Farzaneh Darbeheshti

 Journal Papers

• Darbeheshti F, Zokaei E, Mansoori Y, Emadi S, Kamaliyan Z, Kadkhoda S,Tavakkoly Bazzaz J, Rezaei N, Shakoori A.
  Circular RNA hsa_circ_0044234 as distinct molecular signature of triple negative breast cancer: a potential regulator of GATA3. Cancer Cell International. 2021;
  https://doi.org/10.1186/s12935-021-02015-6
• Darbeheshti F, Rezaei N, Amoli MM, Mansoori Y, Tavakkoly Bazzaz J. Integrative analyses of triple negative dysregulated transcripts compared with non‐triple negative tumors and their functional and molecular interactions. Journal of cellular physiology. 2019; https://doi.org/10.1002/jcp.28804
• Darbeheshti F, Mahdiannasser M, Uhal BD, Ogino S, Gupta S, Rezaei N. Interindividual immunogenic variants: Susceptibility to coronavirus, respiratory syncytial virus and influenza virus. Reviews in Medical Virology. 2021;
  https://doi.org/10.1002/rmv.2234
• Darbeheshti F, Izadi P, Razavi ANE, Yekaninejad MS, Bazzaz JT. Comparison of BRCA1 expression between triple-negative and luminal breast tumors. Iranian biomedical journal. 2018;
  https://doi.org/10.22034/ibj.22.3.210
• Darbeheshti F, Izadi P, Emami Razavi AN, Kamali F, Yekaninejad MS, Tavakkoly Bazzaz J. Significance of EGFR mRNA expression in luminal and triple negative breast tumors. International Journal of Cancer Management. 2018;
  https://doi.org/10.5812/ijcm.9763
• Darbeheshti F, Rezaei N. Genetic predisposition models to COVID-19 infection. Medical hypotheses. 2020;
  10.1016/j.mehy.2020.109818
• Kadkhoda S, Darbeheshti F, Tavakkoly‐Bazzaz J. Identification of dysregulated miRNAs‐genes network in ovarian cancer: An integrative approach to uncover the molecular interactions and oncomechanisms. Cancer Reports. 2020;
  https://doi.org/10.1002/cnr2.1286
• Hajimaghsoudi E, Darbeheshti F, Kalantar SM, Javaheri A, Mirabutalebi SH, Sheikhha MH. Investigating the expressions of miRNA-125b and TP53 in endometriosis. Does it underlie cancer-like features of endometriosis? A case-control study. International Journal of Reproductive BioMedicine. 2020;
   10.18502/ijrm.v13i10.7767
• Kadkhoda S, Darbeheshti F, Rezaei N, Azizi-Tabesh G, Zolfaghari F, Tavakolibazaz S, et al. Investigation of circRNA-miRNA-mRNA network in colorectal cancer using an integrative bioinformatics approach. Gastroenterology and Hepatology From Bed to Bench. 2021; PMID: 33968341
• Mansoori H, Darbeheshti F, Daraei A, Mokhtari M, Tabei MB, Abdollahzadeh R, et al. Expression signature of lncRNA APTR in clinicopathology of breast cancer: Its potential oncogenic function in dysregulation of ErbB signaling pathway. Gene Reports. 2021;
  
  https://doi.org/10.1016/j.genrep.2021.101116
• Jalalvand M, Darbeheshti F, Rezaei N. Immune checkpoint inhibitors: review of the existing evidence and challenges in breast cancer. Immunotherapy. 2021;
  https://doi.org/10.2217/imt-2020-0283

Book Chapters

• Darbeheshti F, Abolhassani H, Bashashati M, Ghavami S, Shahkarami S, Zoghi S, et al. Coronavirus: Pure Infectious Disease or Genetic Predisposition. Coronavirus Disease-COVID-19. 2021; Springer;
  https://doi.org/10.1007/978-3-030-63761-3
• Uhal B.D, Connolly D, Darbeheshti F, Zheng Y, Ifeanyichukwu E. Chung Y, Samavati L. Host and Pathogen-Specific Drug Targets in COVID-19. COVID-19: from Bench to Bedside. Taylor & Francis; under publication
  https://www.routledge.com/COVID-19-From-Bench-to-Bedside/Barh-Lundstrom/p/book/9781032040622
• Darbeheshti F. Immunogenetics of Melanoma. The Immunogenetics of Dermatologic Diseases. Springer; in editorial process.

Journal articles under review

• Darbeheshti F, Kadkhoda S, Keshavarz M, Razi S, Bahramy A, Mansoori Y, Rezaei N. Investigation of BRCAness Associated miRNA-gene Axes in Breast Cancer: Cell-free miR-182-5p as a Potential Expression Signature of BRCAness.
• Darbeheshti F; Mansoori Y; Azizi-Tabesh G; Zolfaghari F; Kadkhoda S; Tavakkoly Bazzaz J; Shakoori A; Rezaei N. Evaluation of Circ_0000977-mediated Regulatory Network in Breast Cancer: A Potential Discriminative Biomarker for Triple Negative Tumors.
• Darbeheshti F, Mahdiannasser M, Noroozi Z, Firoozi Z, Mansoori B, Daraei A, et al. Circular RNA-associated ceRNA Network Involved in HIF-1 Signaling in Triple Negative Breast Cancer: circ_0047303 as a Potential Key Regulator.
• Pastaki Khoshbin A, Darbeheshti F, Doosti-Irani A, Keshavarz-Fathi M, Mansournia M.A, Rezaei N. Efficacy and safety of small-molecule Human Epidermal Growth Factor Receptor 2 (HER2)-targeting tyrosine kinase inhibitor-containing regimens for metastatic HER2-positive breast cancer: a systematic review and network meta-analysis of randomized clinical trials.

Experience

Researcher:

Tehran University of Medical Sciences,
School of Medicine,Department of Medical Genetics

Breast Cancer Association (BrCA), Universal Scientific Education and Research network (USERN)

Cancer Immunology Project (CIP), Universal Scientific Education and Research network (USERN)

• Conducted research in evaluating microarray data and gene expression profiling for breast cancer
  
• Used an integrative bioinformatics approach for system biology-based cancer research
• Identified cell-free diagnostic and prognostic biomarkers for triple negative breast cancers
• Investigated underlying inter-individuals’ variants in susceptibility to coronavirus     
  
• Analysisand Writing:

− Performed quantitative and qualitative data management, analysis, and interpretation of the findings

− Manipulated, analyzed, and presented a high volume of data with SPSS, Prism, Cytoscape, R Studio, and Excel

− Provided a state-of-the-art and literature review of related topics

− Adapted work schedules with the team and PI to meet the internal and external deadlines

− Presented high-impact visuals skills and reporting for the projects results and
findings

Lecturer:

Honors:

• Ranked third in national university entrance exam for M.Sc. degree in Human Genetics in year 2014
• Awarded Exceptional Talent Development Center
  Scholarship, July 2018
• Ranked third in national university entrance exam for Ph.D. degree in Medical Genetics in year 2019