Soren Paludan

EDUCATION

June 2003.       Doctor of Medical Sciences, Aarhus University (AU), DK

Nov 2000.        PhD, Faculty of Science, AU, DK

June 1998.       Master of Science, Molecular Biology, AU, DK  

EMPLOYMENT

2013-Pres.       Professor in Molecular virology and immunology, Dept. Biomedicine, AU, DK

2019-pres.       Vice-chairman for Research, Department of Biomedicine, AU, DK

2018-2020.      Guest professor (20%), Sahlgrenska Academy, Gothenborg University, S 

2010-2013.      Professor MSO in Molecular virology, Dept. Biomedicine, AU, DK

2003-2010.      Associate professor, Dept. Medical Microbiol & Immunol, AU, DK

2000-2003.      Assistant prof., Dept. Medical Microbiol & Immunol, AU, DK

STUDIES/RESEARCH AT INSTITUTIONS OUTSIDE DENMARK

2013.              Sabbatical in London/Cambridge. Collaborations with groups at ICL and Cambridge

1998-1999.      Research Fellow, The Cleveland Clinic Foundation, Dept. Immunol, Cleveland, USA

1995-1996.      University of Oxford, Dept. Biochemistry, Oxford, UK

SCIENTIFIC LEADERSHIP ACTIVITIES

2018-2019.      Novo Nordisk Foundation Investigator Leadership

Development Program

2016-2020.      Coordinator of EDGE, a H2020-funded ITN Network on herpes virology and immunology

2012-2016.      Leader of AUFF pilot center “Center for Innate Immunology”

2003.               Establishment of my laboratory at AU

MAJOR GRANTS RECEIVED AS PRINCIPLE INVESTIGATOR

I Have obtained more than 15 mio Euros in grants as PI since year 2003 from Danish and Swedish National Research Councils, private funding bodies, and EU programs.

2019-2023.      Lundbeck Foundation. Large program grant (1.5 Mio Euros)

2019-2021.      The Swedish Research Council (0.6 mio Euros)

2018-2023.      ERC Advanced Grant (2.5 Mio Euros)

2018-2023.      Novo Nordisk Foundation Distinguished Investigator (1.5 Mio Euros)

2018-2022.      Lundbeck Foundation. Large program grant (1.5 Mio Euros)

2016-2020.      Lundbeck Foundation. Large program grant (1.5 Mio Euros)

2016-2020.      HORIZON2020. ITN PhD training network (3.9 Mio Euros). PI and coordinator

2013-2017.      Sapere aude – Advanced Grant. The Danish Research Council (1.6 Mio Euros)

SCIENTIFIC HONORS

2011.              EliteForsk Prize.

2011.              Anders Jahre Junior prize.

2012.              DFF -Advanced Grant (Sapere aude Topforsker).

2018.              Guest professorship (Sahlgrenska Academy, Gothenburg University).

2018.              ERC Advanced Grant. 

SUPERVISION AND MENTORING OF GRADUATE STUDENTS, POSTDOCS, AND JUNIOR FACULTY

2003-pres.       Previous students: 15 PhD and 8 Master students. Mentored 8 postdocs (5 now associate professors at universities. one is Founder and CEO in biotech company).                               Currently supervisor for 5 PhD students and mentor for 5 postdocs.

2015-pres.       AU mentor for 2 associate professors; mentor for 1 Lundbeck Fellow; International mentor for junior faculty at Montpellier Uni. (ERC StG awardée)

TEACHING ACTIVITIES

2000-pres.       Virology and immunology at the bachelor and master level for Medical and Molecular medicine students, AU

2000-pres.       Frequent teacher graduate courses at courses outside AU. E.g. Karolinska Institute, Stockholm (2015); Barcelona (2016); University of Copenhagen (2018) 2019.              Summer School of Immunotherapy, Aarhus University (co-organizer)

ORGANISATION OF INTERNATIONAL CONFERENCES

2018.              Symposium on Host-Pathogen Communication (Weizmann Institute of Science, Israel).                        (organizing committee). Keynote speaker: Nobel laureate Bruce Beutler

2020.              34th Annual Meeting of the European Macrophage and Dendritic Cell Society. Aarhus.                          Chairman of organizing committee

OUTREACH TO SOCIETY

Academic mentor for one High school student under the “Research shoot” program. 3 x Participation in the “book a researcher” event. Teaching/information on research for Science students at Egå and Ikast High Schools.

Numerous participations in TV, news paper, and Science website interviews (e.g. DR, Information, Videnskab.dk). More than 10 press releases following key publications.

COMMISSIONS OF TRUST

Scientific journals

2015-pres.  Associate editor, Journal of Immunology

2012-pres.  Editorial boards: Cytokine; Genes & Immunity

2003-pres.  Ad hoc reviewer. Past year: e.g. Nature, Science, Nat Immunol, and Nat.Med
Funding agencies

2014-pres.  ERC StG evaluation panel LS6 “Infection and Immunity” (chairman 2016 and 2018)

2003-pres.  Ad hoc reviewer e.g. ERC CoG, SyG, Welcome Trust, INSERM, and NIH (PO1)
Academic institutions

2016.         MRC IIB Scientific Review of the MRC Human Immunology Unit, University of Oxford

2010-pres  Evaluation for leading institutions. e.g. The Pasteur Institute (2016), Johns Hopkins Univ (2018), Ecole Polytechnique Federale de Lausanne (2018)

2003-pres. Examiner on 16 PhD theses (11 in DK; 7 in non-DK Europe)

Biotech Industry

2016-pres.  ISD Immunotech (Chair of scientific advisory board). Focus: STING antagonist

2018-pres.  NoToVir (SAB). Focus: Immuno-targeting of virus infections

CAREER BREAKS

6 months paternity leaves. Two month per child (2005, 2007, 2011)

PATENTS

• •  Peptides having immune suppressive domains for transfection (WO 2014/166500A2) •  Modulation of IFI16 and STING activity (WO/2018/029256)

PUBLICATION SUMMARY

Peer-reviewed articles (since 1997): 132

Citations: 10206 (h-index: 49) (source: Scopus)

Top publications (IF>10): Nature Immunology (x4), Nature Medicine (x1), Nature Microbiology (x1), Nature Reviews Immunology (x2), Immunity (x1), Nature Communications (x3), Journal of Experimental Medicine (x1), Journal of Clinical Investigation (x2), Hepatology (x1), Trends Reviews (x3), The EMBO J (x6).

PUBLICATIONS

2021

A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology. / Prabakaran, Thaneas; Troldborg, Anne; Kumpunya, Sarinya; Alee, Isara; Marinković, Emilija; Windross, Samuel J; Nandakumar, Ramya; Narita, Ryo; Zhang, Bao-Cun; Carstensen, Mikkel; Vejvisithsakul, Pichpisith; Marqvorsen, Mikkel H S; Iversen, Marie B; Holm, Christian K; Østergaard, Lars J; Pedersen, Finn Skou; Pisitkun, Trairak; Behrendt, Rayk; Pisitkun, Prapaporn; Paludan, Søren R.

In: EBioMedicine, Vol. 66, 01.04.2021, p. 103314.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun. / Riedel, Maria; Berthelsen, Martin F.; Cai, Huiqiang; Haldrup, Jakob; Borre, Michael; Paludan, Søren R.; Hager, Henrik; Vendelbo, Mikkel H.; Wagner, Erwin F.; Bakiri, Latifa; Thomsen, Martin K.

In: Oncogene, Vol. 40, No. 13, 04.2021, p. 2437–2447.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Constitutive immune mechanisms : mediators of host defence and immune regulation. / Paludan, Søren R.; Pradeu, Thomas; Masters, Seth L.; Mogensen, Trine H.

In: Nature Reviews Immunology, Vol. 21, No. 3, 03.2021, p. 137-150.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice. / Ling, Sikai; Yang, Shiqi; Hu, Xinde; Yin, Di; Dai, Yao; Qian, Xiaoqing; Wang, Dawei; Pan, Xiaoyong; Hong, Jiaxu; Sun, Xiaodong; Yang, Hui; Paludan, Soren Riis; Cai, Yujia.

In: Nature Biomedical Engineering, Vol. 5, No. 2, 02.2021, p. 144-156.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production. / Reinert, Line S; Rashidi, Ahmad S; Tran, Diana N; Katzilieris-Petras, Georgios; Hvidt, Astrid K; Gohr, Mette; Fruhwürth, Stefanie; Bodda, Chiranjeevi; Thomsen, Martin K; Vendelbo, Mikkel H; Khan, Ahmad R; Hansen, Brian; Bergström, Petra; Agholme, Lotta; Mogensen, Trine H; Christensen, Maria H; Nyengaard, Jens R; Sen, Ganes C; Zetterberg, Henrik; Verjans, Georges Mgm; Paludan, Søren R.

In: Journal of Clinical Investigation, Vol. 131, No. 1, e136824, 01.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity. / Fougeroux, Cyrielle; Goksøyr, Louise; Idorn, Manja; Soroka, Vladislav; Myeni, Sebenzile K.; Dagil, Robert; Janitzek, Christoph M.; Søgaard, Max; Aves, Kara Lee; Horsted, Emma W.; Erdoğan, Sayit Mahmut; Gustavsson, Tobias; Dorosz, Jerzy; Clemmensen, Stine; Fredsgaard, Laurits; Thrane, Susan; Vidal-Calvo, Elena E.; Khalifé, Paul; Hulen, Thomas M.; Choudhary, Swati; Theisen, Michael; Singh, Susheel K.; Garcia-Senosiain, Asier; Van Oosten, Linda; Pijlman, Gorben; Hierzberger, Bettina; Domeyer, Tanja; Nalewajek, Blanka W.; Strøbæk, Anette; Skrzypczak, Magdalena; Andersson, Laura F.; Buus, Søren; Buus, Anette Stryhn; Christensen, Jan Pravsgaard; Dalebout, Tim J.; Iversen, Kasper; Harritshøj, Lene H.; Mordmüller, Benjamin; Ullum, Henrik; Reinert, Line S.; de Jongh, Willem Adriaan; Kikkert, Marjolein; Paludan, Søren R.; Theander, Thor G.; Nielsen, Morten A.; Salanti, Ali; Sander, Adam F.

In: Nature Communications, Vol. 12, No. 1, 324, 01.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro. / Svenningsen, Esben B; Thyrsted, Jacob; Blay-Cadanet, Julia; Liu, Han; Lin, Shaoquan; Villameriel, Jaime Moyano; Olagnier, David; Idorn, Manja; Paludan, Søren R; Holm, Christian K; Poulsen, Thomas B.

In: Antiviral Research, Vol. 185, 104988, 01.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Letter › peer-review

2020

Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. / Hait, Alon Schneider; Olagnier, David; Sancho-Shimizu, Vanessa; Skipper, Kristian Alsbjerg; Helleberg, Marie; Larsen, Simon Muller; Bodda, Chiranjeevi; Moldovan, Liviu Ionut; Ren, Fanghui; Brinck Andersen, Nanna-Sophie; Thomsen, Michelle M; Freytag, Mette Ratzer; Darmalinggam, Sathya; Parkes, Isobel; Kadekar, Darshana D; Rahbek, Stine Hess; van der Horst, Demi; Kristensen, Lasse Sommer; Eriksson, Kristina; Kjems, Jørgen; Mostowy, Serge; Christiansen, Mette; Mikkelsen, Jacob Giehm; Brandt, Christian Thomas; Paludan, Søren R; Mogensen, Trine H.

In: Science Immunology, Vol. 5, No. 54, eabc2691, 12.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Author Correction : STEEP mediates STING ER exit and activation of signaling (Nature Immunology, (2020), 21, 8, (868-879), 10.1038/s41590-020-0730-5). / Zhang, Bao-cun; Nandakumar, Ramya; Reinert, Line S.; Huang, Jinrong; Laustsen, Anders; Gao, Zong-liang; Sun, Cheng-long; Jensen, Soren Beck; Troldborg, Anne; Assil, Sonia; Berthelsen, Martin F.; Scavenius, Carsten; Zhang, Yan; Windross, Samuel J.; Olagnier, David; Prabakaran, Thaneas; Bodda, Chiranjeevi; Narita, Ryo; Cai, Yujia; Zhang, Cong-gang; Stenmark, Harald; Doucet, Christine M.; Noda, Takeshi; Guo, Zheng; Goldbach-Mansky, Raphaela; Hartmann, Rune; Chen, Zhijian J.; Enghild, Jan J.; Bak, Rasmus O.; Thomsen, Martin K.; Paludan, Soren R.

In: Nature Immunology, Vol. 21, No. 11, 11.2020, p. 1468-1469.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate › Research › peer-review

Characterization of distinct molecular interactions responsible for IRF₃ and IRF₇ phosphorylation and subsequent dimerization. / Dalskov, Louise; Narita, Ryo; Andersen, Line L.; Jensen, Nanna; Assil, Sonia; Kristensen, Kennith H.; Mikkelsen, Jacob G.; Fujita, Takashi; Mogensen, Trine H.; Paludan, Søren R.; Hartmann, Rune.

In: Nucleic Acids Research, Vol. 48, No. 20, 11.2020, p. 11421-11433.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Corona's new coat : SARS-CoV-2 in Danish minks and implications for travel medicine. / Larsen, Carsten Schade; Paludan, Søren Riis.

In: Travel Medicine and Infectious Disease, Vol. 38, 101922, 11.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Editorial › peer-review

Author Correction : SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob; Blay-Cadanet, Julia; Herengt, Angela; Idorn, Manja; Hait, Alon; Hernaez, Bruno; Knudsen, Alice; Iversen, Marie Beck; Schilling, Mirjam; Jørgensen, Sofie E; Thomsen, Michelle; Reinert, Line S; Lappe, Michael; Hoang, Huy-Dung; Gilchrist, Victoria H; Hansen, Anne Louise; Ottosen, Rasmus; Nielsen, Camilla G; Møller, Charlotte; van der Horst, Demi; Peri, Suraj; Balachandran, Siddharth; Huang, Jinrong; Jakobsen, Martin; Svenningsen, Esben B; Poulsen, Thomas B; Bartsch, Lydia; Thielke, Anne L; Luo, Yonglun; Alain, Tommy; Rehwinkel, Jan; Alcamí, Antonio; Hiscott, John; Mogensen, Trine H; Paludan, Søren R; Holm, Christian K.

In: Nature Communications, Vol. 11, No. 1, 5419, 21.10.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate › Research › peer-review

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. / Olagnier, David; Farahani, Ensieh; Thyrsted, Jacob; Blay-Cadanet, Julia; Herengt, Angela; Idorn, Manja; Hait, Alon; Hernaez, Bruno; Knudsen, Alice; Iversen, Marie Beck; Schilling, Mirjam; Jørgensen, Sofie E; Thomsen, Michelle; Reinert, Line S; Lappe, Michael; Hoang, Huy-Dung; Gilchrist, Victoria H; Hansen, Anne Louise; Ottosen, Rasmus; Nielsen, Camilla G; Møller, Charlotte; van der Horst, Demi; Peri, Suraj; Balachandran, Siddharth; Huang, Jinrong; Jakobsen, Martin; Svenningsen, Esben B; Poulsen, Thomas B; Bartsch, Lydia; Thielke, Anne L; Luo, Yonglun; Alain, Tommy; Rehwinkel, Jan; Alcamí, Antonio; Hiscott, John; Mogensen, Trine H.; Paludan, Søren R; Holm, Christian K.

In: Nature Communications, Vol. 11, No. 1, 4938, 10.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation. / Thim-uam, Arthid; Prabakaran, Thaneas; Tansakul, Mookmanee; Makjaroen, Jiradej; Wongkongkathep, Piriya; Chantaravisoot, Naphat; Saethang, Thammakorn; Leelahavanichkul, Asada; Benjachat, Thitima; Paludan, Søren; Pisitkun, Trairak; Pisitkun, Prapaporn.

In: iScience, Vol. 23, No. 9, 101530, 09.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. / Bodda, Chiranjeevi; Reinert, Line S.; Fruhwürth, Stefanie; Richardo, Timmy; Sun, Chenglong; Zhang, Bao Cun; Kalamvoki, Maria; Pohlmann, Anja; Mogensen, Trine H.; Bergström, Petra; Agholme, Lotta; O'Hare, Peter; Sodeik, Beate; Gyrd-Hansen, Mads; Zetterberg, Henrik; Paludan, Søren R.

In: Journal of Experimental Medicine, Vol. 217, No. 7, e20191422, 07.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation. / Guerra, J.; Valadao, A. L.; Vlachakis, D.; Polak, K.; Vila, I. K.; Taffoni, C.; Prabakaran, T.; Marriott, A. S.; Kaczmarek, R.; Houel, A.; Auzemery, B.; Déjardin, S.; Boudinot, P.; Nawrot, B.; Jones, N. J.; Paludan, S. R.; Kossida, S.; Langevin, C.; Laguette, N.

In: Science Advances, Vol. 6, No. 21, 05.2020, p. eaax3333.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma. / Thomsen, Martin K.; Skouboe, Morten K.; Boularan, Cedric; Vernejoul, Fabienne; Lioux, Thierry; Leknes, Siv L.; Berthelsen, Martin F.; Riedel, Maria; Cai, Huiqiang; Joseph, Justin V.; Perouzel, Eric; Tiraby, Michele; Vendelbo, Mikkel H.; Paludan, Søren R.

In: Oncogene, Vol. 39, No. 8, 02.2020, p. 1652-1664.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient. / Brinck Andersen, Nanna Sophie; Jørgensen, Sofie Eg; Skipper, Kristian Alsbjerg; Larsen, Simon Müller; Heinz, Johanna; Thomsen, Michelle Mølgaard; Farahani, Ensieh; Cai, Yujia; Hait, Alon Schneider; Kay, Lise; Giehm Mikkelsen, Jacob; Høgsbjerg Schleimann, Mariane; Thomsen, Martin Kristian; Paludan, Søren R.; Mogensen, Trine H.

In: Autophagy, 2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

STEEP mediates STING ER exit and activation of signaling. / Zhang, Bao cun; Nandakumar, Ramya; Reinert, Line S.; Huang, Jinrong; Laustsen, Anders; Gao, Zong liang; Sun, Cheng long; Jensen, Søren Beck; Troldborg, Anne; Assil, Sonia; Berthelsen, Martin F.; Scavenius, Carsten; Zhang, Yan; Windross, Samuel J.; Olagnier, David; Prabakaran, Thaneas; Bodda, Chiranjeevi; Narita, Ryo; Cai, Yujia; Zhang, Cong gang; Stenmark, Harald; Doucet, Christine M.; Noda, Takeshi; Guo, Zheng; Goldbach-Mansky, Raphaela; Hartmann, Rune; Chen, Zhijian J.; Enghild, Jan J.; Bak, Rasmus O.; Thomsen, Martin K.; Paludan, Søren R.

In: Nature Immunology, Vol. 21, No. 8, 2020, p. 868-879.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4. / Juul-Madsen, Kristian; Qvist, Per; Bendtsen, Kirstine L; Langkilde, Annette E; Vestergaard, Bente; Howard, Ken; Dehesa-Etxebeste, Martxel; Paludan, Søren R; Andersen, Gregers Rom; Jensen, Poul Henning; Otzen, Daniel E; Romero-Ramos, Marina; Vorup-Jensen, Thomas.

In: Journal of Immunology, Vol. 204, No. 5, 2020, p. 1345-1361.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2019

Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis. / Lafaille, Fabien G.; Harschnitz, Oliver; Lee, Yoon Seung; Zhang, Peng; Hasek, Mary L.; Kerner, Gaspard; Itan, Yuval; Ewaleifoh, Osefame; Rapaport, Franck; Carlile, Thomas M.; Carter-Timofte, Madalina E.; Paquet, Dominik; Dobbs, Kerry; Zimmer, Bastian; Gao, Daxing; Rojas-Duran, Maria F.; Kwart, Dylan; Rattina, Vimel; Ciancanelli, Michael J.; McAlpine, Jessica L.; Lorenzo, Lazaro; Boucherit, Soraya; Rozenberg, Flore; Halwani, Rabih; Henry, Benoit; Amenzoui, Naima; Alsum, Zobaida; Marques, Laura; Church, Joseph A.; Al-Muhsen, Saleh; Tardieu, Marc; Bousfiha, Ahmed Aziz; Paludan, Søren R.; Mogensen, Trine Hyrup; Quintana-Murci, Lluis; Tessier-Lavigne, Marc; Smith, Gregory A.; Notarangelo, Luigi D.; Studer, Lorenz; Gilbert, Wendy; Abel, Laurent; Casanova, Jean Laurent; Zhang, Shen Ying.

In: Nature Medicine, Vol. 25, No. 12, 01.12.2019, p. 1873-1884.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling. / Nandakumar, Ramya; Tschismarov, Roland; Meissner, Felix; Prabakaran, Thaneas; Krissanaprasit, Abhichart; Farahani, Ensieh; Zhang, Bao cun; Assil, Sonia; Martin, Amandine; Bertrams, Wilhelm; Holm, Christian K.; Ablasser, Andrea; Klause, Tanja; Thomsen, Martin K.; Schmeck, Bernd; Howard, Kenneth A.; Henry, Thomas; Gothelf, Kurt V.; Decker, Thomas; Paludan, Søren R.

In: Nature Microbiology, Vol. 4, 04.2019, p. 701-713.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

DNA-stimulated cell death : implications for host defence, inflammatory diseases and cancer. / Paludan, Søren R.; Reinert, Line S.; Hornung, Veit.

In: Nature Reviews Immunology, Vol. 19, No. 3, 01.03.2019, p. 141-153.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection. / Stempel, Markus; Chan, Baca; Juranić Lisnić, Vanda; Krmpotić, Astrid; Hartung, Josephine; Paludan, Søren R.; Füllbrunn, Nadia; Lemmermann, Niels A.W.; Brinkmann, Melanie M.

In: EMBO Journal, Vol. 38, No. 5, e100983, 01.03.2019.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection. / Carter-Timofte, Madalina E; Hansen, Anders F; Christiansen, Mette; Paludan, Søren R; Mogensen, Trine H.

In: Genes and Immunity, Vol. 20, No. 3, 03.2019, p. 214-223.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs. / Frich, Camilla Kaas; Krüger, Franziska; Walther, Raoul; Domar, Cecilie; Andersen, Anna H. F.; Tvilum, Anne ; Dagnæs-Hansen, Frederik; Denton, Paul W.; Tolstrup, Martin; Paludan, Søren Riis; Münch, jJan; Zelikin, Alexander N.

In: Journal of Controlled Release, Vol. 294, 28.01.2019, p. 298-310.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids. / Sun, Chenglong; Luecke, Stefanie; Bodda, Chiranjeevi; Jønsson, Kasper L.; Cai, Yujia; Zhang, Bao Cun; Jensen, Søren B.; Nordentoft, Iver; Jensen, Jacob M.; Jakobsen, Martin R.; Paludan, Sren R.

In: Journal of Interferon and Cytokine Research, Vol. 39, No. 4, 2019, p. 191-204.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate