MA

Maliheh Moradzadeh


  Education



  1. 2018- until now: Assistant Professor of Molecular Medicine

Joint, Bone, Connective tissue, Rheumatology Research Center (JBCRC), Sayyad Shirazi Teaching Hospital, Golestan University of Medical Sciences, Gorgan, Iran.


Email: [email protected],
[email protected], Tel-Fax:
+98 17 32239791


2. 2011-2017:
Ph.D. in Molecular Medicine                                                                                  


Mashhad University of Medical Sciences, Mashhad, Iran.


Dissertation Title: "The Effect of
crocetin on differentiation and multi-drug resistance
genes expressions in cells derived from
patients with Acute Promyelocytic Leukemia (APL)". (score: 19.85 out of 20)


Supervisors: Dr. Hamid Reza Sadeghnia, Dr. Alijan Tabarraei


3. 2006-2008: M.Sc. in Biochemistry                                                                                                       


My thesis was "Cloning and selection of camel antibody gene against human epidermal growth factor receptor-2 (HER-2)", at
Endocrinology and Metabolism Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. (score: 19.90 out of 20)


4. 2002-2006: B.Sc. in Biology                                                                                      


Arak University, Arak, Iran.



Work Experiences    
                                                                                                                  



  1. 2009-2011: Research Expert, Biochemistry and Metabolic Disorder Research Center
    (BMDRC), Golestan University of Medical Sciences, Gorgan, Iran.
  2. 2008-2009: Laboratory Expert, Golestan Cohort study, Atrak clinic, Khatam-al-Anbya Hospital, Gonbad-e kavus, Golestan Province, Iran.

Teaching Assistantship



  1. 2020: “Diabetes” course in 12th
    Medical Students' Scientific Olympiad, Golestan University of
    Medical Sciences, Gorgan, Iran.    (Education Development Center [EDC])
  2. 2019: “Personalized Medicine” course in
    11th Medical Students' Scientific Olympiad, Golestan
    University of Medical Sciences, Gorgan, Iran.(EDC)               
  3. 2014: “Gene Therapy” course in 6th
    Medical Students' Scientific Olympiad, Mashhad University of
    Medical Sciences, Mashhad, Iran.    (EDC)   
  4.  2008-2010:
    “Biochemistry” course, Islamic Azad University of Kalaleh, Golestan province, Iran. (4 semesters)   


 Honors and Research Fundings



  1. 2021:
    Dr. shahriari prize, Iran's National Elites Foundation, Tehran, Iran. 
  2. 2020: Top researcher, Golestan University of
    Medical Sciences, Gorgan, Iran.
  3. 2019: Top researcher, Golestan University of
    Medical Sciences, Gorgan, Iran.
  4. 2019: Grant of strugger assistant professor,
    Golestan University of Medical Sciences, Gorgan, Iran. (100,000,000 Rials)
  5. 2018: Grant of young assistant professor, Ministry of Science, Research and Technology, Tehran, Iran. (150,000,000 Rials)
  6. 2005: First top talented student, Arak University, Arak, Iran.
     
  7.  2004:First top
    student, Arak University, Arak, Iran. 
  8. 1999:
    First top student, second grade of high school, Somayeh high school, Gonbad-e kavus,
    Golestan province, Iran.
  9. 1998: First top student, first grade of high school, Somayeh high school, Gonbad-e kavus,
    Golestan province, Iran.

10.  1994: First top
student, Fifth grade elementary, Zeinab elementary school, Gonbad-e kavus,
Golestan province, Iran.


                                            


Patents



  1. 2017: Moradzadeh M, Sadeghnia HR and
    Tabaraei A. The compound for inhibiting proliferation and inducing cell differentiation in acute promyelocytic leukemia. Iran Patent and Trademark Office. No: 94216.
  2. 2021: Soltani A, Abdollahi N, Aghaei M, Arabi M, Moradzadeh M,
    Damavandi kamali K, Heidari F, Honarvar MR. The process of preparing collagen type I from chicken legs.     Iran Patent and Trademark Office. No: 103418.


Book


2017: Moradzadeh M, Ayatollahi H. Molecular Pathology of Cancer. Mashhad University of medical sciences publication, Mashhad, Iran.
 



Publications


1.Moradzadeh M, Sadeghnia HR, Tabarraei A, Sahebkar A. Anti-tumor effects of crocetin and related molecular targets. Journal of cellular physiology. 2018;233(3):2170-82.
(IF: 5.5, Q1)


2. Kashafi E, Moradzadeh M, Mohamadkhani A, Erfanian S. Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways. Biomedicine & pharmacotherapy. 2017 Feb 28;89:573-7. (IF: 4.5, Q1) (Co-First author)


3.  Moradzadeh M, Ghorbani A, Erfanian S, Mohaddes ST, Rahimi H, Karimiani EG, et al. Study of the mechanisms of crocetin-induced differentiation and apoptosis in human acute promyelocytic leukemia cells. Journal of cellular biochemistry. 2019;120(2):1943-57. (IF: 4.2, Q2)


4. Moradzadeh M, Kalani MR, Avan A. The antileukemic effects of saffron (Crocus sativus L.) and its related molecular targets: A mini review. Journal of cellular biochemistry. 2019;120(4):4732-8.
(IF: 4.2, Q2) (Corresponding author)


5.Moradzadeh M, Tabarraei A, Sadeghnia HR, Ghorbani A, Mohamadkhani A, Erfanian S, et al. Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes. Journal of cellular biochemistry. 2018;119(2):2288-97.(IF: 4.2, Q2)


6.Moradzadeh M, Roustazadeh A, Tabarraei A, Erfanian S, Sahebkar A. Epigallocatechin‐3‐gallate enhances differentiation of acute promyelocytic leukemia cells via inhibition of PML-RARα and HDAC1. Phytotherapy research. 2018;32(3):471-9. (IF: 4.0, Q2)


7. Pourahmadi M, Erfanian S,
Moradzadeh M, Sotoodeh Jahromi A. Non-association between rs7903146 and rs12255372 polymorphisms in transcription factor 7-like 2 gene and type 2 diabetes mellitus in Jahrom City, Iran. Diabetes & metabolism journal. 2015;39(6):512-7. (IF:
3.0, Q1)


8.Moradzadeh M, Hosseini A, Erfanian S, Rezaei H. Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase. Pharmacological Reports. 2017;69(5):924-8.(IF: 2.7, Q2)


9. Ghasemi S, Moradzadeh M, Hosseini M, Beheshti F, Sadeghnia HR. Beneficial effects of Urtica dioica on scopolamine-induced memory impairment in rats: protection against acetylcholinesterase activity and neuronal oxidative damage. Drug and chemical toxicology. 2019;42(2):167-75. (IF: 2.4, Q3)


10.  Moradzadeh M, Aghaei M, Mehrbakhsh Z, Arab-Bafrani Z, Abdollahi N.
Efficacy and safety of Rituximab therapy in patients with systemic sclerosis disease (SSc): Systematic review and meta-analysis. Clinical Rheumatology.2021:1-22.(IF: 2.3, Q2)


11.  Mohamadkhani A, Naderi E, Sharafkhah M, Fazli HR,
Moradzadeh M, Pourshams A. Detection of TP53 R249 mutation in Iranian patients with pancreatic cancer. Journal of oncology. 2013; 2013.(IF:
2.2, Q2)


12.  Moradzadeh M, Sadeghnia HR, Mousavi SH, Mahmoodi M, Hosseini A. Ferula gummosa gum induces apoptosis via ROS mechanism in human leukemic cells. Cellular and molecular biology (Noisy-le-Grand, France). 2017;63(11):17-22.(IF: 1.4, Q3)


13.  Ghasemi S,
Moradzadeh M, Mousavi S, Sadeghnia HR. Cytotoxic effects of Urtica dioica radix on human colon (HT29) and gastric (MKN45) cancer cells mediated through oxidative and apoptotic mechanisms. Cellular and molecular biology (Noisy-le-Grand, France). 2016;62(9):90. (IF: 1.4, Q3)


14.  Rajabian A, Sadeghnia HR,
Moradzadeh M, Hosseini A. Rheum turkestanicum reduces glutamate toxicity in PC12 and N2a cell lines. Folia neuropathologica. 2018;56(4):354-61.
(IF: 1.2, Q3)


15.  Sadeghnia HR, Rajabian A, Ghorbani A,
Moradzadeh M, Hosseini A. Effects of standardized extract of Ferula gummosa root on glutamate-induced neurotoxicity. Folia neuropathologica. 2017;55(4):340-6.
(IF: 1.2, Q3)


16.  Moradzadeh M, Sargazi N, Pourasgari M, Besharat S, Beygi S, Mohamadkhani A. Increasing Neutrophil Elastase and Decreasing Its Inhibitor, Alpha 1-Antitrypsin, in Patients with Non-Alcoholic Fatty Liver Disease. Hepatitis Monthly. 2020 January; 20(1): e99735. (IF:0.7, Q3)


17.  Moradzadeh M, Tabarraei A, Ghorbani A, Hosseini A, Sadeghnia HR. Short-term in vitro exposure to crocetin promotes apoptosis in human leukemic HL-60 cells via intrinsic pathway. Acta Poloniae Pharmaceutica - Drug Research. 2018. (IF:0.4, Q3)


18.  Moradzadeh M, Tayebi S, Poustchi H, Sayehmiri K, Shahnazari P, Naderi E, et al. The possible role of TLR2 in chronic hepatitis B patients with precore mutation. Advances in virology. 2013;2013.(ISI, Q2)


19.  Moradzadeh M, Hosseini A, Rakhshandeh H, Aghaei A, Sadeghnia HR. Cuscuta campestris induces apoptosis by increasing reactive oxygen species generation in human leukemic cells. Avicenna journal of phytomedicine. 2018;8(3):237.(ISI)


20. 
Moradzadeh M, Rajabian A, Aghaei A, Hosseini A, Sadeghnia HR. Rheum turkestanicum Induced Apoptosis Through ROS Without a Differential Effect on Human Leukemic Cells. Jundishapur Journal of Natural Pharmaceutical Products. 2019 November; 14(4):e12198. (ISI)


21.  Erfanian S,
Moradzadeh M, Solhjoo K, Sotoodeh Jahromi A. Data describing the association between rs266729 polymorphism inadiponectin promoter gene and Type 2 Diabetes Mellitus. Data in Brief. 2016;9:1138-40. (ISI)


22.  Moradzadeh M, Jokar MH, Sedighi S. A comparative study of anti-leukemic effects of kaempferol and epigallocatechin-3-gallate (EGCG) on human leukemia HL-60 cells. Avicenna Journal of Phytomedicine. 2021. (ISI(
)Corresponding author)


23.  Masoudi S, Nemati AH, Fazli HR, Beygi S,
Moradzadeh M, Pourshams A, Mohamadkhani A. An Increased Level of Aryl Hydrocarbon Receptor in Patients with Pancreatic Cancer. Middle East Journal of Digestive Diseases (MEJDD). 2018;11(1):38-44. 2018.126. (Pubmed)


24.  Hashemzadeh K, Jokar MH, Sedighi S,
Moradzadeh M. Therapeutic Potency of PI3K Pharmacological Inhibitors of Gastrointestinal Cancer. Middle East Journal of Digestive Diseases (MEJDD). 2018;11(1):5-16. 2018.122. (Pubmed(
)Corresponding author)


25.  Jafaripour S, Sedighi S, Jokar MH, Aghaei M,
Moradzadeh M. Inflammation, diet, and type 2 diabetes: a mini-review. Journal of Immunoassay and Immunochemistry. 2020:1-10. (Pubmed(
)Corresponding author)


26.  Shakeri M, Hashemi Tayer A, Shakeri H, Sotoodeh Jahromi A,
Moradzadeh M, Hojjat-Farsangi M. Toxicity of Saffron Extracts on Cancer and Normal Cells: A Review Article. Asian Pacific Journal of Cancer Prevention. 2020;21(7):1867-75. (Pubmed)


27.  Fazli HR,
Moradzadeh M, Mehrbakhsh Z, Sharafkhah M, Masoudi S, Pourshams A,
Mohamadkhani A. Diagnostic significance of serum fatty acid synthase in patients with pancreatic cancer. Middle East Journal of Digestive Diseases (MEJDD). 2021.
(Pubmed(
)Co-First author)


28.  Jokar MH, Sedighi S, Aghaei M, Mohamadkhani A,
Moradzadeh M. Inflammatory Cytokines and type 2 diabetes. Koomesh. 2020, 22(3).
(Scopus(
)Corresponding author)


29.  Sedighi S,
Moradzadeh M, Aghaei M, Mohamadkhani A, Jokar MH.
Familial adenomatous polyposis: diagnosis and surveillance strategies: review article. Tehran University Medical Journal. 2020.
78(7): p. 407-415. (Scopus)


30.  Sedighi S, Jokar MH,
Moradzadeh M. Hamartomatous Polyposis Syndromes: Management and Surveillance Strategies. SSU_Journals. 2020;28(6):2720-33. (Corresponding author)


31.  Sotoodeh Jahromi A,
Moradzadeh M, Kargar M, Kafilzadeh F, Jamalidoust M. Effect of Crocin on cell apoptosis and miRNA-15a expression in EBV infected transformed B cell-CO 88BV59-1 LCL. Pars of Jahrom university of Medical Sciences. 2020;18(3):21-31.


32.  Sotoodeh Jahromi A, Kargar M,
Moradzadeh M, Kafilzadeh F, Jamalidoust M. Effect of Cyclophosphamide on miRNA-15a expression in EBV infected transformed B cell. Pars of Jahrom university of Medical Sciences. 2020, 19 (1). (Corresponding author)


33.  Jokar MH, Sedighi S,
Moradzadeh M. Hereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies. SSU_Journals. 2021. (Corresponding author)


34.  Moradzadeh M, Aghaei M, Mehrbakhsh Z, Abdollahi N, Arab Baferani Z. Efficacy and safety of Rituximab therapy for patients with systemic sclerosis disease (SSc): Systematic review and meta-analysis. Prospero. 2018. CRD42018103751. [Protocol].


35.  Jokar MH, Sedighi S,
Moradzadeh M. Differentiation-inducing activity of the Phyto-polyphenols Epigallocatechin-3-gallate
and Kaempferol on NB4 cells. Journal of Advances in Medical and Biomedical Research. 2021. [Scopus,
Accepted] (Corresponding author)


36.  Jokar MH, Mohamadkhani F,
Moradzadeh M, Beygi S, Mohamadkhani A. Nickel nanoparticles/recycled PET nanofibers web reduced algD expression of Pseudomonas aeruginosa. Medical Laboratory Journal. 2021. [Accepted]



Lecturer in Conferences




  1. Moradzadeh M, Omidfar K, Ghashghaei M, Moein far Z, Tavangar M, Larijani B. Immunohistochemical Study of EGFRvIII in thyroid carcinoma by camel antibodies. 1st National Student Biology and Modern World Conference, Gorgan, Iran. 16-17 Oct 2008.
  2. Moradzadeh M, Tabarraei A, Sadeghnia HR. Crocetin promotes apoptosis in human leukemic HL-60 cells via intrinsic pathway. The 10th International Conference of Asian Pacific Organization for Cancer Prevention (APOCP) General Assembly and Conferences, Tehran, Iran. November 2020.
  3. Moradzadeh M,
    Tabarraei A, Sadeghnia HR. Crocetin-induced differentiation and apoptosis mechanisms in human acute promyelocytic leukemia cells. 3rd Hyrcania Medical Laboratory Congress, Gorgan, Iran. 10 Jan 2021. (CEMC: 10 points)

4.              Moradzadeh M, Ghorbani A, Tabarraei A, Sadeghnia HR. Epigallocatechin-3-gallate enhances differentiation in acute promyelocytic leukemia cells via inhibition of PML-RARα and HDAC1. 14th International Congress of Immunology and Allergy, Tehran, Iran. 26-28 April 2018. (CEMC: 4.5 points)




Conferences and poster presentations




  1. Moradzadeh M, Omidfar K, Ghashghaei M. Production of camel antibodies library against EGFRvIII. 8th Iranian Congress of Hematology and Oncology, Oromia, Iran. 18-20 Oct 2008. (Continuing Education of the Medical Community [CEMC]: 2 points)
  2. Moradzadeh M, Omidfar K, Kargar S. Production of a camel antibody gene library: by phage display technique. Iranian Congress on Biology and Applications of Stem Cells, Mashhad, Iran. 26-28 April 2011.
  3. Kargar S, Kargar M, Moradzadeh M. Analysis of jurisprudence new approach of unfertilization treatment on stem cell. Iranian Congress on Biology and Applications of Stem Cells, Mashhad, Iran. 26-28 April 2011.
  4. Moradzadeh M, Poursharifi N, Balkhi K, Behnampour N, Asadi J. 
    The prevalence of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody at Gorgan South-East Caspian Sea of Northern Iran. 4th Congress of Laboratory and Clinic, Tehran, Iran. 20-22 Dec 2011.(CEMC: 10 points)
  5. Moradzadeh M, Asadi J, Joshaghani H, Poursharifi N. Cloning of recombinant nanobody gene against Epidermal Growth Factor Receptor family (EGFR). 4th Congress of Laboratory and Clinic, Tehran, Iran. 20-22 Dec 2011.
  6. Moradzadeh M, Poursharifi N. The prevalence of antinuclear antibody levels in Gorgan, North-east Iran.
    4th International Congress of Biochemistry & Molecular Biology,
    Mashhad, Iran. 6-9 Sep 2011. (Published: Clinical Biochemistry Journal; Vol. 44, Num. 13, pp180, Sep 2011.
    [IF: 2.5]).
  7. Moradzadeh M, Kargar S, Kargar Jahromy H, Omidfar K. Cloning and selection of camel antibody gene against human epidermal growth factor receptor-2 (HER-2). 10th Biophysical Chemistry Conference, Jahrom, Iran. Feb 2011. (Published: Journal of the Iranian Chemical Society; Vol. 8, Suppl. 2, pp19, Feb 2011.
    [IF: 1.5]).
  8. Moradzadeh M, Moradzadeh F, Ghasemi bezdi K. Evaluation of callus induction and explants regeneration of cotton different varieties in vitro. National Agriculture Management Congress, Jahrom, Iran. 25-26 May 2011.
  9. Moradzadeh M, Moradzadeh F, Ghasemi bezdi K. Evaluation of callus induction of cotton varieties in medium containing different dose of hormone.7th National Biotechnology Congress, Tehran, Iran. 11-13 Sep 2011.

10.  Moradzadeh F, Moradzadeh M, Ghasemi bezdi K. The effect of explant type and hormonal composition on culture response of cotton Cocker-312. 3th Biosafety and genetic engineering congress, Tehran, Iran. 13-15 June 2011.


11.  Moradzadeh M, Erfanian S, Karimi Jashni H, kashafi E. Evaluation of the synovium- derived mesenchymal stem cell differentiates in to neural cells in vitro. 5th International Conference of Medical Students, Mazandaran, Iran. 28-30 Oct 2013.


12.  Moradzadeh M, Hoseini SF, Mazandarani M, Khori V, Seifi A, Baiat H. Investigation potential role of Nitergic and Cholinergic system on Anti-spasmodic properties of Matricaria Recutita cultivated in Golestan province. 5th International Conference of Medical Students, Mazandaran, Iran. 28-30 Oct 2013.


13.  Hoseini SF,
Moradzadeh M, Mazandarani M, Baiat H. Phytochemical investigation Matricaria Recutita & Achillea Millefolium in Golestan province. 5th International Conference of Medical Students, Mazandaran, Iran. 28-30 Oct 2013.


14.  Moradzadeh M, Erfanian S, Solhjoo K. The association of adiponectin gene RS266729 polymorphism with lipid profile in diabetes type 2 patients of Jahrom city. 1st National Conference of Molecular Medicine, Tehran, Iran. 7 March 2014.


15.  Moradzadeh M, Tabarraei A, Sadeghnia HR. The role of Histone Deacetylase (HDAC) as biomarker in cancer. 4th Congress of Medical Oncology and Hematology Association, Mashhad, Iran. 13 Oct 2015.


16.  Moradzadeh M, Erfanian S, Hoseini A. In Vitro Cytotoxic Effects of Epigallocatechin-3-Gallate on human breast cancer Cell Line. 2nd national conference on molecular medicine in diagnosis and treatment of diseases, Tehran, Iran. 17 Feb 2015.
(CEMC: 2 points)


17.  Moradzadeh M, Erfanian S, Hoseini A. Evaluation of different levels of Epigallocatechin-3-Gallate on telomerase and bcl2 genes expression in Breast Cancer Cell Line. 3rd International Congress of Immunology, Asthma and Allergy & the First symposium on Food and Drug Allergy, Mashhad, Iran. 3-6 May
2016.


18.  Moradzadeh
M, Sadeghnia HR, Erfanian S, Rakhshandeh H, Hoseini A, Aghaei A. In Vitro Cytotoxic Effects of Cuscuta epithymum whole extract on human acute promyeloblastic leukemia cell Line. 13th International Congress of Immunology and Allergy, Tabriz, Iran. 26-29 April 2016.


19.  Hosseini A, Sadeghnia HR,
Moradzadeh M, Rajabian A. Rheum Turkestanicum Reduces Glutamate Toxicity in PC12 and N2a cell lines. The 3th international neuroinflammation congress & student festival of neuroscience, Mashhad, Iran. 11-13 June 2019.


20.  Moradzadeh M, Erfanian S.
Comparative study of the anti-leukemic effects of kaempferol and Epigallocatechin-3-gallate (EGCG) on Human Leukemia HL-60 Cells. 3rd Hyrcania Medical Laboratory Congress, Gorgan, Iran. 10 Jan 2021.


21.  Moradzadeh M. Differentiation-inducing activity of Epigallocatechin-3-gallate (EGCG) and Kaempferol on NB4 cells. 14th Annual Research Congress of the Eastern Medical Sciences Students. North Khorasan university of medical sciences, Bojnord, Iran. 27 Feb 2021.



Attendance in conferences:




  1. Moradzadeh M. International Diabetic Foot Seminar, Tehran University of Medical Sciences, Tehran, Iran. 2007.
    (CEMC: 9 points)
  2. Moradzadeh M. Third International Seminar on Diabetes News, Tehran University of Medical Sciences, Tehran, Iran. 2007. (CEMC: 6 points)
  3. Moradzadeh M. Pertussis training seminar, Pasteur Institute of Iran, Tehran, Iran. 2007. (CEMC: 1.5 points)
  4. Moradzadeh M. 1st international congress on health genomics and biotechnology, and 4th Iranian Congress of genetic disorders and disabilities, Tehran, Iran. 2007.
  5. Moradzadeh M. 10th Iranian Genetics Congress, Iranian Genetics Society, Tehran, Iran. 2008.
  6. Moradzadeh M. Second Congress of Hircania Laboratory, Golestan University of Medical Sciences, Gorgan, Iran. 3 Oct 2019. (CEMC: 7 points)


Projects



  1. Effect of Crocin and Crocetin on miRNA-15a, miRNA-16-1, bcl-2, p53 genes in EBV infected transformed B cell (CO 88BV59-1 LCL).
    Jahrom University of Medical Sciences, Iran. 2018. (Co-investigator, Supervisor of Ph.D. student)
  2. The effects of crocetin on the gene expression of TLR9 on PBMCs of systemic lupus erythematosus patients. Golestan and Jahrom Universities of Medical Sciences, Iran. 2018. (Co-Investigator, Supervisorof GP student, Joint Project)
  3. The effects of crocetin on the gene expression of TLR3 on PBMCs of systemic lupus erythematosus patients. Golestan and Jahrom Universities of Medical Sciences, Iran. 2019. (PI, Supervisor of GP student, Joint Project)
  4. Study of cytotoxic effect of Janerin by triggering apoptosis in Leukemia cancer cell line HL-60. Golestan and Jahrom Universities of Medical Sciences, Iran. 2019. (PI, Supervisor of GP student, Joint Project)
  5. Study of Anti-proliterative effects of Janerin on Leukemia cancer cell line Jurkat. Golestan and Jahrom Universities of Medical Sciences, Iran. 2019. (PI, Supervisor of GP student, Joint Project)
  6. Study of molecular mechanism of apoptosis induction by cinaropicrin in Leukemic cancer cell line HL-60. Golestan and Jahrom Universities of Medical Sciences, Iran. 2019. (PI, Supervisor of GP student, Joint Project)
  7. Study of the effect of cinaropicrin isolated from Centaurea behen L. on P53 and caspase 3 & 8 genes, and induction of apoptosis in Jurkat cell line. Golestan and Jahrom Universities of Medical Sciences, Iran. 2019. (PI, Supervisor of GP student, Joint Project)
  8. Study of cytotoxic effect of Janerin by triggering apoptosis in Leukemia cancer cell line THP1. Ministry of Science, Research and Technology, Iran. 2019. (PI, Grant)
  9. Study of anti-tumor activity of Cinaropicrin on Leukemia cancer cell line THP1. Golestan University of Medical Sciences, Iran. 2019. (PI, Grant)

10.  Efficacy and safety of Rituximab therapy for patients with systemic sclerosis disease (SSc): Systematic review and meta-analysis. Golestan University of Medical Sciences, Iran. 2018. (PI)


11.  The effect of different doses of crocetin on apoptosis and growth inhibition in acute promyelocytic leukemia cell lines. Jahrom University of Medical Sciences, Iran. 2015. (PI)


12.  The effect of different doses of EGCG on apoptosis and growth inhibition in acute promyelocytic leukemia cell lines. Jahrom University of Medical Sciences, Iran. 2015. (PI)


13.  The effect of different doses of EGCG on apoptosis and growth inhibition in breast cancer T47D cell line. Jahrom University of Medical Sciences, Iran. 2013. (PI)


14.  The effect of crocetin on differentiation and drug resistance genes expression in cells derived from patients with acute promyelocytic leukemia (APL). Mashhad and Golestan Universities of Medical Sciences, Iran. 2014. (PI, Joint Project)


15.  The effect of vitamin C administration on the status of oxidative enzymes in neonate poisoned rats Lead. Golestan University of Medical Sciences, Iran. 2011. (PI)


16.  Evaluation of chromosomal cleavage by radiological imaging of preterm infants during NICU hospitalization in Sayad Hospital of Gorgan. Golestan University of Medical Sciences, Iran. 2019. (Co-Investigator)


17.  The effect of hydro-alcoholic extract of
Aftymon Basil (Cuscuta campestris) on apoptosis and differentiation of acute promyelocytic leukemia cell lines. Mashhad University of Medical Sciences, Iran. 2016. (Co-Investigator)


18.  The effects of hydro-alcoholic extract of Rheum turkestanicum roots on apoptosis and differentiation in acute promyelocytic leukemia cell lines. Mashhad University of Medical Sciences, Iran. 2016. (Co-Investigator)


19.  The effect of galbanum gum on apoptosis and differentiation in acute promyelocytic leukemia cell lines. Mashhad University of Medical Sciences, Iran. 2016. (Co-Investigator)


20.  The hypnotic effect of hydro-alcoholic extract of
Aftymon Basil (Cuscuta campestris) in mice. Mashhad University of Medical Sciences, Iran. 2016. (Co-Investigator(


21.  Effect of hydro alcoholic extract of Urtica dioica on memory, learning and oxidative damage in brain of Rats in a scopolamine-induced memory disorder model. Mashhad University of Medical Sciences, Iran. 2016. (Co-Investigator)


22.  The effect of different doses of crocetin on stem cell differentiation. Jahrom University of Medical Sciences, Iran. 2015. (Co-Investigator)


23.  The effect of different doses of EGCG on telomerase in breast cancer T47D cell line.
Jahrom University of Medical Sciences, Iran. 2014. (Co-Investigator)


24.  The comparison of serum markers and vitamins A and E in patients with inflammatory bowel disease and irritable bowel syndrome in Golestan province. Golestan University of Medical Sciences, Iran. 2010. (Co-Investigator)


25.  The measurement of serum magnesium, calcium, iron and zinc in children with febrile convulsion referred to Taleghani Hospital. Golestan University of Medical Sciences, Iran. 2010. (Co-Investigator)


26.  Comparison of serum levels of vitamins A, E and lipid profiles in cardiovascular patients with healthy people. Golestan University of Medical Sciences, Iran. 2010. (Co-Investigator)


27.  Effect NGEN on apoptosis and gene expression of telomerase in breast cancer cell line. Golestan University of Medical Sciences, Iran. 2010. (Co-Investigator)


28.  Evaluation of P-gp and MRP1 gene expression in patients with acute drug-resistant leukemia in adults and children before and after chemotherapy in Golestan province. Golestan University of Medical Sciences, Iran. 2010. (Co-Investigator)


29.  Effect of metformin on cell cycle apoptotic process in T47D breast cancer cell line. Golestan University of Medical Sciences, Iran. 2010. (Co-Investigator)


30.  Determination of apolipoprotein E polymorphism and its relationship with serum lipid profile in Turkmen in Golestan province. Golestan University of Medical Sciences, Iran. 2010. (Co-Investigator)


31.  Comparison of serum biological markers in healthy and breast cancer patients referred to hospitals and medical centers in Gorgan. Golestan University of Medical Sciences, Iran. 2010. (Co-Investigator)


32.  The thermotherapy of cancer using gold plated silicon dioxide nanoparticles and antibody against human epidermal growth factor 1 and 2. Tehran University of Medical Sciences, Iran. 2006. (Co-Investigator)



   Reviewer of Journals:



  1. Journal of cellular physiology. (IF: 5.5, Q1) (2 papers)
  2. Journal of Cellular Biochemistry. (IF: 4.2, Q2)
  3. International Journal of Oncology. (IF: 3.8, Q2) (2 papers)
  4. Oncology Reports. (IF: 3.4, Q1) (3 papers)
  5. Cancer Med. (IF: 3.4, Q1)
  6. Journal of Biomedical Materials Research: Part B – Applied Biomaterials.
    (IF: 2.8, Q2)
  7. Oncology letters. (IF: 2.3, Q3) (11 papers)
  8. BioMed Research International. (IF: 2.2, Q2)
  9. Molecular Medicine Reports. (IF: 2.1, Q3) (4 papers)

10.  Experimental and Therapeutic Medicine.
(IF: 1.7, Q2)


11. Molecular and Clinical Oncology.
(ISI) (3 papers)


12. Biomedical Reports. (ISI)


13. Asian Pacific Journal of cancer Prevention. (PubMed) (3 papers)


14. Medicine International.


15. Jorjani Biomedicine Journal. (7
papers)


16. Pars Journal of Medical Sciences.



Staff Board:



  1. 2021: Reviewer board of 14th Annual Research Congress of the Eastern Medical Sciences Students. North Khorasan university of medical sciences, Bojnord, Iran.
  2. 2021-until now: Founding Board of
    Joint, Bone, Connective tissue, Rheumatology Research Center (JBCRC), Golestan University of Medical Sciences, Gorgan, Iran.
  3. 2018- until now: Editorial board of Jorjani Biomedicine Journal, Gorgan, Iran.
  4. 2018-until now:
    Reviewer board of Golestan University of Medical Sciences, Gorgan, Iran.


Workshop instructor:



  1. 2021:

1-1- Oral & poster presentation. Golestan University of Medical Sciences, Gorgan, Iran.


1-2- Real time PCR. Golestan University of Medical Sciences, Gorgan, Iran.


1-3- Primer design. Golestan University of Medical Sciences, Gorgan, Iran.



  1. 2014: Gene Therapy. Jahrom
    University of Medical Sciences, Jahrom, Iran.


Member of the Scientific Committee



  1. International Federation of Inventors' Associations (IFIA).
  2. Iranian Inventors Associations (IIA).
  3. Iranian Genetics Society (IGS).
  4. Biochemical Society of Iran (BSI).
  5. Iranian Society of Biology (ISB).
  6. Iranian Laboratory Research Society (ILRS).
  7. Iranian Society for Immunology and Allergy (ISIA).
  8. Iranian Society of Physiology & Pharmacology (ISPP).
  9. Biosafety Society of Iran (BSI).

10.  Iranian Medicinal Plants Society (IMPS).


11.  Iranian Society of Neuroscience (ISN).


12.  Iranian Biotechnology Society (IBS).


13.  Iranian Health Education and Promotion Association (IHEPA)


14.  The Iranian Association of Medical Law (IAML).


15.  Global Burden of Disease (GBD) Collaborator Network.


16.  Universal Scientific Education and Research Network (USERN).



Workshops



  1. Cultural Point

1.1.2018: Research Ethics (10 h). Golestan University of Medical Sciences, Gorgan, Iran.


1.2.2019: How to submit articles in prestigious scientific journals How to judge articles with research ethics approach
(3.5 h); Familiarity with marketing concepts
(1 h); The nature and form of the Islamic Revolution (12 h, Supreme Leader); Jihadi camp command system in the incident and crisis management executive programs in the health system
(6 h); Designing epidemiological studies in crisis and disasters (2 h); Laboratory Animal Ethic (5.5 h); Iranian and Complementary Medicine (7.5 h); Analysis of current political issues
(2 h, Supreme Leader). Golestan University of Medical Sciences, Gorgan, Iran.


1.3.2020: Ethics in Entrepreneurship
(6 h); Ethical workshop (22 h, 2.75 points, [includes: Ethical requirements in clinical education in crisis conditions; Ethics in providing health care services in a corona epidemic condition; Ethics in teaching student relationship communication skills with the cyberspace approach; Conscious satisfaction in research and treatment; Ethics in publishing research works; Ethical challenges of educating and treating patients together in the teaching and medical hospital of the country; Ethical considerations in diagnostic and therapeutic surgery in cancer patients; A practical approach to solving ethical challenges; Organizational ethics; Student Scientific Ethics Ethics in Research; Ethics and art, the role of using the arts in ethics and medicine]); Hosseini Virtual Tent-6 (1h). Golestan University of Medical Sciences, Gorgan, Iran.


1.4.2021:
11th Simorgh festival.
Golestan University of Medical Sciences, Gorgan, Iran.




  1. Empowering Professors

2.1.2018: Internal evaluation of training groups (2h). Golestan University of Medical Sciences, Gorgan, Iran.


2.2.2019: Implement a research project in education (2h); Understanding student-centered teaching methods (2h); e-learning (2h); Methods for evaluating of test learning
(Written-oral-practical) (2h); Methods for evaluating of test learning (OSCE-DOPS) (2 h); Evidenced based medicine (EBM) (2 h); Google's tools in training and learning management system Navid
(4h). Golestan University of Medical Sciences, Gorgan, Iran.


2.3. 2020: Problem based learning-PBL (2 h); reviewing and response to review of scientific articles (3 h).
Golestan University of Medical Sciences, Gorgan, Iran.




  1. General:

3.1.2000:
General First Aid Course (50 h). Red Crescent Organization, Gonbad-e kavus, Golestan province, Iran.


3.2.2003: International Computer Driving Licence (ICDL) (160h, score: 92). Technical and Vocational Education Organization, Gonbad-e kavus, Golestan province, Iran.


3.3.2007:
Introduction to Advanced Molecular and Cytogenetic Techniques: Applications in Clinic. The National Molecular Medicine Network and Pasteur's Institute, Tehran, Iran.


3.4.2010


3.4.1.      Real Time PCR (8h);
quality control of volumetric base tools (Podman, 8h); Physical mobility and
prevention of Cardiovascular Diseases (8h). Golestan University of Medical Science, Gorgan, Iran.


3.4.2.      Liquid volume calibration; SDS-PAGE and Western Blot & Laboratory Animals Experimentation & Real-time PCR & Real-time PCR Primer and Probe Design. Summer school of Pasteur's Institute, Tehran, Iran.


3.4.3.      Lentivirus in gene therapy (23h). Ferdowsi University of Mashhad, Mashhad, Iran.


3.5.2011


3.5.1.      HPLC technique (8h). Innovation and Entrepreneurship Development Center of Science and Technology Park, University of Tehran, Tehran, Iran.


3.5.2.   How to Invent and Use International Inventions and Databases (3 h);
Civil Service Management (Podmani, score: 81, 8h); The system of targeting subsidies (Podmani, score: 77, 8h); Modify consumption patterns (Podmani, score: 79, 8h).
Golestan University of Medical Sciences, Gorgan, Iran.


3.6.2012: Electronic Signature. Mashhad University of Medical Sciences, Mashhad, Iran.


3.7.2013


3.7.1.      Isolation and Culture of Mesenchymal Stem Cell from Rat Bone Marrow; In vitro fertilization in mice, Jahrom University of Medical Sciences, Jahrom, Iran.


3.7.2.      Molecular aspects of the metabolic syndrome (Advanced school); Safety principles in biological technologies; Research Idea (4h), Medical Journalism (12h). Mashhad University of Medical Sciences, Mashhad, Iran.


3.8.    2014: Biotechnology is a new approach in medical sciences;
Real Time PCR technique (4h); MicroRNA Analysis using Real Time PCR (4h); Molecular phylogeny with Geneious software (4h);
Primer design with Primer3 software (4h);
Middle Cerebral Artery Occlusion Model in RAT; Plagiarism (4h); Data Analysis in medical sciences (12h); Simulation of Genome Wide Association studies using HapMap Data; Bioinformatics application in cloning using Geneious software
(4h); Zotero software (4h); Systematic Review and Meta-analysis (12h); Cochrane standard training;
Scientific writing (12h). Mashhad University of Medical Sciences, Mashhad, Iran.


3.9.2015: Electronic Questionnaire (2h); Professional Word (2h); Resume Writing (2h); Methods and strategies of export management and international marketing (5h). Mashhad University of Medical Sciences, Mashhad, Iran.


3.10.     2016: Prism Statistical Software (2h); Reference management (Endnote) (2h); Scopus (2h); ISI (2h).Mashhad University of Medical Sciences, Mashhad, Iran.


3.11.     2017: Systematic Review and Met-analysis (96h). Golestan University of Medical Sciences, Gorgan, Iran. 


3.12.     2018:
Application of bioinformatics in esophagus cancer (8h); Clear and successful scientific writing (National Institute for Medical Research Development [NIMAD]). Golestan University of Medical Sciences, Gorgan, Iran. 


3.13.     2019:
Marketing concepts (8h); Design and testing of diagnostic tests (8h); Sampling techniques, calculation of sample number and power in research studies with software
medcalc and stata (8h); Design Expert (8h). Golestan University of Medical Sciences, Gorgan, Iran.


3.14.     2020:
Ethics in clinical trials (2h); What are the strategies for conducting accountable research?
(2h); Familiarity with concepts and intellectual property (4h); Familiarity with business models
(4h); Understand the importance of marketing
(4h); Familiarity with different types of entrepreneurship (3h); Familiarity with the idea and creativity of exploiting technological opportunities (4h); Research to achieve universal health coverage (2h); Our research meets which health needs? (2h); Application of Geographic Information System (7h); Wealth-building beliefs
(2h); Knowledge translator (1 day-2h); Establishment of registration and pillars of commercial companies
(1 day); Intellectual property and patents
(1 day); Knowledge Based Companies (1 day); Marketing
(1 day); Ethics in research (2h); Researcher (1 day); Ethics in animal research and the principles of correct publication of results (2h); Nutrition and respiratory diseases (3h). Golestan University of Medical Sciences, Gorgan, Iran. 


3.15.     2021:


3.15.1.  Physiologic medium to study human cell biology, Scientific social networking website and producer of educational virtual events and webinars (Labroots).


3.15.2.1.                 International lecturer “Preclinical Imaging of Brown Adipose Tissue & Pancreatic Islets”, TUMS Preclinical Core Facility, Tehran, Iran.


3.15.2.2.                 International lecturer “Probing tumor microstructure using diffusion MRI”, TUMS Preclinical Core Facility, Tehran, Iran.


3.15.3.  Tissue Engineering & Regenerative Medicine, Royan-TESMA International Joint Webinar, Tehran, Iran.



References:



  • Dr. Alijan Tabaraei

Associate Professor in Medical Viorology


Department of Microbiology, Faculty of Medicine, Gorgan University of Medical Sciences,


Gorgan, Iran. Tel: 0098 17 3243 6241, Fax: 0098 17 3244 0721. E-mail:
[email protected]



  • Dr. Hamid Reza Sadeghnia

Associate Professor in Clinical Pharmacology


Pharmacology Department and Department of New Sciences and Technology,


Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


Tel: 0098 51 3882 8566, Fax: 0098 51 3882 8567. E-mail:
[email protected]



  • Dr. Ashraf Mohamadkhani

Assistant Professor in Molecular Genetics


Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Tel: 0098 21 8241 5227, Fax: 0098 21 8241 5400. E-mail:
[email protected]


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