Usern_member

Richard Johnson

USERN Advisory Board
Titles



Tomas Berl Professor of Medicine, University of Colorado Denver, Professor of Physiology and Biophysics, and Chief, Division of Renal Diseases and Hypertension , University of Colorado Denver





Medical School:

MD, University of Minnesota Medical School (1979)



Undergraduate School:

BS, University of Wisconsin–Madison (WI) (1975)



Internship:

University of Washington Program (1980)



Residency:

University of Washington Program, Internal Medicine (1982)



Fellowships:

University of Washington Program, Infectious Disease (1986)

University of Washington Program, Nephrology (1986)





Professional Memberships



American Heart Association (AHA), Member

American Society of Clinical Investigation, Member

American Society of Nephrology, Member

American College of Physicians (ACP), Fellow

American Federation of Clinical Research, Member

International Society of Nephrology, Member

Australian & New Zealand Society of Nephrology, Honorary Member

Association of Subspecialty Professors, Member

American Physiological Society, Member

Archaeological Institute of America, Member

National Kidney Foundation, Member

American Diabetes Association, Member

Western Association of Physicians, Member

Polish Society of Nephrology , Honorary Member





Societies and Honors



Phi Beta Kappa (Junior year, 1974 Univ of WI), Alpha Omega Alpha (Junior year, 1978 Univ of MN), Inaugural Priscilla Kincaid-Smith Visiting Professor, 1993; Young Investigator Award, American Society of Nephrology and American Heart Association, Orlando, Florida, 1994; American Society of Clinical Investigation, 1995; British Medical Association Book Competition in Medicine, Highly Commended award for Comprehensive Clinical Nephrology, First edition; Brenner Lecture, American Society of Nephrology meeting, San Diego, 2003; Elected to Thomas Reuters ISIhighlycited.com as one of the 250 most cited researchers in the field of Clinical Medicine for period from 1992 to 2012 (>20,000 citations); Jaime Herrera Lecture, Mexican Society of Nephrology, 2006; Sir Stanley Davidson Lecturer, Royal College of Physicians of Scotland, Edinburgh Oct 2006; Donald Seldin Lecture, AHA annual meeting, Orlando FL Nov 2007; Hugh DeWardener Lecture, British Society, Glasgow May 2008; Best Doctors in America 1996 to 2006 and 2009 to 2012; American Clinical Climatologic Society (Theodore Woodward Lectureship); International Society of Nephrology; Councilor, Executive Committee Member, and Scientific Director of ISN 2011 in Vancouver CA; Editor, Comprehensive Clinical Nephrology (editions 1 through 4);Who’sWho in America (Marquis); Who’s Who in America (Madison); University of Colorado Denver Medical Campus New Inventor of the Year 2011





Editorial Boards



Reviewing Editor, Journal of the American Society of Nephrology 1992-2001, Member of Editorial Board, Journal of the American Society of Nephrology 2001-2002; Consulting Editor, Kidney International 1996-1999; Consulting Editor, Nephrology 1995-1997; Associate Editor, American Journal of Kidney Disease 1996-2001; Member of Editorial Board, American Journal of Physiology, Renal Physiology 2000-2004; Member of Editorial Board, Hypertension, 2003 – 2010; Member of Editorial Board, Kidney International 2004-2006; Member of Editorial Board, American Journal of Nephrology, 2003-present; Advisory Board, “In Translation” Feature for American Journal of Kidney Diseases, 2007-2014; Editorial Board, Nephron Experimental Nephrology, 2007-2010; Internal and Emergency Medicine, Advisory Board (2007-); Editorial Board, Internet Journal of Nephrology (2007-); Editorial Board, Am J Physiol Renal Physiol (2008-); Editorial Board, Nature Clinical Practice Nephrology (2009-)





Research Interests



I have performed both basic, translational and clinical research. Major interests have included the pathogenesis of glomerulonephritis and nephrotic syndrome, and the underlying mechanisms driving diabetic and nondiabetic renal disease. I have also been interested in mechanisms underlying acute renal failure. I have also a longstanding interest in the role of subtle renal injury in causing hypertension, and specifically on the role of the microvasculature and inflammatory cells. Most of my current work is focused on the role of fructose and uric acid in the pathogenesis of acute and chronic renal disease, and also in the pathogenesis of metabolic syndrome and diabetes. I also have some research interests in the epidemics of chronic kidney disease occurring in Nicaragua and Sri Lanka, and also in the renal disease that occurs at high altitude.





Johnson Lab



The work of the Johnson lab focuses on how diet (and in particular, fructose) as well as serum uric acid may have a role in the epidemics of obesity, diabetes, hypertension, and kidney disease. The lab’s work includes studies in cell culture, animal models, epidemiological studies and clinical trials. Recent studies include studies of fructose induced obesity, insulin resistance, leptin resistance, and fatty liver. The lab is also interested in the subcellular, and especially effects on the mitochondria in response to fructose and uric acid. Most recently the lab’s work has focused on how a reduction in ATP generation in response to fructose and uric acid may translate not only into obesity, but also into fatigue and decreased exercise.





Recent experimental studies include the role of ATP depletion from fructose in the proinflammatory response, the mechanisms of urate uptake, regulation of fructokinase, and the mitochondrial effects of uric acid. The Johnson lab is also studying the role of NADPH oxidase in response to fructose and uric acid, mechanisms of endothelial dysfunction, and the development of leptin and insulin resistance.  Clinical studies include trials to lower fructose intake or to pharmacologically reduce uric acid as a means for preventing or treating features of the metabolic syndrome.







Publications:



  • Piani F, Johnson RJ. Does gouty nephropathy exist, and is it more common than we think?. Kidney Int. 2021 Jan;99(1):31-33. PubMed PMID: 33390238
  • Floege J, Johnson RJ. Hyperuricemia and progression of chronic kidney disease: to treat or not to treat?. Kidney Int. 2021 Jan;99(1):14-16. PubMed PMID: 33390225
  • Maier S, Wieland A, Cree-Green M, Nadeau K, Sullivan S, Lanaspa MA, Johnson RJ, Jensen T. Lean NAFLD: an underrecognized and challenging disorder in medicine. Rev Endocr Metab Disord. 2021 Jan 3. [Epub ahead of print] PubMed PMID: 33389543
  • Andres-Hernando A, Jensen TJ, Kuwabara M, Orlicky DJ, Cicerchi C, Li N, Roncal-Jimenez CA, Garcia GE, Ishimoto T, Maclean PS, Bjornstad P, Sanchez-Lozada LG, Kanbay M, Nakagawa T, Johnson RJ, Lanaspa MA. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. JCI Insight. 2021 Jan 11;6(1). PubMed PMID: 33320834
  • Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR. Fructose and hepatic insulin resistance. Crit Rev Clin Lab Sci. 2020 Jan 14;:1-15. [Epub ahead of print] PubMed PMID: 31935149
  • Piani F, Melena I, Tommerdahl KL, Nokoff N, Nelson RG, Pavkov ME, van Raalte DH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P. Sex-related differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications. J Diabetes Complications. 2020 Dec 31;:107841. [Epub ahead of print] PubMed PMID: 33423908
  • García-Arroyo FE, Tapia E, Muñoz-Jiménez I, Gonzaga-Sánchez G, Arellano-Buendía AS, Osorio-Alonso H, Manterola-Romero L, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage. Oxid Med Cell Longev. 2020;2020:8850266. PubMed PMID: 33354281
  • Johnson RJ, Lanaspa MA, Fox JW. Upper Paleolithic Figurines Showing Women with Obesity may Represent Survival Symbols of Climatic Change. Obesity (Silver Spring). 2020 Dec 1. [Epub ahead of print] PubMed PMID: 33258218
  • Ebert T, Painer J, Bergman P, Qureshi AR, Giroud S, Stalder G, Kublickiene K, Göritz F, Vetter S, Bieber C, Fröbert O, Arnemo JM, Zedrosser A, Redtenbacher I, Shiels PG, Johnson RJ, Stenvinkel P. Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears. Sci Rep. 2020 Nov 23;10(1):20323. PubMed PMID: 33230252
  • Li JW, Yin D, Wang Z, Brigham MD, LaMoreaux BD, Kent JD, Francis-Sedlak M, Johnson RJ, Hadker N, Francis KM, Sanchez HA, Miyasato G. New-Onset Gout as an Independent Risk Factor for Returning to Dialysis After Kidney Transplantation. Transplant Direct. 2020 Dec;6(12):e634. PubMed PMID: 33225059
  • Kang DH, Sanchez-Lozada LG, Johnson RJ. Allopurinol and Chronic Kidney Disease. N Engl J Med. 2020 Oct 22;383(17):1687-1688. PubMed PMID: 33085871
  • Johnson RJ, Gomez-Pinilla F, Nagel M, Nakagawa T, Rodriguez-Iturbe B, Sanchez-Lozada LG, Tolan DR, Lanaspa MA. Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer's Disease. Front Aging Neurosci. 2020;12:560865. PubMed PMID: 33024433
  • Khanna P, Johnson RJ, Marder B, LaMoreaux B, Kumar A. Systemic Urate Deposition: An Unrecognized Complication of Gout?. J Clin Med. 2020 Oct 3;9(10). PubMed PMID: 33023045
  • Dally M, Butler-Dawson J, Johnson RJ, Krisher L, Jaramillo D, Newman KL, Newman LS. Creatinine Fluctuations Forecast Cross-Harvest Kidney Function Decline Among Sugarcane Workers in Guatemala. Kidney Int Rep. 2020 Sep;5(9):1558-1566. PubMed PMID: 32954081
  • Schaeffer JW, Adgate JL, Reynolds SJ, Butler-Dawson J, Krisher L, Dally M, Johnson RJ, James KA, Jaramillo D, Newman LS. A Pilot Study to Assess Inhalation Exposures among Sugarcane Workers in Guatemala: Implications for Chronic Kidney Disease of Unknown Origin. Int J Environ Res Public Health. 2020 Aug 7;17(16). PubMed PMID: 32784623
  • Borghi C, Agabiti-Rosei E, Johnson RJ, Kielstein JT, Lurbe E, Mancia G, Redon J, Stack AG, Tsioufis KP. Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease. Eur J Intern Med. 2020 Oct;80:1-11. PubMed PMID: 32739239
  • Vinovskis C, Li LP, Prasad P, Tommerdahl K, Pyle L, Nelson RG, Pavkov ME, van Raalte D, Rewers M, Pragnell M, Mahmud FH, Cherney DZ, Johnson RJ, Nadeau KJ, Bjornstad P. Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes. Diabetes. 2020 Dec;69(12):2700-2708. PubMed PMID: 32737116
  • Stenvinkel P, Shiels PG, Painer J, Miranda JJ, Natterson-Horowitz B, Johnson RJ. A planetary health perspective for kidney disease. Kidney Int. 2020 Aug;98(2):261-265. PubMed PMID: 32709283
  • Nakagawa T, Lanaspa MA, Millan IS, Fini M, Rivard CJ, Sanchez-Lozada LG, Andres-Hernando A, Tolan DR, Johnson RJ. Fructose contributes to the Warburg effect for cancer growth. Cancer Metab. 2020;8:16. PubMed PMID: 32670573
  • Stenvinkel P, Painer J, Shiels PG, Bansal A, Fereidouni S, Natterson-Horowitz B, Johnson RJ, Miranda JJ. SARS-COV-2 and biomimetics: What saves the planet will save our health. J Intern Med. 2020 Jun 24. [Epub ahead of print] PubMed PMID: 32583447
  • Andres-Hernando A, Kuwabara M, Orlicky DJ, Vandenbeuch A, Cicerchi C, Kinnamon SC, Finger TE, Johnson RJ, Lanaspa MA. Sugar causes obesity and metabolic syndrome in mice independently of sweet taste. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E276-E290. PubMed PMID: 32574112
  • Andres-Hernando A, Orlicky DJ, Kuwabara M, Ishimoto T, Nakagawa T, Johnson RJ, Lanaspa MA. Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction. Cell Metab. 2020 Jul 7;32(1):117-127.e3. PubMed PMID: 32502381
  • Hansson E, Glaser J, Jakobsson K, Weiss I, Wesseling C, Lucas RAI, Wei JLK, Ekström U, Wijkström J, Bodin T, Johnson RJ, Wegman DH. Pathophysiological Mechanisms by which Heat Stress Potentially Induces Kidney Inflammation and Chronic Kidney Disease in Sugarcane Workers. Nutrients. 2020 Jun 2;12(6). PubMed PMID: 32498242
  • Aguilar-Ramirez D, Raña-Custodio A, Villa A, Rubilar X, Olvera N, Escobar A, Johnson RJ, Sanchez-Lozada L, Obrador GT, Madero M. Decreased kidney function and agricultural work: a cross-sectional study in middle-aged adults from Tierra Blanca, Mexico. Nephrol Dial Transplant. 2020 May 22. [Epub ahead of print] PubMed PMID: 32443156
  • Kuwabara M, Kanbay M, Niwa K, Ae R, Andres-Hernando A, Roncal-Jimenez CA, Garcia G, Sánchez-Lozada LG, Rodriguez-Iturbe B, Hisatome I, Lanaspa MA, Johnson RJ. Hyperosmolarity and Increased Serum Sodium Concentration Are Risks for Developing Hypertension Regardless of Salt Intake: A Five-Year Cohort Study in Japan. Nutrients. 2020 May 14;12(5). PubMed PMID: 32423124
  • Cara-Fuentes G, Venkatareddy M, Verma R, Segarra A, Cleuren AC, Martínez-Ramos A, Johnson RJ, Garg P. Glomerular endothelial cells and podocytes can express CD80 in patients with minimal change disease during relapse. Pediatr Nephrol. 2020 Oct;35(10):1887-1896. PubMed PMID: 32399663
  • Phadke G, Kaushal A, Tolan DR, Hahn K, Jensen T, Bjornstad P, Roncal-Jimenez C, Hernando AA, Lanaspa MA, Alexander MP, Kukla A, Johnson RJ. Osmotic Nephrosis and Acute Kidney Injury Associated With SGLT2 Inhibitor Use: A Case Report. Am J Kidney Dis. 2020 Jul;76(1):144-147. PubMed PMID: 32387022
  • Sato Y, Feig DI, Stack AG, Kang DH, Lanaspa MA, Ejaz AA, Sánchez-Lozada LG, Kuwabara M, Borghi C, Johnson RJ. Reply to 'The case for evidence-based medicine for the association between hyperuricaemia and CKD'. Nat Rev Nephrol. 2020 Jul;16(7):422-423. PubMed PMID: 32313213
  • Li JW, Suh M, Brigham MD, Kent JD, LaMoreaux B, Johnson RJ, Mandell BF, Hadker N, Sanchez H, Francis K, Miyasato G. A Retrospective Cohort Study of the Effect of Gout on Mortality Among Patients with a History of Kidney Transplantation. Ann Transplant. 2020 Apr 14;25:e920553. PubMed PMID: 32284525
  • Nakagawa T, Johnson RJ, Andres-Hernando A, Roncal-Jimenez C, Sanchez-Lozada LG, Tolan DR, Lanaspa MA. Fructose Production and Metabolism in the Kidney. J Am Soc Nephrol. 2020 May;31(5):898-906. PubMed PMID: 32253274
  • Kuwabara M, Hisatome I, Niwa K, Bjornstad P, Roncal-Jimenez CA, Andres-Hernando A, Kanbay M, Johnson RJ, Lanaspa MA. The Optimal Range of Serum Uric Acid for Cardiometabolic Diseases: A 5-Year Japanese Cohort Study. J Clin Med. 2020 Mar 30;9(4). PubMed PMID: 32235468
  • Kuwabara M, Borghi C, Johnson RJ. Febuxostat and atrial fibrillation. Eur Heart J. 2020 Aug 7;41(30):2916-2917. PubMed PMID: 32227166
  • Brigham MD, Milgroom A, Lenco MO, Wang Z, Kent JD, LaMoreaux B, Johnson RJ, Mandell BF, Hadker N, Sanchez H, Francis K, Radeck LP, Miyasato G, Li JW. Immunosuppressant Use and Gout in the Prevalent Solid Organ Transplantation Population. Prog Transplant. 2020 Jun;30(2):103-110. PubMed PMID: 32208882
  • Sanchez-Lozada LG, Rodriguez-Iturbe B, Kelley EE, Nakagawa T, Madero M, Feig DI, Borghi C, Piani F, Cara-Fuentes G, Bjornstad P, Lanaspa MA, Johnson RJ. Uric Acid and Hypertension: An Update With Recommendations. Am J Hypertens. 2020 Jul 18;33(7):583-594. PubMed PMID: 32179896
  • Butler-Dawson J, Dally M, Johnson RJ, Johnson EC, Krisher L, Sánchez-Lozada LG, Griffin BR, Brindley S, Newman LS. Association of Copeptin, a Surrogate Marker of Arginine Vasopressin, with Decreased Kidney Function in Sugarcane Workers in Guatemala. Ann Nutr Metab. 2020;76(1):30-36. PubMed PMID: 32172243
  • Dally M, Butler-Dawson J, Cruz A, Krisher L, Johnson RJ, Asensio C, Pilloni WD, Asturias EJ, Newman LS. Longitudinal trends in renal function among first time sugarcane harvesters in Guatemala. PLoS One. 2020;15(3):e0229413. PubMed PMID: 32142520
  • Golembiewska E, Qureshi AR, Dai L, Lindholm B, Heimbürger O, Söderberg M, Brismar TB, Ripsweden J, Barany P, Johnson RJ, Stenvinkel P. Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5. BMC Nephrol. 2020 Feb 7;21(1):43. PubMed PMID: 32033584
  • Kanbay M, Siriopol D, Ozdogan E, Afsar B, Ertuglu LA, Grigore M, Sag AA, Kuwabara M, Lanaspa MA, Ortiz A, Johnson RJ, Covic A. Serum osmolarity as a potential predictor for contrast-induced nephropathy following elective coronary angiography. Int Urol Nephrol. 2020 Mar;52(3):541-547. PubMed PMID: 32008199
  • Wesseling C, Glaser J, Rodríguez-Guzmán J, Weiss I, Lucas R, Peraza S, da Silva AS, Hansson E, Johnson RJ, Hogstedt C, Wegman DH, Jakobsson K. Chronic kidney disease of non-traditional origin in Mesoamerica: a disease primarily driven by occupational heat stress. Rev Panam Salud Publica. 2020;44:e15. PubMed PMID: 31998376
  • Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR. Fructose and hepatic insulin resistance. Crit Rev Clin Lab Sci. 2020 Aug;57(5):308-322. PubMed PMID: 31935149
  • Aslan G, Afsar B, Sag AA, Camkiran V, Erden N, Yilmaz S, Siriopol D, Incir S, You Z, Garcia ML, Covic A, Cherney DZI, Johnson RJ, Kanbay M. The Effect of Urine pH and Urinary Uric Acid Levels on the Development of Contrast Nephropathy. Kidney Blood Press Res. 2020;45(1):131-141. PubMed PMID: 31865342
  • Joosten LAB, Crisan TO, Bjornstad P, Johnson RJ. Asymptomatic hyperuricaemia: a silent activator of the innate immune system. Nat Rev Rheumatol. 2020 Feb;16(2):75-86. PubMed PMID: 31822862
  • García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Corrigendum to "Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages" [Free Radic. Biol. Med. 141 (2019) 182-191]. Free Radic Biol Med. 2020 May 20;152:865-866. PubMed PMID: 31813623
  • Thornley S, King R, Marshall R, Oakley A, Sundborn G, Harrower J, Reynolds E, Arbuckle M, Johnson RJ. How strong is the relationship between scabies and acute rheumatic fever? An analysis of neighbourhood factors. J Paediatr Child Health. 2020 Apr;56(4):600-606. PubMed PMID: 31774599
  • Andrews P, Johnson RJ. Evolutionary basis for the human diet: consequences for human health. J Intern Med. 2020 Mar;287(3):226-237. PubMed PMID: 31733113
  • Stenvinkel P, Painer J, Johnson RJ, Natterson-Horowitz B. Biomimetics - Nature's roadmap to insights and solutions for burden of lifestyle diseases. J Intern Med. 2020 Mar;287(3):238-251. PubMed PMID: 31639885
  • Johnson RJ, Stenvinkel P, Andrews P, Sánchez-Lozada LG, Nakagawa T, Gaucher E, Andres-Hernando A, Rodriguez-Iturbe B, Jimenez CR, Garcia G, Kang DH, Tolan DR, Lanaspa MA. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med. 2020 Mar;287(3):252-262. PubMed PMID: 31621967
  • Al-Ozairi E, Rivard CJ, Sanchez Lozada LG, Lanaspa MA, Bjornstad P, Al Salem D, Alhubail A, Megahed A, Kuwabara M, Johnson RJ, Asad RA. Fructose tolerance test in obese people with and without type 2 diabetes. J Diabetes. 2020 Mar;12(3):197-204. PubMed PMID: 31472036
  • Aslan G, Afsar B, Sag AA, Camkiran V, Erden N, Yilmaz S, Siriopol D, Incir S, You Z, Garcia ML, Covic A, Cherney DZI, Johnson RJ, Kanbay M. The Effect of Urine pH and Urinary Uric Acid Levels on the Development of Contrast Nephropathy. Kidney Blood Press Res. 2019 Dec 20;:1-11. [Epub ahead of print] PubMed PMID: 31865342
  • Joosten LAB, Crisan TO, Bjornstad P, Johnson RJ. Asymptomatic hyperuricaemia: a silent activator of the innate immune system. Nat Rev Rheumatol. 2019 Dec 10. [Epub ahead of print] PubMed PMID: 31822862
  • García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Corrigendum to "Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages" [Free Radic. Biol. Med. 141 (2019) 182-191]. Free Radic Biol Med. 2019 Dec 5. [Epub ahead of print] PubMed PMID: 31813623
  • Thornley S, King R, Marshall R, Oakley A, Sundborn G, Harrower J, Reynolds E, Arbuckle M, Johnson RJ. How strong is the relationship between scabies and acute rheumatic fever? An analysis of neighbourhood factors. J Paediatr Child Health. 2019 Nov 27. [Epub ahead of print] PubMed PMID: 31774599
  • García-Arroyo FE, Muñoz-Jiménez I, Gonzaga G, Tapia E, Osorio-Alonso H, Roncal-Jiménez CA, Iroz A, Vecchio M, Reyes-García JG, Johnson RJ, Sánchez-Lozada LG. A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose. Int J Mol Sci. 2019 Nov 16;20(22). PubMed PMID: 31744099
  • Brigham MD, Milgroom A, Lenco MO, Tudor T, Kent JD, LaMoreaux B, Johnson RJ, Mandell BF, Hadker N, Francis K, Sanchez H, Radeck LP, Li JW. Prevalence of Gout in the Surviving United States Solid Organ Transplantation Population. Transplant Proc. 2019 Dec;51(10):3449-3455. PubMed PMID: 31733798
  • Andrews P, Johnson RJ. Evolutionary basis for the human diet: consequences for human health. J Intern Med. 2019 Nov 16. [Epub ahead of print] PubMed PMID: 31733113
  • Stenvinkel P, Painer J, Johnson RJ, Natterson-Horowitz B. Biomimetics - Nature's roadmap to insights and solutions for burden of lifestyle diseases. J Intern Med. 2019 Oct 22. [Epub ahead of print] PubMed PMID: 31639885
  • Johnson RJ, Stenvinkel P, Andrews P, Sánchez-Lozada LG, Nakagawa T, Gaucher E, Andres-Hernando A, Rodriguez-Iturbe B, Jimenez CR, Garcia G, Kang DH, Tolan DR, Lanaspa MA. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med. 2019 Oct 17. [Epub ahead of print] PubMed PMID: 31621967
  • García-Arroyo FE, Monroy-Sánchez F, Muñoz-Jiménez I, Gonzaga G, Andrés-Hernando A, Zazueta C, Juárez-Rojas JG, Lanaspa MA, Johnson RJ, Sánchez-Lozada LG. Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats. Biomolecules. 2019 Oct 11;9(10). PubMed PMID: 31614639
  • Ko J, Kang HJ, Kim DA, Kim MJ, Ryu ES, Lee S, Ryu JH, Roncal C, Johnson RJ, Kang DH. Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding. FASEB J. 2019 Dec;33(12):13334-13345. PubMed PMID: 31553887
  • Isom R, Shoor S, Higgins J, Cara-Fuentes G, Johnson RJ. Abatacept in Steroid-Dependent Minimal Change Disease and CD80-uria. Kidney Int Rep. 2019 Sep;4(9):1349-1353. PubMed PMID: 31517155
  • Bursill D, Taylor WJ, Terkeltaub R, Abhishek A, So AK, Vargas-Santos AB, Gaffo AL, Rosenthal A, Tausche AK, Reginato A, Manger B, Sciré C, Pineda C, van Durme C, Lin CT, Yin C, Albert DA, Biernat-Kaluza E, Roddy E, Pascual E, Becce F, Perez-Ruiz F, Sivera F, Lioté F, Schett G, Nuki G, Filippou G, McCarthy G, da Rocha Castelar Pinheiro G, Ea HK, Tupinambá HA, Yamanaka H, Choi HK, Mackay J, ODell JR, Vázquez Mellado J, Singh JA, Fitzgerald JD, Jacobsson LTH, Joosten L, Harrold LR, Stamp L, Andrés M, Gutierrez M, Kuwabara M, Dehlin M, Janssen M, Doherty M, Hershfield MS, Pillinger M, Edwards NL, Schlesinger N, Kumar N, Slot O, Ottaviani S, Richette P, MacMullan PA, Chapman PT, Lipsky PE, Robinson P, Khanna PP, Gancheva RN, Grainger R, Johnson RJ, Te Kampe R, Keenan RT, Tedeschi SK, Kim S, Choi SJ, Fields TR, Bardin T, Uhlig T, Jansen T, Merriman T, Pascart T, Neogi T, Klück V, Louthrenoo W, Dalbeth N. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. Ann Rheum Dis. 2019 Nov;78(11):1592-1600. PubMed PMID: 31501138
  • Al-Ozairi E, Rivard CJ, Sanchez Lozada LG, Lanaspa MA, Bjornstad P, Al Salem D, Alhubail A, Megahed A, Kuwabara M, Johnson RJ, Asad RA. Fructose tolerance test in obese people with and without type 2 diabetes. J Diabetes. 2019 Aug 31. [Epub ahead of print] PubMed PMID: 31472036
  • Wiromrat P, Bjornstad P, Vinovskis C, Chung LT, Roncal C, Pyle L, Lanaspa MA, Johnson RJ, Cherney DZ, Reznick-Lipina TK, Bishop F, Maahs DM, Wadwa RP. Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes. Pediatr Diabetes. 2019 Dec;20(8):1110-1117. PubMed PMID: 31433534
  • Johnson RJ, Wesseling C, Newman LS. Chronic Kidney Disease of Unknown Cause in Agricultural Communities. Reply. N Engl J Med. 2019 Aug 15;381(7):689. PubMed PMID: 31412197
  • Andres-Hernando A, Lanaspa MA, Kuwabara M, Orlicky DJ, Cicerchi C, Bales E, Garcia GE, Roncal-Jimenez CA, Sato Y, Johnson RJ. Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F941-F948. PubMed PMID: 31411075
  • Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ. Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1111-F1121. PubMed PMID: 31390229
  • Kanbay M, Yilmaz S, Dincer N, Ortiz A, Sag AA, Covic A, Sánchez-Lozada LG, Lanaspa MA, Cherney DZI, Johnson RJ, Afsar B. Antidiuretic Hormone and Serum Osmolarity Physiology and Related Outcomes: What Is Old, What Is New, and What Is Unknown?. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5406-5420. PubMed PMID: 31365096
  • Sato Y, Feig DI, Stack AG, Kang DH, Lanaspa MA, Ejaz AA, Sánchez-Lozada LG, Kuwabara M, Borghi C, Johnson RJ. The case for uric acid-lowering treatment in patients with hyperuricaemia and CKD. Nat Rev Nephrol. 2019 Dec;15(12):767-775. PubMed PMID: 31296965
  • Hayasaki T, Ishimoto T, Doke T, Hirayama A, Soga T, Furuhashi K, Kato N, Kosugi T, Tsuboi N, Lanaspa MA, Johnson RJ, Maruyama S, Kadomatsu K. Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase. J Nutr Biochem. 2019 Sep;71:54-62. PubMed PMID: 31276916
  • Brigham MD, Radeck LP, Mendonca CM, Lang I, Li JW, Kent JD, LaMoreaux B, Mandell BF, Johnson RJ. Gout Severity in Recipients of Kidney Transplant. Transplant Proc. 2019 Jul - Aug;51(6):1816-1821. PubMed PMID: 31256872
  • Wiromrat P, Bjornstad P, Roncal C, Pyle L, Johnson RJ, Cherney DZ, Lipina T, Bishop F, Maahs DM, Wadwa RP. Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes. J Diabetes Complications. 2019 Sep;33(9):648-650. PubMed PMID: 31253490
  • García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages. Free Radic Biol Med. 2019 Sep;141:182-191. PubMed PMID: 31212064
  • Johnson RJ, Sánchez-Lozada LG, Newman LS, Lanaspa MA, Diaz HF, Lemery J, Rodriguez-Iturbe B, Tolan DR, Butler-Dawson J, Sato Y, Garcia G, Hernando AA, Roncal-Jimenez CA. Climate Change and the Kidney. Ann Nutr Metab. 2019;74 Suppl 3:38-44. PubMed PMID: 31203298
  • Andres-Hernando A, Johnson RJ, Lanaspa MA. Endogenous fructose production: what do we know and how relevant is it?. Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):289-294. PubMed PMID: 31166222
  • Hooper PL, Swenson ER, Johnson RJ. Carbonic Anhydrase Inhibitors for the Treatment of High-Altitude Hypoxemia. Am J Med. 2019 Nov;132(11):e799-e800. PubMed PMID: 31152716
  • Johnson RJ, Choi HK, Yeo AE, Lipsky PE. Pegloticase Treatment Significantly Decreases Blood Pressure in Patients With Chronic Gout. Hypertension. 2019 Jul;74(1):95-101. PubMed PMID: 31079535
  • Johnson RJ, Wesseling C, Newman LS. Chronic Kidney Disease of Unknown Cause in Agricultural Communities. N Engl J Med. 2019 May 9;380(19):1843-1852. PubMed PMID: 31067373
  • Sundborn G, Thornley S, Merriman TR, Lang B, King C, Lanaspa MA, Johnson RJ. Are Liquid Sugars Different from Solid Sugar in Their Ability to Cause Metabolic Syndrome?. Obesity (Silver Spring). 2019 Jun;27(6):879-887. PubMed PMID: 31054268
  • Nakagawa T, Lanaspa MA, Johnson RJ. The effects of fruit consumption in patients with hyperuricaemia or gout. Rheumatology (Oxford). 2019 Jul 1;58(7):1133-1141. PubMed PMID: 31004140
  • Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 Jun;33(6):434-436. PubMed PMID: 31003921
  • Butler-Dawson J, Krisher L, Yoder H, Dally M, Sorensen C, Johnson RJ, Asensio C, Cruz A, Johnson EC, Carlton EJ, Tenney L, Asturias EJ, Newman LS. Evaluation of heat stress and cumulative incidence of acute kidney injury in sugarcane workers in Guatemala. Int Arch Occup Environ Health. 2019 Oct;92(7):977-990. PubMed PMID: 30997573
  • Ejaz AA, Johnson RJ, Shimada M, Mohandas R, Alquadan KF, Beaver TM, Lapsia V, Dass B. The Role of Uric Acid in Acute Kidney Injury. Nephron. 2019;142(4):275-283. PubMed PMID: 30991383
  • James WPT, Johnson RJ, Speakman JR, Wallace DC, Frühbeck G, Iversen PO, Stover PJ. Nutrition and its role in human evolution. J Intern Med. 2019 May;285(5):533-549. PubMed PMID: 30772945
  • Sánchez-Lozada LG, Roncal-Jimenez CA, García-Arroyo FE, Jensen T, Lanaspa MA, Johnson RJ. The perils of rehydrating with soft drinks following heat and exercise. Am J Physiol Regul Integr Comp Physiol. 2019 Mar 1;316(3):R187-R188. PubMed PMID: 30673300
  • Sanchez-Lozada LG, Andres-Hernando A, Garcia-Arroyo FE, Cicerchi C, Li N, Kuwabara M, Roncal-Jimenez CA, Johnson RJ, Lanaspa MA. Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. J Biol Chem. 2019 Mar 15;294(11):4272-4281. PubMed PMID: 30651350
  • Eren OC, Ortiz A, Afsar B, Covic A, Kuwabara M, Lanaspa MA, Johnson RJ, Kanbay M. Multilayered Interplay Between Fructose and Salt in Development of Hypertension. Hypertension. 2019 Feb;73(2):265-272. PubMed PMID: 30595116
  • Sorensen CJ, Butler-Dawson J, Dally M, Krisher L, Griffin BR, Johnson RJ, Lemery J, Asensio C, Tenney L, Newman LS. Risk Factors and Mechanisms Underlying Cross-Shift Decline in Kidney Function in Guatemalan Sugarcane Workers. J Occup Environ Med. 2019 Mar;61(3):239-250. PubMed PMID: 30575695
  • Kuwabara M, Chintaluru Y, Kanbay M, Niwa K, Hisatome I, Andres-Hernando A, Roncal-Jimenez C, Ohno M, Johnson RJ, Lanaspa MA. Fasting blood glucose is predictive of hypertension in a general Japanese population. J Hypertens. 2019 Jan;37(1):167-174. PubMed PMID: 30507865
  • Bjornstad P, Wiromrat P, Johnson RJ, Sippl R, Cherney DZI, Wong R, Rewers MJ, Snell-Bergeon JK. Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 Years in Adults With Type 1 Diabetes: The CACTI Study. Diabetes Care. 2019 Feb;42(2):297-302. PubMed PMID: 30482755
  • Rodriguez-Iturbe B, Johnson RJ. Genetic Polymorphisms in Hypertension: Are We Missing the Immune Connection?. Am J Hypertens. 2019 Jan 15;32(2):113-122. PubMed PMID: 30418477
  • Jensen T, Bjornstad P, Johnson RJ, Sippl R, Rewers M, Snell-Bergeon JK. Copeptin and Estimated Insulin Sensitivity in Adults With and Without Type 1 Diabetes: The CACTI Study. Can J Diabetes. 2019 Feb;43(1):34-39. PubMed PMID: 30026043
  • Rodriguez-Iturbe B, Lanaspa MA, Johnson RJ. The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension. Br J Pharmacol. 2019 Jun;176(12):1829-1838. PubMed PMID: 29679484
  • Stenvinkel P, Painer J, Kuro-O M, Lanaspa M, Arnold W, Ruf T, Shiels PG, Johnson RJ. Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nat Rev Nephrol. 2018 Jan 15. [Epub ahead of print] PubMed PMID: 29332935
  • Harland TA, Winston KR, Jovanovich AJ, Johnson RJ. Shunt Nephritis: An Increasingly Unfamiliar Diagnosis. World Neurosurg. 2018 Jan 8. [Epub ahead of print] PubMed PMID: 29325951
  • Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, Nakagawa T, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Rodriguez-Iturbe B, Ohno M, Lanaspa MA, Johnson RJ. Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study. Hypertension. 2018 Jan;71(1):78-86. PubMed PMID: 29203632
  • Bjornstad P, Wiromrat P, Johnson RJ, Sippl R, Cherney DZ, Wong R, Rewers MJ, Snell-Bergeon JK. Serum Uromodulin Predicts Less Coronary Artery Calcification and Diabetic Kidney Disease Over 12 years in Adults With Type 1 Diabetes: The CACTI Study. Diabetes Care. 2018 Nov 27. [Epub ahead of print] PubMed PMID: 30482755
  • Rodriguez-Iturbe B, Johnson RJ. Genetic polymorphisms in Hypertension: are we missing the Immune Connection?. Am J Hypertens. 2018 Nov 10. [Epub ahead of print] PubMed PMID: 30418477
  • Johnson RJ, Perez-Pozo SE, Lillo JL, Grases F, Schold JD, Kuwabara M, Sato Y, Hernando AA, Garcia G, Jensen T, Rivard C, Sanchez-Lozada LG, Roncal C, Lanaspa MA. Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress. BMC Nephrol. 2018 Nov 8;19(1):315. PubMed PMID: 30409184
  • Sánchez-Lozada LG, García-Arroyo FE, Gonzaga G, Silverio O, Blas-Marron MG, Muñoz-Jimenez I, Tapia E, Osorio-Alonso H, Madero M, Roncal-Jiménez CA, Weiss I, Glaser J, Johnson RJ. Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate. Am J Nephrol. 2018;48(5):339-348. PubMed PMID: 30391956
  • Dally M, Butler-Dawson J, Krisher L, Monaghan A, Weitzenkamp D, Sorensen C, Johnson RJ, Carlton EJ, Asensio C, Tenney L, Newman LS. The impact of heat and impaired kidney function on productivity of Guatemalan sugarcane workers. PLoS One. 2018;13(10):e0205181. PubMed PMID: 30289894
  • Griffin BR, Butler-Dawson J, Dally M, Krisher L, Cruz A, Weitzenkamp D, Sorensen C, Tenney L, Johnson RJ, Newman LS. Unadjusted point of care creatinine results overestimate acute kidney injury incidence during field testing in Guatemala. PLoS One. 2018;13(9):e0204614. PubMed PMID: 30261074
  • Kanbay M, Aslan G, Afsar B, Dagel T, Siriopol D, Kuwabara M, Incir S, Camkiran V, Rodriguez-Iturbe B, Lanaspa MA, Covic A, Johnson RJ. Acute effects of salt on blood pressure are mediated by serum osmolality. J Clin Hypertens (Greenwich). 2018 Oct;20(10):1447-1454. PubMed PMID: 30232829
  • García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Blas-Marron MG, Silverio O, Tapia E, Soto V, Ranganathan N, Ranganathan P, Vyas U, Irvin A, Ir D, Robertson CE, Frank DN, Johnson RJ, Sánchez-Lozada LG. Probiotic supplements prevented oxonic acid-induced hyperuricemia and renal damage. PLoS One. 2018;13(8):e0202901. PubMed PMID: 30142173
  • Jensen T, Niwa K, Hisatome I, Kanbay M, Andres-Hernando A, Roncal-Jimenez CA, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ, Kuwabara M. Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver. Sci Rep. 2018 Aug 6;8(1):11735. PubMed PMID: 30082907
  • Kuwabara M, Kuwabara R, Niwa K, Hisatome I, Smits G, Roncal-Jimenez CA, MacLean PS, Yracheta JM, Ohno M, Lanaspa MA, Johnson RJ, Jalal DI. Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects. Nutrients. 2018 Aug 3;10(8). PubMed PMID: 30081468
  • Jensen T, Bjornstad P, Johnson RJ, Sippl R, Rewers M, Snell-Bergeon JK. Copeptin and Estimated Insulin Sensitivity in Adults With and Without Type 1 Diabetes: The CACTI Study. Can J Diabetes. 2018 Mar 14. [Epub ahead of print] PubMed PMID: 30026043
  • Milagres T, García-Arroyo FE, Lanaspa MA, Garcia G, Ishimoto T, Andres-Hernando A, Kuwabara M, Jensen T, Sato Y, Glaser J, Sánchez-Lozada LG, Johnson RJ, Roncal-Jimenez C. Rehydration with fructose worsens dehydration-induced renal damage. BMC Nephrol. 2018 Jul 13;19(1):180. PubMed PMID: 30005632
  • Johnson RJ. Finding the truth: multivariable analysis and the assassination of Abraham Lincoln. J R Coll Physicians Edinb. 2018 Jun;48(2):153-154. PubMed PMID: 29992207
  • Kuwabara M, Hisatome I, Roncal-Jimenez CA, Niwa K, Andres-Hernando A, Jensen T, Bjornstad P, Milagres T, Cicerchi C, Song Z, Garcia G, Sánchez-Lozada LG, Ohno M, Lanaspa MA, Johnson RJ. Correction: Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study. PLoS One. 2018;13(5):e0197941. PubMed PMID: 29772014
  • Afsar B, Kuwabara M, Ortiz A, Yerlikaya A, Siriopol D, Covic A, Rodriguez-Iturbe B, Johnson RJ, Kanbay M. Salt Intake and Immunity. Hypertension. 2018 Jul;72(1):19-23. PubMed PMID: 29760151
  • Rivard CJ, Tanabe T, Lanaspa MA, Watanabe H, Nomura S, Andres-Hernando A, Garth K, Sekijima M, Ishimoto T, Ariyoshi Y, Garcia GE, Shah J, Lennan B, Tasaki M, Pomposelli T, Shimizu A, Sachs DH, Johnson RJ, Yamada K. Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - an experimental study. Transpl Int. 2018 Oct;31(10):1164-1177. PubMed PMID: 29722117
  • Trostel J, Truong LD, Roncal-Jimenez C, Miyazaki M, Miyazaki-Anzai S, Kuwabara M, McMahan R, Andres-Hernando A, Sato Y, Jensen T, Lanaspa MA, Johnson RJ, Garcia GE. Different effects of global osteopontin and macrophage osteopontin in glomerular injury. Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F759-F768. PubMed PMID: 29717936
  • Johnson RJ, Rodriguez-Iturbe B. Rethinking progression of CKD as a process of punctuated equilibrium. Nat Rev Nephrol. 2018 Jul;14(7):411-412. PubMed PMID: 29717190
  • Shah JA, Lanaspa MA, Tanabe T, Watanabe H, Johnson RJ, Yamada K. Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation. J Immunol Res. 2018;2018:6413012. PubMed PMID: 29687010
  • Rodriguez-Iturbe B, Lanaspa MA, Johnson RJ. The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension. Br J Pharmacol. 2018 Apr 21. [Epub ahead of print] PubMed PMID: 29679484
  • Johnson RJ. Finding the truth: blind faith and the lemming phenomenon. J R Soc Med. 2018 May;111(5):175-176. PubMed PMID: 29672200
  • Roncal-Jimenez CA, Sato Y, Milagres T, Andres Hernando A, García G, Bjornstad P, Dawson JB, Sorensen C, Newman L, Krisher L, Madero M, Glaser J, Gárcía-Trabanino R, Romero EJ, Song Z, Jensen T, Kuwabara M, Rodriguez-Iturbe B, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Experimental heat stress nephropathy and liver injury are improved by allopurinol. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F726-F733. PubMed PMID: 29667911
  • Doke T, Ishimoto T, Hayasaki T, Ikeda S, Hasebe M, Hirayama A, Soga T, Kato N, Kosugi T, Tsuboi N, Lanaspa MA, Johnson RJ, Kadomatsu K, Maruyama S. Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice. Metabolism. 2018 Aug;85:161-170. PubMed PMID: 29604362
  • Rodríguez-Iturbe B, Johnson RJ. Heat shock proteins and cardiovascular disease. Physiol Int. 2018 Mar 1;105(1):19-37. PubMed PMID: 29602292
  • Kuwabara M, Borghi C, Cicero AFG, Hisatome I, Niwa K, Ohno M, Johnson RJ, Lanaspa MA. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan. Int J Cardiol. 2018 Jun 15;261:183-188. PubMed PMID: 29551256
  • Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. J Clin Invest. 2018 Jun 1;128(6):2226-2238. PubMed PMID: 29533924
  • Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3138-3143. PubMed PMID: 29507217
  • Bjornstad P, Maahs DM, Roncal CA, Snell-Bergeon JK, Shah VN, Milagres T, Ellis SL, Hatch M, Chung LT, Rewers MJ, Garg S, Cherney DZ, Pyle L, Nadeau KJ, Johnson RJ. Role of bicarbonate supplementation on urine uric acid crystals and diabetic tubulopathy in adults with type 1 diabetes. Diabetes Obes Metab. 2018 Jul;20(7):1776-1780. PubMed PMID: 29498467
  • Johnson RJ, Bakris GL, Borghi C, Chonchol MB, Feldman D, Lanaspa MA, Merriman TR, Moe OW, Mount DB, Sanchez Lozada LG, Stahl E, Weiner DE, Chertow GM. Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation. Am J Kidney Dis. 2018 Jun;71(6):851-865. PubMed PMID: 29496260
  • Cara-Fuentes G, Lanaspa MA, Garcia GE, Banks M, Garin EH, Johnson RJ. Urinary CD80: a biomarker for a favorable response to corticosteroids in minimal change disease. Pediatr Nephrol. 2018 Jul;33(7):1101-1103. PubMed PMID: 29492674
  • Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol. 2018 May;68(5):1063-1075. PubMed PMID: 29408694
  • King C, Lanaspa MA, Jensen T, Tolan DR, Sánchez-Lozada LG, Johnson RJ. Uric Acid as a Cause of the Metabolic Syndrome. Contrib Nephrol. 2018;192:88-102. PubMed PMID: 29393133
  • Stenvinkel P, Painer J, Kuro-O M, Lanaspa M, Arnold W, Ruf T, Shiels PG, Johnson RJ. Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nat Rev Nephrol. 2018 Apr;14(4):265-284. PubMed PMID: 29332935
  • Harland TA, Winston KR, Jovanovich AJ, Johnson RJ. Shunt Nephritis: An Increasingly Unfamiliar Diagnosis. World Neurosurg. 2018 Mar;111:346-348. PubMed PMID: 29325951
  • Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, Nakagawa T, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Rodriguez-Iturbe B, Ohno M, Lanaspa MA, Johnson RJ. Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study. Hypertension. 2018 Jan;71(1):78-86. PubMed PMID: 29203632
  • Hurtado-Arestegui A, Plata-Cornejo R, Cornejo A, Mas G, Carbajal L, Sharma S, Swenson ER, Johnson RJ, Pando J. Higher prevalence of unrecognized kidney disease at high altitude. J Nephrol. 2018 Apr;31(2):263-269. PubMed PMID: 29119539
  • Bjornstad P, Pyle L, Cherney DZI, Johnson RJ, Sippl R, Wong R, Rewers M, Snell-Bergeon JK. Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant. 2018 Jul 1;33(7):1189-1196. PubMed PMID: 28992280
  • Hurtado-Arestegui A, Plata-Cornejo R, Cornejo A, Mas G, Carbajal L, Sharma S, Swenson ER, Johnson RJ, Pando J. Higher prevalence of unrecognized kidney disease at high altitude. J Nephrol. 2017 Nov 8. [Epub ahead of print] PubMed PMID: 29119539
  • Bjornstad P, Pyle L, Cherney DZI, Johnson RJ, Sippl R, Wong R, Rewers M, Snell-Bergeon JK. Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant. 2017 Aug 21. [Epub ahead of print] PubMed PMID: 28992280
  • Yamada K, Shah JA, Tanabe T, Lanaspa MA, Johnson RJ. Xenotransplantation: Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials. Curr Transplant Rep. 2017 Jun;4(2):101-109. PubMed PMID: 28989853
  • Todd AS, Walker RJ, MacGinley RJ, Kelly J, Merriman TR, Major TJ, Johnson RJ. Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans. Am J Hypertens. 2017 Nov 6;30(12):1196-1202. PubMed PMID: 28985270
  • García-Arroyo FE, Tapia E, Blas-Marron MG, Gonzaga G, Silverio O, Cristóbal M, Osorio H, Arellano-Buendía AS, Zazueta C, Aparicio-Trejo OE, Reyes-García JG, Pedraza-Chaverri J, Soto V, Roncal-Jiménez C, Johnson RJ, Sánchez-Lozada LG. Vasopressin Mediates the Renal Damage Induced by Limited Fructose Rehydration in Recurrently Dehydrated Rats. Int J Biol Sci. 2017;13(8):961-975. PubMed PMID: 28924378
  • Kuwabara M, Kuwabara R, Hisatome I, Niwa K, Roncal-Jimenez CA, Bjornstad P, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Ohno M, Hill JO, Lanaspa MA, Johnson RJ. "Metabolically Healthy" Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study. Obesity (Silver Spring). 2017 Nov;25(11):1997-2008. PubMed PMID: 28922565
  • Johnson RJ, Shimada M. Contemporary Management of Hepatitis C in Patients with CKD. Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1563-1565. PubMed PMID: 28882856
  • Sharma S, Gralla J, Ordonez JG, Hurtado ME, Swenson ER, Schoene RB, Kelly JP, Callacondo D, Rivard C, Roncal-Jimenez C, Sirota J, Fuquay R, Jackson BP, Swenson KE, Johnson RJ, Hurtado A, Escudero E. Acetazolamide and N-acetylcysteine in the treatment of chronic mountain sickness (Monge's disease). Respir Physiol Neurobiol. 2017 Dec;246:1-8. PubMed PMID: 28720395
  • Hahn K, Kanbay M, Lanaspa MA, Johnson RJ, Ejaz AA. Serum uric acid and acute kidney injury: A mini review. J Adv Res. 2017 Sep;8(5):529-536. PubMed PMID: 28748118
  • Rodriguez-Iturbe B, Pons H, Johnson RJ. Role of the Immune System in Hypertension. Physiol Rev. 2017 Jul 1;97(3):1127-1164. PubMed PMID: 28566539
  • Johnson RJ, Sánchez-Lozada LG, Andrews P, Lanaspa MA. Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes. Adv Nutr. 2017 May;8(3):412-422. PubMed PMID: 28507007
  • Cara-Fuentes G, Segarra A, Silva-Sanchez C, Wang H, Lanaspa MA, Johnson RJ, Garin EH. Angiopoietin-like-4 and minimal change disease. PLoS One. 2017;12(4):e0176198. PubMed PMID: 28441404
  • Johnson RJ. Pro: Heat stress as a potential etiology of Mesoamerican and Sri Lankan nephropathy: a late night consult with Sherlock Holmes. Nephrol Dial Transplant. 2017 Apr 1;32(4):598-602. PubMed PMID: 28407135
  • Johnson RJ. Opponent's comments. Nephrol Dial Transplant. 2017 Apr 1;32(4):606-607. PubMed PMID: 28407134
  • Kuwabara M, Niwa K, Hisatome I, Nakagawa T, Roncal-Jimenez CA, Andres-Hernando A, Bjornstad P, Jensen T, Sato Y, Milagres T, Garcia G, Ohno M, Lanaspa MA, Johnson RJ. Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study. Hypertension. 2017 Jun;69(6):1036-1044. PubMed PMID: 28396536
  • Kuwabara M, Bjornstad P, Hisatome I, Niwa K, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Milagres T, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ. Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function. Am J Nephrol. 2017;45(4):330-337. PubMed PMID: 28285309
  • Andres-Hernando A, Li N, Cicerchi C, Inaba S, Chen W, Roncal-Jimenez C, Le MT, Wempe MF, Milagres T, Ishimoto T, Fini M, Nakagawa T, Johnson RJ, Lanaspa MA. Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice. Nat Commun. 2017 Feb 13;8:14181. PubMed PMID: 28194018
  • Kuwabara M, Sato Y, Kanbay M, Johnson RJ. Uric Acid and Left Ventricular Hypertrophy: A Potentially New Modifiable Target?. Am J Hypertens. 2017 Mar 1;30(3):229-231. PubMed PMID: 28096149
  • Kuwabara M, Hisatome I, Roncal-Jimenez CA, Niwa K, Andres-Hernando A, Jensen T, Bjornstad P, Milagres T, Cicerchi C, Song Z, Garcia G, Sánchez-Lozada LG, Ohno M, Lanaspa MA, Johnson RJ. Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study. PLoS One. 2017;12(1):e0169137. PubMed PMID: 28081152
  • Roncal-Jimenez CA, Milagres T, Andres-Hernando A, Kuwabara M, Jensen T, Song Z, Bjornstad P, Garcia GE, Sato Y, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Effects of exogenous desmopressin on a model of heat stress nephropathy in mice. Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F418-F426. PubMed PMID: 28003190
  • Bjornstad P, Johnson RJ, Snell-Bergeon JK, Pyle L, Davis A, Foster N, Cherney DZ, Maahs DM. Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank. J Diabetes Complications. 2017 Feb;31(2):387-389. PubMed PMID: 27979439
  • Song ??? Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, Oppelt SA, Kuwabara M, Jensen T, Milagres T, Andres-Hernando A, Ishimoto T, Garcia GE, Johnson G, MacLean PS, Sanchez-Lozada LG, Tolan DR, Johnson RJ. Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice. J Neurophysiol. 2017 Feb 1;117(2):646-654. PubMed PMID: 27852737
  • Jalal DI, Decker E, Perrenoud L, Nowak KL, Bispham N, Mehta T, Smits G, You Z, Seals D, Chonchol M, Johnson RJ. Vascular Function and Uric Acid-Lowering in Stage 3 CKD. J Am Soc Nephrol. 2017 Mar;28(3):943-952. PubMed PMID: 27620990
  • Bjornstad P, Pyle L, Kinney GL, Rewers M, Johnson RJ, Maahs DM, Snell-Bergeon JK. Adiponectin is associated with early diabetic kidney disease in adults with type 1 diabetes: A Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. J Diabetes Complications. 2017 Feb;31(2):369-374. PubMed PMID: 27368123
  • Kanbay M, Solak Y, Afsar B, Nistor I, Aslan G, Çaglayan OH, Aykanat A, Donciu MD, Lanaspa MA, Ejaz AA, Johnson RJ, Covic A. Serum Uric Acid and Risk for Acute Kidney Injury Following Contrast. Angiology. 2017 Feb;68(2):132-144. PubMed PMID: 27106252
  • Mendi MA, Afsar B, Oksuz F, Turak O, Yayla C, Ozcan F, Johnson RJ, Kanbay M. Uric Acid is a Useful Tool to Predict Contrast-Induced Nephropathy. Angiology. 2017 Aug;68(7):627-632. PubMed PMID: 27006404
  • Bjornstad P, Snell-Bergeon JK, McFann K, Wadwa RP, Rewers M, Rivard CJ, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Serum uric acid and insulin sensitivity in adolescents and adults with and without type 1 diabetes. J Diabetes Complications. 2013 Dec 27. [Epub ahead of print] PubMed PMID: 24461546
  • Nakagawa T, Sato W, Kosugi T, Johnson RJ. Uncoupling of VEGF with endothelial NO as a potential mechanism for abnormal angiogenesis in the diabetic nephropathy. J Diabetes Res. 2013;2013:184539. PubMed PMID: 24386643
  • Roncal Jimenez CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, González MA, Aragón A, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2013 Dec 11. [Epub ahead of print] PubMed PMID: 24336030
  • Cara-Fuentes G, Wei C, Segarra A, Ishimoto T, Rivard C, Johnson RJ, Reiser J, Garin EH. CD80 and suPAR in patients with minimal change disease and focal segmental glomerulosclerosis: diagnostic and pathogenic significance. Pediatr Nephrol. 2013 Nov 22. [Epub ahead of print] PubMed PMID: 24263531
  • Stenvinkel P, Johnson RJ. Kidney biomimicry--a rediscovered scientific field that could provide hope to patients with kidney disease. Arch Med Res. 2013 Nov;44(8):584-90. PubMed PMID: 24220764
  • Johnson RJ, Nakagawa T, Sánchez-Lozada LG, Lanaspa MA, Tamura Y, Tanabe K, Ishimoto T, Thomas J, Inaba S, Kitagawa W, Rivard CJ. Umami: the taste that drives purine intake. J Rheumatol. 2013 Nov;40(11):1794-6. PubMed PMID: 24187156
  • Cara-Fuentes G, Araya C, Wei C, Rivard C, Ishimoto T, Reiser J, Johnson RJ, Garin EH. CD80, suPAR and nephrotic syndrome in a case of NPHS2 mutation. Nefrologia. 2013;33(5):727-31. PubMed PMID: 24089165
  • Stenvinkel P, Fröbert O, Anderstam B, Palm F, Eriksson M, Bragfors-Helin AC, Qureshi AR, Larsson T, Friebe A, Zedrosser A, Josefsson J, Svensson M, Sahdo B, Bankir L, Johnson RJ. Metabolic changes in summer active and anuric hibernating free-ranging brown bears (Ursus arctos). PLoS One. 2013;8(9):e72934. PubMed PMID: 24039826
  • Bjornstad P, Snell-Bergeon JK, Rewers M, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Early diabetic nephropathy: a complication of reduced insulin sensitivity in type 1 diabetes. Diabetes Care. 2013 Nov;36(11):3678-83. PubMed PMID: 24026551
  • Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434. PubMed PMID: 24022321
  • Johnson RJ, Sánchez-Lozada LG. Chronic kidney disease: Mesoamerican nephropathy--new clues to the cause. Nat Rev Nephrol. 2013 Oct;9(10):560-1. PubMed PMID: 23999393
  • Hernández-Ríos R, Hernández-Estrada S, Cruz-Robles D, Hernández-Lobato S, Villalobos-Martín M, Johnson RJ, Rodríguez-Castellanos F, Salazar J, García-Arroyo F, Sánchez-Lozada LG, Madero M. Low fructose and low salt diets increase mitochondrial DNA in white blood cells of overweight subjects. Exp Clin Endocrinol Diabetes. 2013 Oct;121(9):535-8. PubMed PMID: 23934680
  • Fini MA, Johnson RJ, Stenmark KR, Wright RM. Hypertension, nitrate-nitrite, and xanthine oxidoreductase catalyzed nitric oxide generation: pros and cons. Hypertension. 2013 Sep;62(3):e9. PubMed PMID: 23897071
  • Maahs DM, Jalal D, Chonchol M, Johnson RJ, Rewers M, Snell-Bergeon JK. Impaired renal function further increases odds of 6-year coronary artery calcification progression in adults with type 1 diabetes: the CACTI study. Diabetes Care. 2013 Sep;36(9):2607-14. PubMed PMID: 23835686
  • Lotan Y, Daudon M, Bruyère F, Talaska G, Strippoli G, Johnson RJ, Tack I. Impact of fluid intake in the prevention of urinary system diseases: a brief review. Curr Opin Nephrol Hypertens. 2013 May;22 Suppl 1:S1-10. PubMed PMID: 23673384

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