Jianing Fu

Gender

Female

Dr. Jianing Fu is an Assistant Professor in the Department of Medicine and a principal investigator at the Columbia Center for Translational Immunology (CCTI). Dr. Fu obtained her BS degree in Pharmaceutical Sciences and MS degree in Chemical Biology from Peking University (China) and received her PhD in Cancer Biology and Immunology from University of South Florida and H. Lee Moffitt Cancer Center. She did a Curricular Practical Training at Medical University of South Carolina to complete her doctoral education. Dr. Fu joined Columbia University in May 2015 to start her postdoctoral training and later took the lead on several projects related to human organ transplantation under the roles of Associate Research Scientist and Instructor.

At Columbia, Dr. Fu’s laboratory is conducting translational research on decoding the graft-versus-host (GvH) and host-versus-graft (HvG) alloreactivity after human intestinal transplantation and lung transplantation. Her research also extends in investigating the phenotype and function of gut and lung hematopoietic stem cells and progenitors, with the ultimate goal of eliminating graft rejection by inducing long persistent blood mixed chimerism. Dr. Fu has established long term multidisciplinary collaboration with transplant surgeons, adult and pediatric physicians, pathologists, bioinformatic scientists and translational immunologists to perform cutting edge human transplantation studies.

Credentials & Experience

Education & Training

BS, 2008 Pharmaceutical Sciences, Peking University

MS, 2010 Chemical Biology, Peking University

Graduate Certificate, 2013 Clinical Investigation, University of South Florida

PhD, 2015 Cancer Biology (and Immunology), University of South Florida

Honors & Awards

2020/2021/2022 Nelson Family Transplant Innovation Awards, CUMC

2022 Community of Transplant Scientists (COTS) registration bursary

2020 The Federation of Clinical Immunology Societies (FOCIS) Travel Award

2020 FCE (FOCIS Center of Excellence) Travel Award

2020 Top scored abstract, The Transplantation Society (TTS)

2019 Discovery Award, Department of Defense

2019 Transplant Forum Scholar Award, CUMC

2019 Medicine Grand Rounds, Fellow Research Presentation Award, CUMC

2018 Outstanding Oral Presentation Award, CCTI Research Day

2017/2018 International Transplantation Science Mentee-Mentor Awards, TTS

2017 Best Abstract, The Intestinal Rehabilitation & Transplant Association (IRTA)

2016 Young Investigator Scientific Award, TTS

2015 Outstanding Thesis & Dissertation Award, University of South Florida (USF)

2012/2014 Abstract Achievement Awards, American Society of Hematology

2012/2013 Cancer Biology Travel Awards, USF

2012 Cancer Biology Student Organization Community Service Award, USF

2008 Excellent Volunteer in Beijing Olympic Games (Anti-doping Agency)

2006/2007/2008 Scholarships for Excellent Medical Students, Peking University

Research

Dr. Jianing Fu is an Assistant Professor in the Department of Medicine and a principal investigator at the Columbia Center for Translational Immunology (CCTI). Dr. Fu obtained her BS degree in Pharmaceutical Sciences and MS degree in Chemical Biology from Peking University (China) and received her PhD in Cancer Biology and Immunology from University of South Florida and H. Lee Moffitt Cancer Center. She did a Curricular Practical Training at Medical University of South Carolina to complete her doctoral education. Dr. Fu joined Columbia University in May 2015 to start her postdoctoral training and later took the lead on several projects related to human organ transplantation under the roles of Associate Research Scientist and Instructor.

At Columbia, Dr. Fu’s laboratory is conducting translational research on decoding the graft-versus-host (GvH) and host-versus-graft (HvG) alloreactivity after human intestinal transplantation and lung transplantation. Her research also extends in investigating the phenotype and function of gut and lung hematopoietic stem cells and progenitors, with the ultimate goal of eliminating graft rejection by inducing long persistent blood mixed chimerism. Dr. Fu has established long term multidisciplinary collaboration with transplant surgeons, adult and pediatric physicians, pathologists, bioinformatic scientists and translational immunologists to perform cutting edge human transplantation studies.

Grants

2022-2023 Nelson Faculty Development Award, CUMC. PI: Fu. Total: $100,000.
Functional profile, migration pattern and microenvironment of human hematopoietic stem and progenitor cells residing in ectopic organ sites under physiological and inflammatory conditions

2021-2023 R21, NIH/NIAID, AI166069. PI: Fu. Total: $445,500.
Immune profiling of gamma delta T cells after human intestinal transplantation.

2021-2022 Nelson Faculty Development Award, CUMC. PI: Fu. Total: $50,000.
Chimerism and immune repertoire of gamma delta T cells after human lung transplantation.

2020-2022 Discovery Award, DoD, W81XWH-20-1-0159. PI: Fu. Total: $324,000.
Single Cell Immune Profiling of Alloreactive T cells Locally and Systemically in Patients Receiving Intestinal Transplantation.

2020-2021 Nelson Faculty Development Award, CUMC. PI: Fu. Total: $100,000.
Phenotypic and clonal tracking of human gamma delta T cells after human intestinal transplantation.

Selected Publications

Wu Y, Zuber J and Fu J*. Editorial: Immunogenomics of Solid Organ and Hematopoietic Stem Cell Transplantation. Frontiers in Immunology. 2022, 13:878314. (*Corresponding author)      

Fu J, Sykes M. Emerging Concepts of Tissue-Resident Memory T cells in Transplantation. Transplantation. 2022 Jun 1;106(6):1132-1142.

Obradovic A, Shen Y, Sykes M, Fu J*. Integrated Analysis Toolset for Defining and Tracking Alloreactive T-cell Clones After Human Solid Organ and Hematopoietic Stem Cell Transplantation. Software Impacts. 2021 (10)100142 (*Corresponding author)

Fu J#, Khosravi-Maharlooei M, Sykes M. High throughput human T cell receptor sequencing: a new window into repertoire establishment and alloreactivity. Frontiers in Immunology.2021, 12:777756. #Co-first author.

Fu J, Zuber J, Shonts B, Obradovic A, Wang Z, Frangaj K, Meng W, Rosenfeld A, Waffarn E, Liou P, Lau S-p, Savage T, Yang S, Rogers K, Danzl Nichole, Ravella S, Satwani P, Iuga A, Ho S-h, Griesemer A, Shen Y, Luning-Prak E, Martinez M, Kato T, Sykes M. Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation. Journal of Clinical Investigation.2021 Apr 15;131(8):e141698.

Fu J, Zuber J, Martinez M, Shonts B, Obradovic A, Wang H, Lau S-p, Xia A, Waffarn E, Frangaj K, Savage T, Simpson T, Yang S, Guo X, Miron M, Senda T, Rogers K, Rahman A, Ho S-h, Shen Y, Griesemer A, Farber D, Kato T, Sykes M. Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that are Maintained by a Circulating Pool. Cell Stem Cell. 2019 Feb 7;24(2):227-239.e8. (Commentary: “We Could Use More Tolerance: Role of Intestinal-Allograft- Derived Human Stem Cells”.)

Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, and Yu X-Z. T-bet promotes acute graft-versus-host disease by regulating recipient hematopoietic cells in mice. J Immunol. 2016 Apr 1; 196 (7): 3168-3179. Cover Article.

Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K, Bastian D, McDonald D, Anasetti C, and Yu X-Z. T-bet is critical for the development of acute graft-versus-host disease through controlling T-cell differentiation and function. J Immunol. 2015 Jan 1;194(1):388-97.

Fu J, Heinrichs J, Yu X. Helper T-cell Differentiation in Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. Arch Immunol Ther Exp. 2014 Aug; 62(4): 277-301.