Usern_member

Saeid Ghavami

USERN Advisory Board

Curriculum Vitae


Saeid Ghavami , B.Sc, M.Sc, Ph.D


Contact Information:


Dept. of Human Anatomy and Cell Science, University of Manitoba


Winnipeg, MB, R3E 3P4


 


Tel: +1-(204) 612-8956      E-mail: [email protected], [email protected]


                                    


Education


Ph.D in Clinical Biochemistry                                                                                                        1998-2004


Tarbiat Modarres University, School of Medicine, Tehran, Iran.


Thesis title: Apoptotic effect of Calprotectin (S100A8/A9) on colon cancer cells (HT29/219 and SW742).


 


M.Sc in Clinical Biochemistry                                                                                                        1993-1996


Tarbiat Modarres University, School of Medicine, Tehran, Iran.


Thesis title: Role of Alpha-1 antitrypsin in idiopathic neonatal liver disease.


 


B.Sc in chemistry, Shiraz University, School of Sciences, Iran.                                            1984-1989


 


Nationality


Canadian


Iranian


 


Current Position:


University of Manitoba, Canada


 


Tenure Track Assistant Professor: Department of Human Anatomy and Cell Science       Nov 2013-Present


 


Current Position: Shiraz University of Medical Sciences


Honorary Professor: Shiraz University of Medical Sciences, Health Research Policy Centre,                                                                           June 2014-Present


Founder and Co-director of Autophagy Research Center: Iranian Elite Center, Shiraz University of Medical Sciences, Health Research Policy Centre,    January 2016-Present


 


Post Doctoral Training and Research Experience


1) Visiting Scientist/Assistant Professor in Airway Biology                                           Sept 2013-Oct. 2013


Project Title:  Role of Autophagy and ER-stress in Airway Biology


Mentor: Dr. Amir Zeki, Division of Respiratory, Critical Care & Sleep, University of California Davis


Davis, California, USA


 


2) Senior Post Doctoral Fellow in Heart Disease                                                                Dec 2012-Aug. 2013


Project Title:  Role of Autophagy and ER-stress in Cellular Phenotype Conversion


Mentor: Dr. Ian Dixon, Departments of Physiology, University of Manitoba


Winnipeg, Manitoba, Canada


 


3) Visiting Scientist in ER-Stress and Autophagy Cross-talk                                           Nov 2012-Dec. 2012


Mentor: Dr. Afshin Samali, PhD. Departments of Biochemistry, National University of Ireland, Galway, Ireland


 


4) Parker B Francis Fellow in Respiratory Disease,                                                           Jan 2010-Sep. 2012


Project Title:  Role of S100A8/A9 in Airway Remodeling during Asthma


Mentor: Dr. Andrew J Halayko, PhD. Departments of Physiology & Internal Medicine, and Section of Respiratory


Disease, University of Manitoba, Winnipeg, Manitoba, Canada


 


5) Post Doctoral Fellow                                                                                                 July 2007-Jan 2010


Project Title: Application of Cell Death in Airway Remodeling and Asthma Therapy


Mentor: Dr. Andrew J Halayko, PhD. Departments of Physiology & Internal Medicine, and Section of Respiratory


Disease, University of Manitoba, Winnipeg, Manitoba, Canada


 


6) Post Doctoral Fellow                                                                                                  Nov 2004-July 2007


Project Title: Application of Cell Death in New Cancer Therapy


Mentor: Dr. Marek Los, MD/PhD, Manitoba Institute of Cell Biology, CancerCare Manitoba, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada


 


Current Funding



  1. National Institute for Medical Research Development (NIMAD) (55,000 C$): Tittle: Elucidating autophagy pathways as a new therapeutic target for leukemia drug development. Role: Co-applicant            March 2015-March 2018.

  2. Health Science Foundation (70,000 C$): Tittle: Simvastatin and Glioblastoma Chemotherapy. Role: Co-applicant.                                                                                               September 2016-August 2018

  3. MITACS Accelerate (45,000 C$): TMZ and Glioblastoma Chemotherapy. January 2017- January 2018

  4. National Institute for Medical Research Development (NIMAD) (65,000 C$): Tittle: How Mevalonate Cascade inhibition modulates TMZ induced cell death in glioblastoma. Role: Principal Investigator,  October 2016-March 2019.

  5. University Collaborative Research Program (URCP) (25,000 C$): Tittle: Therapeutic effect of Temozolomide in Rhabdomyosarcoma: how autophagy regulated Temozolomide induced Cell Death. Role: Principal Investigator.   March 2017-March 2019.

  6. Children Hospital Research Institute of Manitoba (CHRIM) Operating Grant (40,000): Tittle: Investigating the role of Mcl-1 in Temozolomide-induced cell death in Rhabdomyosarcoma Cells. Role: Principal Investigator. June 2017-June 2018.

  7. Research Manitoba New Investigator Operating Grant (225,000 C$):  Title: Autophagy and Metastasis in Non-Small Lung Cancer: How does Autophagy Modulate Epithelial Mesenchymal Transition., Role: Principle Investigator, , September 2017-August 2020.

  8. National Institute for Medical Research Development (NIMAD) (100,000 C$): Tittle: Asthma and Allergic Asthma. Role: Principal Investigator, September 2017-August 2020.


 


Applied Funding (Pending and Under Review)



  1. Cancer Research Society Operating Grant (February 2018) (120,000 C$): Title: Investigating the role of temozolomide-induced autophagy and cell death in 2D and 3D bioengineered culture platform for treatment of rhabdomyosarcoma, (Under Review), Principal Investigator, September 2017-August 2019.

  2. NSERC Discovery Grant (November 2017) (275,000 C$): Tittle: Mitophagy and Lung Cellular Phenotype, (Under Review), Principal Investigator, September 2018-August 2023.

  3. Thorlakson Operating Grant (March 2018) (30,000 C$): Tittle: Mitophagy and Regualtion of Lung Cancer Metastasis (Under Review), Principal Investigator, September 2018-August 2019.


 


Previous Operating Research Grants



  1. Start up Fund (125,000 C$)                                                                                                 2014-2017

  2. Research Manitoba Graduate Studentship (Mr. Javad Alizadeh)   (17,000 C$), Tittle: Autophagy and EMT in Non-small Cell Lung Cancer.                                                                    Sept 2016-Sept 2017

  3. International Cooperation for Applied Research Development (ICARD) (15,000 C$): Tittle: Targeting Autophagy as a Strategy for Modulation of Leukemic Stem Cell Differentiation/Dediffernatiotion in Acute Myelocytic Leukemia. Role: Co-applicant.                                                             Sept 2015-Sept 2017

  4. Manitoba Medical Foundation Service Operating Grant (April 2015) (21,500 C$), Tittle: Autophagy is a Target for Modulation of Epithelial Mesenchymal Transition in Lung Cancer, Role: Principle Investigator,                                                                                                                     2015-2016.

  5. University of Manitoba Research Grant (June 2015), Title: Autophagy and Tumor Metastasis in Lung Cancer, Role: Principle Investigator, (Funded) (7,500 C$).                            June 2015-January 2016.

  6. MITACS Globalink Program (June 2016), Title: Mevalonate Cascade and Glioblastoma Multifom, Role: Principal Investigator, (Funded, 10,000 C$)). Summer 2016.

  7. MITACS Globalink Program (June 2015), Title: Improving Breast Cancer Therapy Strategies by Inhibiting the Cholesterol Biosynthesis Pathway, Role: Principal Investigator, (Funded, 10,000 C$)). Summer 2015.

  8. Manitoba-Regional Partnership Program with CIHR (Co-Applicant with Dr. Andrew J Halayko), “The S100A8/A9-RAGE Axis in Airway Inflammation, Hyper-Responsiveness, and Remodeling”          (227,824 CAN$)   

  9. Canadian Institute of Health Research (Dr. Andrew J Halayko, Dr. Saeid Ghavami, Dr. John Gordon), “The S100A8/A9-RAGE Axis in Airway Inflammation, Hyper-Responsiveness, and Remodeling” (150,000 CAN$/year)                October 2010-2015

  10. Research Operating Grant “Degradation of alpha 1 antitrypsin by matrix metalloproteinase and its role in Vernalkeratocunjunctivitis” , Zahedan Medical University, Zahedan, Iran, Principle Investigator                                                           2002-2004

  11. Research Operating Grant “Role of Alpha-1Antitrypsinn Phenotypes in Uveitis”, Zahedan Medical University, Zahedan, Iran, Principle Investigator                                                                         1995-1999

  12. Research Grant “Alpha-1 Antitrypsin in Viral Hepatitis B and C”, Zahedan, Medical University, Zahedan, Iran, Principle Investigator                                            1993-2000


 


Fellowships



  1. Parker B Francis Career Development Fellowship in Respiratory Disease, “Role of S100A8/A9 in Airway Remodeling in Asthma” (156,000 US$) (Ranked top ten in North America)                                                                                                                                             2010- 2013                                                                                                                

  2. CIHR/CLA/GSK PDF in Respiratory Disease (90,000 CAN$) (Ranked Number 1 in basic research in Canada)                                                           2008-January 2010

  3. CIHR PDF Award, National Training Program in Allergy and Asthma (12,000 CAN$)                                                                                                                       2007-2009

  4. Manitoba Institute of Child Health PDF Award (70,000 CAN$)                        2007-2009

  5. Manitoba Health Research Council PDF Award (38,750 CAN$)


            (Ranked Number 1 in Manitoba)                                             June 2006- June 2007



  1. Manitoba Health Research Council PDF Award (36,250 CAN$, Declined)


      (Ranked Number 3 in Manitoba)                                                                         2007



  1. CIHR PDF Award (30,000 CAN$, Declined)                                                          2006

  2. Health Science Center, University of Manitoba PDF Award (15,000 CAN$, Declined)                                                                                                            2006

  3. CancerCare Manitoba Foundation PDF Award (30,000 CAN$)     June 2005- June 2006

  4. Postgraduate Scholarship, Iran Ministry of Health and Medical Education      1993- 1995


 


Honors and Travel Awards



  1. I got CIHR/CCS/OICR early career New Investigator Award                                                                                           Nov. 2017

  2. My PDF (Dr. Shojaei) got CIHR/CCS/OICR early career New Investigator Award                                                                                           Nov. 2017

  3. I got the award of “Science and Innovation Center (SIC) Rising Star of Research” from American Thoracic Society RSF Assembly                                                                                            May 2017

  4. Mr. Adel Rezaei Moghadam (my MSc. Student) got Experimental Biology Travel Award (1000 US$)                                                                                                 January 2017

  5. Mr. Adel Rezaei Moghadam (my MSc. Student) got Bronze medal for presentation in Children Hospital Research Day (1000 US$)                                                                                                 October 2016

  6. Mr. Javad Alizadeh (my MSc. Student) got first prize for Human Anatomy and Cell Science Poster Award Presentation (400 C$)                                                                                                

  7. Mr. Javad Alizadeh (my MSc. Student) got Ralph Mann award for excellence of Research      Jan 2016  

  8. Ranked as 5th Biomedical Researcher in 18th International Razi Medical Award                             2013

  9. CTS McDonald Memorial  Travel Award (500 C$)                                                                                2013

  10. Travel Award From American Thoracic Society (ATS) Meeting, (RCMB) (500 US$)                                                                                                                           2011

  11. Manitoba Institute of Child Health travel Award for attending ATS (1,000 C$)          2011

  12. Travel Award, Keystone Symposia “Extra-cellular Matrix Remodeling in Cardiovascular Disease”      (1,200 US$)                                                                     Jan 23-28 2011

  13. Travel Award, Society of the Free Radical Biology and Medicine (1,000 US$)  Nov 2009

  14. First Prize in Manitoba Research Day in Post Doctoral Category (1,500 C$)                                                               June 2009

  15. Manitoba Institute of Child Health travel Award for attending Third Cell Death Meeting and Training Meeting (APOTRAIN), Ulm, Germany (1,500 C$)                               2008

  16. Third Prize in CancerCare Research Day Competition, Manitoba (250 C$)            March 30th 2007


 


Current Supervisory and Co-Supervisory Trainee



  1. BSc. Project Student (Mr. Arya Emami) Supervisor.


                           Project: Statin/TMZ combination in treatment of Rhabdomyosarcoma         May 2017-August 2018



  1. BSc. Project Student (Mr. Amir Vosoughi) Supervisor.


                          Project: Statin/TMZ combination in treatment of Glioblastoma        May 2017-August 2018.



  1. Postdoctoral Research Fellow (Dr. Shahla Shojaei) Co-Supervisor with Dr. Thomas Klonisch .


                           Project: Statin/TMZ combination in treatment of Glioblastoma        Jan 2017-Jan 2018.


      5. Postdoctoral Research Fellow (Dr. Mozaher Ahmadi) Co-Supervisor with Dr. Madrakian .


                        Project: Biosynthesis and Characterization of Statin Nanoparticle to target glioblastoma cells       Aug   2017-Aug 2018.


      6. Postdoctoral Research Fellow (Dr. Hesamaldin Movassagh) Co-Supervisor with Dr. Ji Hyun Ko .


                          Project: Targeting Mitophagy in Non-small cell lung cancer mouse model to modulate metastasis      Nov 2017-Nov 2019.


      7.   BSc. Med. Student (Mr. Daniel Kroft), Co-Supervisor,


           Project: Statin/Metformin Combination new target for Medulloblastoma     June 2017-September 2019


 


Current Academic Advisory Graduate Student


     1.   MSc. Student (Mrs. Sanjana Seyeda),


          Project: Epithelial to Mesenchymal Transition and Lung Disease: a 3 dimensional approach     October 2017-October 2019


     2.   MSc. Student (Mrs. Aida Feiz Barazandeh),


           Project: PEPCK and Leishmania and Importance of Bioenergetics                                      September 2017-September 2019


 


     3.   MSc. Student (Mr. Abdulah Ramadan),


           Project: Vasomotor Changes in the Striatum Associated with Levodopa-Induced Dyskinesia in Parkinsonian Rat Model   May 2017-September 2019


 


     4.   PhD. Student (Mrs. Niketa Sareen),


           Project: Allogeneic Mesenchymal Stem Cell Mediated Cardiac Regeneration     October 2015-September 2020


 


     5.   PhD. Student (Mr. Nagakannan Pandian),


           Project: Role of Thioredoxin system in regulation of cell death mechanisms after oxidative stress October 2015-September 2020


 


     6.   PhD. Student (Mrs. Jessica Jarmaz),


           Project: Epigenetic and FASD                                                                 October 2014-September 2019


 


Previous Supervisory and Co-Supervisory Trainee



  1. MSc student (Mr. Javad Alizadeh) Supervisor.


                     Project: Autophagy and Modulation of Lung Cellular Phenotype in Non-Small Lung Cancer


                     January 2015-August 2017, Current Position: PhD student University of Vermont, USA.


        2. MSc student (Mr. Adel Rezaei Moghadam) Co-Supervisor.


                            Project: Autophagy/Unfolded Protein Response and Rhabdomyosarcoma treatment        


                        January 2016-May 2018, Current Position: Research Assistant, University of Manitoba, Winnipeg, Canada.


        3. MITACs Globalink International Intern Program (Mr. Mohammed Alsultan Albokashy, Supervision,       Project: Role of Mevalonate Cascade in Brain Tumor, June-September 2015, Current Position. Family Physician: Saudi Arabia.


         4. MSc student (Mrs. Niloufar Ashtari) Co-supervisor with Dr. Hassan Marzban.


                      Project: Role MAPK Signaling in Development of Cerebellum in Nax mouse model. September  2014-May 2017, Current Position: Research Assitant, Sickkids Hospital, University of Toronto, Canada.


         5. PhD student (Ms. Parvaneh Mehrbod, UPM University of Malaysia). Co-Supervisor


                      Project: Consideration of Statins in H1N1 Infection, January 2010-2014, Current Position: Faculty                   member, Iran Institute of Pasture.


         6. PhD Student (Dr. Peyman Peymani, Shiraz Medical University). Project Leader


                   Project: Role of Autophagy/Apoptosis/ER-Stress in Viral Hepatitis C  September 2011-September 2015, Current Position, Assistant Professor, Health Policy Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.


          7. Undergraduate summer student (Ms. Anna Serebrin) in the laboratory of Dr. Andrew J. Halayko.


                       Project: Autophagy regulation of TGF-induced Fibrosis in airways. Summer 2009. Current Position: Internal Medicine Specialist.


 


           8.  Summer student (Mr. Hasan Pirzadeh) in the laboratory of Dr Marek Los. Project: Death signaling pathway of S100A8/A9 in neuroblastoma. Summer 2006. Current position: Family Physician, Winnipeg, Manitoba.


 


           9. MD fellow in Ophthalmology (Dr. Mahmoud Kazemi). Project: Role of Alpha 1 antitrypsin phenotypes in Uveitis patients in South East Iran. 1996-1998. Current Position: Passed Away in car accident.


          10. MD fellow in Ophthalmology (Dr. Mahmoud Mobaleghi). Project: Role of Alpha 1 antitrypsin phenotypes in VKC patients in South East Iran. 1997-1999, Current Position: Pro Khorfessor of Ophthalmology, Khorram Abad University, Iran.


 


Laboratory courses, Certifications




  • Cell Death Training Workshop, July 2008, European APOTRAIN program, Marie Curie Research Program, University of Ulm, Ulm, Germany.




  • Presentation Skills workshop, January 2007-March 2007, University of Manitoba, Winnipeg, Canada.




  • Principles of Microscopy and Imaging, November 2006, Innovative Technologies in Multidisciplinary Health Research Training (ITMHRT), Winnipeg, Canada.




  • Teaching Competency, Sept 1993-March 1996, Teaching Competency Program , Tarbiat Modarres University, Tehran, Iran. 


     


    Journal Editor and Reviewer




  • Reviewer of The Prostate                                                                                          September 2010-Present




  • Reviewer of PLOS ONE                                                                                            September 2010-Present




  • Reviewer of Autophagy                                                                                             September 2010-Present




  • Reviewer of Biomedical Pharmacology                                            &



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