بسم الله الرحمن الرحیم

گزارشیاز فعالیت­های آموزشی،پژوهشی و درمانی

دکتر آزاده کیومرثی

فوق تخصص خون و سرطان و پیوند سلول های بنیادی کودکان

استادیار پژوهشی دانشگاه علوم پزشکی تهران (پژوهشکده انکولوژی- هماتولوژی و سل تراپی)

مشخصات عمومي 

*     نام پدر: طهمورث

*     تاریخ تولد: 21/01/1362 

*     محل تولد: تهران

*     کد ملی: 0064743896

سوابق تحصيلي و تجربی

• کسب ديپلم تجربی از دبيرستان
  نمونه مردمی هدی تهران و ورود به دوره پزشکی عمومی دانشگاه علوم پزشکی شهید بهشتی در سال 1380
• احراز شرایط آیین نامه استعداد های درخشان (EDC) در سال 1387
• فارغ التحصیلی از دوره پزشکی عمومی و ورود به دستیاری تخصصی کودکان در سال 1388
• فارغ التحصیلی از دوره دستیاری و کسب دانشنامه تخصصی کودکان و رتبه چهارم کشوری در سال 1391
• گذراندن مدت 9 ماه از دوره تعهدات خدمت در دانشگاه علوم پزشکی شهید بهشتی (در بیمارستان لقمان) با سمت هیئت علمی آموزشی ضریب کا در سال 1391-1392
• تدریس در دانشکده پرستاری و مامایی دانشگاه علوم پزشکی شهید بهشتی در سال 1391-1392
• ورود به دوره دستیاری فوق تخصصی خون و انکولوژی کودکان دانشگاه علوم پزشکی ایران در سال 1392
• فارغ التحصیلی از دوره دستیاری فوق تخصصی خون و انکولوژی کودکان با رتبه برتر در سال 1396
• گذراندن دوره 6 ماهه پیوند سلول های بنیادی در بیمارستان شریعتی در سال 1397
• گذراندن دوره پیشرفته استفاده از نرم افزارهای آماری و نگارش مقالات مرور سیستماتیک و کارآزمایی بالینی در سال 1397

• شروع به کار از آبان 1398 در پژوهشکده انکولوژی، هماتولوژی و سل تراپی به عنوان پژوهشگر غیرهیات علمی و سپس به عنوان هیات علمی پژوهشی ضریب کا از اسفند 1398 تا کنون.
• مشارکت در درمان و انجام بیش از  200مورد پیوند سلول های بنیادی در گروه سنی کودک و نوجوان
• برگزاری کلاس های آموزشی برای کارآموزان بخش هماتولوژی و انکولوژی
  
• برگزاری کلاس های آموزشی برای دستیاران فوق تخصص خون و سرطان کودکان و بالغین
• مشارکت درنگارش گایدلاین کووید-19 در بیماران انکولوژی مورد تایید معاونت درمان وزارت بهداشت ، درمان و آموزش پزشکی
• مشارکت درنگارش “ شناسنامه و استاندارد خدمت سلول های بنیادی (پروژنیتور) خونساز؛ پیوند آلوژنیک برای هر اهداکننده” ( معاونت درمان وزارت بهداشت ، درمان و آموزش پزشکی)
• مشارکت درنگارش “ شناسنامه و استاندارد خدمت سلول های بنیادی (پروژنیتور) خونساز؛ پیوند اتولوگ 
  برای هر اهداکننده” ( معاونت درمان وزارت بهداشت ، درمان و آموزش پزشکی)

طرح های تحقیقاتی:
(Ongoing/finished)

1. Phase I Clinical Trial on the Safety of Anti-CD19 CAR-T Cells in Treatment of Patients with Relapsed/Refractory Acute B-Cell Lymphoblastic Leukemia (R/R B-ALL).
2. Donor-derived BK Virus-Specific Cytotoxic T Lymphocyte Therapy For Hemorrhagic Cystitis Following Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation: A Pilot Study
   
3. Evaluation of Clinical Variables associated with the Occurrence and Severity of Hemorrhagic Cystitis after Allogeneic Hematopoietic Cell Transplantation in Pediatric Patients with Acute Leukemia
4. Unmanipulated Peripheral Blood Stem Cell Transplantation with non-TBI Myeloablative Conditioning Regimen from Haploidentical and Unrelated versus Related Donors for Acute Leukemia in Children, Adolescents and Young Adults (CAYA): A Competing Risk Analysis
5. Post-transplant Infusuion of Expanded, Activated Haploidentical Natural Killer Cells in Haploidentical Hematopoietic Stem Cell Transplantation for Pediatric Patients with Acute Myeloid Leukemia: A Pilot Study
6. Expanded, Activated Haploidentical Natural Killer Cells Infusion before Autologous Stem Cell Transplantation in High risk Neuroblastoma: A prospective single arm study
7. The Effect of Bone Marrow-Derived Mesenchymal Stem Cells Co-transplantation with Hematopoietic Stem Cells on Liver Fibrosis Alleviation in Patients with β-thalassemia Major.
8. Evaluation of Fertility in male thalassemic patients who had undergone Hematopoietic Stem cell Transplantation.
   
9. Long-term outcome of a pediatric-inspired regimen used for Acute Lymphoblastic Leukemia in Adolescent and Young Adult Patients: A Non- Randomized Clinical Trial.
   

10.  Design and developing an erythroid-specific lentiviral vector driving the expression of the human β-globin gene.

11.  Evaluation of overall survival and disease free survival in patients with thalassemia major class III underwent HSCT with Flu-Bu-Cy as conditioning regimen.

12.  Evaluation of OS and DFS in adolescent and young adult patients with Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia by adding Bortezomib to Augmented BFM protocol.

13.  Evaluation of the relationship between Cytogenetics and treatment outcome in adolescents and young adults with acute lymphoblastic leukemia (ALL).

14.  Identifying Philadelphia Chromosome-Like Signature For Therapeutic Targeting and Clinical Intervention in adolescents and young adults with acute lymphoblastic leukemia (ALL).

15.  Outcome of Cord-blood transplantation from related and unrelated donors in Shariati Hospital.

16.  Expanded, Activated Haploidentical Natural Killer Cells Infusion before Autologous Stem Cell Transplantation in High risk Neuroblastoma: A prospective single arm study.

17.  Impact of donor KIR genotype on the outcome of haploidentical Hematopoietic stem-cell transplantation (HSCT) in Acute myeloid leukemia (AML) patients.

مقالات:

1. Ansari Sh, Kiumarsi A, Rostami T. Cardiac Impairment Due To Hypocalcemia In A Multitransfused Patient With Thalassemia Major. The Internet Journal of Hematology. 2014 Volume 10 Number 1.
2. Ansari Sh, Rostami T, Kiumarsi A. Central Hypothyroidism: A Rare Complication in a Child Undergoing Chemotherapy for Acute Lymphoblastic Leukemia. IRANIAN JOURNAL OF BLOOD AND CANCER Volume 7 Issue 1 Autumn 2014.
3. Ansari S, Kiumarsi A, Rostami T, Shirzadi E.  Fungal Infections in Pediatric Patients with Hematologic Malignancies. IRANIAN JOURNAL OF BLOOD AND CANCER .Volume 6 Issue 4 Summer 2014.
4. Ansari Sh, Sabzechian M, Kiumarsi A, Sabzechian M, Rostami T, Rouhani F. Suppression of adrenal axis function after high-dose steroid therapy for childhood acute lymphoblastic leukemia in Iran. 
   International Journal of Contemporary Pediatrics  Int J Contemp Pediatr. 2014 Nov;1(3):164-167.
5. Ansari Sh, Kiumarsi A, Rostami T. Cytomegalovirus retinitis in a child with lymphoblastic lymphoma. memo - Magazine of European Medical Oncology, March, 2015. DOI 10.1007/s12254-015-0195-7.
6. Khatami A, Allameh MM, Shahnazi M, Kiumarsi A, Tajik A. A comparison between gastroesophagheal ultrasonography vs. barium swallow in determining the pattern of gastroesophageal reflux in a pediatric population. Medical Ultrasonography, March 2015, Volume 17, Number 1.
7. Arjmandi K, Rostami T, Yusefian S, Miri-Aliabad G, Kiumarsi A, Mehrazma M. Brain Metastasis in Wilms' Tumor: a Case Report. Acta Medica Iranica. 2015 Nov 29;53(11):731-2.
8. Ansari S, Azarkeivan A, Miri-Aliabad G, Yousefian S, Rostami T. Comparison of iron chelation effects of deferoxamine, deferasirox, and combination of deferoxamine and deferiprone on liver and cardiac T2* MRI in thalassemia maior. Caspian journal of internal medicine. 2017;8(3):159.
9. Behfar M, Dehghani SS, Rostami T, Ghavamzadeh A, Hamidieh AA. Non‐sibling hematopoietic stem cell transplantation using myeloablative conditioning regimen in children with Maroteaux‐Lamy syndrome: A brief report. Pediatric transplantation. 2017 Aug;21(5):e12981.

10.  Rostami T, Hamidieh AA, Behfar M, Hosseini AS, Ghavamzadeh A. Allogeneic Hematopoietic Stem Cell Transplantation for Pediatric Acute B-Cell Lymphoblastic Leukemia Carrying High Risk Chromosomal Translocations: A Retrospective Single Center Study. Biology of Blood and Marrow Transplantation. 2017 Mar 1;23(3):S244.

11.  Hamidieh AA, Rostami T, Ostadali M, Behfar M, Hosseini AS, Ghavamzadeh A. Outcomes of Unrelated Donor Hematopoietic Stem Cell Transplantation for Pediatric Patients: The First Report From Iran. Biology of Blood and Marrow Transplantation. 2017 Mar 1;23(3):S122.

12.  Hamidieh AA, Rostami T, Behfar M, Kiumarsi A, Ghavamzadeh A. Favorable outcome of allogenic hematopoietic stem cell transplantation in farber disease. Inl J Clin Rheumatol. 2018;13.

13.  Ansari S, Rostami T, Kiumarsi A. Predictive value of Serum IL-6 level and CRP titer in Determining the need for Antifungal Therapy in Pediatric Patients with Febrile Neutropenia. Madridge J Cancer Stud Res. 2018 Jul 27;2(1):55-8.

14.  Ghavamzadeh A, Rostami T, Nikbakht M, Kasaeian A, Kiumarsi A. Twenty-six Years OF Experience on Allogeneic HSCT in Thalassemia Major Patients: A Long-term Survey and Co-transplantation of Mesenchymal Stem Cells (MSCs). InBONE MARROW TRANSPLANTATION 2018 Sep 1 (Vol. 53, pp. 485-485). MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND: NATURE PUBLISHING GROUP.

15.  Ghavamzadeh A, Kasaeian A, Rostami T, Kiumarsi A. Comparable outcomes of allogeneic peripheral blood versus bone marrow hematopoietic stem cell transplantation in major thalassemia: a multivariate long-term cohort analysis. Biology of Blood and Marrow Transplantation. 2019 Feb 1;25(2):307-12.

16.  Hamidieh AA, Babaki AE, Rostami T, Kasaeian A, Koochakzadeh L, Aliabadi LS, Behfar M, Ghavamzadeh A. A Single-Center Experience With Hematopoietic Stem Cell Transplantation for Pediatric Acute Lymphoblastic Leukemia: A Modest Pitch for Non-Total Body Irradiation Conditioning Regimens. Experim Clin Transp. 2019 Apr 1;17(2): 243-50.

17.  Sadighi J, Tavousi M, Montazeri A, Mozafari Kermani R, Eslami M, Rostami R, Rostami T. Fertility indicators and its correlates among women in Iran. Payesh (Health Monitor). 2020 Dec 15;19(6):645-72.

18.  Behfar M, Koochakzadeh L, Yazdanian N, Salajegheh P, Rostami T, Khodayari-Namini N, Ghavamzadeh A, Hamidieh AA. Outcome of allogeneic Hematopoietic Stem Cell Transplantation on Diamond-Blackfan anemia using busulfan-based myeloablative regimen. The Turkish journal of pediatrics. 2019 May 1;61(3):407-12.

19.  Rostami T, Kiumarsi A. An Experience of Donor Lymphocyte Infusion after Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease. Pediatric Reports. 2020 Dec;12(3):149-54.

20.  Rostami T, Mousavi SA, Rad S, Kiumarsi A, Hesabi A, Rostami M, Mirhoseini SA, Hedayatiasl A. Pediatric Hematopoietic Stem Cell Transplant in the COVID-19 Pandemic: The Problems We Faced and The Strategies We Adopted. Archives of Pediatric Infectious Diseases. 2020 Oct 31;8(4).

21.  Rostami T, Kiumarsi A, Asl AA. Successful allogeneic hematopoietic stem cell transplantation in a child with transfusion-dependent pyridoxine refractory hereditary sideroblastic anaemia. Hematol Transfus Int J. 2020;8(1):1-2.

22.  Rostami T, Kasaeian A, Kiumarsi A, Rad S, Mohammadzadeh E, Mousavi SA. Comparison of Umbilical Cord Blood Transplantation with Bone Marrow or Peripheral Blood Derived Stem-Cell Transplantation in Transfusion Dependent Thalassemia Patients: A Single Center Propensity Score Matching Analysis.

23.  Rostami T, Mohammadifard MA, Ansari S, Kiumarsi A, Maleki N, Kasaeian A, Aghamahdi F, Rad S, Ghavamzadeh A. Indicators of male fertility potential in adult patients with beta-thalassemia major: a comparative study between patients undergone allogeneic stem cell transplantation and transfusion-dependent patients. Fertility research and practice. 2020 Dec;6(1):1-7.

24.  Mousavi SA, Rad S, Rostami T, Rostami M, Mousavi SA, Mirhoseini SA, Kiumarsi A. Hematologic predictors of mortality in hospitalized patients with COVID-19: a comparative study. Hematology. 2020 Jan 1;25(1):383-8.

25.  Mousavi SA, Rad S, Rostami T, Vaezi M, Fumani HK, Babakhani D, Shiraji ST, Barkhordar M, Bahri T, Asl AH, Kiumarsi A. Guidance for facing dilemmas of hematopoietic stem cell transplant clinicians in the COVID-19 pandemic: An Iranian Consensus. Mediterranean Journal of Hematology and Infectious Diseases. 2020;12(1).

26.  Rostami T, Hedayati Asl A, ManafiFarid R, Kiumarsi A, Mousavi SA (2021) Reduced-Intensity Unmanipulated Haploidentical Stem Cell Transplantation for Relapsed High-risk Neuroblastoma after Autologous Stem Cell Transplantation. J Neoplasm Vol.6 No.0:5

27.  Rostami T, Kasaeian A, Maleki N, Nikbakht M, Kiumarsi A, Tavangar SM, Taheri AP, Mousavi SA, Ghavamzadeh A. The effect of bone marrow-derived mesenchymal stem cell co-transplantation with hematopoietic stem cells on liver fibrosis alleviation and survival in patients with class III β-thalassemia major. Stem cell research & therapy. 2021 Dec;12(1):1-2.

28.  Mousavi SA, Rostami T, Kiumarsi A, Rad S, Rostami M, Motamedi F, Gandomi-Mohammadabadi A, Mirhosseini A. COVID-19 and cancer: A comparative case series. Cancer Treatment and Research Communications. 2021 Jan 1;27:100339.

29.  Rostami T, Maleki N, Kasaeian A, Nikbakht M, Kiumarsi A, Asadollah Mousavi S, Ghavamzadeh A. Co‐transplantation of bone marrow‐derived mesenchymal stem cells with hematopoietic stem cells does not improve transplantation outcome in class III beta‐thalassemia major: A prospective cohort study with long‐term follow‐up. Pediatric Transplantation. 2021 May;25(3):e13905.

30.  Rostami T, Kiumarsi A, Alijani N, Rad S, Mirhoseini SA, Rostami M, Mousavi SA. Tocilizumab in Post Hematopoietic Stem Cell Transplant COVID-19: A Pediatric Case Report. Bone Marrow Transplantation. 2021:270-.

31.  Allameh MM, Shiari R, Kiumarsi A. Toddler’s fracture: False positive radiologic considerations. J Clin Med Img Case Rep. 2021;1(1):1019.

32.  Roshanaei G, Kiumarsi A, Kasaeian A, Safari M, Abbasi M, Rahimi A. Influential factors on survival in gastric cancer: A single-center study. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences. 2022;27.

33.  Rostami T, Mousavi SA, Kiumarsi A, Kasaeian A, Rad S, Yaghmaie M, Ghavamzadeh A, Mousavi SA. Radiation-free reduced-intensity hematopoietic stem cell transplantation with in vivo T-cell depletion from matched related and unrelated donors for Fanconi anemia: prognostic factor analysis. Experimental Hematology. 2022 May 1;109:27-34.

34.  Rostami T, Kiumarsi A, Tavakolifar Y, Rostami M, Alijani N, Mirhoseini SA, Mousavi SA. Haploidentical peripheral blood stem cell transplantation with radiation-free myeloablative conditioning regimen and dual in-vivo T-cell depletion by anti-thymocyte globulin and post-transplantation cyclophosphamide in pediatric patients with acute leukemia. PEDIATRIC TRANSPLANTATION 2022 Apr 1 (Vol. 26). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY.

35.  Rostami T, Rostami MR, Kiumarsi A, Kasaeian A, Alijani N, Fumani HK, Rad S, Babakhani D, Bahri T, Vaezi M, Barkhordar M. Peripheral blood stem cell transplantation from haploidentical and unrelated versus related donors for acute leukemia in children, adolescents and young adults (CAYA): A competing risk analysis.
Cell Ther Transplant 2022; 11(1): 24-35.

چاپ کتاب:

1. Rostami T, Kiumarsi A, Azarkeivan Azita. A Diagnostic Manual of Hemoglobinopathies. 2021
   
2. Seied Asadollah Mousavi, Rostami T, Kiumarsi A. Immunization Post Hematopoietic Stem Cell Transplantation.2021
   
3. Rostami T, Kiumarsi A, Pediatric Immunization Schedule Post Hematopoietic Stem Cell Transplantation.2021
   
4. Patient Information Guide Book for Pediatric Hematopoietic Stem Cell Transplantation.2021