, Garcia GP, Aguirre-Acevedo DC, Geier EG, Cochran JN, Quiroz YT, Myers RM, Yokoyama JS, Kosik KS, Lopera F.Alzheimers Dement. 2019 May;15(5):709-719. doi: 10.1016/j.jalz.2018.12.010. Epub 2019 Feb 10.PMID: 30745123 

The outer subventricular zone and primate-specific cortical complexification.

Dehay C, Kennedy H, Kosik KS.Neuron. 2015 Feb 18;85(4):683-94. doi: 10.1016/j.neuron.2014.12.060.PMID: 25695268  Review.

MicroRNAs tell an evo-devo story.

Kosik KS.Nat Rev Neurosci. 2009 Oct;10(10):754-9. doi: 10.1038/nrn2713. Epub 2009 Sep 9.PMID: 19738624 Review.

Tau protein and neurodegeneration.

Kosik KS.Mol Neurobiol. 1990 Fall-Winter;4(3-4):171-9. doi: 10.1007/BF02780339.PMID: 2135393 Review.

The impact of SARS-CoV-2 in dementia across Latin America: A call for an urgent regional plan and coordinated response.

Ibanez A, Santamaria-Garcia H, Guerrero Barragan A, Kornhuber A, Ton AMM, Slachevsky A, Teixeira AL, Mar Meza BM, Serrano CM, Cano C, Arias Gonzalez C, Gonzalez-Billault C, Butler C, Bustin J, Duran-Aniotz C, Acosta D, Matallana DL, Acosta-Alvear D, Trépel D, Resende EPF, de Oliveira FF, Ibanez F, De Felice FG, Navarrete G, Tarnanas I, Meier IB, Smid J, Llibre-Guerra J, Llibre-Rodriguez JJ, Fajersztajn L, Takada LT, Duque L, Okada de Oliveira M, Bicalho MAC, Behrens MI, Pintado-Caipa M, Parra M, Wilson MZ, De La Cruz Puebla M, Custodio N, Santibanez R, Serafim RB, Tavares RM, Piña Escudero SD, Leon Rodriguez T, Dawson W, Miller BL, Kosik KS.Alzheimers Dement (N Y). 2020 Nov 23;6(1):e12092. doi: 10.1002/trc2.12092. eCollection 2020.PMID: 33283036 

Delta-catenin at the synaptic-adherens junction.

Kosik KS, Donahue CP, Israely I, Liu X, Ochiishi T.Trends Cell Biol. 2005 Mar;15(3):172-8. doi: 10.1016/j.tcb.2005.01.004.PMID: 15752981 Review.

Phosphorylated tau and the neurodegenerative foldopathies.

Kosik KS, Shimura H.Biochim Biophys Acta. 2005 Jan 3;1739(2-3):298-310. doi: 10.1016/j.bbadis.2004.10.011. Epub 2004 Nov 26.PMID: 15615647  Review.

Noncoding RNAs in Long-Term Memory Formation.

Mercer TR, Dinger ME, Mariani J, Kosik KS, Mehler MF, Mattick JS.Neuroscientist. 2008 Oct;14(5):434-45. doi: 10.1177/1073858408319187.PMID: 18997122 Review.

Synaptic tagging -- who's it?

Martin KC, Kosik KS.Nat Rev Neurosci. 2002 Oct;3(10):813-20. doi: 10.1038/nrn942.PMID: 12360325 Review. No abstract available.

Cofactors are essential constituents of stable and seeding-active tau fibrils.

Fichou Y, Lin Y, Rauch JN, Vigers M, Zeng Z, Srivastava M, Keller TJ, Freed JH, Kosik KS, Han S.Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13234-13239. doi: 10.1073/pnas.1810058115. Epub 2018 Dec 11.PMID: 30538196 

 

RNA stores tau reversibly in complex coacervates.

Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I, Guzman E, Kosik KS, Han S.PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul.PMID: 28683104 

Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH.J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):741-6. doi: 10.1093/gerona/gls110. Epub 2012 Apr 20.PMID: 22522509  Review.

Life at Low Copy Number: How Dendrites Manage with So Few mRNAs.

Kosik KS.Neuron. 2016 Dec 21;92(6):1168-1180. doi: 10.1016/j.neuron.2016.11.002.PMID: 28009273  Review.

iPSCs-derived nerve-like cells from familial Alzheimer's disease PSEN 1 E280A reveal increased amyloid-beta levels and loss of the Y chromosome.

Mendivil-Perez M, Velez-Pardo C, Kosik KS, Lopera F, Jimenez-Del-Rio M.Neurosci Lett. 2019 Jun 11;703:111-118. doi: 10.1016/j.neulet.2019.03.032. Epub 2019 Mar 20.PMID: 30904577 

MicroRNA regulation of neural stem cells and neurogenesis.

Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S, Neveu P, Kosik KS.J Neurosci. 2010 Nov 10;30(45):14931-6. doi: 10.1523/JNEUROSCI.4280-10.2010.PMID: 21068294  Review.

The Elegance of the MicroRNAs: A Neuronal Perspective.

Kosik KS, Krichevsky AM.Neuron. 2005 Sep 15;47(6):779-82. doi: 10.1016/j.neuron.2005.08.019.PMID: 16157272  Review.

Tau protein and Alzheimer's disease.

Kosik KS.Curr Opin Cell Biol. 1990 Feb;2(1):101-4. doi: 10.1016/s0955-0674(05)80038-9.PMID: 2109621 Review. No abstract available.

Neurodegeneration: new clues on inclusions.

Lansbury PT Jr, Kosik KS.Chem Biol. 2000 Jan;7(1):R9-R12. doi: 10.1016/s1074-5521(00)00068-5.PMID: 10662685 Review.

MicroRNAs and cellular phenotypy.

Kosik KS.Cell. 2010 Oct 1;143(1):21-6. doi: 10.1016/j.cell.2010.09.008.PMID: 20887887 

MEA Viewer: A high-performance interactive application for visualizing
electrophysiological data.

Bridges DC, Tovar KR, Wu B, Hansma PK, Kosik KS.PLoS One. 2018 Feb 9;13(2):e0192477. doi: 10.1371/journal.pone.0192477. eCollection 2018.PMID: 29425223 

MicroRNA-124: micromanager of neurogenesis.

Papagiannakopoulos T, Kosik KS.Cell Stem Cell. 2009 May 8;4(5):375-6. doi: 10.1016/j.stem.2009.04.007.PMID: 19427286 

Parallel discovery of Alzheimer's therapeutics.

Lo AW, Ho C, Cummings J, Kosik KS.Sci Transl Med. 2014 Jun 18;6(241):241cm5. doi: 10.1126/scitranslmed.3008228.PMID: 24944190

Alzheimer's disease: a cell biological perspective.

Kosik KS.Science. 1992 May 8;256(5058):780-3. doi: 10.1126/science.1589757.PMID: 1589757 Review.

Tau immunization: a cautionary tale?

Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM.Neurobiol Aging. 2015 Mar;36(3):1316-32. doi: 10.1016/j.neurobiolaging.2014.11.022. Epub 2014 Dec 30.PMID: 25619661

Exploring the early origins of the synapse by comparative genomics.

Kosik KS.Biol Lett. 2009 Feb 23;5(1):108-11. doi: 10.1098/rsbl.2008.0594.PMID: 19049956  Review.

New approaches to the discovery of cdk5 inhibitors.

Glicksman MA, Cuny GD, Liu M, Dobson B, Auerbach K, Stein RL, Kosik KS.Curr Alzheimer Res. 2007 Dec;4(5):547-9. doi: 10.2174/156720507783018181.PMID: 18220519 Review.

Action potential propagation recorded from single axonal arbors using multielectrode arrays.

Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS.J Neurophysiol. 2018 Jul 1;120(1):306-320. doi: 10.1152/jn.00659.2017. Epub 2018 Apr 11.PMID: 29641308 

Personalized medicine for effective Alzheimer disease treatment.

Kosik KS.JAMA Neurol. 2015 May;72(5):497-8. doi: 10.1001/jamaneurol.2014.3445.PMID: 25730751 No abstract available.

Detection of Prokaryotic Genes in the Amphimedon queenslandica Genome.

Conaco C, Tsoulfas P, Sakarya O, Dolan A, Werren J, Kosik KS.PLoS One. 2016 Mar 9;11(3):e0151092. doi: 10.1371/journal.pone.0151092. eCollection 2016.PMID: 26959231 

Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments.

Reiman EM, Langbaum JB, Fleisher AS, Caselli RJ, Chen K, Ayutyanont N, Quiroz YT, Kosik KS, Lopera F, Tariot PN.J Alzheimers Dis. 2011;26 Suppl 3(Suppl 3):321-9. doi: 10.3233/JAD-2011-0059.PMID: 21971471  Review.

The molecular and cellular biology of tau.

Kosik KS.Brain Pathol. 1993 Jan;3(1):39-43. doi: 10.1111/j.1750-3639.1993.tb00724.x.PMID: 8269082 Review.

A microRNA-mRNA expression network during oral siphon regeneration in Ciona.

Spina EJ, Guzman E, Zhou H, Kosik KS, Smith WC.Development. 2017 May 15;144(10):1787-1797. doi: 10.1242/dev.144097. Epub 2017 Apr 21.PMID: 28432214 

PhDs: what's left if science abdicates?

Kosik KS.Nature. 2011 May 19;473(7347):284. doi: 10.1038/473284b.PMID: 21593846 No abstract available.

SMN regulates axonal local translation via miR-183/mTOR pathway.

Kye MJ, Niederst ED, Wertz MH, Gonçalves Ido C, Akten B, Dover KZ, Peters M, Riessland M, Neveu P, Wirth B, Kosik KS, Sardi SP, Monani UR, Passini MA, Sahin M.Hum Mol Genet. 2014 Dec 1;23(23):6318-31. doi: 10.1093/hmg/ddu350. Epub 2014 Jul 4.PMID: 25055867 

 

MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth.

DiTella MC, Feiguin F, Carri N, Kosik KS, Cáceres A.J Cell Sci. 1996 Feb;109 ( Pt 2):467-77.PMID: 8838670 

Staged miRNA re-regulation patterns during reprogramming.

Henzler CM, Li Z, Dang J, Arcila ML, Zhou H, Liu J, Chang KY, Bassett DS, Rana TM, Kosik KS.Genome Biol. 2013 Dec 31;14(12):R149. doi: 10.1186/gb-2013-14-12-r149.PMID: 24380417 

Age-related modifications of MAP-2.

Kosik KS, Bakalis S, Galibert L, Selkoe DJ, Duffy LK.Ann N Y Acad Sci. 1986;466:420-2. doi: 10.1111/j.1749-6632.1986.tb38412.x.PMID: 2873778 No abstract available.

 

Reconstructing ancestral genome
content based on symmetrical best alignments and Dollo parsimony.

Sakarya O, Kosik KS, Oakley TH.Bioinformatics. 2008 Mar 1;24(5):606-12. doi: 10.1093/bioinformatics/btn005. Epub 2008 Jan 9.PMID: 18184685

Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs.

Corbel C, Hernandez I, Wu B, Kosik KS.Neural Dev. 2015 Sep 17;10:20. doi: 10.1186/s13064-015-0047-5.PMID: 26381867 

Diseases: Study neuron networks to tackle Alzheimer's.

Kosik KS.Nature. 2013 Nov 7;503(7474):31-2. doi: 10.1038/503031a.PMID: 24218661 No abstract available.

Molecular biology: Circles reshape the RNA world.

Kosik KS.Nature. 2013 Mar 21;495(7441):322-4. doi: 10.1038/nature11956. Epub 2013 Feb 27.PMID: 23446351 No abstract available.

In vivo phosphorylation sites in fetal and adult rat tau.

Watanabe A, Hasegawa M, Suzuki M, Takio K, Morishima-Kawashima M, Titani K, Arai T, Kosik KS, Ihara Y.J Biol Chem. 1993 Dec 5;268(34):25712-7.PMID: 8245007 

The Alzheimer's disease sphinx: a riddle with plaques and tangles.

Kosik KS.J Cell Biol. 1994 Dec;127(6 Pt 1):1501-4. doi: 10.1083/jcb.127.6.1501.PMID: 7798306  Review. No abstract available.

The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation.

Golkaram M, Jang J, Hellander S, Kosik KS, Petzold LR.Sci Rep. 2017 Oct 17;7(1):13307. doi: 10.1038/s41598-017-13731-3.PMID: 29042584 

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ.Neuron. 2015 Jun 3;86(5):1215-27. doi: 10.1016/j.neuron.2015.05.005. Epub 2015 May 21.PMID: 26004914 

Along the way to a neurofibrillary tangle: a look at the structure of tau.

Kosik KS, Kowall NW, McKee A.Ann Med. 1989;21(2):109-12. doi: 10.3109/07853898909149195.PMID: 2504256 Review.

Homozygosity of the autosomal dominant Alzheimer disease presenilin 1 E280A mutation.

Kosik KS, Muñoz C, Lopez L, Arcila ML, García G, Madrigal L, Moreno S, Ríos Romenets S, Lopez H, Gutierrez M, Langbaum JB, Cho W, Suliman S, Tariot PN, Ho C, Reiman EM, Lopera F.Neurology. 2015 Jan 13;84(2):206-8. doi: 10.1212/WNL.0000000000001130. Epub 2014 Dec 3.PMID: 25471389  No abstract available.

Dementia in Latin America: Paving the way toward a regional action plan.

Parra MA, Baez S, Sedeño L, Gonzalez Campo C, Santamaría-García H, Aprahamian I, Bertolucci PH, Bustin J, Camargos Bicalho MA, Cano-Gutierrez C, Caramelli P, Chaves MLF, Cogram P, Beber BC, Court FA, de Souza LC, Custodio N, Damian A, de la Cruz M, Diehl Rodriguez R, Brucki SMD, Fajersztajn L, Farías GA, De Felice FG, Ferrari R, de Oliveira FF, Ferreira ST, Ferretti C, Figueredo Balthazar ML, Ferreira Frota NA, Fuentes P, García AM, Garcia PJ, de Gobbi Porto FH, Duque Peñailillo L, Engler HW, Maier I, Mata IF, Gonzalez-Billault C, Lopez OL, Morelli L, Nitrini R, Quiroz YT, Guerrero Barragan A, Huepe D, Pio FJ, Suemoto CK, Kochhann R, Kochen S, Kumfor F, Lanata S, Miller B, Mansur LL, Hosogi ML, Lillo P, Llibre Guerra J, Lira D, Lopera F, Comas A, Avila-Funes JA, Sosa AL, Ramos C, Resende EPF, Snyder HM, Tarnanas I, Yokoyama J, Llibre J, Cardona JF, Possin K, Kosik KS, Montesinos R, Moguilner S, Solis PCL, Ferretti-Rebustini REL, Ramirez JM, Matallana D, Mbakile-Mahlanza L, Marques Ton AM, Tavares RM, Miotto EC, Muniz-Terrera G, Muñoz-Nevárez LA, Orozco D, Okada de Oliveira M, Piguet O, Pintado Caipa M, Piña Escudero SD, Schilling LP, Rodrigues Palmeira AL, Yassuda MS, Santacruz-Escudero JM, Serafim RB, Smid J, Slachevsky A, Serrano C, Soto-Añari M, Takada LT, Grinberg LT, Teixeira AL, Barbosa MT, Trépel D, Ibanez A.Alzheimers Dement. 2021 Feb;17(2):295-313. doi: 10.1002/alz.12202. Epub 2020 Nov 20.PMID: 33634602 

Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury.

Lisi V, Singh B, Giroux M, Guzman E, Painter MW, Cheng YC, Huebner E, Coppola G, Costigan M, Woolf CJ, Kosik KS.Cell Rep. 2017 Aug 1;20(5):1136-1147. doi: 10.1016/j.celrep.2017.07.010.PMID: 28768198 

 

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ.Neuron. 2016 May 4;90(3):662. doi: 10.1016/j.neuron.2016.04.025.PMID: 27151643  No abstract available.

Deep annotation of mouse iso-miR and iso-moR variation.

Zhou H, Arcila ML, Li Z, Lee EJ, Henzler C, Liu J, Rana TM, Kosik KS.Nucleic Acids Res. 2012 Jul;40(13):5864-75. doi: 10.1093/nar/gks247. Epub 2012 Mar 19.PMID: 22434881 

A Scalable, Easy-to-Deploy Protocol for Cas13-Based Detection of SARS-CoV-2 Genetic Material.

Rauch JN, Valois E, Solley SC, Braig F, Lach RS, Audouard M, Ponce-Rojas JC, Costello MS, Baxter NJ, Kosik KS, Arias C, Acosta-Alvear D, Wilson MZ.J Clin Microbiol. 2021 Mar 19;59(4):e02402-20. doi: 10.1128/JCM.02402-20. Print 2021 Mar 19.PMID: 33478979 

Particle display: a quantitative screening method for generating high-affinity aptamers.

Wang J, Gong Q, Maheshwari N, Eisenstein M, Arcila ML, Kosik KS, Soh HT.Angew Chem Int Ed Engl. 2014 May 5;53(19):4796-801. doi: 10.1002/anie.201309334. Epub 2014 Mar 18.PMID: 24644057 

Functionalization of a protosynaptic gene expression network.

Conaco C, Bassett DS, Zhou H, Arcila ML, Degnan SM, Degnan BM, Kosik KS.Proc Natl Acad Sci U S A. 2012 Jun 26;109 Suppl 1(Suppl 1):10612-8. doi: 10.1073/pnas.1201890109. Epub 2012 Jun 20.PMID: 22723359 

Tracking Down Mutations Cell
by Cell.

Kosik KS.Neuron. 2016 Mar 16;89(6):1126-1127. doi: 10.1016/j.neuron.2016.02.042.PMID: 26985720 

Identification of piRNAs in the central nervous system.

Lee EJ, Banerjee S, Zhou H, Jammalamadaka A, Arcila M, Manjunath BS, Kosik KS.RNA. 2011 Jun;17(6):1090-9. doi: 10.1261/rna.2565011. Epub 2011 Apr 22.PMID: 21515829 

iPhemap: an atlas of phenotype
to genotype relationships of human iPSC models of neurological diseases.

Hollingsworth EW, Vaughn JE, Orack JC, Skinner C, Khouri J, Lizarraga SB, Hester ME, Watanabe F, Kosik KS, Imitola J.EMBO Mol Med. 2017 Dec;9(12):1742-1762. doi: 10.15252/emmm.201708191.PMID: 29051230 

NMDA mediated contextual conditioning changes miRNA expression.

Kye MJ, Neveu P, Lee YS, Zhou M, Steen JA, Sahin M, Kosik KS, Silva AJ.PLoS One. 2011;6(9):e24682. doi: 10.1371/journal.pone.0024682. Epub 2011 Sep 12.PMID: 21931811 

RNAi functions in cultured mammalian neurons.

Krichevsky AM, Kosik KS.Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11926-9. doi: 10.1073/pnas.182272699. Epub 2002 Aug 21.PMID: 12192088 

Processes induced by tau expression in Sf9 cells
have an axon-like microtubule organization.

Baas PW, Pienkowski TP, Kosik KS.J Cell Biol. 1991 Dec;115(5):1333-44. doi: 10.1083/jcb.115.5.1333.PMID: 1955477 

Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.

Laha JK, Zhang X, Qiao L, Liu M, Chatterjee S, Robinson S, Kosik KS, Cuny GD.Bioorg Med Chem Lett. 2011 Apr 1;21(7):2098-101. doi: 10.1016/j.bmcl.2011.01.140. Epub 2011 Feb 3.PMID: 21353545 

Haploinsufficiency of BAZ1B contributes to Williams syndrome through
transcriptional dysregulation of neurodevelopmental pathways.

Lalli MA, Jang J, Park JH, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D, Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS.Hum Mol Genet. 2016 Apr 1;25(7):1294-306. doi: 10.1093/hmg/ddw010. Epub 2016 Jan 10.PMID: 26755828

A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA.

Rani N, Nowakowski TJ, Zhou H, Godshalk SE, Lisi V, Kriegstein AR, Kosik KS.Neuron. 2016 Jun 15;90(6):1174-1188. doi: 10.1016/j.neuron.2016.05.005. Epub 2016 Jun 2.PMID: 27263970 

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.

Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL.Cell Rep. 2015 Sep 1;12(9):1414-29. doi: 10.1016/j.celrep.2015.07.061. Epub 2015 Aug 20.PMID: 26299970 

Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease.

Lalli MA, Cox HC, Arcila ML, Cadavid L, Moreno S, Garcia G, Madrigal L, Reiman EM, Arcos-Burgos M, Bedoya G, Brunkow ME, Glusman G, Roach JC, Hood L, Kosik KS, Lopera F.Alzheimers Dement. 2014 Oct;10(5 Suppl):S277-S283.e10. doi: 10.1016/j.jalz.2013.09.005. Epub 2013 Nov 13.PMID: 24239249 

Cellular aspects of Alzheimer neurofibrillary pathology.

Kosik KS.Prog Clin Biol Res. 1992;379:183-93.PMID: 1409744 Review. No abstract available.

Hirano bodies contain tau protein.

Galloway PG, Perry G, Kosik KS, Gambetti P.Brain Res. 1987 Feb 17;403(2):337-40. doi: 10.1016/0006-8993(87)90071-0.PMID: 3103867

β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.

Piedrahita D, Castro-Alvarez JF, Boudreau RL, Villegas-Lanau A, Kosik KS, Gallego-Gomez JC, Cardona-Gómez GP.Front Cell Neurosci. 2016 Jan 8;9:498. doi: 10.3389/fncel.2015.00498. eCollection 2015.PMID: 26778963 

Primary Cilium-Autophagy-Nrf2 (PAN) Axis Activation Commits Human Embryonic Stem Cells to a Neuroectoderm Fate.

Jang J, Wang Y, Lalli MA, Guzman E, Godshalk SE, Zhou H, Kosik KS.Cell. 2016 Apr 7;165(2):410-20. doi: 10.1016/j.cell.2016.02.014. Epub 2016 Mar 24.PMID: 27020754 

Traveling the tau pathway: a personal account.

Kosik KS.J Alzheimers Dis. 2006;9(3 Suppl):251-6. doi: 10.3233/jad-2006-9s327.PMID: 16914863 Review.

Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns.

Arcila ML, Betizeau M, Cambronne XA, Guzman E, Doerflinger N, Bouhallier F, Zhou H, Wu B, Rani N, Bassett DS, Borello U, Huissoud C, Goodman RH, Dehay C, Kosik KS.Neuron. 2014 Mar 19;81(6):1255-1262. doi: 10.1016/j.neuron.2014.01.017. Epub 2014 Feb 27.PMID: 24583023 

A Fast and Accessible Method for the Isolation of RNA, DNA, and Protein To Facilitate the Detection of SARS-CoV-2.

Ponce-Rojas JC, Costello MS, Proctor DA, Kosik KS, Wilson MZ, Arias C, Acosta-Alvear D.J Clin Microbiol. 2021 Mar 19;59(4):e02403-20. doi: 10.1128/JCM.02403-20. Print 2021 Mar 19.PMID: 33293367 

 

Statistical analysis of dendritic spine distributions in rat hippocampal cultures.

Jammalamadaka A, Banerjee S, Manjunath BS, Kosik KS.BMC Bioinformatics. 2013 Oct 2;14:287. doi: 10.1186/1471-2105-14-287.PMID: 24088199 

The Amphimedon queenslandica genome and the evolution of animal complexity.

Srivastava M, Simakov O, Chapman J, Fahey B, Gauthier ME, Mitros T, Richards GS, Conaco C, Dacre M, Hellsten U, Larroux C, Putnam NH, Stanke M, Adamska M, Darling A, Degnan SM, Oakley TH, Plachetzki DC, Zhai Y, Adamski M, Calcino A, Cummins SF, Goodstein DM, Harris C, Jackson DJ, Leys SP, Shu S, Woodcroft BJ, Vervoort M, Kosik KS, Manning G, Degnan BM, Rokhsar DS.Nature. 2010 Aug 5;466(7307):720-6. doi: 10.1038/nature09201.PMID: 20686567 

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.

Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ.Stem Cell Reports. 2016 Sep 13;7(3):325-340. doi: 10.1016/j.stemcr.2016.08.001. Epub 2016 Sep 1.PMID: 27594585 

Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation.

Corbel C, Zhang B, Le Parc A, Baratte B, Colas P, Couturier C, Kosik KS, Landrieu I, Le Tilly V, Bach S.Chem Biol. 2015 Apr 23;22(4):472-482. doi: 10.1016/j.chembiol.2015.03.009. Epub 2015 Apr 9.PMID: 25865311

A quantitative framework to evaluate modeling of cortical
development by neural stem cells.

Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH.Neuron. 2014 Jul 2;83(1):69-86. doi: 10.1016/j.neuron.2014.05.035.PMID: 24991955 

Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models.

Zhang X, Hernandez I, Rei D, Mair W, Laha JK, Cornwell ME, Cuny GD, Tsai LH, Steen JA, Kosik KS.J Biol Chem. 2013 Jul 26;288(30):22042-56. doi: 10.1074/jbc.M112.436402. Epub 2013 Jun 4.PMID: 23737518 

MCP-1 and eotaxin-1 selectively and negatively
associate with memory in MCI and Alzheimer's disease dementia phenotypes.

Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH.Alzheimers Dement (Amst). 2016 Jun 22;3:91-7. doi: 10.1016/j.dadm.2016.05.004. eCollection 2016.PMID: 27453930 

Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells.

Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y.Stem Cell Reports. 2013 Aug 29;1(3):226-34. doi: 10.1016/j.stemcr.2013.08.001. eCollection 2013.PMID: 24319659 

Regulation of AMPA receptor trafficking by delta-catenin.

Ochiishi T, Futai K, Okamoto K, Kameyama K, Kosik KS.Mol Cell Neurosci. 2008 Dec;39(4):499-507. doi: 10.1016/j.mcn.2008.06.002. Epub 2008 Jun 17.PMID: 18602475

Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.<