Kiarash Saleki

 

Kiarash Saleki,

MD-MSc-HMBA student

Research Center for Immunodeficiencies (RCID) | Tehran University of Medical Sciences

BioDiscovery Institute | University of Nottingham, UK

 

Background  

Affiliation:Shahid Beheshti University of Medical Sciences, Tehran, Iran; Babol University of Medical Sciences, Babol, Iran.

_{Semester: Medical Extern (5th Year Medical Student, and 1st Year Master’s Student)}

Research Profiles  

H-index: 14/ Citations: 761

Google Scholar: https://scholar.google.com/citations?hl=en&user=-n4yL8kAAAAJ ORCID: https://orcid.org/0000-0003-4159-7299

Scopus: https://www.scopus.com/authid/detail.uri?authorId=57217035040

Education  

• Doctor of Medicine (MD.), Babol University of Medical Sciences, Babol, Mazandaran, Iran | 2017-2024 (Expected)  

Master of Science (MSc.) of E-Learning in Medical Sciences, School of Management and Medical Education, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

• Shahid Beheshti High School, National Organization for Development of Exceptional Talents (NODET), Babol, Mazandaran, Iran | Sep 2013 B Jun 2017 (Diploma of Natural/Experimental Science)  

• Shahid Beheshti Middle-School, National Organization for Development of Exceptional Talents  (NODET), Babol, Mazandaran, Iran | Sep 2010 B Jun 2013  

Schools and Undergraduate programs

• Participated and Lecture Presentation at Global Health School, Akkon University/Institute for

Research in International Assistance (IRIA), Berlin, Germany | August 2022

• NeuroTRACT International Summer School, Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran | 2019

_{Birthdate: 1}^th December 1999  

Gender: Male  

Nationality: Iranian  

Email Address: [email protected], [email protected]  

Phone: (+98) 936 174 5755  

Research Interests  

• Interdisciplinary Sciences and Translational research

• Public health

• Molecular Neuroimmunology  

• Translational Neuroscience and Immunoinformatics  

• In'silico'Protein Engineering for Neuropsychiatric conditions  

• Interdisciplinary research involving Molecular Immunology and Bioinformatics  

Publications 

1. The involvement of the central nervous system in patients with COVID-19

K Saleki, M  Banazadeh, A Saghazadeh, N Rezaei*

Reviews in the Neurosciences  (2020);  Impact factor: 4.35

2. Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and  meta-analysis of clinical studies K Saleki, S Yaribash, M Banazadeh, E Hajihosseinlou, M  Gouravani, A Saghazadeh, N Rezaei* European Journal of Pharmacology906, 174248 (2021)  Impact factor: 5.2

3. Applying high throughput and comprehensive immunoinformatics approaches to design a  trivalent subunit vaccine for induction of immune response against emerging human  coronaviruses SARSBCoV, MERSBCoV, and SARSBCoV-2.

A Rahmani*, M Baee*, K Saleki*, S  Moradi, HR Nouri  

Journal of Biomolecular Structure and Dynamics, 1-17; (2021) Impact factor: 5.24    

*Co-first author

 

4. Vaccine-induced immune thrombotic thrombocytopenia after vaccination against Covid-19: A  clinical dilemma for clinicians and patients Z Mohseni Afshar, A Babazadeh, A Janbakhsh, M  Afsharian, K Saleki, M Barary, S Ebrahimpour Reviews in medical virology 32 (2), e2273 (2022)  Impact factor: 6.99  

5. Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled  degeneration of the central nervous and vascular systems in stroke A Rahmani*, K Saleki*, N  Javanmehr*, J Khodaparast*, P Saadat, HR Nouri Ageing Research Reviews, 101106 (2020)  Impact factor: 10.89  

^*Co-first author

 

6. Addiction and the cerebellum with a focus on actions of opioid receptors

H Ranjbar*, M  Soti*, M Banazadeh*, K Saleki*, KA Kohlmeier, M Shabani

Neuroscience & Biobehavioral Reviews 131, 229-247 (2021) Impact factor: 8.99  

^*Co-first author

7. Early environmental enrichment prevents cognitive impairments and developing addictive  behaviours in a mouse model of prenatal psychological and physical stress

M Razavinasab, S  Parsania, M Nikootalab, M Khaleghi, K Saleki, Mohammad Banazadeh, Mohammad Shabani  International Journal of Developmental Neurosciences Impact factor: 2.61  

8. Indomethacin attenuates neuroinflammation and memory impairment in an STZ-induced  model of Alzheimer’s like disease

A Karkhah, M Saadi, F Pourabdolhossein, K Saleki, HR  Nouri Immunopharmacology and Immunotoxicology 43 (6), 758-766 Impact factor: 2.7  

9. Contribution of inflammasome complex in inflammatory-related eye disorders and its  implications for antiB inflammasome therapy SA Rasoulinejad, A Karkhah, A Paniri, K Saleki, M  Pirzadeh, HR Nouri Immunopharmacology and Immunotoxicology 42 (5), 400B407 Impact  factor: 2.7  

10. Triangle of cytokine storm, central nervous system involvement, and viral infection in  COVID-19: The role of sFasL and neuropilin-1  

Reviews in the Neurosciences 33 (2), 147B160 (2022) Impact factor: 4.35 K Saleki, M Banazadeh,  NS Miri, A Azadmehr Cite by 1  

11. Pathophysiological roles of chronic lowBgrade inflammation mediators in polycystic ovary

syndrome  

Journal of Cellular Physiology (2020); Impact factor: 6.38 Cited by 39  

12. Engineering a novel immunogenic chimera protein utilizing bacterial infections associated  with atherosclerosis to induce a deviation in adaptive immune responses via  Immunoinformatics approaches (Accepted, In production); I

nfection, Genetics, and Evolution (2022). Impact factor: 4.39

K Saleki*, P Alijanizade1,2*, S Moradi, A Rahmani, M Banazadeh, MH Mohamadi, F Shahabi,  and HR Nouri  

13. Ageing Testosterone and Neuroplasticity: Friend or Foe?  

Reviews in the Neurosciences (2022) Impact factor: 4.70 Q1  

K Saleki, M Banazadeh, A Saghzadeh, and N Rezaei  

14. In silico design of a TLR4-mediating multiepitope chimeric vaccine against amyotrophic  lateral sclerosis via advanced Immunoinformatics  

Journal of Leukocyte Biology (2022) Impact factor: 6.01 Q1  

K Saleki, MH Mohamadi, M Banazadeh, P Alijanizadeh, N Javanmehr, R Pourahmad, HR Nouri

15. Determination of plasma Transcobalamin-II and Zinc Levels in Newly–Diagnosed and Long– Standing Grand mal Epileptic Patients  

Caspian Journal of Internal Medicine (2023) In-production  

A Aman-Mohammady, P Saadat, D Qujeq B, K Hajian-Tilaki, K Saleki

16. Serum soluble Fas ligand is a severity and mortality prognostic marker for COVID-19 patients

Frontiers in Immunology (2022) Impact factor: 8.78 Q1

K Saleki, M Shirzad, M Javanian, S Mohammadkhani, MH Alijani, NS Miri, M Oladnabi, A  Azadmehr

 

17. Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases

N Javanmehr*, K Saleki*, P Alijanizadeh, and N Rezaei

Journal of Neuroinflammation (2022) Impact factor: 9.58 Q1

^*Co-first author

 

18. Utilizing Immunoinformatics to Target Brain Tumors; An Aid to Current Neurosurgical Practice

Interventional Pain Medicine and Neuromodulation (2022)

K Saleki, P Payandeh, M Shakeri, R Pourahmad, M Banazadeh, P Alijanizadeh, MH Mohamadi, and M Akhlaghdoust*

19. Cell-derived Microparticles in the Central Nervous System: Complicated Pattern Quantifiers of Neuroimmunology, Disease, and Recovery

Ageing Research Reviews (2022, Accepted), Impact factor 11.78 Top 5%, best ageing journal in the world (Q1)

K Saleki, M. Banazadeh, S. Momtazmanesh, A. Saghazadeh, S. Najdaghi, and N Rezaei*

Book Chapters

1. Integrated Science 2050: Multidisciplinarity and Interdisciplinarity in Health Multidisciplinarity and Interdisciplinarity in Health, Springer, 2022

N Rezaei et al.  

https://link.springer.com/chapter/10.1007/978B3B030B96814B4_30

 

2. Integrated, Multidisciplinary, and Interdisciplinary Medical Education Multidisciplinarity and Interdisciplinarity in Health, Springer, 2022

N Samieefar et al.

https://link.springer.com/chapter/10.1007/978B3B030B96814B4_27

3. Vaccination against COVID-19: New Technologies and approaches

Translation (Chief; N Rezaei)

https://teimourzadehmarket.com/?p=19901

4. Calcium and Parkinson’s Disease, Book: Nutrition and Neurological Disorders - Vitamins  and Minerals in Neurological Disorders  

Edited by C. Martin, V.B. Patel, and V. Preedy (Accepted, In-production), Elsevier 2022 K Saleki and P Saadat*  

5. Infection and Immunity

Clinical Immunology Edited by N Rezaei 2022, Elsevier

K Saleki, Sepideh Razi, and Nima Rezaei*  

https://www.elsevier.com/books/clinicalBimmunology/rezaei/978B0B12B818006B8

6. Astrocytic abnormalities in Schizophrenia  

Astrocytes in Brain Communication and Disease, 2022

K Saleki, M Banazadeh, B Abadi, Z Pirmoradi, Z Esmaili, S Amiri, R Pourahmad, KA Kohlmeier,  and M Shabani*  

 

7. Aptamer-functionalized silicon nanoparticles for targeted cancer therapy

M Banazadeh, M Mohajeri, K Saleki, B Behnam, Y Teng, P Kesharwani and AH Sahebkar

 

8. Role of Inflammasomes in Epilepsy, Translational Neuroimmunology,

Elsevier 2022

K Saleki, MH Mohammadi, P Alijanizadeh, and N. Rezaei*

 

9. Role of T-cell exhaustion in cancers

Handbook of cancer and immunology, Springer

K Saleki and Nima Rezaei*

 

10. Targeting Toll-like receptors in cancer immunotherapy

Handbook of cancer and immunology, Springer

K Saleki and Nima Rezaei*

 

11. Pediatric eye infections

K Saleki et al., 2023, Edited: Nima Rezaei

 

12. Common protozoan infections in pediatrics

Mohamamd Amin Khazeei Tabari, P Darzi1,2, K Saleki, Narges shaterian, and Nima Rezaei*, Edited: Nima Rezaei 2023

Skills

Statistical Skills  

• Systematic Review and MetaBanalysis (Published firstBauthor metaBanalysis in Q1 journal)   

• Familiar with biostatistics and common software packages 4  

• GraphPad Prism  

• Comprehensive MetaBanalysis (CMA)  

• RevMan  

• Stata  

• SPSS  

Lab skills

• Hands-on experience with PCR  

• Hands-on experience with Western Blotting  

• Hands-on experience with Flow Cytometry  

• Hands-on experience with ELISA  

• Cell culture (I have worked with Neural Stem Cells)  

• Statistical Methodology  

Bioinformatics and Programming Skills  

• Advanced Molecular Dynamics Simulation  

• BioEdit Software  

• UCSF MODELLER software | Protein Modelling  

• UCSF Chimera Software  

• GROningen MAchine for Chemical Simulations (GROMACS) | Molecular Dynamics Simulation  • SPSS | Advanced Statistics  

• C++/Python Programming  

Examinations

_{• Top 0.09% national 576}^th _{country rank (251}^st ₂^nd region) in annual national entrance exam  (Natural Sciences Konkour) out of 640,000 participants | Iranian Evaluation Organization  http://www.kanoon.ir/Public/StudentProfile/943441384  

• GPA for all 12 years of basic education: 20.00, (2005B2017)  

• Diploma GPA: 20.00  

• MD. GPA (2017-Ongoing): 17.5

Honors and Awards

 nternational Razi Award Winner, Best Undergraduate Student of Iran, 2023

Winner of National Elite Foundation, Distinguished Student Scholarship (Jayeze tahsili daneshamukhte bartar Vezvai), 2022

Best Student of the Year 2022 at 1^st National Students’ Research and Technology Festival, Vice-Chancellery for Research and Technology, Ministry of Health, Iran.

 

• Best Researcher/Publication of the Year Award, Vice-Chancellor for Research and Technology, Babol University of Medical Sciences, Research Week 2022.  

 

• Executive director of USERN MUBabol Office, Selected as the Best USERN Office of 2022.

• Executive director of USERN MUBabol Office, Selected as Top-3 International Universal Scientific Education and Research Network (USERN) Offices among 50 offices, 2021

• 4-time National Gold Medalist in Mobtakeran National Mathematical Olympiad for Adolescents (2010-2013)  

https://www.mobtakeran.com/Default.aspx?tabid=1675&PageID=2952&articleType=ArticleView&articleId=67

 

• Participated in 5^th and 6^th Research-Based Teams Projects (Ahmad Roshan), National Elite Foundation, Iran.

• Member of National Organization of Development of Exceptional Talents (NODET), Iran 2022- present  

• Distinguished Researcher, Iran Ministry of Health, Tehran, Iran. (2022)

Research Grants  

1. Received Grant from National Elite Foundation Research Project  

“Exploring the role of Fas, FasL, CCL2, and MMPs in Neuroinflammatory Pathways in COVID-19”.

2. Received grant from National Elite Foundation 2022;  

Production and evaluation of acellular amniotic membrane enhanced with glutaraldehyde and Ethidium Bromide (EDC)

3. Bioinformatical design of a threeBpotency multiBepitope chimeric vaccine against SARSBCoV,  MERSBCoV, and SARSBCoVB2  

http://pajouhan.mubabol.ac.ir/webdocument/load.action?webdocument_code=1000&master Code=11006130

4. The effects of crocin and crocinBloaded in a nanoBparticle on proliferation, migration, and  differentiation of human brain neural stem cells in LPSBinduced inflammation condition  http://research.mums.ac.ir/webdocument/load.action?webdocument_code=1000&masterCod e=8023259

5. Cerebellum and Opioid Receptors  

http://research.kmu.ac.ir/webdocument/load.action?webdocument_code=8000&masterCode= 81007265

6. The role of exosomes, stem cells, and miRNAs in stroke: A narrative review

7. Evaluating inflammasome complex genes expression in patients referred to Rouhani  Hospital

8. Evaluating TLR2 expression in COVID-19 patients referred to Rouhani Hospital 9. Evaluating Furin expression in COVID-19 patients referred to Rouhani Hospital

10. Evaluating CD147 and TGFBβ in patients with COVID-19 referred to Rouhani Hospital

 

11. microRNAs, Inflammasomes, and Epilepsy

Center: Research Center for Immundeficiences, Tehran University of Medical Sciences, Tehran, Iran.

 

12. M1/M2 macrophage polarization in Huntington’s disease

 

13. Na levels in pediatric bronchiolitis; A clinical study

 

14. TLR4/T-cell exhaustion in Neuropsychiatric SLE

Attended Congresses  

• Novel Concepts in Immunity 2021, Tübingen University, Tübingen, Germany.  

• ₆^th International Universal Scientific Education and Research Network (USERN) Congress,  Istanbul, Turkey  2021.  

• ₅^th International Universal Scientific Education and Research Network (USERN) Congress,  Tehran, Iran 2020.  

• ₁^st International Conference on System Biology, Bioinformatics, and Drug Design, Tehran,  Iran 2019.  

• ₂₀^th Razi and ₁^st Motahari’s National Congress on Medical Education, Tehran, Iran 2018.  

• ₄^th International Neuroinflammation congress, Mashhad University of Medical Sciences,  Mashhad, Iran  2020.  

• 1^st international conference on system biology, bioinformatics & drug design (ICSBD), Tehran,  Iran 2019.  

• 23^rd Medical Students Annual National Research Congress and 9th Medical Students International Research Congress, Ardabil, Iran.

• 7^th Universal Scientific Education and Research Network Congress, Muscat, Oman.

• 11^th Basic and Clinical neurosciences Congress, Tehran, Iran.


• Inflammation Congress on COVID-19, Children’s Medical Center, Tehran, Iran.


• 4^th national students’ congress of Hormozgan University of Medical Sciences, Hormozgan, Iran.

 

Congress Papers  

1. Presented a poster entitled "Design of a TLR4 mediating vaccine against amyotrophic lateral sclerosis by Immunoinformatics approaches", Novel Concepts in Innate Immunity 2021,  Tübingen university, Tübingen, DE.  

2. Presented a poster entitled “Computational design and validation of a new chimeric vaccine  _{for multiple sclerosis through targeting myelin and EpsteinBBarr virus”, 4}^th Neuroinflammation  Congress, Mashhad University of Medical Sciences, Mashhad, Iran 2021.  

3. Presented a poster entitled “Computational design of a novel chimeric multiBepitope vaccine  _{against Alzheimer Disease using immunoinformatics approaches”, 4}^th Neuroinflammation  Congress, Mashhad University of Medical Sciences, Mashhad, Iran 2021.  

4. Presented an oral presentation entitled "Interferon therapy in patients with SARS, MERS, and  COVID-19; A systematic review and metaBanalysis of the clinical literature", USERN congress  2021, Istanbul, Turkey  

5. CrossBmatch word puzzle of protein Biochemistry for improving learning process for Medical

_{Students | Presented Poster 1}^st Motahari’s Festival for Novel Ideas  

6. Presented oral presentation entitled "Engineering a Novel Immunogenic Chimeric Vaccine to  Deviate Specific Immune System Responses in Atherosclerosis via Robust Immunoinformatics  Approaches" in USERN 2020 Congress, Tehran, Iran.

7. Pathophysiological syndrome ovary polycystic in Mediators Rostamtabar; International  congress of Immunology and Allergy 2021, Ahvaz, Iran.

8. Development of a Novel Chimeric Multi-Epitope Vaccine via Cancer-Testis antigen against  colorectal cancer using Immunoinformatics and reverse vaccinology approaches; International  congress of Immunology and Allergy 2021, Ahvaz, Iran.  

9. The involvement of the central nervous system in patients with COVID-19, 10th Basic and  Clinical Neuroscience Conference, 2021, Tehran, Iran.  

10. Cerebellum and addiction with an emphasis on functions of opioid receptors, 10th Basic and  Clinical Neuroscience Conference, 2021, Tehran, Iran.

11. Presented lecture Developing a uniform research framework to improve the homogeneity of evidence  synthesized by systematic review and metaBanalysis (International School Lecture) Akkon University USERN Public Health School, Berlin, Germany 2022

12. Design of a novel chimeric multi-epitope vaccine against Alzheimer’s Disease using immunoinformatics approaches

23^rd Medical Students Annual National Research Congress and 9th Medical Studnets International Research Congress, Ardabil, Iran.

13. Presented poster “The Influence of Parkinson’s Disease on Severity and Death by COVID-19: A Systematic Review and Meta-Analysis of Clinical Research”

23^rd Medical Students Annual National Research Congress and 9th Medical Studnets International Research Congress, Ardabil, Iran.

14. Presented oral presentation The role of Toll-like receptors in neuropsychiatric disorders; Beyond expectations

7^th Universal Scientific Education and Research Network Congress, Muscat, Oman 2022

15. Accepted Abstract “Immunoinformatics analysis of Fas/MMP-FasL interactions to evaluate molecular basis of cytokine storm activation in COVID-19 patients”, Artificial Intelligence in Medical Sciences, Kish, Iran.

16. Accepted Abstract “Immunoinformatics vaccine design against neurological disorders; Machine learning-based reverse vaccinology approaches”, Artificial Intelligence in Medical Sciences, Kish, Iran.

 

Countries Visited  

• Germany  

• Netherlands  

• Italy  

• France  

• Belgium  

• Turkey  

• Austria  

• Netherlands  

• United Arab Emirates (UAE)  

• •  Iran

• Oman

Affiliations

• School of Management and Medical Education, Shahid Beheshti University of Medical Sciences, Tehran, Iran (2022 – present).

• Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education  and Research Network (USERN), Tehran, Iran (2020- present).  

• Executive director, USERN MUBabol Office, Babol University of Medical Sciences, Babol, Iran  (2020-present)  

•School of Medicine, Babol University of Medical Sciences, Babol, Iran (2017- present).  

• National Elite Foundation, Mazandaran province, Mazandaran, Iran (grant for research-based  projects). (2021-present)

Editorial Roles

• Topic co-ordinator for Frontiers in Immunology (Q1, IF=8.78) and Frontiers in Neurology (IF=4.09) “Neuroimmune cell signaling in COVID-19”

https://www.frontiersin.org/researchBtopics/43983/neuroimmune cell signaling in covid-19

• Editorial Board for Addiction & Health Journal (PubMed)


• Editor at Frontiers in Public Health (IF=6.4)


• Editor at Frontiers in Medicine (IF=5.1)


• Frontiers in Public Health, Review Editor

 

Journal Peer-reviewer  

•           Addiction and Health Journal (PubMed)  

• PeerJ journal (ISI, Q1)  


• Canon Journal of Medicine


• BMC Infectious disease


• Frontiers in Public Health


• Frontiers in Neurology

 

Workshops  

All workshop certificates: https://uupload.ir/view/awards_and_certies_5eql.pdf/

• Systematic Review Workshop by Dr. A. Saghazadeh | Universal Scientific Education and  Research Network (USERN), Tehran, Iran 2020  

• MetaBAnalysis Workshop by Dr. A. Saghazadeh | Universal Scientific Education and Research  Network (USERN), Tehran, Iran 2020  

• Systematic Review and MetaBAnalysis Dr. A. Keshtkar 2020  

• USERN Lab technique workshop series (Flow cytometry, PCR, Cell culture, Western blotting,  NGS) 2022  

• USERN Lab Technique Internship program 2022 (9Bmonth of hands on experience with lab  techniques)

• GROMACS Molecular Dynamics by Dr. SS. Arab, Tarbiat Modarres University, Codecool  Bioinformatics Institute, Iran 2020  

• Publishing Book wish international publisher (Virtual) Prof. N. Rezaei 2020  • Microarray analysis Bioinformatics Workshop by ViraNovin Group  

• Scientific Writing by Prof. N. Rezaei | Universal Scientific Education and Research Network  (USERN),  Tehran, Iran 2020

• 2-week Proposal Writing and Presentation | Mashhad University of Medical Sciences (MUMS)  2019  

• EndNote Workshop | Student Research Committee, Babol University of Medical Sciences,  Babol, Iran  

• Basic Statistics by Dr. M. Mayeli | Students’ Scientific Research Center (SSRC), Tehran, Iran  2019  

• Scientific Writing by Dr. M. Mayeli | Students’ Scientific Research Center (SSRC), Tehran, Iran  2019  

• Real-Time PCR by Dr. M. Khoshmirsafa | Iran Core Laboratory, Iran University of Medical  Sciences, Tehran, Iran 2019

• Western-blotting by Dr. R. Falak | Iran Core Laboratory, Iran University of Medical Sciences,  Tehran, Iran 2019

• BLAST and Primer Design by Dr. M. Barati | Iran Core Laboratory, Iran University of Medical  Sciences, Tehran, Iran 2019  

• Systematic Review and Meta Analysis by Dr. Abbas Keshtar, 23^rd Medical Students Annual National Research Congress and 9th Medical Students International Research Congress, Ardabil, Iran 2022

Workshop Instructor

• Bioinformatics one-week workshop, USERN MUBabol Office, Babol University of Medical Sciences, Babol, Iran.


• National Systematic Review and Meta-Analysis School, Babol University of Medical Sciences, Babol, Iran.  


• Bioinformatics Study Group Sessions, USERN MUBabol Office, Babol University of Medical Sciences, Babol, Iran., 2020-2021.  


• Advanced Molecular Dynamics Simulation, USERN MUBabol Office, Babol University of Medical Sciences, Babol, Iran.  


• Regional Organizer of USERN Miniature talk 2022, USERN MUBabol Office, Babol University of  Medical Sciences, Babol, Iran.  

Language  

• English: Fluent  

• Persian: Native  

• Arabic: Intermediate    

Hobbies  

• Table tennis  

• Technology enthusiast