Usern_member

David Greenblatt

USERN Advisory Board

Education


BA, Mathematics, Amherst College

MD, Harvard Medical School

Postdoctoral Training, Harvard Medical School


Selected Publications



  1. Ng I, Greenblatt HK, Greenblatt DJ. Stereo-Psychopharmacology: The Case of Citalopram and Escitalopram. Clin Pharmacol Drug Dev. 2016 Sep; 5(5):331-5. PMID: 27452501.

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  3. Greenblatt DJ, Abourjaily PN. Pharmacokinetics and Pharmacodynamics for Medical Students: A Proposed Course Outline. J Clin Pharmacol. 2016 Oct; 56(10):1180-95. PMID: 26987681.

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  4. Elliott KR, Harmatz JS, Zhao Y, Greenblatt DJ. Body Size Changes Among National Collegiate Athletic Association New England Division III Football Players, 1956-2014: Comparison With Age-Matched Population Controls. J Athl Train. 2016 May; 51(5):373-81. PMID: 27159189.

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  5. Greenblatt HK, Greenblatt DJ. Use of Antipsychotics for the Treatment of Behavioral Symptoms of Dementia. J Clin Pharmacol. 2016 Sep; 56(9):1048-57. PMID: 26953213.

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  6. Greenblatt HK, Greenblatt DJ. Meldonium (Mildronate): A Performance-Enhancing Drug? Clin Pharmacol Drug Dev. 2016 May; 5(3):167-9. PMID: 27128409.

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  7. Banankhah PS, Garnick KA, Greenblatt DJ. Ketoconazole-Associated Liver Injury in Drug-Drug Interaction Studies in Healthy Volunteers. J Clin Pharmacol. 2016 Oct; 56(10):1196-202. PMID: 26829173.

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  8. Greenblatt DJ, Abernethy DR. In Memoriam: David A. Flockhart, 1952-2015. J Clin Pharmacol. 2016 Apr; 56(4):509-10. PMID: 26919538.

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  9. Greenblatt DJ, Abernethy DR. In Memoriam: David A. Flockhart, 1952-2015. Clin Pharmacol Drug Dev. 2016 Mar; 5(2):89-90. PMID: 27138021.

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  10. Weiss MD, Macklin EA, Simmons Z, Knox AS, Greenblatt DJ, Atassi N, Graves M, Parziale N, Salameh JS, Quinn C, Brown RH, Distad JB, Trivedi J, Shefner JM, Barohn RJ, Pestronk A, Swenson A, Cudkowicz ME. A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression. Neurology. 2016 Apr 19; 86(16):1474-81. PMID: 26911633.

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  11. Greenblatt DJ. Evidence-based choice of ritonavir as index CYP3A inhibitor in drug-drug interaction studies. J Clin Pharmacol. 2016 Feb; 56(2):152-6. PMID: 26239522.

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  12. Qian Y, Sherbini A, Matin B, Zhao Y, Castellot J, Greenblatt DJ. Inhibition of 2-methoxyestradiol glucuronidation by probenecid. J Pharm Pharmacol. 2015 Nov; 67(11):1585-92. PMID: 26272356.

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  13. Greenblatt DJ. The Pharmacovigilance Syndrome. J Clin Psychopharmacol. 2015 Aug; 35(4):361-3. PMID: 26066340.

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  14. Greenblatt DJ. Clinical pharmacology in drug development - an update. Clin Pharmacol Drug Dev. 2015 Jul; 4(4):243-4. PMID: 27136903.

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  15. Zhao Y, Harmatz JS, Epstein CR, Nakagawa Y, Kurosaki C, Nakamura T, Kadota T, Giesing D, Court MH, Greenblatt DJ. Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen. Br J Clin Pharmacol. 2015 Nov; 80(5):1076-85. PMID: 25808818.

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  16. Greenblatt DJ, Harmatz JS. Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies. Br J Clin Pharmacol. 2015 Sep; 80(3):342-50. PMID: 25923589.

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  17. Greenblatt HK, Greenblatt DJ. Altered drug disposition following bariatric surgery: a research challenge. Clin Pharmacokinet. 2015 Jun; 54(6):573-9. PMID: 25782774.

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  18. Greenblatt DJ, Peter RM. American college of clinical pharmacology commentary on the Strategic Plan 2010-2014 Progress Report from the Office of Dietary Supplements, National Institutes of Health. J Clin Pharmacol. 2015 Jul; 55(7):723-4. PMID: 25882480.

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  19. Harmatz JS, Greenblatt DJ. Regression and Correlation. Clin Pharmacol Drug Dev. 2015 Mar; 4(3):161-2. PMID: 27140795.

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  20. Greenblatt DJ. A soft benzodiazepine. Clin Pharmacol Drug Dev. 2015 Mar; 4(2):81-2. PMID: 27128211.

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  21. Greenblatt DJ. Aspartame - Is there new information? Clin Pharmacol Drug Dev. 2015 Jan; 4(1):1. PMID: 27127997.

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  22. Greenblatt DJ. A tribute to dr. Hermann R. Ochs, 1943-2013. J Clin Psychopharmacol. 2014 Dec; 34(6):669-70. PMID: 25319882.

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  23. Shader RI, Greenblatt DJ. Editors' note: retraction notice. J Clin Psychopharmacol. 2014 Dec; 34(6):671. PMID: 25409237.

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  24. Greenblatt DJ. Volume of distribution - Again. Clin Pharmacol Drug Dev. 2014 Nov; 3(6):419-20. PMID: 27129116.

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  25. Cudkowicz ME, Titus S, Kearney M, Yu H, Sherman A, Schoenfeld D, Hayden D, Shui A, Brooks B, Conwit R, Felsenstein D, Greenblatt DJ, Keroack M, Kissel JT, Miller R, Rosenfeld J, Rothstein JD, Simpson E, Tolkoff-Rubin N, Zinman L, Shefner JM. Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 Nov; 13(11):1083-91. PMID: 25297012; NIHMSID: NIHMS635313 [Available on 11/01/15].

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  26. Greenblatt HK, Greenblatt DJ. Liver injury associated with ketoconazole: Review of the published evidence. J Clin Pharmacol. 2014 Dec; 54(12):1321-9. PMID: 25216238.

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  27. Greenblatt DJ, Harmatz JS, Singh NN, Steinberg F, Roth T, Harris SC, Kapil RP. Pharmacokinetics of zolpidem from sublingual zolpidem tartrate tablets in healthy elderly versus non-elderly subjects. Drugs Aging. 2014 Oct; 31(10):731-6. PMID: 25246162.

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  28. Pomara N, Lee SH, Bruno D, Silber T, Greenblatt DJ, Petkova E, Sidtis JJ. Adverse performance effects of acute lorazepam administration in elderly long-term users: Pharmacokinetic and clinical predictors. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2; 56:129-35. PMID: 25195839; NIHMSID: NIHMS629465 [Available on 01/02/16].

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  29. Greenblatt DJ. Antiretroviral boosting by cobicistat, a structural analog of ritonavir. Clin Pharmacol Drug Dev. 2014 Sep; 3(5):335-7. PMID: 27129004.

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  30. Greenblatt DJ. Drug interactions with methadone: Time to revise the product label. Clin Pharmacol Drug Dev. 2014 Jul; 3(4):249-51. PMID: 27128829.

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  31. Zhao Y, Cudkowicz ME, Shefner JM, Krivickas L, David WS, Vriesendorp F, Pestronk A, Caress JB, Katz J, Simpson E, Rosenfeld J, Pascuzzi R, Glass J, Rezania K, Harmatz JS, Schoenfeld D, Greenblatt DJ. Systemic pharmacokinetics and cerebrospinal fluid uptake of intravenous ceftriaxone in patients with amyotrophic lateral sclerosis. J Clin Pharmacol. 2014 Oct; 54(10):1180-7. PMID: 24771634.

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  32. Court MH, Almutairi FE, Greenblatt DJ, Hazarika S, Sheng H, Klein K, Zanger UM, Bourgea J, Patten CJ, Kwara A. Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6. Antimicrob Agents Chemother. 2014 Jul; 58(7):4145-52. PMID: 24820076; PMCID: PMC4068589 [Available on 01/01/15].

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  33. Greenblatt DJ. Sleep-promoting medications: Weighing the hazards of use versus non-use. Clin Pharmacol Drug Dev. 2014 May; 3(3):167-9. PMID: 27128605.

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  34. Greenblatt DJ. In vitro prediction of clinical drug interactions with CYP3A substrates: we are not there yet. Clin Pharmacol Ther. 2014 Feb; 95(2):133-5. PMID: 24448459.

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  35. Greenblatt DJ. The ketoconazole legacy. Clin Pharmacol Drug Dev. 2014 Jan; 3(1):1-3. PMID: 27128223.

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  36. Epstein LC, Masse G, Harmatz JS, Scott TM, Papas AS, Greenblatt DJ. Characterization of cognitive dysfunction in Sjögren's syndrome patients. Clin Rheumatol. 2014 Apr; 33(4):511-21. PMID: 24337727.

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  37. Greenblatt DJ, Harmatz JS, Singh NN, Steinberg F, Roth T, Moline ML, Harris SC, Kapil RP. Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration. J Clin Pharmacol. 2014 Mar; 54(3):282-90. PMID: 24203450.

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  38. Court MH, Peter I, Hazarika S, Vasiadi M, Greenblatt DJ, Lee WM. Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure. Drug Metab Dispos. 2014 Jan; 42(1):28-32. PMID: 24104197; PMCID: PMC3876784 [Available on 01/01/15].

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  39. Greenblatt DJ. Hepatic Clearance of Drugs in Patients With Renal Insufficiency. Clin Pharmacol Drug Dev. 2013 Oct; 2(4):295-7. PMID: 27121933.

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  40. Greenblatt DJ, Harmatz JS, Singh NN, Roth T, Harris SC, Kapil RP. Influence of food on pharmacokinetics of zolpidem from fast dissolving sublingual zolpidem tartrate tablets. J Clin Pharmacol. 2013 Nov; 53(11):1194-8. PMID: 23939537.

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  41. Berry JD, Shefner JM, Conwit R, Schoenfeld D, Keroack M, Felsenstein D, Krivickas L, David WS, Vriesendorp F, Pestronk A, Caress JB, Katz J, Simpson E, Rosenfeld J, Pascuzzi R, Glass J, Rezania K, Rothstein JD, Greenblatt DJ, Cudkowicz ME. Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis. PLoS One. 2013; 8(4):e61177. PMID: 23613806; PMCID: PMC3629222.

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  42. Greenblatt DJ, Derendorf H. Grapefruit-medication interactions. CMAJ. 2013 Apr 2; 185(6):507. PMID: 23550054; PMCID: PMC3612155.

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  43. Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013 Apr; 75(4):1041-52. PMID: 22943633; PMCID: PMC3612722.

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  44. Greenblatt DJ. The Seventy-Kilogram Fantasy. Clin Pharmacol Drug Dev. 2013 Apr; 2(2):101-2. PMID: 27121664.

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  45. Greenblatt DJ, Harmatz JS, Roth T, Singh NN, Moline ML, Harris SC, Kapil RP. Comparison of pharmacokinetic profiles of zolpidem buffered sublingual tablet and zolpidem oral immediate-release tablet: results from a single-center, single-dose, randomized, open-label crossover study in healthy adults. Clin Ther. 2013 May; 35(5):604-11. PMID: 23541711.

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  46. Yasar U, Greenblatt DJ, Guillemette C, Court MH. Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers. J Pharm Pharmacol. 2013 Jun; 65(6):874-83. PMID: 23647681.

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  47. Greenblatt DJ. Into the Second Year. Clin Pharmacol Drug Dev. 2013 Jan; 2(1):1. PMID: 27121554.

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  48. Court MH, Freytsis M, Wang X, Peter I, Guillemette C, Hazarika S, Duan SX, Greenblatt DJ, Lee WM. The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure. J Pharmacol Exp Ther. 2013 May; 345(2):297-307. PMID: 23408116; PMCID: PMC3629801.

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  49. Lee JY, Luc S, Greenblatt DJ, Kalish R, McAlindon TE. Factors associated with blood hydroxychloroquine level in lupus patients: renal function could be important. Lupus. 2013 Apr; 22(5):541-2. PMID: 23396569.

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  50. Volak LP, Hanley MJ, Masse G, Hazarika S, Harmatz JS, Badmaev V, Majeed M, Greenblatt DJ, Court MH. Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers. Br J Clin Pharmacol. 2013 Feb; 75(2):450-62. PMID: 22725836; PMCID: PMC3579260.

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See more publications on: https://profiles.med.tufts.edu/profiles/display/139275

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