Livio Luongo

List of publications

2019

1. Boccella S, Guida F, De Logu F, De Gregorio D, Mazzitelli M, Belardo C, Iannotta M, Serra N, Nassini R, de Novellis V, Geppetti P, Maione S, Luongo L. Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain. FASEB J. 2019 ;33(1):1062-1073.
2. Ligresti A, Silvestri C, Vitale RM, Martos JL, Piscitelli F, Wang JW, Allarà M, Carling RW, Luongo L, Guida F, Illiano A, Amoresano A, Maione S, Amodeo P, Woodward DF, Di Marzo V, Marino G. FAAH-Catalyzed C-C Bond Cleavage of a New Multitarget Analgesic Drug. ACS Chem Neurosci. 2018 Oct 4. doi: 10.1021/acschemneuro.8b00315
3. Boccella S, Cristiano C, Romano R, Iannotta M, Belardo C, Farina A, Guida F, Piscitelli F, Palazzo E, Mazzitelli M, Imperatore R, Tunisi L, de Novellis V, Cristino L, Di Marzo V, Calignano A, Maione S, Luongo L. Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.
   Neurobiol Dis. 2019 Jan;121:106-119.
4. Trotta MC, Maisto R, Guida F, Boccella S, Luongo L, Balta C, D'Amico G, Herman H, Hermenean A, Bucolo C, D'Amico M. The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome. PLoS One. 2019 Jan 18;14(1):e0211005.
5. Schiano C, Grimaldi V, Boccella S, Iannotta M, Zullo A, Luongo L, Mancini FP, Maione S, Napoli C. Sweeteners modulate bioactivity of endothelial progenitor cells but not induce detrimental effects both on inflammation and behavioural changes. Int J Food Sci Nutr. 2019 18:1-13

2018:

1. Marabese I, Boccella S, Iannotta M, Luongo L, de Novellis V, Guida F, Serra N, Farina A, Maione S, Palazzo E. Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats. Neuropharmacology. 2018;135:86-99.

1. Luongo L, Salvemini D. Targeting metabotropic adenosine receptors for neuropathic pain: Focus on A2A. Brain Behav Immun. 2018;69:60-61.

1. Wahlman C, Doyle TM, Little JW, Luongo L, Janes K, Chen Z, Esposito E, Tosh DK, Cuzzocrea S, Jacobson KA, Salvemini D. Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms. Pain. 2018 ;159(6):1025-1034.

1. Boccella S, Guida F, Palazzo E, Marabese I, de Novellis V, Maione S,
   Luongo L. Spared Nerve Injury as a Long-Lasting Model of Neuropathic Pain. Methods Mol Biol. 2018;1727:373-378

1. Petrelli R, Scortichini M, Belardo C, Boccella S,
   Luongo L, Capone F, Kachler S, Vita P, Del Bello F, Maione S, Lavecchia A, Klotz KN, Cappellacci L. Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A1 Adenosine Receptor Agonists. J Med Chem. 2018;61(1):305-318

1. Mhillaj E, Morgese MG, Tucci P, Furiano A, Luongo L, Bove M, Maione S, Cuomo V, Schiavone S, Trabace L. Celecoxib Prevents Cognitive Impairment and Neuroinflammation in Soluble Amyloid β-treated Rats. Neuroscience. 2018;372:58-73.

1. Coraggio V, Guida F, Boccella S, Scafuro M, Paino S, Romano D, Maione S,
   Luongo L. Neuroimmune-Driven Neuropathic Pain Establishment: A Focus on Gender Differences. Int J Mol Sci. 2018;19(1).

1. Guida F, Turco F, Iannotta M, De Gregorio D, Palumbo I, Sarnelli G, Furiano A, Napolitano F, Boccella S,
   Luongo L, Mazzitelli M, Usiello A, De Filippis F, Iannotti FA, Piscitelli F, Ercolini D, de Novellis V, Di Marzo V, Cuomo R, Maione S. Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice. Brain Behav Immun. 2018 Jan;67:230-245.

 

2017

 

1. D'Aniello A, Luongo L, Romano R, Iannotta M, Marabese I, Boccella S, Belardo C, de Novellis V, Arra C, Barbieri A, D'Aniello B, Scandurra A, Magliozzi L, Fisher G, Guida F, Maione S. d-Aspartic acid ameliorates painful and neuropsychiatric changes and reduces β-amyloid Aβ1-42 peptide in a long lasting model of neuropathic pain. Neurosci Lett. 2017;651:151-158.

1. Petrelli R, Scortichini M, Kachler S, Boccella S, Cerchia C, Torquati I, Del Bello F, Salvemini D, Novellino E,
   Luongo L, Maione S, Jacobson KA, Lavecchia A, Klotz KN, Cappellacci L. Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice. J Med Chem. 2017; 60(10):4327-4341.

1. Guida F*, Luongo L*, Boccella S, Giordano ME, Romano R, Bellini G, Manzo I, Furiano A, Rizzo A, Imperatore R, Iannotti FA, D'Aniello E, Piscitelli F, Sca Rossi F, Cristino L, Di Marzo V, de Novellis V, Maione S. Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor. Sci Rep. 2017;7(1):375.

1. Guida F, Boccella S, Iannotta M, De Gregorio D, Giordano C, Belardo C, Romano R, Palazzo E, Scafuro MA, Serra N, de Novellis V, Rossi F, Maione S,
   Luongo L. Palmitoylethanolamide Reduces Neuropsychiatric Behaviors by Restoring Cortical Electrophysiological Activity in a Mouse Model of Mild Traumatic Brain Injury. Front Pharmacol. 2017;8:95.

1. Luongo L, Starowicz K, Maione S, Di Marzo V. Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE). Pharmacol Res. 2017 ;119:272-277.

1. Bellini G, Torella M, Manzo I, Tortora C, Luongo L, Punzo F, Colacurci N, Nobili B, Maione S, Rossi F. PKCβII-mediated cross-talk of TRPV1/CB2 modulates the glucocorticoid-induced osteoclast overactivity. Pharmacol Res. 2017;115:267-274.

1. Palazzo E, Marabese I, Luongo L, Guida F, de Novellis V, Maione S. Nociception modulation by supraspinal group III metabotropic glutamate receptors. J Neurochem. 2017;141(4):507-519.

2016:

1. Rossi F, Bellini G, Luongo L, Manzo I, Tolone S, Tortora C, Bernardo ME, Grandone A, Conforti A, Docimo L, Nobili B, Perrone L, Locatelli F, Maione S, Del Giudice EM.
   Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation.
   J Clin Endocrinol Metab. 2016 ;101(9):3469-78.
2. Palazzo E, Luongo L, Guida F, Marabese I, Romano R, Iannotta M, Rossi F, D'Aniello A, Stella L, Marmo F, Usiello A, de Bartolomeis A, Maione S, de Novellis V. D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice. Amino Acids. 2016
3. Moriello AS, Luongo L, Guida F, Christodoulou MS, Perdicchia D, Maione S, Passarella D, Di Marzo V, De Petrocellis L. Chalcone derivatives activate and desensitize the transient receptor potential ankyrin 1 cation channel, subfamily A, member 1 TRPA1 ion channel: structure-activity relationships in vitro and anti-nociceptive and anti-inflammatory activity in vivo. CNS Neurol Disord Drug Targets. 2016
   In press
4. Punzo D, Errico F, Cristino L, Sacchi S, Keller S, Belardo C,
   Luongo L, Nuzzo T, Imperatore R, Florio E, De Novellis V, Affinito O, Migliarini S, Maddaloni G, Sisalli MJ, Pasqualetti M, Pollegioni L, Maione S, Chiariotti L, Usiello A. Age-Related Changes in d-Aspartate Oxidase Promoter Methylation Control Extracellular d-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging.
   J Neurosci. 2016;36(10):3064-78.
5. Aiello F, Badolato M, Pessina F, Sticozzi C, Maestrini V, Aldinucci C,
   Luongo L, Guida F, Ligresti A, Artese A, Allarà M, Costa G, Frosini M, Schiano Moriello A, De Petrocellis L, Valacchi G, Alcaro S, Maione S, Di Marzo V, Corelli F, Brizzi A. Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress. ACS Chem Neurosci. 2016 In press.
6. Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A,
   Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016;59(6):2612-32.
7. Cristino L*, Luongo L*, Imperatore R, Boccella S, Becker T, Morello G, Piscitelli F, Busetto G, Maione S, Di Marzo V. Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signalling Deficiency. Neuropsychopharmacology. 2016 Jan;41(2):508-20

2015

1. Rinaldi B, Guida F, Furiano A, Donniacuo M, Luongo L, Gritti G, Urbanek K, Messina G, Maione S, Rossi F, de Novellis V. Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction. Neural Plast. 2015;2015:265967. doi: 10.1155/2015/265967
2. Guida F*, Luongo L*, Marmo F, Romano R, Iannotta M, Napolitano F, Belardo C, Marabese I, D'Aniello A, De Gregorio D, Rossi F, Piscitelli F, Lattanzi R, de Bartolomeis A, Usiello A, Di Marzo V, de Novellis V, Maione S. Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice. Mol Brain.
   2015 Aug 12;8:47. doi: 10.1186/s13041-015-0139-5
3. Imperatore R, Morello G, Luongo L, Taschler U, Romano R, De Gregorio D, Belardo C, Maione S, Di Marzo V, Cristino L. Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB1 R signaling and anxiety-like behavior. J Neurochem. 2015. doi: 10.1111/jnc.13267
4. Rossi F, Bellini G, Tortora C, Bernardo ME, Luongo L, Conforti A, Starc N, Manzo I, Nobili B, Locatelli F, Maione S. CB2 and TRPV1 receptors oppositely modulate in vitro human osteoblast activity. Pharmacol Res. 2015. pii: S1043-6618(15)00124-3. doi: 10.1016/j.phrs.2015.06.010
5. Lorenzo Di Cesare Mannelli, Alessandra Pacini, Francesca Corti, Serena Boccella,
   Livio Luongo, Emanuela Esposito, Salvatore Cuzzocrea, Sabatino Maione, Antonio Calignano, Carla Ghelardini Antineuropathic profile of N-Palmitoylethanolamine in a rat model of oxaliplatin-induced neurotoxicity, Plos One
   in press
6. Calzetta L, Luongo L, Cazzola M, Page C, Rogliani P, Facciolo F, Maione S, Capuano A, Rinaldi B, Matera MG.
   Contribution of sensory nerves to LPS-induced hyperresponsiveness of human isolated bronchi. Life Sci. 2015;131:44-50.
   
7. Luongo L, Malcangio M, Salvemini D, Starowicz K. Chronic pain: new insights in molecular and cellular mechanisms. Biomed Res Int.; 2015:676725.
   
8. Spaziano G°, Luongo L°, Guida F, Petrosino S, Matteis M, Palazzo E, Sullo N, de Novellis V, Di Marzo V, Rossi F, Maione S, D'Agostino B. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. Biomed Res Int.; 2015:980983.
   
9. Cristino L°, Luongo L°, Squillace M, Paolone G, Mango D, Piccinin S, Zianni E, Imperatore R, Iannotta M, Longo F, Errico F, Vescovi AL, Morari M, Maione S, Gardoni F, Nisticò R, Usiello A. d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain. Neurobiol Aging. 2015; 36(5):1890-902.
   
10. Palazzo E, Romano R, Luongo L, Boccella S, De Gregorio D, Giordano ME, Rossi F, Marabese I, Scafuro MA, de Novellis V, Maione S. MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. Pain. 2015;156(6):1060-73.
    
11. Petrelli R, Torquati I, Kachler S, Luongo L, Maione S, Franchetti P, Grifantini M, Novellino E, Lavecchia A, Klotz KN, Cappellacci L. 5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists. J Med Chem. 2015;58(5):2560-6.
    
12. Lopez-Canul M, Palazzo E, Dominguez-Lopez S, Luongo L, Lacoste B, Comai S, Angeloni D, Fraschini F, Boccella S, Spadoni G, Bedini A, Tarzia G, Maione S, Granados-Soto V, Gobbi G. Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain. 2015;156(2):305-17.
    
13. Maione S, Radanova L, De Gregorio D, Luongo L, De Petrocellis L, Di Marzo V, Imming P. Effects of metabolites of the analgesic agent dipyrone (metamizol) on rostral ventromedial medulla cell activity in mice. Eur J Pharmacol. 2015;748:115-22.
14. Guida F, Lattanzi R, Boccella S, Maftei D, Romano R, Marconi V, Balboni G, Salvadori S, Scafuro MA, de Novellis V, Negri L, Maione S,
    Luongo L. PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice.
    Pharmacol Res. 2015;91:36-46.
15. Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J,
    Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, Salvemini D. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain. 2015;138(Pt 1):28-35.
    

       2014:

 

1. Rossi F, Perrotta S, Bellini G, Luongo L, Tortora C, Siniscalco D, Francese M, Torella M, Nobili B, Di Marzo V, Maione S. Iron overload causes osteoporosis in Thalassemia Major patients through interaction with TRPV1 channels. Haematologica. 2014, 99(12):1876-84
2. Maftei D, Marconi V, Florenzano F, Giancotti LA, Castelli M, Moretti S, Borsani E, Rodella LF, Balboni G,
   Luongo L, Maione S, Sacerdote P, Negri L, Lattanzi R. Controlling the activation of the Bv8/Prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals. Br J Pharmacol. 2014, 171(21):4850-65
   
3. Brizzi A, Aiello F, Marini P, Cascio MG, Corelli F, Brizzi V, De Petrocellis L, Ligresti A,
   Luongo L, Lamponi S, Maione S, Pertwee RG, Di Marzo V 
   Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist. Bioorg Med Chem. 2014 ;22(17):4770-83.
4. Luongo L, Maione S, Di Marzo V. Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions. Eur J Neurosci. 2014;39(3):401-8
   
5. Rossi F, Bellini G, Torella M, Tortora C, Manzo I, Giordano C, Guida F, Luongo L, Papale F, Rosso F, Nobili B, Maione S. The genetic ablation or pharmacological inhibition of TRPV1 signalling is beneficial for the restoration of quiescent osteoclast activity in ovariectomized mice. Br J Pharmacol. 2014; 171(10):2621-30
   
6. Rossi F, Marabese I, De Chiaro M, Boccella S, Luongo L, Guida F, De Gregorio D, Giordano C, de Novellis V, Palazzo E, Maione S. Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions. J Neurophysiol. 2014;111(11):2196-209
   
7. Luongo L, Guida F, Imperatore R, Napolitano F, Gatta L, Cristino L, Giordano C, Siniscalco D, Di Marzo V, Bellini G, Petrelli R, Cappellacci L, Usiello A, de Novellis V, Rossi F, Maione S. The A1 adenosine receptor as a new player in microglia physiology. Glia. 2014;62(1):122-32
8. Ligresti A, Martos J, Wang J, Guida F, Allarà M, Palmieri V, Luongo L, Woodward D, Di Marzo V. Prostamide F(2) α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition. Br J Pharmacol. 2014;171(6):1408-19

          2013:

 

1. Rossi F, Bernardo ME, Bellini G, Luongo L, Conforti A, Manzo I, Guida F, Cristino L, Imperatore R, Petrosino S, Nobili B, Di Marzo V, Locatelli F, Maione S. The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. PLoS One. 2013;
   8(11):e80022
2. Palazzo E, Marabese I, Luongo L, Boccella S, Bellini G, Giordano ME, Rossi F, Scafuro M, Novellis Vd, Maione S. Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat.
   Mol Pain. 2013;9:44.
3. De Scalzi F, Ulivi V, Cancedda R, Piscitelli F, Luongo L, Guida F. Gatta L, Maione s , Di Marzo V. Platelet Rich Plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. Tissue Eng Part A. 2013 9(19-20):2120-9.
4. Luongo L, Guida F, Boccella S, Bellini G, Gatta L, Rossi F, de Novellis V, Maione S. Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice. CNS Neurol Disord Drug Targets. 2013;12(1):45-54.
   
5. Caraglia M, Luongo L, Salzano G, Zappavigna S, Marra M, Guida F, Lusa S, Giordano C, de Novellis V, Rossi F, Abbruzzese Saccardi A, De Rosa G, Maione S. Stealth liposomes encapsulating zoledronic acid: a new opportunity to treat neuropathic pain. Mol Pharm. 2013, 10(3):1111-8.
6. Luongo L, Petrelli R, Gatta L, Giordano C, Guida F, Vita P, Franchetti P, Grifantini M, de Novellis V, Cappellacci L, Maione S. 5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions. Molecules. 2012;17(12):13712-26.
   
7. Rossi F, Bellini G, Luongo L, Mancusi S, Torella M, Tortora C, Manzo I, Guida F, Nobili B, de Novellis V, Maione S. The 17-β-oestradiol inhibits osteoclast activity by increasing the cannabinoid CB2 receptor expression. Pharmacol Res. 2013 ;68(1):7-15.
8. Luongo L, de Novellis V, Gatta L, Palazzo E, Vita D, Guida F, Giordano C, Siniscalco D, Marabese I, De Chiaro M, Boccella S, Rossi F, Maione S. Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat. Neuropharmacology. 2013; 66:317-29.
   

            2012:

 

1. Guida F, Luongo L, Aviello G, Palazzo E, De Chiaro M, Gatta L, Boccella S, Marabese I, Zjawiony JK, Capasso R, Izzo AA, de Novellis V, Maione S. Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. Mol Pain. 2012;8:60.
2. Luongo L, Costa B, D'Agostino B, Guida F, Comelli F, Gatta L, Matteis M, Sullo N, De Petrocellis L, de Novellis V, Maione S, Di Marzo V. Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature. Pharmacol Res. 2012;66(3):243-50.
   
3. Palazzo E, Luongo L, Bellini G, Guida F, Marabese I, Boccella S, Rossi F, Maione S, de Novellis V. Changes in Cannabinoid Receptor Subtype 1 Activity and Interaction with Metabotropic Glutamate Subtype 5 Receptors in the Periaqueductal Gray-Rostral Ventromedial Medulla Pathway in a Rodent Neuropathic Pain Model. CNS Neurol Disord Drug Targets. 2012
   11(2):148-61.
4. Pasquini S, Mugnaini C, Ligresti A, Tafi A, Brogi S, Falciani C, Pedani V, Pesco N, Guida F, Luongo L, Varani K, Borea PA, Maione S, Di Marzo V, Corelli F. Design, synthesis, and pharmacological characterization of indol-3-ylacetamides, indol-3-yloxoacetamides, and indol-3-ylcarboxamides: potent and selective CB2 cannabinoid receptor inverse agonists.
   J Med Chem. 2012;55(11):5391-402.
5. Rossi F, Bellini G, Tolone C, Luongo L, Mancusi S, Papparella A, Sturgeon C, Fasano A, Nobili B, Perrone L, Maione S, Miraglia Del Giudice E. The Cannabinoid Receptor type 2 Q63R variant increases the risk of celiac disease: Implication for a novel molecular biomarker and future therapeutic intervention. Pharmacol Res. 2012; 66(1):88-94
   
6. Mugnaini C, Nocerino S, Pedani V, Pasquini S, Tafi A, De Chiaro M, Bellucci L, Valoti M, Guida F,
   Luongo L, Dragoni S, Ligresti A, Rosenberg A, Bolognini D, Cascio MG, Pertwee RG, Moaddel R, Maione S, Di Marzo V, Corelli F. Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part 5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach. ChemMedChem. 2012;7(5):920-34.
   
7. de Novellis V°, Luongo L°, Guida F, Cristino L, Palazzo E, Russo R, Marabese I, D'Agostino G, Calignano A, Rossi F, Di Marzo V, Maione S. Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity. Eur J Pharmacol. 2012 ;676(1-3):41-50.
   
8. Lattanzi R, Sacerdote P, Franchi S, Canestrelli M, Miele R, Barra D, Visentin S, DeNuccio C, Porreca F, De Felice M, Guida F, Luongo L, de Novellis V, Maione S, Negri L. Pharmacological activity of a Bv8 analogue modified in position 24. Br J Pharmacol. 2012;166(3):950-63.

2011:

 

1. Giordano C°, Cristino L°, Luongo L°, Siniscalco D, 
   Petrosino S, Fabiana P, Marabese I, Gatta L, Rossi F,  Imperatore R, Palazzo E, de Novellis V, 
   Di Marzo V and Maione S. TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception, 2011 Cerebral Cortex, 22(11):2495-518
   
2. D Siniscalco, C Giordano, U Galderisi, L Luongo, V de Novellis, F Rossi and S Maione.
   Long lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviours, cellular and biomolecular modifications in neuropathic mice Front Integr Neurosci. 2011;5:79
   
3. Palazzo E, Luongo L, de Novellis V, Rossi F, Marabese I, Maione S. Transient receptor potential vanilloid type 1 and pain development. Curr Opin Pharmacol. 2011
   
4. Palazzo E, Guida F, Gatta L, Luongo L, Boccella S, Bellini G, Marabese I, de Novellis V, Rossi F, Maione S. EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat. Mol Pain. 2011 ;7(1):82.
   
5. Pasquini S, De Rosa M, Pedani V, Mugnaini C, Guida F, Luongo L, De Chiaro M, Maione S, Dragoni S, Frosini M, Ligresti A, Di Marzo V, Corelli F. Investigations on the 4-quinolone-3-carboxylic acid motif.
   4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. 
   J Med Chem. 2011;54(15):5444-53
6. G Aviello, F Borrelli, F Guida, B Romano, K Lewellyn, M De Chiaro,
   L Luongo, J K Zjawiony, S Maione, A A Izzo, R Capasso Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo J Mol Med. 2011 89(9):891-902.
   
7. Giordano C, Siniscalco D, Melisi D, Luongo L, Curcio A, Soukupova M, Palazzo E, Marabese I, De Chiaro M, Rimoli MG, Rossi F, Maione S, de Novellis V. The galactosylation of N(ω)-nitro-L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic mice. Eur J Pharmacol. 2011;656(1-3):52-62.
   
8. de Novellis V, Vita D, Gatta L, Luongo L, Bellini G, De Chiaro M, Marabese I, Siniscalco D, Boccella S, Piscitelli F, Di Marzo V, Palazzo E, Rossi F, Maione S. The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats. Mol Pain. 2011;7:7
   
9.  Rossi Francesca, Bellini Giulia,
   Luongo Livio, Torella Marco, Mancusi Silvia, De Petrocellis Luciano, Petrosino Stefania, Siniscalco Dario, Colacurci Nicola, Perrotta Silverio, Nobili Bruno, Di Marzo Vincenzo, Maione Sabatino The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy. Bone 2011;48(5):997-1007
10. Enza Palazzo, Ida Marabese, Marie Soukupova, Livio Luongo, Serena Boccella, Catia Giordano, Vito de Novellis, Francesca Rossi and Sabatino Maione.
    Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release and rostral ventromedial medulla cell activity in inflammatory pain. The Journal of Neuroscience 2011;31(12):4687-97
    
11. De Filippis D, Luongo L, Cipriano M, Palazzo E, Cinelli MP, de Novellis V, Maione S and Iuvone T Palmitoylthanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. Molecular Pain 2011, 7:3

2010:

 

1. Palazzo E, Luongo L, de Novellis V, Berrino L, Rossi F, Maione S. Moving towards supraspinal TRPV1 receptors for chronic pain relief. 
   Mol Pain. 2010; 6:66.
2. Soukupova M, Palazzo E, Chiaro MD, Gatta L, Migliozzi AL, Guida F,
   Luongo L, Giordano C, Siniscalco D, Novellis VD, Marabese I, Krsiak M, Maione S. Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol. Neuro Endocrinol Lett. 2010;31(4)
   
3. Enza Palazzo , Livio Luongo , Vito de Novellis , Francesco Rossi 
   and Sabatino Maione, The Role of Cannabinoid Receptors in the Descending Modulation of Pain, Pharmaceuticals 2010, 3(8), 2661-2673
   
4. Siniscalco D, Giordano C, Galderisi U, Luongo L, Alessio N, Di Bernardo G, de Novellis V, Rossi F, Maione S.
   Human mesenchymal stem cells as novel neuropathic pain tool. J Stem Cells Regen Med. 2010 ;6(2):127.
   
5. Pasquini S, Ligresti A, Mugnaini C, Semeraro T, Cicione L, De Rosa M, Guida F,
   Luongo L, De Chiaro M, Cascio MG, Bolognini D, Marini P, Pertwee R, Maione S, Di Marzo V, Corelli F. Investigations on the 4-quinolone-3-carboxylic acid motif.
   3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands.J Med Chem. 2010;53(16):5915-28
6. Luongo L, Palazzo E, de Novellis V, Maione S. Role of endocannabinoid system in neuron-glia cross-talk .
   The Open Pain Journal, 2010, 3, 29-36
7. Siniscalco D, Giordano C, Galderisi U, Luongo L, Alessio N, Di Bernardo G, de Novellis V, Rossi F, Maione S. Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice. Cell Mol Life Sci. 2010 ;67(4):655-69.
8. Luongo L, Palazzo E, Tambaro S, Giordano C, Gatta L, Scafuro MA, Rossi FS, Lazzari P, Pani L, de Novellis V, Malcangio M, Maione S. 1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice. Neurobiol Dis. 2010;37(1):177-85
   

          2009:

 

1. Palazzo E, Guida F, Migliozzi A, Gatta L, Marabese I,
   Luongo L, Rossi C, de Novellis V, Fernández-Sánchez E, Soukupova M, Zafra F, Maione S. Intraperiaqueductal gray glycine and D-serine exert dual effects on rostral ventromedial medulla ON- and OFF-cell activity and thermoceptive threshold in the rat. J.Neurophysiol. 2009;102(6):3169-79.
2. Maione S, Starowicz K, Cristino L,  Guida F, 
   Palazzo E, Luongo L, Rossi F, Marabese I , de Novellis V and Di Marzo V. Functional interaction between TRPV1 and μ-opioid receptors in descending antinociceptive pathway activates glutamate transmission and induces analgesia. J. Neurophys., 2009;101(5):2411-22.
3. Franchetti P, Cappellacci L, Vita P, Petrelli R, Lavecchia A, Kachler S, -Norbert K, Marabese I,
   Luongo L, Maione S, and Grifantini M, N6-Cycloalkyl-, and N6-Bicycloalkyl-C5'(C2')-modified Adenosine Derivatives as High-Affinity and Selective Agonists at Human A1 Adenosine Receptor with Antinociceptive Effects in Mice J. Med. Chem., 2009;52(8):2393-406
4. Rossi F, Siniscalco D, Luongo L, De Petrocellis L, Bellini G, Petrosino S,Torella M, Santoro C, Nobili B, Perrotta S, Di Marzo V, Maione S,
   The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption,
   BONE 2009, 44:476-84

2008:

1. Maione S, Morera E, Marabese I, Ligresti A, Luongo L, Ortar G, Di Marzo V. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. Br J Pharmacol. 2008, 155:775-82.
2. de Novellis V, Palazzo E, Rossi F, De Petrocellis L, Petrosino S, Guida F,
   Luongo L, Migliozzi A, Cristino L, Marabese I, Starowicz K, Di Marzo V, Maione S;.The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. Neuropharmacology. 2008, 55(7):1105-13.
   
3. Luongo L, Sajic M, Grist J, Clark AK, Maione S, Malcangio M. Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barré syndrome. Neurosci Lett. 2008, 30;437(2):98-102.
   
4. Siniscalco D, Giordano C, Fuccio C, Luongo L, Ferraraccio F, Rossi F, de Novellis V, Roth KA, Maione S. Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats. Pharmacol Res. 2008, 57(3):223-33.

2007:

1. Maione S, de Novellis V, Cappellacci L, Palazzo E, Vita D,
   Luongo L, Stella L, Franchetti P, Marabese I, Rossi F, Grifantini M.The antinociceptive effect of 2-chloro-2'-C-methyl-N6-cyclopentyladenosine (2'-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat. Pain 2007, 131(3):281-92.
   
2. Siniscalco D, Fuccio C, Giordano C, Ferraraccio F, Palazzo E,
   Luongo L, Rossi F, Roth KA, Maione S, de Novellis V. Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain. Pharmacol Res. 2007, 55(2):158-66.