Network of Dermatology Research (NDR)
Objective
Our aim is to build a platform for students interested in dermatology to get involved in research under the supervision of great experts in dermatology and immunology.
Definition
Network of Dermatology Research (NDR) basically deals with the cutaneous diseases such as pemphigus, psoriasis, alopecia areata, vitiligo, and skin cancers such as melanoma. Pathophysiologic, genetic and immunologic aspects of the cutaneous diseases, as well as target-oriented treatments, are our area of interest.
Group members
Founder
Managing Director
Member
Book
- Immunogenetics of Dermatologic Diseases
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There is a very much entangled relationship between dermatology and immunology. Many diseases that primarily affect the skin have a pure immunological etiology like pemphigus, allergic contact dermatitis, and urticaria. Others such as atopic dermatitis and psoriasis might be considered as immune-mediated with both adoptive and innate pathways taking a considerable part in their pathogenesis. The immune responses in both physiologic and pathological states are greatly influenced by genetic factors. In particular, allelic variants play a great role in shaping the immunological responses at numerous levels such as production and release of cytokines, adhesion molecule, and antibodies. They also regulate the affinity of receptors, and cellular functions such as apoptosis, phagocytosis, and antigen presentation. These genetic associations could be common between a range of immune-mediated diseases such as PTPN22, cytokine, and cytokine signaling genes. They could also be specific to a single disease such as human leukocyte antigens (HLA). Our knowledge of immunogenetics has been greatly improved in recent years owing to both technological advancements and lower costs of the genetic sequencing. This knowledge may start a revolution in treatment strategies by allowing us to get closer to designing personalized treatment approaches for every individual based on their specific genetic background. Our intention in proposing this book is to investigate the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. This may enable us to predict the severity of the disease and its response to treatment. We intend to cover as many cutaneous diseases as possible along we avoiding common areas that have already been discussed in rheumatology textbooks such as lupus erythematosus and dermatomyositis.
- Genetic Syndromes, Chapters covering Genodermatoses
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- Cancer Immunotherapy, Chapter on Immunotherapy for NMSC
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Paper
- Macrophage migration inhibitory factor polymorphism (rs755622) in alopecia areata: a possible role in disease prevention.
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Archives of dermatological research
- The Association between Genetic Variation in Wnt Transcription Factor TCF7L2 (TCF4) and Alopecia Areata.
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Immunological Investigations
- Patients with alopecia areata show signs of insulin resistance.
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Archives of dermatological research