William Gause

Dr. William C. Gause received his bachelor's from the University of Virginia and his Ph.D. at Cornell University (1986). After a postdoctoral fellowship at the National Institutes of Health, Dr. Gause joined the Uniformed Services University of the Health Sciences (USUHS) in Bethesda, MD as a faculty member in the Department of Microbiology and Immunology in 1989. In 2004, Dr. Gause left USUHS and joined the University of Medicine and Dentistry of New Jersey (now Rutgers University) as the Senior Associate Dean for Research, Director of the Center for Immunity and Inflammation, and University Professor of Medicine at New Jersey Medical School. Dr. Gause?s research is internationally recognized and has been continuously funded by the National Institutes of Health since 1991. He has published over 100 papers in the area of infectious disease and inflammation, many in prestigious journals including Nature Medicine, Journal of Experimental Medicine, Nature Reviews Immunology, and Nature Immunology. Dr. Gause has served on numerous NIH study sections, journal editorial boards, given talks and organized and chaired symposia at major national and international scientific meetings, and received a number of awards. His research has recently focused on understanding macrophage function during the type 2 immune response and its role in controlling inflammation and mediating resistance.

Education:

BA, Biology, 1980, University of Virginia, Charlottesville, VA 
PhD, Immunology, 1986, Cornell University, Ithaca, NY
Post Doc, Molecular Immunology, 1986, National Institutes of Health, Bethesda, MD

Positions:

1982-1985 Graduate Research Assistant, Cornell University
1986-1988 Staff Fellow, National Institutes of Health
1988-1989 Sr. Research Fellow, National Institutes of Health
1989-1994 Assist. Professor, Microbiology, Uniformed Services Univ. of the Health Sciences  
1994-1998 Associate Professor, Department of Microbiology, USUHS
1994-2002 Director, Molecular and Cell Biology Program, USUHS
1998-2004 Professor, Department of Microbiology and Immunology, USUHS
2002-2004 Director, University Core Facilities, USUHS
2002-2004 Vice Chair, Department of Microbiology and Immunology, USUHS
2004-07/01/13 Sr. Assoc. Dean for Research, Univ. of Medicine & Dentistry of NJ-NJ Medical School
2004-07/01/13 University Professor, Department of Medicine, UMDNJ – New Jersey Medical School
2006-07/01/13 Director, Center for Immunity and Inflammation, UMDNJ – New Jersey Medical School
07/01/13-present Sr. Assoc. Dean for Research, Rutgers-NJ Medical School
07/01/13-present University Professor, Department of Medicine, Rutgers-NJ Medical School
07/01/13-present Director, Center for Immunity and Inflammation, Rutgers-NJ Medical School

Honors and Scholarships:

1986 Bruchner Research Award for outstanding doctoral research at Cornell
1988 Arthritis Foundation Fellowship
1988 NIAID National Research Service Award Fellowship
1993-1995 Associate Editor, Journal of Immunology
1993-Present Review Committees (Study Section), NIH, NIAID 
1995-1999 Section Editor, Journal of Immunology
1995-Present Adhoc Reviewer, Journal of Clinical Investigation, Immunity, Journal Exp’l Medicine
2004  Outstanding Biomedical Graduate Educator Award (USUHS)

Current Research:

Gause Lab
Metazoan parasites have coevolved with vertebrates over hundreds of millions of years, shaping the activation and function of the immune response including the development of potent immune regulatory pathways and enhanced immune cell-mediated wound healing effects. Understanding the molecular signaling events that trigger this type of immune response can provide insights into new approaches to regulate harmful inflammation and is an important area of Dr. Gause?s research. Research led by Dr. Gause also includes mining the products produced by these parasites for the development of novel therapies to control harmful inflammation and promote tissue repair.

Selected Publications (from over 100 published):

1. Anthony, RM, Urban, J.F., Alem, F., Hamed, H.A., Rozo, C.T., Boucher, J-L, VanRooijen, N., Gause, WC  Memory Th2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nature Medicine 12(8):955-960, 2006  PMC1955764
2. Patel N, Kreider T, Urban JF Jr, Gause WC.  Characterization of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites.  Int J Parasitol. 2009 Jan; 39(1): 13-21. NIHMS87146
3. Liu Z, Liu Q, Bleich D, Salgame P, Gause WC.  Regulation of type 1 diabetes, tuberculosis, and asthma by parasites.  J Mol Med. 2009 Oct 21. [Epub ahead of print]  NIHMSID#182968
4. Liu Q, Sundar K, Mishra PK, Mousavi G, Liu Z, Gaydo A, Alem F, Lagunoff D, Bleich D, Gause WC.  Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms., Infect Immun. 2009 Dec;77(12):5347-58. Epub 2009 Sep 14. PMC2786463 
5. Liu Z, Liu Q, Bleich D, Salgame P, Gause WC.  Regulation of type 1 diabetes, tuberculosis, and asthma by parasites, J Mol Med. 2010 Jan;88(1):27-38.  PMID: 19844667 PMC2863045
6. Liu Q, Kreider T, Bowdridge S, Liu Z, Song Y, Gaydo AG, Urban JF Jr, Gause WC.  B cells have distinct roles in host protection against different nematode parasites J Immunol. 2010 May 1;184(9):5213-23. Epub 2010 Mar 31.PMID: 20357259
7. Bowdridge S, Gause WC.  Regulation of alternative macrophage activation by chromatin remodeling, Nat Immunol. 2010 Oct;11(10):879-81. PMID: 20856215
8. Harris N, Gause WC.  To B or not to B: B cells and the Th2-type immune response to helminths, Trends Immunol. 2010 Dec 13. [Epub ahead of print] PMID: 21159556
9. Maizels RM, Hewitson JP, Gause WC.  Heligmosomoides polygyrus: one species still. Trends Parasitol. 2010 Dec 13. [Epub ahead of print] PMID: 21159557
10. Mishra PK, Wu W, Rozo C, Hallab NJ, Benevenia J, Gause WC.  Micrometer-Sized Titanium Particles Can Induce Potent Th2-Type Responses through TLR4-Independent Pathways. J Immunol. 2011 Nov 16, PMID: 22095717
11. Csóka B, Selmeczy Z, Koscsó B, Németh ZH, Pacher P, Murray PJ, Kepka-Lenhart D, Morris SM Jr, Gause WC, Leibovich SJ, Haskó G.  Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J. 2011 Sep 16, PMID: 21926236
12. Potian JA, Rafi W, Bhatt K, McBride A, Gause WC, Salgame P.  Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway. J Exp Med. 2011 Aug 29;208(9):1863-74, PMID: 21825018
13. Chen F, Liu Z, Wu W, Rozo C, Bowdridge S, Millman A, Van Rooijen N, Urban, JF, Wynn TA, and Gause WC.  An essential role for the Th2-type response in limiting tissue damage during helminth infection, Nat Med. 2012 Jan 15;18(2):260-6. PMID: 22245779  PMCID: PMC3274634
14. Mishra PK, Patel N, Wu W, Bleich D, Gause WC.  Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response. Mucosal Immunol. 2013 Mar;6(2):297-308. doi: 10.1038/mi.2012.71.  Epub 2012 Jul 18, PMID: 22806101
15. Gause WC, Wynn TA, Allen, JE.  Type 2-immunity and wound healing: evolutionary refinement of adaptive immunity by helminthes, 2013, Nat Rev Immunol. 2013 Aug;13(8):607-14. doi: 10.1038/nri3476. Epub 2013 Jul 5.
16. Esser-von BJ, Mosconi I, Guiet R, Piersgilli A, Volpe B, Chen F, Gause WC, Seitz A, Verbeek JS, Harris NL.  Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages.PLoS Pathog. 2013 Nov;9(11):e1003771. doi: 10.1371/journal.ppat.1003771. Epub 2013 Nov 14.
17. Salgame P, Yap GS, Gause WC.  Effect of helminth-induced immunity on infections with microbial pathogens.  Nat Immunol. 2013 Oct 21;14(11):1118-26. doi: 10.1038/ni.2736.
18. Patel N, Wu W, Mishra PK, Chen F, Millman A, Csóka B, Koscso´ B, Eltzschig HK, Haskó G, Gause WC.  A2B Adenosine Receptor Induces Protective Antihelminth Type 2 Immune Responses.  Cell Host & Microbe.  2014 Mar 12;15(3):339-50. doi: 10.1016/j.chom.2014.02.001.
19. Mishra PK, Palma M, Bleich D, Loke P, Gause WC.  Effects of intestinal nematode infection on systemic immune responses.  Mucosal Immunology.  (in press).