Mona Sadeghalvad
Mona Sadeghalvad
Ph.D. student of Clinical Immunology
Immunology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ø Summary:
I’m an Immunologist with a focus on the molecular pathways that are involved in Cancer. I’m interested in investigating the effect of genetic alterations on disease development including Cancer, Infectious disease, Autoimmune disease, and Immunodeficiency disorders. I’m trying to learn more techniques for improving my knowledge about these diseases.
Ø Personal details:
Date of Birth: 1985/09/20
Nationality: Iranian
Marital Status: Married
Ø Contact information:
E-mail address-1: [email protected]
E-mail address-2: [email protected]
Phone: 0098-9199104764
Address: Immunology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ø Education and qualifications:
B. Sc: Cellular and Molecular Biology-Microbiology, Arak University, Arak, Iran
(2004-2008).
M. Sc: Clinical Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran (2010-2013).
Ph.D.: Clinical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (2016-present).
Ø Honors and Awards:
Brilliant-talent Student at Tehran University of Medical Sciences (2019)
Brilliant-talent Student at Kermanshah University of Medical Sciences (2013)
Ø Work experience/employment history:
Laboratory Technician in Molecular Biology laboratory, Kermanshah University of
Medical Sciences, Molecular Biology Research Center (MBRC), (2013-2015).
Lecturer of Immunology, Kermanshah University of Medical Sciences, Faculty of Medicine, Department of Immunology (2015-2017).
Teaching assistant, Tehran University of Medical Sciences, Faculty of Medicine, Department of Immunology (2016-present).
Ø Teaching experience:
• Immunology course. Department of Immunology. School of Medicine.
Kermanshah University of Medical Sciences (2015-2017)
• Immunology course. Department of Immunology. School of Medicine. Tehran University of Medical Sciences (2016-2019)
Ø Experiences and expertise, skills:
Computer skills (Microsoft Office, Spreadsheets, PowerPoint, Microsoft Access, Web and Social Skills, Graphic and Writing Skills)
PCR and Real Time PCR Techniques
Nucleic acid extraction
Primer design
ELISA Technique
Proteomics Techniques (SDS-PAGE, Western Blotting, 2D-electrophoresis)
Types of Chromatographic Techniques
Protein Purification
Cell culture
Work with mouse model
Serology diagnosis tests
Ø Books publication:
• Immunology. Dr. Mohammad vodjgani.
Jahade Daneshgahi Publisher. 13th edition. 2018.
• Cellular and Molecular Immunology (Abul K. Abbas). Translation.
Artin Teb Publisher. 9th
edition. 2018.
• Professional Immunology Textbook. Compilation Group Dr Khalili Publisher. 2017.
• Cellular and Molecular Immunology (Abul K. Abbas). Translation.
Compilation Group Dr Khalili Publisher. 9th
edition. 2012.
Ø Publications:
Soybean Bowman-Birk Protease Inhibitor (BBI): Identification of the Mechanisms of BBI Suppressive Effect on Growth of Two Adenocarcinoma Cell Lines: AGS and HT29. Amirhossein Fereidunian,
Mona Sadeghalvad, Maryam Omidi Oscoie, and Ali Mostafaiea.
Arch Med Res. 2014; 45: 455–461.
2-Methylpyridine-1-ium-1-sulfonate as an Inducer of Apoptosis and Cell Cycle Arrest: A comparative in vitro and Computational Study. Hamid-Reza Mohammadi- Motlagh, Reza Yarani,
Mona Sadeghalvad, Elham Adham, Hassan Rasouli, and Ali Mostafaie.
Nutrition Cancer. 2018; 1-14.
The effect of CYP2C9*2, CYP2C9*3, and VKORC1-1639 G>A polymorphism in patients under warfarin therapy in city of Kermanshah. Zohreh Hosseinkhani,
Mona Sadeghalvad, Fathemeh Norooznezhad, Reza Khodarahmi, Mohammad Fazilati, Azadeh Mahnam, Ali Fattahi, and Kamran Mansouri. Res Pharm Sci. 2018; 13: 377- 384.
CYP2C9*1*2 and VKORC1-1639 AA polymorphisms correlation with warfarin dose requirement: A case report. Zohreh Hoseinkhani, Reza Khodarahmi,
Mona Sadeghalvad, Fathemeh Norooznezhad, Kamran Mansouri . J. Rep Pharma
Sci. 2018; 7: 88-91.
Influenza vaccine: Where are we and where do we go? Mohsen Keshavarz, Hamed Mirzaei, Maryam Salemi, Fatemeh Momeni, Mohammad Javad Mousavi,
Mona Sadeghalvad, Yaser Arjeini, Farid Solaymani-Mohammadi, Javid Sadri Nahand, Haideh Namdari, Talat Mokhtar Azad, Farhad Rezaei. Rev Med Virol. 2018.
In vivo anti-inflammatory efficacy of the combined Bowman-Birk trypsin inhibitor and Genistein isoflavone, two biological compounds from soybean.
Mona Sadeghalvad, Hamid-Reza Mohammadi-Motlagh, Ali Gorgin Karaji, Ali Mostafaie. J Biochem Mol Toxicol. 2019; doi.org/10.1002/jbt.22406.
Evaluation of Beclin-1 and Atg5 genes expression levels in peripheral blood cells of patients with rheumatoid arthritis. Kardideh B,
Sadeghalvad M, Samimi Z, Mohammadi-Motlagh HR, Taghadosi M. Feyz journal. 2019; 23(2): 135-142.
ØLecturer of Workshop:
• Primer Design for Real Time PCR. Kermanshah University of Medical Sciences, Molecular Biology Research Center (2014).
ØResearch Projects:
1-Study of relationship between gene expression of ZBTB 25(KUP) with NFAT gene expression and plasma levels of IL2 and methylation of ZBTB25 factor in the patients with rheumatoid arthritis.
2-Study of relationship between gene expression of Runx3 and the autophagy-related genes in patients with rheumatoid arthritis.
3-Study of effect of amino acid L-arginine on angiogenesis by human umbilical vein endothelial cells
(HUVEC) in the presence of 5-fluorouracil.
4-Study of designing a molecular diagnostic kit to detect Human papillomavirus (HPV) types 16 and 18 using Real-Time PCR.
5-Study of effect of soybean Bowman-birk trypsin inhibitor (BBI) on autophagy- related genes expression in the glial cancer cell line U87MG.
5-Study of purification of trypsin inhibitor protein from chickpea seed and its anti- angiogenesis effects on human umbilical vein endothelial cells in collagen matrix.
6-Comparison study of anti-inflammatory effect of peduncles and roots extracts and essential oil of
Echinacea purpurea in LPS induce inflammation in mouse.
7-Study of Ellagic acid purification from pomegranate skin and determination of its anti-inflammatory effect in
Mus musculus.
8-Study of production of a conjugate of soybean trypsin inhibitor (BBI) with genistein and comparing its anti-inflammatory effects with BBI and genistein alone in inflammatory mouse model.
9-Investigation of the biological role of cancer-associated fibroblasts (CAFs) on the inducing of PI3K-Akt-mTOR signaling pathway in human breast cancer tumor cells by the downstream non-coding RNA HOTAIR.
10-Investigation of the biological role of cancer-associated fibroblasts cells (CAFs) in the proliferation and invasion of human breast cancer tumor cells by the downstream non-coding RNA HOTAIR and mTOR signaling molecule.
Ø Congresses:
• Comparison of anti-inflammatory potentials of the soybean bowman-birk trypsin inhibitor (BBI), genistein, and mixture of BBI and genistein in BALB/c mouse model.
12th International Congress of Immunology and Allergy. April 2012, Tehran, Iran
(Oral presentation).
• Conjugation of genistein and Bowman-Birk trypsin inhibitor (BBI) and study of anti-inflammatory effect of the conjugate on BALB/c mice.
12th International Congress of Immunology and Allergy. April 2012, Tehran, Iran
(poster presentation).
• Anticancer activity of a natural effective compound from shallot in MCF-7 cell line through cell growth arrest and apoptosis induction.
13th International Congress of Immunology and Allergy
April 2016, Tabriz, Iran (poster presentation).
• Increased autophagy in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis patients.
14th International Congress of Immunology and Allergy
April 2018, Tehran, Iran (Oral presentation).
• Induced Regulatory B Cells in Invasive Breast Cancer: A New Proposed Signaling Pathway by Cancer Associated Fibroblasts (CAFs). 4th USERN congress in Budapest, Hungary on November 2019.
(Oral presentation).
• International Rumi Pediatric Conference (IRUPEC 2019) and the 3rd J Project Congress (JPC3) on Primary Immunodeficiencies. Konya, Turkey. December 4-7, 2019. (Attendance)
Ø Research Interests:
Cancer Immunology
Immunodeficiency disease
Infectious disease
Autoimmune disease
Genomics
Molecular biology and signaling pathways
Inflammation pathways
Proteomics
Ø Referees:
Prof. Nima Rezaei
(Supervisor of my Ph.D. Thesis)
Professor of Clinical Immunology, Tehran University of Medical Sciences, Tehran, Iran. E-mail:
[email protected]
Tel: (+982166419536); P.O.Box: 1417613151
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